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Volumn 298, Issue 5600, 2002, Pages 1993-1996

Ectoderm to mesoderm lineage switching during axolotl tail regeneration

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; MUSCLE;

EID: 0037032827     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077804     Document Type: Article
Times cited : (195)

References (28)
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    • note
    • In this system, the GFAP promoter drives expression of the Gal4-VP16 gene and GFP is driven by the Gal4UAS. Inclusion of the Gal4-VP16 enhancer system ensured that GFP persisted, even if cells tumed off the GFAP promoter and transdifferentiated, because of high levels of the Gal4-VP16 protein initially produced.
  • 27
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    • note
    • In most examples, the labeled cells migrated out to a certain point in the regenerate and then started dividing 2 to 4 days postamputation. In many examples, during spinal cord regeneration we observed one GFAP-positive radial glial cell giving rise to 8 to 10 progeny.
  • 28
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    • note
    • We thank R. Koster and M. Matyash for the kind gifts of plasmids. We are grateful to H. Andreas for dedicated axolotl care and to F. Buchholz, J. Clarke, and A. Hyman for critical reading of the manuscript. This work was funded by grant TA 274/1-1 from the Deutsche Forschungsgemeinschaft.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.