Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts

Aging Cell

Volumn 5, Issue 6, 2006, Pages 451-461

  Rhim, Ji Heon ^a   Jang, Ik Soon ^b   Yeo, Eui Ju ^c   Song, Kye Yong ^d   Park, Sang Chul ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Gachon University College of Medicine   (South Korea)

^d Chung Ang University College of Medicine   (South Korea)

Author keywords

A kinase anchoring proteins; Adenylyl cyclase; CAMP; Lysophosphatidic acid; Protein kinase C; Senescence; Small interference RNA

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; LYSOPHOSPHATIDIC ACID; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; SMALL INTERFERING RNA;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL AGING; CONTROLLED STUDY; DATA ANALYSIS; DIPLOIDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENYLATE CYCLASE; ANIMALS; CELL AGING; CELL CYCLE PROTEINS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIPLOIDY; DOWN-REGULATION; FIBROBLASTS; HUMANS; INFANT, NEWBORN; LYSOPHOSPHOLIPIDS; MALE; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33751219924     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2006.00239.x     Document Type: Article

References (50)

1. An S, Bleu T, Zheng Y, Goetzl EJ (1998) Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol. Pharmacol. 54, 881-888.
2. Beazely MA, Alan JK, Watts VJ (2005) Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells. Mol. Pharmacol. 67, 250-259.
3. Bol GF, Gros C, Hulster A, Bosel A, Pfeuffer T (1997a) Phorbol ester-induced sensitisation of adenylyl cyclase type II is related to phosphorylation of threonine 1057. Biochem. Biophys. Res. Commun. 237, 251-256.
4. Bol GF, Hulster A, Pfeuffer T (1997b) Adenylyl cyclase type II is stimulated by PKC via C-terminal phosphorylation. Biochim. Biophys. Acta 1358, 307-313.
5. Boyce ST, Ham RG (1983) Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J. Invest. Dermatol. 81, 33s-40s.
6. Carlson CR, Ruppelt A, Tasken K (2003) A kinase anchoring protein (AKAP) interaction and dimerization of the RIα and RIβ regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J. Mol. Biol. 327, 609-618.
7. Carnegie GK, Scott JD (2003) A-kinase anchoring proteins and neuronal signaling mechanisms. Genes Dev. 17, 1557-1568.
8. Chou JL, Huang CL, Lai HL, Hung AC, Chien CL, Kao YY, Chern Y (2004) Regulation of type VI adenylyl cyclase by Snapin, a SNAP25-binding protein. J. Biol. Chem. 279, 46271-46279.
9. Chun J, Contos JJ, Munroe D (1999) A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem. Biophys. 30, 213-242.
10. Clegg RA, Gardner RA, Sumathipala RN, Lavialle F, Boisgard R, Ollivier-Bousquet M (2000) Targeting of PKA in mammary epithelial cells. Mechanisms and functional consequences. Adv. Exp. Med. Biol. 480, 99-105.
11. Coghlan VM, Perrino BA, Howard M, Langeberg LK, Hicks JB, Gallatin WM, Scott JD (1995) Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267, 108-111.
12. Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J (2002) Characterization of lpa (2) (Edg4) and lpa (1)/lpa (2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to lpa (2). Mol. Cell Biol. 22, 6921-6929.
13. Dodge K, Scott JD (2000) AKAP79 and the evolution of the AKAP model. FEBS Lett. 476, 58-61.
14. Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR (1997) Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 16, 35-43.
15. Edwards AS, Scott JD (2000) A-kinase anchoring proteins: Protein kinase A and beyond. Curr. Opin. Cell Biol. 12, 217-221.
16. Faux MC, Rollins EN, Edwards AS, Langeberg LK, Newton AC, Scott JD (1999) Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. Biochem. J. 343 (Pt 2), 443-452.
17. 2+/Calmodulin. J. Biol. Chem. 272, 17038-17044.
18. Fukushima N, Chun J (2001) The LPA receptors. Prostaglandins 64, 21-32.
19. Goetzl EJ, An S (1998) Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12, 1589-1598.
20. Grove BD, Bruchey AK (2001) Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells. J. Vasc. Res. 38, 163-175.
21. Hansson V, Skalhegg BS, Tasken K (2000) Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA. J. Steroid Biochem. Mol. Biol. 73, 81-92.
