Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17231-17236

  Batra, Vinod K ^a   Shock, David D ^a   Prasad, Rajendra ^a   Beard, William A ^a   Hou, Esther W ^a   Pedersen, Lars C ^a   Sayer, Jane M ^b   Yagi, Haruhiko ^b   Kumar, Subodh ^c   Jerina, Donald M ^b   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c BUFFALO STATE COLLEGE   (United States)

Author keywords

DNA adduct; DNA repair; Fidelity; Mutagenesis

Indexed keywords

BENZO[C]PHENANTHRENE DIOL EPOXIDE; CYTOSINE; DEOXYGUANOSINE; DNA DIRECTED DNA POLYMERASE BETA; EPOXIDE; GUANINE; MUTAGENIC AGENT; NUCLEOSIDE TRIPHOSPHATE; PHENANTHRENE DERIVATIVE; PURINE NUCLEOTIDE; UNCLASSIFIED DRUG; URACIL;

ARTICLE; BASE PAIRING; BINDING SITE; CRYSTAL STRUCTURE; DEAMINATION; DNA ADDUCT; DNA SYNTHESIS; DNA TEMPLATE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; EXCISION REPAIR; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DNA BINDING;

DNA ADDUCTS; DNA POLYMERASE BETA; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PHENANTHRENES; PROTEIN STRUCTURE, TERTIARY; TEMPLATES, GENETIC; URACIL;

EID: 33751218929     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605069103     Document Type: Article

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