Trans-differentiation of adult stem cells - Is it possible that cells become more naive?;Trans-differenzierung von adulten stammzellen - Ist eine veränderung in richtung naiverer zellen möglich?

Journal fur Reproduktionsmedizin und Endokrinologie

Volumn 3, Issue 5, 2006, Pages 324-330

  Koestenbauer, Sonja ^a   Zech, N H ^b   Dohr, G ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

Author keywords

De differentiation; Fusion; Stem cell plasticity; Trans differentiation

Indexed keywords

CELL CULTURE; CELL DIFFERENTIATION; CELL FUSION; CELL TRANSPLANTATION; EUPHORIA; GERM LAYER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE SPECIFICITY;

EID: 33751335423     PISSN: 18102107     EISSN: 18109292     Source Type: Journal    
DOI: None     Document Type: Review

References (96)

1. Zech N. Adult stem cell manipulation and possible clinical perspectives. J Reproduktionsmed Endokrinol 2004; 1: 91-9.
2. Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 1957; 257: 491-6.
3. Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963; 197: 452-4.
4. Siminovitch L, McCulloch EA, Till JE. The distribution of colony-forming cells among spleen colonies. J Cell Physiol 1963; 62: 327-36.
5. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-6.
6. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78: 7634-8.
7. Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 321: 1174-8.
8. Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996; 380: 64-6.
9. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145-7.
10. Gage FH. Mammalian neural stem cells. Science 2000; 287: 1433-8.
11. Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006; 441: 1068-74.
12. Wernig M, Scheffler B, Brüstle O. Medizinische Perspektiven der Stammzellforschung. In: Ganten D, Ruckpaul K (Hrsg). Grundlagen der Molekularen Medizin. Springer-Verlag, Berlin, 2003; 680-710.
13. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature 2001; 414: 98-104.
14. Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science 2000; 287: 1427-30.
15. Raff M. Adult stem cell plasticity: fact or artifact? Annu Rev Cell Dev Biol 2003; 19: 1-22.
16. Zech N. Plasticity of stem cells: cell-fusion versus transdifferentiation. J Reproduktionsmed Endokrinol 2005; 2: 239-45.
17. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998; 279: 1528-30.
18. Bhatia M, Wang JC, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA 1997; 94: 5320-5.
19. Grompe M. Pancreatic-hepatic switches in vivo. Mech Dev 2003; 120: 99-106.
20. Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF, Kunkel LM, Mulligan RC. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999; 401: 390-4.
21. Nilsson SK, Johnston HM, Coverdale JA. Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood 2001; 97: 2293-9.
22. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701-5.
23. Overturf K, al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997; 151: 1273-80.
24. Shen CN, Horb ME, Slack JM, Tosh D. Transdifferentiation of pancreas to liver. Mech Dev 2003; 120: 107-16.
25. Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J, Wright NA. Hepatocytes from non-hepatic adult stem cells. Nature 2000; 406: 257.
26. Austin TW, Lagasse E. Hepatic regeneration from hematopoietic stem cells. Mech Dev 2003; 120: 131-5.
27. Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999; 283: 534-7.
28. Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000; 290: 1775-9.
29. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369-77.
30. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229-34.
31. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779-82.
32. Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002; 109: 1291-302.
33. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, Scott EW. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002; 416: 542-5.
34. Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature 2002; 416: 545-8.
35. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez-Buylla A. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425: 968-73.
36. Vassilopoulos G, Russell DW. Cell fusion: an alternative to stem cell plasticity and its therapeutic implications. Curr Opin Genet Dev 2003; 13: 480-5.
37. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003; 422: 897-901.
38. Matsuya Y, Green H, Basilico C. Properties and uses of human-mouse hybrid cell lines. Nature 1968; 220: 1199-202.
39. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495-7.
40. Johnson PA, Andrews PW. Cell fusion and the differentiated state. In: Lanza R, Blau H, Gearhart J, Hogan B, Melton D, Moore M, Pedersen R, Thomas ED, Thomson J, Verfaillie C, Weissman I, West M (eds). Handbook of Stem Cells. Vol 1. Elsevier Academic Press, Amsterdam, 2004; 111-8.
41. Avital I, Inderbitzin D, Aoki T, Tyan DB, Cohen AH, Ferraresso C, Rozga J, Arnaout WS, Demetriou AA. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophys Res Commun 2001; 288: 156-64.
42. Sugie Y, Yoshikawa M, Ouji Y, Saito K, Moriya K, Ishizaka S, Matsuura T, Maruoka S, Nawa Y, Hara Y. Photoreceptor cells from mouse ES cells by co-culture with chick embryonic retina. Biochem Biophys Res Commun 2005; 332: 241-7.
43. Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 2004; 6: 532-9.
44. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 2004; 430: 350-6.
45. Badorff C, Brandes RP, Popp R, Rupp S, Urbich C, Aicher A, Fleming I, Busse R, Zeiher AM, Dimmeler S. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation 2003; 107: 1024-32.
46. Koh SH, Choi HS, Park ES, Kang HJ, Ahn HS, Shin HY. Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. Biochem Biophys Res Commun 2005; 329: 1039-45.
47. Sigurjonsson OE, Perreault MC, Egeland T, Glover JC. Adult human hematopoietic stem cells produce neurons efficiently in the regenerating chicken embryo spinal cord. Proc Natl Acad Sci USA 2005; 102: 5227-32.
48. Yokoo T, Ohashi T, Shen JS, Sakurai K, Miyazaki Y, Utsunomiya Y, Takahashi M, Terada Y, Eto Y, Kawamura T, Osumi N, Hosoya T. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci USA 2005; 102: 3296-300.
49. Priller J, Persons DA, Klett FF, Kempermann G, Kreutzberg GW, Dirnagl U. Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J Cell Biol 2001; 155: 733-8.
50. Weimann JM, Johansson CB, Trejo A, Blau HM. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol 2003; 5: 959-66.
51. Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 2004; 305: 90-3.
52. Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA 1999; 96: 14482-6.
53. Pang W. Role of muscle-derived cells in hematopoietic reconstitution of irradiated mice. Blood 2000; 95: 1106-8.
54. Asakura A, Seale P, Girgis-Gabardo A, Rudnicki MA. Myogenic specification of side population cells in skeletal muscle. J Cell Biol 2002; 159: 123-34.
55. McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci USA 2002; 99: 1341-6.
56. Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA. Pax7 is required for the specification of myogenic satellite cells. Cell 2000; 102: 777-86.
57. Morrison SJ. Stem cell potential: can anything make anything? Curr Biol 2001; 11: R7-R9.
58. Medvinsky A, Smith A. Stem cells: fusion brings down barriers. Nature 2003; 422: 823-5.
59. Wurmser AE, Gage FH. Stem cells: cell fusion causes confusion. Nature 2002; 416: 485-7.
60. Hoofnagle MH, Wamhoff BR, Owens GK. Lost in transdifferentiation. J Clin Invest 2004; 113: 1249-51.
61. Alison MR, Poulsom R, Otto WR, Vig P, Brittan M, Direkze NC, Preston SL, Wright NA. Plastic adult stem cells: will they graduate from the school of hard knocks? J Cell Sci 2003; 116: 599-603.
62. Hawley RG, Sobieski DA. Somatic stem cell plasticity: to be or not to be. Stem Cells 2002; 20: 195-7.
63. Eisenberg LM, Eisenberg CA. Stem cell plasticity, cell fusion, and transdifferentiation. Birth Defects Res C Embryo Today 2003; 69: 209-18.
64. Brockes JP. Amphibian limb regeneration: rebuilding a complex structure. Science 1997; 276: 81-7.
65. Brockes JP, Kumar A. Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nat Rev Mol Cell Biol 2002; 3: 566-74.
66. Eguchi G, Kodama R. Transdifferentiation. Curr Opin Cell Biol 1993; 5: 1023-8.
67. Stone LS. An investigation recording all salamanders which can and cannot regenerate a lens from the dorsal iris. J Exp Zool 1967; 164: 87-103.
