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Volumn 188, Issue 8, 1998, Pages 1511-1520

Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a peptide from human myelin basic protein

Author keywords

Autoimmunity; Crystal structure; HLA DR2; Multiple sclerosis; Myelin basic protein

Indexed keywords

ALANINE; HLA DR2 ANTIGEN; HLA DR4 ANTIGEN; MYELIN BASIC PROTEIN; PHENYLALANINE; T LYMPHOCYTE RECEPTOR;

EID: 0032547858     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.8.1511     Document Type: Article
Times cited : (260)

References (56)
  • 2
    • 0025817428 scopus 로고
    • MHC class-II molecules and autoimmunity
    • Nepom, G.T., and H. Erlich. 1991. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9:493-525.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 493-525
    • Nepom, G.T.1    Erlich, H.2
  • 4
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • The Multiple Sclerosis Study Group. 1996. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13:469-471.
    • (1996) Nat. Genet. , vol.13 , pp. 469-471
  • 7
    • 0020334818 scopus 로고
    • The genetics of susceptibility to multiple sclerosis
    • Spielman, R.S., and N. Nathenson. 1982. The genetics of susceptibility to multiple sclerosis. Epidemol. Rev. 4:45-65.
    • (1982) Epidemol. Rev. , vol.4 , pp. 45-65
    • Spielman, R.S.1    Nathenson, N.2
  • 8
    • 0028153827 scopus 로고
    • The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families
    • Hillert, J., T. Kall, M. Vrethem, S. Fredrikson, M. Ohlson, and O. Olerup. 1994. The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families. J. Neuroimmunol. 50:95-100.
    • (1994) J. Neuroimmunol. , vol.50 , pp. 95-100
    • Hillert, J.1    Kall, T.2    Vrethem, M.3    Fredrikson, S.4    Ohlson, M.5    Olerup, O.6
  • 10
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann, P.V., T. Forsthuber, A. Miller, and E.E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:155-157.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 11
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 12
    • 0023931606 scopus 로고
    • Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
    • Linington, C., M. Bradl, H. Lassmann, C. Brunner, and K. Vass. 1988. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am. J. Pathol. 130:443-454.
    • (1988) Am. J. Pathol. , vol.130 , pp. 443-454
    • Linington, C.1    Bradl, M.2    Lassmann, H.3    Brunner, C.4    Vass, K.5
  • 13
    • 0023597814 scopus 로고
    • A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease
    • Schluesener, H.J., R.A. Sobel, C. Linington, and H.L. Weiner. 1987. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 139:4016-4021.
    • (1987) J. Immunol. , vol.139 , pp. 4016-4021
    • Schluesener, H.J.1    Sobel, R.A.2    Linington, C.3    Weiner, H.L.4
  • 14
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota, K., M. Matsui, E.L. Milford, G.A. Mackin, H.L. Weiner, and D.A. Hafler. 1990. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346:183-187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 15
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
    • Pette, M., K. Fujita, D. Wilkinson, D.M. Altmann, J. Trowsdale, G. Giegerich, A. Hinkkanen, J.T. Epplen, L. Kappos, and H. Wekerle. 1990. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA. 87:7968-7972.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3    Altmann, D.M.4    Trowsdale, J.5    Giegerich, G.6    Hinkkanen, A.7    Epplen, J.T.8    Kappos, L.9    Wekerle, H.10
  • 16
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • Martin, R., D. Jaraquemada, M. Flerlage, J. Richert, J. Whitaker, E.O. Long, D.E. McFarlin, and H.F. McFarland. 1990. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:540-548.
    • (1990) J. Immunol. , vol.145 , pp. 540-548
    • Martin, R.1    Jaraquemada, D.2    Flerlage, M.3    Richert, J.4    Whitaker, J.5    Long, E.O.6    McFarlin, D.E.7    McFarland, H.F.8
