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Volumn 11, Issue 4, 2006, Pages 651-664

Emerging drugs in chronic myelogenous leukaemia

Author keywords

BCR ABL; Chronic myelogenous leukaemia; Drug resistance; Imatinib; Immunotherapy; Kinase inhibitor; Vaccine

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; 4 METHYL N [3 (4 METHYL 1 IMIDAZOLYL) 5 (TRIFLUOROMETHYL)PHENYL] 3 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINO]BENZAMIDE; 6 (2,6 DICHLOROPHENYL) 2 (4 FLUORO 3 METHYLANILINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; AP 23573; BUSULFAN; CGP 76030; EVEROLIMUS; GELDANAMYCIN; HYDROXYUREA; IMATINIB; LONAFARNIB; N (2 CHLORO 6 METHYLPHENYL) 2 [6 [4 (2 HYDROXYETHYL) 1 PIPERAZINYL] 2 METHYL 4 PYRIMIDINYLAMINO] 5 THIAZOLECARBOXAMIDE; NILOTINIB; ON 012380; OSU 03012; PD 166326; PD 173955; PENICILLOYL POLYLYSINE; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; TEMSIROLIMUS; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VX 680; WORTMANNIN;

EID: 33750949760     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.11.4.651     Document Type: Review
Times cited : (11)

References (92)
  • 1
    • 0020333906 scopus 로고
    • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
    • DE KLEIN A, VAN KESSEL AG, GROSVELD G et al.: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature (1982) 300:765-767.
    • (1982) Nature , vol.300 , pp. 765-767
    • De Klein, A.1    Van Kessel, A.G.2    Grosveld, G.3
  • 2
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • SHTIVELMAN E, LIFSHITZ B, GALE RP, CANAANI E: Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature (1985) 315:550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 3
    • 0021926819 scopus 로고
    • The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity
    • KLOETZER W, KURZROCK R, SMITH L et al.: The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity. Virology (1985) 140:230-238.
    • (1985) Virology , vol.140 , pp. 230-238
    • Kloetzer, W.1    Kurzrock, R.2    Smith, L.3
  • 4
    • 0027164941 scopus 로고
    • Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: Prolongation of survival by hydroxyurea
    • The German CML Study Group
    • HEHLMANN R, HEIMPEL H, HASFORD J et al.: Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group. Blood (1993) 82:398-407.
    • (1993) Blood , vol.82 , pp. 398-407
    • Hehlmann, R.1    Heimpel, H.2    Hasford, J.3
  • 6
    • 0030715606 scopus 로고    scopus 로고
    • Interferon alfa versus chemotherapy for chronic myeloid leukemia: A meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group
    • NO AUTHORS LISTED: Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials: Chronic Myeloid Leukemia Trialists' Collaborative Group. J. Natl. Cancer Inst. (1997) 89:1616-1620.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1616-1620
  • 7
    • 0022622360 scopus 로고
    • Marrow transplantation for the treatment of chronic myelogenous leukemia
    • THOMAS ED, CLIFT RA, FEFER A et al.: Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann. Intern. Med. (1986) 104:155-163.
    • (1986) Ann. Intern. Med. , vol.104 , pp. 155-163
    • Thomas, E.D.1    Clift, R.A.2    Fefer, A.3
  • 8
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells
    • DRUKER BJ, TAMURA S, BUCHDUNGER E et al.: Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells. Nat. Med. (1996) 2:561-566.
    • (1996) Nat. Med. , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 9
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • DRUKER BJ, TALPAZ M, RESTA DJ et al.: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. (2001) 344:1031-1037.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 10
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • KANTARJIAN H, SAWYERS C, HOCHHAUS A et al.: Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N. Engl. J. Med. (2002) 346:645-652.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 11
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a Phase II study
    • TALPAZ M, SILVER RT, DRUKER BJ et al.: Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a Phase II study. Blood (2002) 99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 12
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a Phase II study
    • SAWYERS CL, HOCHHAUS A, FELDMAN E et al.: Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a Phase II study. Blood (2002) 99:3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 13
    • 0037105560 scopus 로고    scopus 로고
    • A Phase II study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
    • OTTMANN OG, DRUKER BJ, SAWYERS CL et al.: A Phase II study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood (2002) 100:1965-1971.
