Comparison of proposed putative active conformations of myelin basic protein epitope 87-99 linear altered peptide ligands by spectroscopic and modelling studies: The role of positions 91 and 96 in T-cell receptor activation

Journal of Medicinal Chemistry

Volumn 49, Issue 23, 2006, Pages 6683-6691

  Mantzourani, Efthimia D ^a,b   Tselios, Theodore V ^b   Grdadolnik, Simona Golic ^c   Platts, James A ^d   Brancale, Andrea ^e   Deraos, George N ^b   Matsoukas, John M ^b   Mavromoustakos, Thomas M ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MYELIN; MYELIN BASIC PROTEIN; MYELIN BASIC PROTEIN[87-99][ALANINE 91,96]; MYELIN BASIC PROTEIN[87-99][ARGININE 91, ALANINE 96]; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ARTICLE; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; T LYMPHOCYTE ACTIVATION;

EPITOPES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 33751015761     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060040z     Document Type: Article

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