  • 17
    • 0028120895 scopus 로고
    • Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
    • Wucherpfennig, K.W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J.L. Strominger, and D.A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279-290.
    • (1994) J. Exp. Med. , vol.179 , pp. 279-290
    • Wucherpfennig, K.W.1    Sette, A.2    Southwood, S.3    Oseroff, C.4    Matsui, M.5    Strominger, J.L.6    Hafler, D.A.7
  • 18
    • 0027389119 scopus 로고
    • Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients
    • Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E.D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J. Clin. Invest. 91:616-628.
    • (1993) J. Clin. Invest. , vol.91 , pp. 616-628
    • Valli, A.1    Sette, A.2    Kappos, L.3    Oseroff, C.4    Sidney, J.5    Miescher, G.6    Hochberger, M.7    Albert, E.D.8    Adorini, L.9
  • 19
    • 0025138302 scopus 로고
    • T cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta, M., J.A. Nicklas, S. Sriram, and R.J. Albertini. 1990. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science. 247:718-721.
    • (1990) Science , vol.247 , pp. 718-721
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 20
    • 0028238201 scopus 로고
    • Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide
    • Wucherpfennig, K.W., J. Zhang, C. Witek, M. Matsui, K. Ota, and D.A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 150:5581-5592.
    • (1994) J. Immunol. , vol.150 , pp. 5581-5592
    • Wucherpfennig, K.W.1    Zhang, J.2    Witek, C.3    Matsui, M.4    Ota, K.5    Hafler, D.A.6
  • 21
    • 0028951840 scopus 로고
    • Clonal expansion of myelin basic protein-reactive T cells in patients with multiple sclerosis: Restricted T cell receptor V gene rearrangements and CDR3 sequence
    • Vandevyver, C., N. Mertens, P. van den Elsen, R. Medaer, J. Raus, and J. Zhang. 1995. Clonal expansion of myelin basic protein-reactive T cells in patients with multiple sclerosis: restricted T cell receptor V gene rearrangements and CDR3 sequence. Eur. J. Immunol. 25:958-968.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 958-968
    • Vandevyver, C.1    Mertens, N.2    Van Den Elsen, P.3    Medaer, R.4    Raus, J.5    Zhang, J.6
  • 22
    • 0031892792 scopus 로고    scopus 로고
    • Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation
    • Scholz, C., K.T. Patton, D.E. Anderson, G.J. Freeman, and D.A. Hafler. 1998. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol. 160:1532-1538.
    • (1998) J. Immunol. , vol.160 , pp. 1532-1538
    • Scholz, C.1    Patton, K.T.2    Anderson, D.E.3    Freeman, G.J.4    Hafler, D.A.5
  • 23
    • 0029808087 scopus 로고    scopus 로고
    • Expression of HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers
    • Kalandadze, A., M. Galleno, L. Foncerrado, J.L. Strominger, and K.W. Wucherpfennig. 1996. Expression of HLA-DR2 molecules: replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers. J. Biol. Chem. 271:20156-20162.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20156-20162
    • Kalandadze, A.1    Galleno, M.2    Foncerrado, L.3    Strominger, J.L.4    Wucherpfennig, K.W.5
  • 24
    • 0028233838 scopus 로고
    • Functional soluble major histocompatibility proteins with covalently bound peptides
    • Kozono, H., J. White, J. Clements, P. Marrack, and J.W. Kappler. 1994. Functional soluble major histocompatibility proteins with covalently bound peptides. Nature. 369:151-154.
    • (1994) Nature , vol.369 , pp. 151-154
    • Kozono, H.1    White, J.2    Clements, J.3    Marrack, P.4    Kappler, J.W.5
  • 25
    • 0002452464 scopus 로고
    • Data collection and processing
    • L. Sawyer, N. Isaacs, and S. Bailey, editors. SERC Daresbury Laboratory, Warrington, UK