    • (2002) Blood , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 14
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'BRIEN S, GUILHOT F, LARSON RA et al.: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl J. Med. (2003) 348:994-1004. This paper reports the most important study comparing imatinib with IFN-α treatment.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 994-1004
    • O'Brien, S.1    Guilhot, F.2    Larson, R.A.3
  • 15
    • 17144409997 scopus 로고    scopus 로고
    • How long will chronic myeloid leukemia patients treated with imatinib mesylate live?
    • HASFORD J, PFIRRMANN M, HOCHHAUS A: How long will chronic myeloid leukemia patients treated with imatinib mesylate live? Leukemia (2005) 19:497-499.
    • (2005) Leukemia , vol.19 , pp. 497-499
    • Hasford, J.1    Pfirrmann, M.2    Hochhaus, A.3
  • 16
    • 33750945598 scopus 로고    scopus 로고
    • Long-term benefit of imatinib for patients newly diagnosed with chronic myeloid leukemia in chronic phase: The 5-year update from IRIS study
    • Atlanta, GA, USA
    • DRUKER B: Long-term benefit of imatinib for patients newly diagnosed with chronic myeloid leukemia in chronic phase: the 5-year update from IRIS study. 2006 ASCO Annual meeting. Atlanta, GA, USA (2006).
    • (2006) 2006 ASCO Annual Meeting
    • Druker, B.1
  • 17
    • 3242816121 scopus 로고    scopus 로고
    • Clinical resistance to imatinib: Mechanisms and implications
    • ix
    • HOCHHAUS A, HUGHES T: Clinical resistance to imatinib: mechanisms and implications. Hematol. Oncol. Clin. North Am. (2004) 18:641-656, ix.
    • (2004) Hematol. Oncol. Clin. North Am. , vol.18 , pp. 641-656
    • Hochhaus, A.1    Hughes, T.2
  • 18
    • 33646806516 scopus 로고    scopus 로고
    • Overcoming drug resistance in chronic myeloid leukemia
    • CORTES J: Overcoming drug resistance in chronic myeloid leukemia. Curr. Opin. Hematol. (2006) 13:79-86.
    • (2006) Curr. Opin. Hematol. , vol.13 , pp. 79-86
    • Cortes, J.1
  • 19
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • BHATIA R, HOLTZ M, NIU N et al.: Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood (2003) 101:4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 20
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI-571 in vitro
    • GRAHAM SM, JORGENSEN HG, ALLAN E et al.: Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI-571 in vitro. Blood (2002) 99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 21
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • HUGHES TP, KAEDA J, BRANFORD S et al.: Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N. Engl. J. Med. (2003) 349:1423-1432. The paper evaluates the rate and entity of molecular response obtained with imatinib in the IRIS study.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 22
    • 2342629325 scopus 로고    scopus 로고
    • Imatinib (STI-571) resistance in chronic myelogenous leukemia: Molecular basis of the underlying mechanisms and potential strategies for treatment
    • COWAN-JACOB SW, GUEZ V, FENDRICH G et al.: Imatinib (STI-571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment. Mini Rev. Med. Chem. (2004) 4:285-299.
    • (2004) Mini Rev. Med. Chem. , vol.4 , pp. 285-299
    • Cowan-Jacob, S.W.1    Guez, V.2    Fendrich, G.3
  • 23
    • 1342343033 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance of leukemia to imatinib mesylate
    • TAUCHI T, OHYASHIKI K: Molecular mechanisms of resistance of leukemia to imatinib mesylate. Leuk. Res. (2004) 28(Suppl. 1):S39-S45.
    • (2004) Leuk. Res. , vol.28 , Issue.SUPPL. 1
    • Tauchi, T.1    Ohyashiki, K.2
  • 24
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI-571: A prospective study
    • VON BUBNOFF N, SCHNELLER F, PESCHEL C, DUYSTER J: BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI-571: a prospective study. Lancet (2002) 359:487-491.
