Increased expression of Gαq protein in the heart of streptozotocin-induced diabetic rats

Experimental and Molecular Medicine

Volumn 31, Issue 4, 1999, Pages 179-184

  Yang, Jung Mee ^a   Cho, Chin Ho ^a   Kong, Kyoung Ae ^a   Jang, Ik Soon ^a   Kim, Hae Won ^b   Juhnn, Yong Sung ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

Calcium calmodulin dependent protein kinase II; cAMP dependent protein kinase; G proteins; Protein kinase; Protein kinase C; Streptozotocin induced diabetes

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; PROTEIN KINASE C; STREPTOZOCIN; CALMODULIN DEPENDENT PROTEIN KINASE I; CALMODULIN-DEPENDENT PROTEIN KINASE I; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; ENZYME ACTIVITY; INSULIN TREATMENT; LIVER; MALE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SECOND MESSENGER; STREPTOZOCIN DIABETES; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HEART MUSCLE; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; INSULIN; LIVER; MALE; MYOCARDIUM; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 0033621277     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1999.29     Document Type: Article

References (27)

1. Aydin, S., Ozturk, Y., Altan, V. M., Yildizoglu-Ari, N. and Ozcelikay, A. T. (1996) Effect of insulin treatment on smooth muscle calmodulin levels in rats with long-term streptozotocin-diabetes. Mol. Cell. Endocrinol. 116: 67-71
2. Berman, D. M. and Gilman, A. G. (1998) Mammalian RGS proteins: barbarians at the gate. J. Biol. Chem. 273: 1269-1272
3. Brownlee, M., Cerami, A. and Vlassara, H. (1988) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 318: 1315-1321
4. Cohen, P. (1978) The role of cyclic-AMP-dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle. Curr. Top. Cell. Regul. 14: 117-196
5. Considine, R. V., Nyce, M. R., Allen, L. E., Morales, L. M., Triester, S., Serrano, J., Colberg, J., Lanza-Jacoby, S. and Caro, J. F. (1995) Protein kinase C is increased in the liver of humans and rats with non- insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. J. Clin. Invest. 95: 2938-2944
6. Fu, L. X., Bergh, C. H., Liang, Q. M., Sjogren, K. G., Xu, X., Eriksson, P., Hoebeke, J. and Hjalmarson, A. (1994) Diabetes-induced changes in the Gi-modulated muscarinic receptor-adenylyl cyclase system in rat myocardium. Pharmacol. Toxicol. 75: 186-193
7. Gabbay, R. A., Siconolfi-Baez, L. and Lebovitz, H. E. (1990) Calcium-dependent protein kinase activity is decreased in diabetic rat sciatic nerve. Endocrinology. 127: 1194-1198
8. Giles, T. D., Ouyang, J., Kerut, E. K., Given, M. B., Allen, G. E., McIlwain, E. F. and Greenberg, S. S. (1998) Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Am. J. Physiol. 274: H295-307
9. Given, M. B., Jie, O., Zhao, X., Giles, T. D. and Greenberg, S. S. (1998) Protein kinase C isozymes in skeletal muscles during the early stage of genetic and streptozocin diabetes. Proc. Soc. Exp. Biol. Med. 218: 382-389
10. Greene, D. A., Lattimer, S. A. and Sima, A. A. (1987) Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N. Engl. J. Med. 316: 599-606
11. 2+/calmodulin-dependent protein kinases. Annu. Rev. Biochem. 61: 559-601
12. Helper J. R. and Gilman, A. G. (1992) G proteins. Trends Biochem. Sci. 17:383-287
13. Ingebretsen, W. R., Jr., Peralta, C., Monsher, M., Wagner, L. K. and Ingebretsen, C. G. (1981) Diabetes alters the myocardial cAMP-protein kinase cascade system. Am. J. Physiol. 240: H375-382
14. Kahn, C. R. (1994) Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43: 1066-1084
15. Keely, S. L. and Eiring, A. (1979) Involvement of cAMP-dependent protein kinase in the regulation of heart contractile force. Am. J. Physiol. 236: H84-91
16. 2+ of Na(+)-H+ exchange in diabetic rat isolated ventricular myocytes. Circ. Res. 80: 253-260
17. Mor, M. A., Vila, J., Ciudad, C. J. and Guinovart, J. J. (1981) Insulin inactivation of rat hepatocyte cyclic AMP-dependent protein kinase. FEBS. Lett. 136: 131-134
18. Parker, P. J., Caudwell, F. B. and Cohen, P. (1983) Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo. Eur. J. Biochem. 130: 227-234
19. Pugazhenthi, S., Mantha, S. V. and Khandelwal, R. L. (1990) Decrease of liver protein kinase C in streptozotocin-induced diabetic rats and restoration by vanadate treatment. Biochem. Int. 21: 651-657
20. Shin, C. J., Kim, Y. S., Park, J. B. and Juhnn, Y. S. (1995) Changes in G protein levels in the hippocampus and the striatum of rat brain after chronic treatment with haloperidol and sulpiride. Neuropharmacology 34: 1335-1338
21. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85
22. i of cardiac myocytes. Kidney Int. 53: 1237-1243
23. Tanaka, Y., Kashiwagi, A., Ogawa, T., Abe N., Asahina, T., Ikebuchi, M., Takagi, Y. and Shigeta, Y. (1991) Effect of verapamil on cardiac protein kinase C activity in diabetic rats. Eur. J. Pharmacol. 200: 353-356
24. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329: 977-986
25. Weber, H. E., Menahan, L. A., Chaudhuri, S. N. and Shipp, J. C. (1977) Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver. Diabetologia 13: 153-157
26. Wichelhaus, A., Russ, M., Petersen, S. and Eckel, J. (1994) G protein expression and adenylate cyclase regulation in ventricular cardiomyocytes from STZ-diabetic rats. Am. J. Physiol. 267: H548-555
27. Williamson, J. R., Chang, K., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., van den Enden, M., Kilo, C. and Tilton, R. G. (1993) Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42: 801-813