    • Otwinowski, Z. 1993. Data collection and processing. In Proceedings of CCP4 Study Weekend. L. Sawyer, N. Isaacs, and S. Bailey, editors. SERC Daresbury Laboratory, Warrington, UK. 56-62.
    • (1993) Proceedings of CCP4 Study Weekend , pp. 56-62
    • Otwinowski, Z.1
  • 26
    • 0031053055 scopus 로고    scopus 로고
    • AMoRe: An automated molecular replacement program package
    • Navaza, J. and P. Saludjian. 1997. AMoRe: an automated molecular replacement program package. Methods Enzymol. 276:581-594.
    • (1997) Methods Enzymol. , vol.276 , pp. 581-594
    • Navaza, J.1    Saludjian, P.2
  • 27
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • Stern, L.J., J.H. Brown, T.S. Jardetzky, R. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature. 368:215-221.
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1    Brown, J.H.2    Jardetzky, T.S.3    Urban, R.4    Strominger, J.L.5    Wiley, D.C.6
  • 28
    • 0026597444 scopus 로고
    • Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
    • Brünger, A.T. 1992. Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature. 355: 472-475.
    • (1992) Nature , vol.355 , pp. 472-475
    • Brünger, A.T.1
  • 29
    • 84889120137 scopus 로고
    • Improved methods for binding protein models in electron density maps and the location of errors in these models
    • Jones, T.A., J.Y. Zou, S.W. Cowan, and Kjeldgaard. 1991. Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A. 47:110-119.
    • (1991) Acta Crystallogr. A , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard4
  • 32
    • 0028823585 scopus 로고
    • The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    • Ghosh, P., M. Amaya, E. Mellins, and D.C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature. 378:457-462.
    • (1995) Nature , vol.378 , pp. 457-462
    • Ghosh, P.1    Amaya, M.2    Mellins, E.3    Wiley, D.C.4
  • 33
    • 0028854145 scopus 로고
    • HLA class II region nucleotide sequences
    • Marsh, S.G.E., and J.G. Bodmer. 1995. HLA class II region nucleotide sequences. Tissue Antigens. 45:258-280.
    • (1995) Tissue Antigens , vol.45 , pp. 258-280
    • Marsh, S.G.E.1    Bodmer, J.G.2
  • 34
    • 0030701632 scopus 로고    scopus 로고
    • X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
    • Dessen, A., C.M. Lawrence, S. Cupo, D.M. Zaller, and D.C. Wiley. 1997. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity. 7:473-481.
    • (1997) Immunity , vol.7 , pp. 473-481
    • Dessen, A.1    Lawrence, C.M.2    Cupo, S.3    Zaller, D.M.4    Wiley, D.C.5
  • 35
    • 0025887850 scopus 로고
    • Effect of a natural polymorphism at residue 86 of the HLA-DR β chain on peptide binding
    • Busch, R., C.M. Hill, J.D. Hayball, J.R. Lamb, and J.B. Rothbard. 1991. Effect of a natural polymorphism at residue 86 of the HLA-DR β chain on peptide binding. J. Immunol. 147:1292-1298.
    • (1991) J. Immunol. , vol.147 , pp. 1292-1298
    • Busch, R.1    Hill, C.M.2    Hayball, J.D.3    Lamb, J.R.4    Rothbard, J.B.5
  • 36
    • 0027937713 scopus 로고
    • Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
    • Hammer, J., E. Bono, F. Gallazzi, C. Belunis, Z. Nagy, and F. Sinigaglia. 1994. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J. Exp. Med. 180:2353-2358.
    • (1994) J. Exp. Med. , vol.180 , pp. 2353-2358
    • Hammer, J.1    Bono, E.2    Gallazzi, F.3    Belunis, C.4    Nagy, Z.5    Sinigaglia, F.6
  • 39
    • 0029782111 scopus 로고    scopus 로고
    • Structures of an MHC class II molecule with covalently bound single peptides
    • Fremont, D.H., W.A. Hendrickson, P. Marrack, and J. Kappler. 1996. Structures of an MHC class II molecule with covalently bound single peptides. Science. 272:1001-1004.
    • (1996) Science , vol.272 , pp. 1001-1004
    • Fremont, D.H.1    Hendrickson, W.A.2    Marrack, P.3    Kappler, J.4
  • 41
    • 0032033678 scopus 로고    scopus 로고
    • d-peptide complexes reveal that high affinity can be achieved without large anchor residues