    • (2002) Lancet , vol.359 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 25
    • 0037508877 scopus 로고    scopus 로고
    • Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
    • TANIS KQ, VEACH D, DUEWEL HS, BORNMANN WG, KOLESKE AJ: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol. Cell. Biol. (2003) 23:3884-3896.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3884-3896
    • Tanis, K.Q.1    Veach, D.2    Duewel, H.S.3    Bornmann, W.G.4    Koleske, A.J.5
  • 26
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • GORRE ME, MOHAMMED M, ELLWOOD K et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (2001) 293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 27
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI-571) therapy
    • HOCHHAUS A, KREIL S, CORBIN AS et al.: Molecular and chromosomal mechanisms of resistance to imatinib (STI-571) therapy. Leukemia (2002) 16:2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 28
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI-571) in chronic phase and blast crisis chronic myeloid leukemia
    • SHAH NP, NICOLL JM, NAGAR B et al.: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI-571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 29
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-posittve acute lymphoblastic leukemia who develop imatinib (STI-571) resistance
    • BRANFORD S, RUDZKI Z, WALSH S et al.: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-posittve acute lymphoblastic leukemia who develop imatinib (STI-571) resistance. Blood (2002) 99:3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 30
    • 33645464074 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations and resistance to imatinib mesylate
    • BRANFORD S, HUGHES T: Detection of BCR-ABL mutations and resistance to imatinib mesylate. Methods Mol. Med. (2006) 125:93-106.
    • (2006) Methods Mol. Med. , vol.125 , pp. 93-106
    • Branford, S.1    Hughes, T.2
  • 31
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • BRANFORD S, RUDZKI Z, WALSH S et al.: Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood (2003) 102:276-283.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 32
    • 4344672552 scopus 로고    scopus 로고
    • Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
    • HOCHHAUS A, LA ROSEE P: Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia (2004) 18:1321-1331.
    • (2004) Leukemia , vol.18 , pp. 1321-1331
    • Hochhaus, A.1    La Rosee, P.2
  • 33
    • 0344305459 scopus 로고    scopus 로고
    • Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI-571) in vitro
    • FERRAO PT, FROST MJ, SIAH SP, ASHMAN LK: Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI-571) in vitro. Blood (2003) 102:4499-4503.
    • (2003) Blood , vol.102 , pp. 4499-4503
    • Ferrao, P.T.1    Frost, M.J.2    Siah, S.P.3    Ashman, L.K.4
  • 35
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • HUGHES T, DEININGER M, HOCHHAUS A et al.: Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood (2006) 108:28-37. This very important paper describes the current guidelines that should be followed for the molecular monitoring of imalinib-treated patients.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3
  • 36
    • 0036738109 scopus 로고    scopus 로고
    • Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha
    • MERX K, MULLER MC, KREIL S et al.: Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha. Leukemia (2002) 16:1579-1583.
    • (2002) Leukemia , vol.16 , pp. 1579-1583
    • Merx, K.1    Muller, M.C.2    Kreil, S.3
  • 37
    • 9144253153 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C
    • MULLER MC, GATTERMANN N, LAHAYE T et al.: Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C. Leukemia (2003) 17:2392-2400.
    • (2003) Leukemia , vol.17 , pp. 2392-2400
    • Muller, M.C.1    Gattermann, N.2    Lahaye, T.3
  • 38
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • WANG L, PEARSON K, FERGUSON JE, CLARK RE: The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br. J. Haematol. (2003) 120:990-999.
    • (2003) Br. J. Haematol. , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 40
    • 14944361257 scopus 로고    scopus 로고
    • Can we afford to let sleeping dogs lie?
    • DEININGER MW, HOLYOAKE TL: Can we afford to let sleeping dogs lie? Blood (2005) 105:1840-1841.
    • (2005) Blood , vol.105 , pp. 1840-1841
    • Deininger, M.W.1    Holyoake, T.L.2
  • 41
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • CORTES J, O'BRIEN S, KANTARJIAN H: Discontinuation of imatinib therapy after achieving a molecular response. Blood (2004) 104:2204-2205.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 42
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN-107, a selective inhibitor of native and mutant Bcr-Abl
    • WEISBERG E, MANLEY PW, BREITENSTEIN W et al.: Characterization of AMN-107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7:129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 43
    • 0037115644 scopus 로고    scopus 로고
    • Activity of the Bcr-Abl kinase inhibitor PD-180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI-571)
    • LA ROSEE P, CORBIN AS, STOFFREGEN EP, DEININGER MW, DRUKER BJ: Activity of the Bcr-Abl kinase inhibitor PD-180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI-571). Cancer Res. (2002) 62:7149-7153.
