Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1

Retrovirology

Volumn 3, Issue , 2006, Pages

  Groot, Fedde ^a,b   Kuijpers, Taco W ^a   Berkhout, Ben ^a   de Jong, Esther C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ADOLESCENT; ARTICLE; CASE REPORT; CHILD; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; LEUKOCYTE ADHERENCE; LEUKOCYTE ADHESION DEFICIENCY; MALE; SEXUAL TRANSMISSION; T LYMPHOCYTE; VIRUS IMMUNITY; VIRUS PATHOGENESIS; VIRUS TRANSMISSION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DENDRITIC CELLS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750970000     PISSN: 17424690     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-3-75     Document Type: Article

References (46)

1. Choi YK, Whelton KM, Mlechick B, Murphey-Corb MA, Reinhart TA: Productive infection of dendritic cells by simian immunodeficiency virus in macaque intestinal tissues. J Pathol 2003, 201:616-628.
2. Hu J, Gardner MB, Miller CJ: Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J Virol 2000, 74:6087-6095.
3. Spira Al, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM, Ho DD: Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 1996, 183:215-225.
4. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
5. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol 2000, 18:767-811.
6. Rowland-Jones SL: HIV: The deadly passenger in dendritic cells. Curr Biol 1999, 9:R248-R250.
7. Pope M, Haase AT: Transmission, acute HIV-1 infection and the quest for strategies to prevent infection. Nat Med 2003, 9:847-852.
8. Sanders RW, de Jong EC, Baldwin CE, Schuitemaker JH, Kapsenberg ML, Berkhout B: Differential transmission of human, immunodeficiency virus type I by distinct subsets of effector dendritic cells. J Virol 2002, 76:7812-7821.
9. McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ: Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 2003, 300:1295-1297.
10. Groot F, van Capel TM, Kapsenberg ML, Berkhout B, de Jong EC: Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition. Blood 2006, 108:1957-1964.
11. Bromley SK, Burack WR, Johnson KG, Somersalo K, Sims TN, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML: The immunological synapse. Annu Rev Immunol 2001, 19:375-396.
12. Dustin ML, Springer TA: T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989, 341:619-624.
13. van Kooyk Y, Kemenade W, Weder P, Kuijpers TW, Figdor CG: Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 1989, 342:811-813.
14. Springer TA: Adhesion receptors of the immune system. Nature 1990, 346:425-434.
15. Hogg N, Bates PA: Genetic analysis of integrin function in man: LAD-1 and other syndromes. Matrix Biol 2000, 19:211-222.
16. Anderson DC, Springer TA: Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987, 38:175-194.
17. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314.
18. Lawrence MB, Springer TA: Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 1991, 65:859-873.
19. von Andrian UH, Chambers JD, McEvoy LM, Bargatze RF, Arfors KE, Butcher EC: Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci U S A 1991, 88:7538-7542.
20. Kuijpers TW, van Lier RA, Hamann D, de Boer M, Thung LY, Weening RS, Verhoeven AJ, Roos D: Leukocyte adhesion deficiency type I (LAD-1)/ variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins. J Clin Invest 1997, 100:1725-1733.
21. Diamond MS, Springer TA: The dynamic regulation of integrin adhesiveness. Curr Biol 1994, 4:506-517.
22. van Kooyk Y, Figdor CG: Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr Opin Cell Biol 2000, 12:542-547.
23. Wlodawer A, Vondrasek J: Inhibitors of HIV-1 protease: a major success of structure-assisted drug design. Annu Rev Biophys Biomol Struct 1998, 27:249-284.
24. Ganesh L, Leung K, Lore K, Levin R, Panet A, Schwartz O, Koup RA, Nabel GJ: Infection of specific dendritic cells by CCRS-tropic human immunodeficiency virus type I promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies. J Virol 2004, 78:11980-11987.
25. Shamri P, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton DE, von Andrian UH, Alon R: Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol 2005, 6:497-506.
26. Ingulli E, Mondino A, Khoruts A, Jenkins MK: In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J Exp Med 1997, 185:2133-2141.
27. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991, 9:271-296.
28. Atarashi K, Hirata T, Matsumoto M, Kanemitsu N, Miyasaka M: Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J Immunol 2005, 174:1424-1432.
29. Carman CV, Springer TA: Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol 2003, 15:547-556.
30. van Kooyk Y, van Vliet SJ, Figdor CG: The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes. J Biol Chem 1999, 274:26869-26877.
31. Hogg N, Henderson R, Leitinger B, McDowall A, Porter J, Stanley P: Mechanisms contributing to the activity of integrins on leukocytes. Immunol Rev 2002, 186:164-171.
32. Constantin G, Majeed M, Giagulli C, Piccio L, Kim JY, Butcher EC, Laudanna C: Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity 2000, 13:759-769.
33. Cairo CW, Mirchev R, Golan DE: Cytoskeletal Regulation Couples LFA-1 Conformational Changes to Receptor Lateral Mobility and Clustering. Immunity 2006, 25:297-308.
34. Porter JC, Bracke M, Smith A, Davies D, Hogg N: Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion. J Immunol 2002, 168:6330-6335.
35. Arrighi JF, Pion M, Garcia E, Escola JM, van Kooyk Y, Geijtenbeek TB, Piguet V: DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J Exp Med 2004, 200:1279-1288.
36. Fortin JF, Cantin R, Tremblay MJ: T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type I particles bearing host-encoded ICAM-1. J Virol 1998, 72:2105-2112.
37. Hioe CE, Chien PC Jr., Lu C, Springer TA, Wang XH, Bandres J, Tuen M: LFA-1 expression on target cells promotes human immunodeficiency virus type I infection and transmission. J Virol 2001, 75:1077-1082.
38. Tardif MR, Tremblay MJ: Presence of host ICAM-1 in human immunodeficiency virus type I virions increases productive infection of CD4+ T lymphocytes by favoring cytosolic delivery of viral material. J Virol 2003, 77:12299-12309.
39. Tardif MR, Tremblay MJ: Regulation of LFA-1 Activity through Cytoskeleton Remodeling and Signaling Components Modulates the Efficiency of HIV Type-1 Entry in Activated CD4+ T Lymphocytes. J Immunol 2005, 175:926-935.
40. Tsunetsugu-Yokota Y, Yasuda S, Sugimoto A, Yagi T, Azuma M, Yagita H, Akagawa K, Takemori T: Efficient virus transmission from dendritic cells to CD4+ T cells in response to antigen depends on close contact through adhesion molecules. Virol 1997, 239:259-268.
41. Bounou S, Giguere JF, Cantin R, Gilbert C, Imbeault M, Martin G, Tremblay MJ: The importance of virus-associated host ICAM-1 in human immunodeficiency virus type I dissemination depends on the cellular context. FASEB J 2004, 18:1294-1296.
42. Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001, 7:687-692.
43. Giguere JF, Tremblay MJ: Statin compounds reduce human immunodeficiency virus type I replication by preventing the interaction between virion-associated host intercellular adhesion molecule I and its natural cell surface ligand LFA-1. J Virol 2004, 78:12062-12065.
44. Anderson ME, Siahaan TJ: Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors. Peptides 2003, 24:487-501.
45. Liu G, Huth JR, Olejniczak ET, Mendoza R, DeVries P, Leitza S, Reilly EB, Okasinski GF, Fesik SW, von Geldern TW: Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. J Med Chem 2001, 44:1202-1210.
46. Shimaoka M, Salas A, Yang W, Weitz-Schmidt G, Springer TA: Small molecule integrin antagonists that bind to the beta2 subunit 1-like domain and activate signals in one direction and block them in the other. Immunity 2003, 19:391-402.