(5R)-5-hydroxytriptolide inhibits IFN-γ-related signaling

Acta Pharmacologica Sinica

Volumn 27, Issue 12, 2006, Pages 1616-1621

  Zhou, Ru ^a   Wang, Jun Xia ^a   Tang, Wei ^a   He, Pei Lan ^a   Yang, Yi Fu ^a   Li, Yuan Chao ^a   Li, Xiao Yu ^a   Zuo, Jian Ping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

(5R) 5 hydroxytriptolide; Chemokine; IFN ; MAPK

Indexed keywords

5 HYDROXYTRIPTOLIDE; CD3 ANTIBODY; CD3 ANTIGEN; CD40 LIGAND; CD69 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOSUPPRESSIVE AGENT; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 2 RECEPTOR ALPHA; LLDT 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OVALBUMIN; STAT1 PROTEIN; STAT4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; T BOX TRANSCRIPTION FACTOR; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOMODULATION; INTERFERON PRODUCTION; LYMPH NODE CELL; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL DIVISION; DITERPENES; FEMALE; INTERFERON TYPE II; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES;

EID: 33751368318     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00457.x     Document Type: Article

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