    • (2002) Cancer Res. , vol.62 , pp. 7149-7153
    • La Rosee, P.1    Corbin, A.S.2    Stoffregen, E.P.3    Deininger, M.W.4    Druker, B.J.5
  • 44
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • SHAH NP, TRAN C, LEE FY, CHEN P, NORRIS D, SAWYERS CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science (2004) 305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 45
    • 33745283618 scopus 로고    scopus 로고
    • The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
    • TOKARSKI JS, NEWITT JA, CHANG CY et al.: The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res. (2006) 66:5790-5797.
    • (2006) Cancer Res. , vol.66 , pp. 5790-5797
    • Tokarski, J.S.1    Newitt, J.A.2    Chang, C.Y.3
  • 46
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • KANTARJIAN H, GILES F, WUNDERLE L et al.: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N. Engl. J. Med. (2006) 354:2542-2551. A fundamental paper on nilotinib.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 47
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • TALPAZ M, SHAH NP, KANTARJIAN H et al.: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. (2006) 354:2531-2541. A fundamental paper on dasatinib.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 48
    • 0141842714 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: An overview of the results of preclinical and clinical investigations
    • BRUNNER TB, HAHN SM, GUPTA AK, MUSHEL RJ, MCKENNA WG, BERNHARD EJ: Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res. (2003) 63:5656-5668.
    • (2003) Cancer Res. , vol.63 , pp. 5656-5668
    • Brunner, T.B.1    Hahn, S.M.2    Gupta, A.K.3    Mushel, R.J.4    McKenna, W.G.5    Bernhard, E.J.6
  • 49
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the farnesyl protein transferase inhibitor SCH-66336 against BCR/ABL-induced murine leukaemia and primary cells from patients with chronic myeloid leukaemia
    • PETERS DG, HOOVER RR, GERLACH MJ et al.: Activity of the farnesyl protein transferase inhibitor SCH-66336 against BCR/ABL-induced murine leukaemia and primary cells from patients with chronic myeloid leukaemia. Blood (2001) 97:1402-1412.
    • (2001) Blood , vol.97 , pp. 1402-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3
  • 50
    • 0344611212 scopus 로고    scopus 로고
    • Efficacy of SCH-663366, farnesyl transferase inhibitor, in conjunction with imatinib agaist BCR-ABL positive cells
    • NAKAJIMA A, TAUCHI T, SUMI M et al.: Efficacy of SCH-663366, farnesyl transferase inhibitor, in conjunction with imatinib agaist BCR-ABL positive cells. Mol. Cancer Ther. (2003) 2:219-224.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 219-224
    • Nakajima, A.1    Tauchi, T.2    Sumi, M.3
  • 51
    • 0029002248 scopus 로고
    • Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules
    • BOCCHIA M, WENTWORTH PA, SOUTHWOOD S et al.: Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules. Blood (1995) 85:2680-2684.
    • (1995) Blood , vol.85 , pp. 2680-2684
    • Bocchia, M.1    Wentworth, P.A.2    Southwood, S.3
  • 53
    • 0029870222 scopus 로고    scopus 로고
    • Specific human cellular immunity to BCR-ABL oncogene-derived peptides
    • BOCCHIA M, KORONTSVIT T, XU Q et al.: Specific human cellular immunity to BCR-ABL oncogene-derived peptides. Blood (1996) 87:3587-3592.
    • (1996) Blood , vol.87 , pp. 3587-3592
    • Bocchia, M.1    Korontsvit, T.2    Xu, Q.3
  • 54
    • 0035892131 scopus 로고    scopus 로고
    • Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
    • CLARK RE, DODI IA, HILL SC et al.: Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood (2001) 98:2887-2893.
    • (2001) Blood , vol.98 , pp. 2887-2893
    • Clark, R.E.1    Dodi, I.A.2    Hill, S.C.3
  • 56
    • 13844312036 scopus 로고    scopus 로고
    • Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial
    • BOCCHIA M, GENTILI S, ABRUZZESE E et al.: Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet (2005) 365:657-662.