22. Higashida H, Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J (2005) Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Neurosci. Res. 51, 231-234.
23. q protein function. Mol. Pharmacol. 59, 294-301.
24. Jacobowitz O, Iyengar R (1994) Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl Acad. Sci. USA 91, 10630-10634.
25. Jang IS, Juhnn YS (2001) Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha. Exp. Mol. Med. 33, 37-45.
26. Jang IS, Rhim JH, Kim KT, Cho KA, Yeo EJ, Park SC (2006a) Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. Mech. Ageing Dev. 127, 481-489.
27. Jang IS, Rhim JH, Park SC, Yeo EJ (2006b) Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts. Exp. Mol. Med. 38, 134-143.
28. Jang IS, Yeo EJ, Park JA, Ahn JS, Park JS, Cho KA, Juhnn YS, Park SC (2003) Altered cAMP signaling induced by lysophosphatidic acid in senescent human diploid fibroblasts. Biochem. Biophys. Res. Commun. 302, 778-784.
29. Keryer G, Rios RM, Landmark BF, Skalhegg B, Lohmann SM, Bornens M (1993) A high-affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II in the centrosome of human cells. Exp. Cell Res. 204, 230-240.
30. Kranenburg O, Moolenaar WH (2001) Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 20, 1540-1546.
31. Li Y, Ndubuka C, Rubin CS (1996) A kinase anchor protein 75 targets regulatory (RII) subunits of cAMP-dependent protein kinase II to the cortical actin cytoskeleton in non-neuronal cells. J. Biol. Chem. 271, 16862-16869.
32. Lin WW, Chang SH, Wang SM (1999) Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages. Br. J. Pharmacol. 128, 1189-1198.
33. Michel JJ, Scott JD (2002) AKAP mediated signal transduction. Annu. Rev. Pharmacol. Toxicol. 42, 235-257.
34. Nauert JB, Klauck TM, Langeberg LK, Scott JD (1997) Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr. Biol. 7, 52-62.
35. Nietgen GW, Durieux ME (1998) Intercellular signaling by lysophosphatidate. Cell Adhes. Commun. 5, 221-235.
36. Piontek J, Brandt R (2003) Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development. J. Biol. Chem. 278, 38970-38979.
37. Randall G, Grakoui A, Rice CM (2003) Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc. Natl Acad. Sci. USA 100, 235-240.
38. Ruehr ML, Russell MA, Bond M (2004) A-kinase anchoring protein targeting of protein kinase A in the heart. J. Mol. Cell Cardiol. 37, 653-665.
39. Scott JD, Dell'Acqua ML, Fraser ID, Tavalin SJ, Lester LB (2000) Coordination of cAMP signaling events through PKA anchoring. Adv. Pharmacol. 47, 175-207.
40. Skalhegg BS, Tasken K (2000) Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA. Front. Biosci. 5, D678-D693.
41. Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF (2005) Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression. J. Biol. Chem. 280, 16962-16968.
42. Takebayashi T, Higashi H, Sudo H, Ozawa H, Suzuki E, Shirado O, Katoh H, Hatakeyama M (2003) NF-κ B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants. J. Biol. Chem. 278, 14897-14905.
43. Tao J, Wang HY, Malbon CC (2003) Protein kinase A regulates AKAP250 (gravin) scaffold binding to the β2-adrenergic receptor. EMBO J. 22, 6419-6429.
44. Taussig R, Iniguez-Lluhi JA, Gilman AG (1993) Inhibition of adenylyl cyclase by Gi alpha. Science 261, 218-221.
45. Ulfig N, Setzer M (1999) Expression of a kinase anchoring protein 79 in the human fetal amygdala. Microsc. Res. Tech. 46, 48-52.
46. q protein in the heart of streptozotocin-induced diabetic rats. Exp. Mol. Med. 31, 179-184.
47. Yang HS, Hinds PW (2003) Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol. Cell 11, 1163-1176.
48. Yang M, Zhong WW, Srivastava N, Slavin A, Yang J, Hoey T, An S (2005) G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway. Proc. Natl Acad. Sci. USA 102, 6027-6032.
49. Yeo EJ, Hwang YC, Kang CM, Choy HE, Park SC (2000) Reduction of UV-induced cell death in the human senescent fibroblasts. Mol. Cells 10, 415-422.
50. Yeo EJ, Park SC (2002) Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: Emergence of the gate theory of aging. Mech. Ageing Dev. 123, 1563-1578.