68. Stroeva OG, Mitashov VI. Retinal pigment epithelium: proliferation and differentiation during development and regeneration. Int Rev Cytol 1983; 83: 221-93.
69. Echeverri K, Tanaka EM. Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science 2002; 298: 1993-6.
70. Dupin E, Glavieux C, Vaigot P, Le Douarin NM. Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor. Proc Natl Acad Sci USA 2000; 97: 7882-7.
71. Dupin E, Real C, Glavieux-Pardanaud C, Vaigot P, Le Douarin NM. Reversal of developmental restrictions in neural crest lineages: transition from Schwann cells to glial-melanocytic precursors in vitro. Proc Natl Acad Sci USA 2003; 100: 5229-33.
72. Kai T, Spradling A. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries. Nature 2004; 428: 564-9.
73. Aguayo AJ, Epps J, Charron L, Bray GM. Multipotentiality of Schwann cells in cross-anastomosed and grafted myelinated and unmyelinated nerves: quantitative microscopy and radioautography. Brain Res 1976; 104: 1-20.
74. Weinberg HJ, Spencer PS. Studies on the control of myelinogenesis. II. Evidence for neuronal regulation of myelin production. Brain Res 1976; 113: 363-78.
75. Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982; 30: 215-24.
76. Matsui Y, Zsebo K, Hogan BL. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 1992; 70: 841-7.
77. Donovan PJ. Growth factor regulation of mouse primordial germ cell development. Curr Top Dev Biol 1994; 29: 189-225.
78. Shamblott MJ, Axelman J, Wang S, Bugg EM, Littlefield JW, Donovan PJ, Blumenthal PD, Huggins GR, Gearhart JD. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 1998; 95: 13726-31.
79. Kondo T, Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 2000; 289: 1754-7.
80. Gat U, DasGupta R, Degenstein L, Fuchs E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 1998; 95: 605-14.
81. Zhu AJ, Watt FM. beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 1999; 126: 2285-98.
82. Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlstrom H, Lendahl U, Frisen J. Generalized potential of adult neural stem cells. Science 2000; 288: 1660-3.
83. Geiger H, Sick S, Bonifer C, Muller AM. Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts. Cell 1998; 93: 1055-65.
84. Harder F, Henschler R, Junghahn I, Lamers MC, Muller AM. Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts. Blood 2002; 99: 719-21.
85. Pochampally RR, Neville BT, Schwarz EJ, Li MM, Prockop DJ. Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion. Proc Natl Acad Sci USA 2004; 101: 9282-5.
86. Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol 2005; 23: 699-708.
87. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433: 760-4.
88. Galli R, Borello U, Gritti A, Minasi MG, Bjornson C, Coletta M, Mora M, De Angelis MG, Fiocco R, Cossu G, Vescovi AL. Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurosci 2000; 3: 986-91.
89. Ball SG, Shuttleworth AC, Kielty CM. Direct cell contact influences bone marrow mesenchymal stem cell fate. Int J Biochem Cell Biol 2004; 36: 714-27.
90. Mikkola I, Heavey B, Horcher M, Busslinger M. Reversion of B cell commitment upon loss of Pax5 expression. Science 2002; 297: 110-3.
91. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 2002; 298: 597-600.
92. Melton D, Cowan C. "Stemness": definition, criteria and standards. In: Lanza JG, Hogan B, Melton D, Pedersen R, Thomson J, West M (eds). Handbook of stem cells. Vol 1. Elsevier Academic Press, Amsterdam, 2004; xxv-xxxi.
93. Inzunza J, Gertow K, Stromberg MA, Matilainen E, Blennow E, Skottman H, Wolbank S, Ahrlund-Richter L, Hovatta O. Derivation of human embryonic stem cell lines in serum replacement medium using postnatal human fibroblasts as feeder cells. Stem Cells 2005; 23: 544-9.
94. Stojkovic P, Lako M, Stewart R, Przyborski S, Armstrong L, Evans J, Murdoch A, Strachan T, Stojkovic M. An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells. Stem Cells 2005; 23: 306-14.
95. Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med 2005; 11: 228-32.
96. Zech NH, Koestenbauer S, Vanderzwalmen P, Schoonjans L, Danloy S, Zech H, Blaschitz A, Dohr G. Paraffin-embedded manipulated blastocysts: a tool to demonstrate stem cell plasticity? Reprod Biomed Online 2005; 10: 406-14.