    • (2005) Lancet , vol.365 , pp. 657-662
    • Bocchia, M.1    Gentili, S.2    Abruzzese, E.3
  • 57
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • MOLLDREM JJ, LEE PP, WANG C et al.: Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat. Med. (2000) 6:1018-1023.
    • (2000) Nat. Med. , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3
  • 58
    • 0029069227 scopus 로고
    • Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias
    • MENSSEN HD, RENKL HJ, RODECK U et al.: Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia (1995) 9:1060-1067.
    • (1995) Leukemia , vol.9 , pp. 1060-1067
    • Menssen, H.D.1    Renkl, H.J.2    Rodeck, U.3
  • 59
    • 0037111734 scopus 로고    scopus 로고
    • Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
    • BELLANTUONO I, GAO L, PARRY S et al.: Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood (2002) 100:3835-3837.
    • (2002) Blood , vol.100 , pp. 3835-3837
    • Bellantuono, I.1    Gao, L.2    Parry, S.3
  • 60
    • 0037833596 scopus 로고    scopus 로고
    • Vaccination with heat shock protein-peptide complexes: From basic science to clinical applications
    • HOOS A, LEVEY DL: Vaccination with heat shock protein-peptide complexes: from basic science to clinical applications. Expert Rev. Vaccines (2003) 2:369-379.
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 369-379
    • Hoos, A.1    Levey, D.L.2
  • 61
    • 20444448873 scopus 로고    scopus 로고
    • Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia
    • LI Z, QIAO Y, LIU B et al.: Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin. Cancer Res. (2005) 11:4460-4468.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4460-4468
    • Li, Z.1    Qiao, Y.2    Liu, B.3
  • 62
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • BANCHEREAU J, STEINMAN RM: Dendritic cells and the control of immunity. Nature (1998) 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 63
    • 33750942632 scopus 로고    scopus 로고
    • Dendritic cells vaccination in BCR/ABL-positive chronic myeloid leukemia. Final results of a Phase I/II study
    • WESTERMANN J, KOPP J, VAN LESSEN A et al.: Dendritic cells vaccination in BCR/ABL-positive chronic myeloid leukemia. Final results of a Phase I/II study. Blood (2004) 104:2943a.
    • (2004) Blood , vol.104
    • Westermann, J.1    Kopp, J.2    Van Lessen, A.3
  • 64
    • 33749983643 scopus 로고    scopus 로고
    • Activity of AMN-107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells
    • In press
    • VERSTOVSEK S, GILES FJ, QUINTAS-CARDAMA A et al.: Activity of AMN-107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells. Leuk. Res. (2006) (In press).
    • (2006) Leuk. Res.
    • Verstovsek, S.1    Giles, F.J.2    Quintas-Cardama, A.3
  • 65
    • 27144551665 scopus 로고    scopus 로고
    • The small molecule tyrosine kinase inhibitor AMN-107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo
    • STOVER EH, CHEN J, LEE BH et al.: The small molecule tyrosine kinase inhibitor AMN-107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo. Blood (2005) 106:3206-3213.
    • (2005) Blood , vol.106 , pp. 3206-3213
    • Stover, E.H.1    Chen, J.2    Lee, B.H.3
  • 66
    • 30444446680 scopus 로고    scopus 로고
    • PKC-412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: Comparison with AMN-107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
    • GLEIXNER KV, MAYERHOFER M, AICHBERGER KJ et al.: PKC-412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN-107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood (2006) 107:752-759.
    • (2006) Blood , vol.107 , pp. 752-759
    • Gleixner, K.V.1    Mayerhofer, M.2    Aichberger, K.J.3
  • 67
    • 33646516407 scopus 로고    scopus 로고
    • Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN-107 in gastrointestinal stromal tumor cell lines
    • PRENEN H, GUETENS G, DE BOECK G et al.: Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN-107 in gastrointestinal stromal tumor cell lines. Pharmacology (2006) 77:11-16.
    • (2006) Pharmacology , vol.77 , pp. 11-16
    • Prenen, H.1    Guetens, G.2    De Boeck, G.3
  • 68
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD-173955 and imatinib (STI-571)
    • NAGAR B, BORNMANN WG, PELLICENA P et al.: Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD-173955 and imatinib (STI-571). Cancer Res. (2002) 62:4236-4243.
