Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 2, 2006, Pages 275-280

  Hahn, Martin ^a   Stachelhaus, Torsten ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b AureoGen Biosciences Inc   (United States)

Author keywords

Nonribosomal peptide synthetase; Peptide antibiotics; Protein protein interaction

Indexed keywords

BACITRACIN; BLEOMYCIN; DAPTOMYCIN; GRAMICIDIN; POLYPEPTIDE ANTIBIOTIC AGENT; SYNTHETASE; TYROCIDINE; VANCOMYCIN;

ARTICLE; CATALYSIS; MOLECULAR CLONING; MOLECULAR INTERACTION; NONRIBOSOMAL PEPTIDE SYNTHESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE BIOSYNTHESIS; PEPTIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES;

EID: 31044442400     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508409103     Document Type: Article

References (15)

1. Finking, R. M. & Marahiel, M. A. (2004) Annu. Rev. Microbiol. 58, 453-488.
2. Cane, D. E. & Walsh, C. T. (1999) Chem. Biol. 6, R319-R325.
3. Doekel, S. & Marahiel, M. A. (2000) Chem. Biol. 7, 373-384.
4. Eppelmann, K., Stachelhaus, T. & Marahiel, M. A. (2002) Biochemistry 41, 9718-9726.
5. Stachelhaus, T., Schneider, A. & Marahiel, M. A. (1995) Science 269, 69-72.
6. Mootz, H. D., Schwarzer, D. & Marahiel, M. A. (2000) Proc. Natl. Acad. Sci. USA 97, 5848-5853.
7. Hahn, M. & Stachelhaus, T. (2004) Proc. Natl. Acad. Sci. USA 101, 15585-15590.
8. Linne, U., Doekel, S. & Marahiel, M. A. (2001) Biochemistry 40, 15824-15834.
9. Keating, T. A., Marshall, C. G., Walsh, C. T. & Keating, A. E. (2002) Nat. Struct. Biol 7, 522-526.
10. Belshaw, P. J., Walsh, C. T. & Stachelhaus, T. (1999) Science 284, 486-489.
11. Broadhurst, R. W., Nietlispach, D., Wheatcroft, M. P., Leadlay, P. F. & Weissman, K. J. (2003) Chem. Biol. 10, 723-731.
12. Linne, U. & Marahiel, M. A. (2000) Biochemistry 39, 10439-10447.
13. Stachelhaus, T., Mootz, H. D., Bergendahl, V. & Marahiel, M. A. (1998) J. Biol. Chem. 273, 22773-22781.
14. Menzella, H. G., Reid, R., Carney, J. R., Chandran, S. S., Reisinger, S. J., Patel, K. G., Hopwood, D. A. & Santi, D. V. (2005) Nat. Biotechnol. 23, 1171-1176.
15. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY).