Antagonistic effects of human cyclic MBP87-99 altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 275-283

  Tselios, Theodore ^a   Apostolopoulos, Vasso ^b   Daliani, Ioanna ^c,d   Deraos, Spyros ^a   Grdadolnik, Simona ^e   Mavromoustakos, Thomas ^d   Melachrinou, Maria ^f   Thymianou, Sotiria ^f   Probert, Lesley ^c   Mouzaki, Athanasia ^f   Matsoukas, John ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b AUSTIN RESEARCH INSTITUTE   (Australia)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

^d INSTITUTE OF BIOLOGY   (Greece)

^e NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^f UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALITIS; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MOLECULAR MODEL; MULTIPLE SCLEROSIS; NONHUMAN; RAT; RAT STRAIN; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ANIMALS; CELL DIVISION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED LEW; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 0037122678     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102147     Document Type: Article

References (51)

1. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
2. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
3. Immunological aspects of demyelinating diseases
4. Immunologic mechanisms and therapy in multiple sclerosis
5. Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives
6. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptides (87-99)
7. The altered peptide ligand in relapsing MS study group. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
8. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
9. Selection of encephalitogenic rat T lymphocyte clones recognizing an immunodominant epitope on myelin basic protein
10. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
11. Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain
12. Circular β-lactamase: Stability enhancement by cyclizing the backbone
13. Design, synthesis, and biological activity of a cyclic peptide: An inhibitor of HIV Tat-Tar interactions in human cells
14. Simultaneous multiple synthesis and selective conjugation of cyclized peptides derived from a surface loop of a meningococcal class 1 outer membrane protein
15. Synthesis of cyclic herpes simplex virus peptides containing 281-284 epitope of glycoprotein D-1 in endo- or exo-position
16. Biological and structural properties of cyclic peptides derived from the alpha-amylase inhibitor tendamistat
17. Synthesis and kinetics of cyclization of MHC class II-derived cyclic peptide vaccine for diabetes
18. g7-derived peptide protects NOD mice from the development of diabetes
19. Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP)
20. Recognition of the encephalitogenic myelin basic protein (74-85) peptide by the immune system: Importance of conformation
21. 74-85 in experimental autoimmune encephalomyelitis: Elaboration of agonist and antagonist motifs
22. Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides
23. Design and synthesis of a potent cyclic analogue of the myelin basic protein epitope MBP72-85: Importance of the Ala81 carboxyl group and of a cyclic conformation for induction of experimental allergic encephalomyelitis
24. Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85
25. Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-LeuLeu-Arg motif: Importance of the Phe/Arg relative conformation and the primary amino group for activity
26. 2 cluster for receptor activation and implications in the design of nonpeptide thrombin receptor mimetics
27. Encephalitogenic epitopes of myelin basic protein
28. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
29. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
30. Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes and multiple sclerosis patients and healthy donors
31. A functional hot spot for antigen recognition in a superagonist TCR-MHC complex
32. IL-10 mediated immunosuppression be avariant CD4 T-cell epitope of plasmodium falciparum
33. Use of APL to modulate immune responses as a possible immunotherapy for allergies
34. Altered peptide ligands narrow the repertoire of cellular immune response by interfering with T-cell priming
35. IL-4, IL-10, IL-13, TGF-b from an altered peptide ligand-specific Th2 cell clone down regulate adoptive transfer of EAE
36. Preparation of new acid-labile resins of sec-alcohol type and their applications in peptide synthesis
37. α)-α protein consisting of 109 amino acid residues
38. 1H-NMR studies of sarmesin and [des1]sarmesin conformation in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: Folding of the N- and C-terminal domains
39. 1] angiotensin II conformation by nuclear Overhauser effect spectroscopy in the rotating frame (ROESY): Clustering of the aromatic rings in dimethylsulfoxide
40. 1,2,3]-angiotensin II
41. Exploring nuclear spin systems by relayed magnetization transfer
42. 1H NMR spectra via two-dimensinal homonuclear Hartmann - Hahn spectroscopy
43. Structure determination of a tetrasaccharide: Transient nuclear Overhauser effects in the rotating frame
44. ROESY
45. Improved spectral resolution in COSY proton NMR spectra of proteins via double quantum filtering
46. Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy
47. Gradient selection in inverse heteronuclear spectroscopy
48. Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy
49. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
50. Investigation of exchange processes by two-dimensional NMR spectroscopy
51. Occurrence of a silencer of the interleukin-2 gene in naïve but not in memory resting T helper lymphocytes