    • (2002) Cancer Res. , vol.62 , pp. 4236-4243
    • Nagar, B.1    Bornmann, W.G.2    Pellicena, P.3
  • 70
    • 33745069351 scopus 로고    scopus 로고
    • BcrR-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN-107)
    • VON BUBNOFF N, MANLEY PW, MESTAN J, SANGER J, PESCHEL C, DUYSTER J: BcrR-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN-107). Blood (2006) 108(4):1328-1333.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1328-1333
    • Von Bubnoff, N.1    Manley, P.W.2    Mestan, J.3    Sanger, J.4    Peschel, C.5    Duyster, J.6
  • 71
    • 19044372472 scopus 로고    scopus 로고
    • Critical role for Gab2 in transformation by BCR/ABL
    • SATTLER M, MOHI MG, PRIDE YB et al.: Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell (2002) 1:479-492.
    • (2002) Cancer Cell , vol.1 , pp. 479-492
    • Sattler, M.1    Mohi, M.G.2    Pride, Y.B.3
  • 72
    • 33750951865 scopus 로고    scopus 로고
    • A Phase II study of nilotinib (AMN-107), a novel inhibitor of bcr-abl, administered to imatinib resitant and intolerant patients with chronic myelogenous leukemia in chronic phase (CP)
    • LE COUTRE P, GATTERMANN N, O'BRIEN S et al.: A Phase II study of nilotinib (AMN-107), a novel inhibitor of bcr-abl, administered to imatinib resitant and intolerant patients with chronic myelogenous leukemia in chronic phase (CP). Haematologica (2006) 91:377.
    • (2006) Haematologica , vol.91 , pp. 377
    • Le Coutre, P.1    Gattermann, N.2    O'Brien, S.3
  • 73
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • LOMBARDO LJ, LEE FY, CHEN P et al.: Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J. Med. Chem. (2004) 47:6658-6661.
    • (2004) J. Med. Chem. , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 74
    • 0038731316 scopus 로고    scopus 로고
    • Juxtamembrane mutant V560GKit is more sensitive to imatinib (STI-571) compared with wild-type c-kit whereas the kinase domain mutant D816VKU is resistant
    • FROST MJ, FERRAO PT, HUGHES TP, ASHMAN LK: Juxtamembrane mutant V560GKit is more sensitive to imatinib (STI-571) compared with wild-type c-kit whereas the kinase domain mutant D816VKU is resistant. Mol. Cancer Ther. (2002) 1:1115-1124.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 1115-1124
    • Frost, M.J.1    Ferrao, P.T.2    Hughes, T.P.3    Ashman, L.K.4
  • 75
    • 16844379200 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses in imatinib-resistant chronic phase chronic myeloid leukemia patients treated with the dual SRC/ABL kinase inhibitor BMS-354825: Results from a Phase I dose escalation study
    • SAWYERS CL, SHAH NP, KANTARJIAN HM et al.: Hematologic and cytogenetic responses in imatinib-resistant chronic phase chronic myeloid leukemia patients treated with the dual SRC/ABL kinase inhibitor BMS-354825: results from a Phase I dose escalation study. Blood (2004) 104:10a.
    • (2004) Blood , vol.104
    • Sawyers, C.L.1    Shah, N.P.2    Kantarjian, H.M.3
  • 76
    • 27744469392 scopus 로고    scopus 로고
    • BMS-354825 potently inhibits the kinase activity of KIT activation loop mutations associated with systemic mastocytosis and induces apoptosis of mastocytosis cell lines
    • SCHITTENHELM M, SHIRAGA S, LEE FY, HEINRICH MC: BMS-354825 potently inhibits the kinase activity of KIT activation loop mutations associated with systemic mastocytosis and induces apoptosis of mastocytosis cell lines. Blood (2004) 104:666a.
    • (2004) Blood , vol.104
    • Schittenhelm, M.1    Shiraga, S.2    Lee, F.Y.3    Heinrich, M.C.4
  • 78
    • 33750940320 scopus 로고    scopus 로고
    • A Phase II study of dasatinib in patients with chronic phase chronic myeloid leukemia who are resistant or intolerant to imatinib: Results of the CA-180013 START-C study
    • HOCHHAUS A, KANTARJIAN H, SHAH NP et al.: A Phase II study of dasatinib in patients with chronic phase chronic myeloid leukemia who are resistant or intolerant to imatinib: results of the CA-180013 START-C study. Haematologica (2006) 91:170.
