Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: A link to tumorigenic activity

Journal of Molecular Biology

Volumn 306, Issue 5, 2001, Pages 1059-1080

  Lin, Chin H ^a   Huang, Xuanwei ^b   Kolbanovskii, Alexander ^b   Hingerty, Brian E ^c   Amin, Shantu ^d   Broyde, Suse ^b   Geacintov, Nicholas E ^b   Patel, Dinshaw J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

"fjord" BPh N2 G versus "bay" BP N2 G adducts; "fjord" BPh N2 G versus "fjord" BPh N6 A adducts; BPh N2 G adducts intercalate without base pair disruption; Stereoisomer related adduct directionality.

Indexed keywords

BENZO[C]PHENANTHRENE N2 GUANINE; CARBON; PHENANTHRENE DERIVATIVE; POLYCYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CARCINOGENIC ACTIVITY; CHEMICAL STRUCTURE; CHIRALITY; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; DNA ADDUCT; DNA CONFORMATION; DNA REPAIR; GENE DISRUPTION; GENETIC LINKAGE; INTERCALATION COMPLEX; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; NOMENCLATURE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ANALYSIS;

EID: 0035830956     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4425     Document Type: Article

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