    • d-peptide complexes reveal that high affinity can be achieved without large anchor residues. Immunity. 8:319-329.
    • (1998) Immunity , vol.8 , pp. 319-329
    • Scott, C.A.1    Peterson, P.A.2    Teyton, L.3    Wilson, I.A.4
  • 42
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 43
    • 0029855347 scopus 로고    scopus 로고
    • Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    • Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:134-141.
    • (1996) Nature , vol.384 , pp. 134-141
    • Garboczi, D.N.1    Ghosh, P.2    Utz, U.3    Fan, Q.R.4    Biddison, W.E.5    Wiley, D.C.6
  • 44
    • 18344405559 scopus 로고    scopus 로고
    • Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/tax peptide complex using different TCR amino acids
    • Ding, Y.-H., K.J. Smith, D.M. Garboczi, U. Utz, W.E. Biddison, and D.C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/tax peptide complex using different TCR amino acids. Immunity. 8:403-411.
    • (1998) Immunity , vol.8 , pp. 403-411
    • Ding, Y.-H.1    Smith, K.J.2    Garboczi, D.M.3    Utz, U.4    Biddison, W.E.5    Wiley, D.C.6
  • 45
    • 0030925578 scopus 로고    scopus 로고
    • Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
    • Hemmer, B., B.T. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K.-H. Wiesmüller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651-1659.
    • (1997) J. Exp. Med. , vol.185 , pp. 1651-1659
    • Hemmer, B.1    Fleckenstein, B.T.2    Vergelli, M.3    Jung, G.4    McFarland, H.5    Martin, R.6    Wiesmüller, K.-H.7
  • 46
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregerson, P.K., J. Silver, and R.J. Winchester. 1987. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30:1205-1213.
    • (1987) Arthritis Rheum. , vol.30 , pp. 1205-1213
    • Gregerson, P.K.1    Silver, J.2    Winchester, R.J.3
  • 48
    • 11944270639 scopus 로고
    • Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris
    • Ahmed, A.R., E.J. Yunis, K. Khatri, R. Wagner, G. Notani, Z. Awed, and C. Alper. 1990. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc. Natl. Acad. Sci. USA. 87:7658-7662.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7658-7662
    • Ahmed, A.R.1    Yunis, E.J.2    Khatri, K.3    Wagner, R.4    Notani, G.5    Awed, Z.6    Alper, C.7
  • 49
    • 0028955365 scopus 로고
    • Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases
    • Wucherpfennig, K.W., and J.L. Strominger. 1995. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J. Exp. Med. 181:1597-1601.
    • (1995) J. Exp. Med. , vol.181 , pp. 1597-1601
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 50
    • 0029932708 scopus 로고    scopus 로고
    • Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen
    • Fugger, L., J.B. Rothbard, and G. Sonderstrup-McDevitt. 1996. Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen. Eur. J. Immunol. 26:928-933.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 928-933
    • Fugger, L.1    Rothbard, J.B.2    Sonderstrup-McDevitt, G.3
  • 53
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
    • Johnson, K.P., B.R. Brooks, J.A. Cohen, C.C. Ford, J. Goldstein, R.P. Lisak, L.W. Myers, H.S. Panitch, J.W. Rose, R.B. Schiffer, et al. 1995. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. Neurology. 45:1268-1276.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3    Ford, C.C.4    Goldstein, J.5    Lisak, R.P.6    Myers, L.W.7    Panitch, H.S.8    Rose, J.W.9    Schiffer, R.B.10
  • 54
    • 0032080646 scopus 로고    scopus 로고
    • Promiscuous binding of synthetic copolymer 1 to purified HLA-DR molecules
    • Fridkis-Hareli, M., and J.L. Strominger. 1998. Promiscuous binding of synthetic copolymer 1 to purified HLA-DR molecules. J. Immunol. 160:4386-4397.
    • (1998) J. Immunol. , vol.160 , pp. 4386-4397
    • Fridkis-Hareli, M.1    Strominger, J.L.2


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