    • (2006) Haematologica , vol.91 , pp. 170
    • Hochhaus, A.1    Kantarjian, H.2    Shah, N.P.3
  • 79
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyl transferee inhibitor R-115777 in adults with refractory and relapsed acute leukemias: A Phase I clinical-laboratory correlative trial
    • KARP JE, LANCET JE, KAUFMANN SH et al.: Clinical and biologic activity of the farnesyl transferee inhibitor R-115777 in adults with refractory and relapsed acute leukemias: a Phase I clinical-laboratory correlative trial. Blood (2001) 97:3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 80
    • 30744446226 scopus 로고    scopus 로고
    • Pilot study of lonafarnib (SCH-66336, Sarasar) a farnesyl transferase inhibitor, in patients with chronic myeloid leukaemia in chronic or accelerated phase resistant or refractory to imatinib
    • BORTHAKUR G, KANTARJIAN H, DALEY GQ et al.: Pilot study of lonafarnib (SCH-66336, Sarasar) a farnesyl transferase inhibitor, in patients with chronic myeloid leukaemia in chronic or accelerated phase resistant or refractory to imatinib. Cancer (2006) 106:346-352.
    • (2006) Cancer , vol.106 , pp. 346-352
    • Borthakur, G.1    Kantarjian, H.2    Daley, G.Q.3
  • 81
    • 28444434844 scopus 로고    scopus 로고
    • A Phase I study of tipifarnib in combination with imatinib mesylate (IM) for patients with chronic myeloid leukaemia in chronic phase who had failed IM therapy
    • CORTES J, GARCIA-MANERO G, O'BRIEN S et al.: A Phase I study of tipifarnib in combination with imatinib mesylate (IM) for patients with chronic myeloid leukaemia in chronic phase who had failed IM therapy. Blood (2004) 104:289a.
    • (2004) Blood , vol.104
    • Cortes, J.1    Garcia-Manero, G.2    O'Brien, S.3
  • 82
    • 1842463073 scopus 로고    scopus 로고
    • Tipifarnib (Zarnestra) and imatinib (Gleevec) combination therapy in patients with advanced chronic myelogenous leukaemia (CML): Prelimnary results of a Phase I study
    • GOTLIB J, MAURO MJ, O'DWYER M et al.: Tipifarnib (Zarnestra) and imatinib (Gleevec) combination therapy in patients with advanced chronic myelogenous leukaemia (CML): prelimnary results of a Phase I study. Blood (2003) 102:909a.
    • (2003) Blood , vol.102
    • Gotlib, J.1    Mauro, M.J.2    O'Dwyer, M.3
  • 83
    • 28444434844 scopus 로고    scopus 로고
    • Phase I study of lonafarnib (SCH-66336) in combination with IM for patients with chronic myeloid leukaemia (CML) after failure to imatinib
    • CORTES J, O'BRIEN S, VERSTOVSEK S et al.: Phase I study of lonafarnib (SCH-66336) in combination with IM for patients with chronic myeloid leukaemia (CML) after failure to imatinib. Blood (2004) 104:288.
    • (2004) Blood , vol.104 , pp. 288
    • Cortes, J.1    O'Brien, S.2    Verstovsek, S.3
  • 84
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • COPLAND M, HAMILTON A, ELRICK LJ et al.: Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood (2006) 107:4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 85
    • 0030946078 scopus 로고    scopus 로고
    • + T lymphocytes respond to dendritic cells pulsed with b3a2 peptide and antigen-presenting cells exposed to b3a2 containing cell lysates
    • + T lymphocytes respond to dendritic cells pulsed with b3a2 peptide and antigen-presenting cells exposed to b3a2 containing cell lysates. Blood (1997) 90:290-297.
    • (1997) Blood , vol.90 , pp. 290-297
    • Mannering, S.I.1    McKenzie, J.L.2    Fearnley, D.B.3    Hart, D.N.4
  • 86
    • 1642500316 scopus 로고    scopus 로고
    • A multivalent BCR-ABL fusion peptide vaccination trial in patients with chronic myeloid leukemia
    • CATHCART K, PINILLA-IBARZ J, KORONTSVIT T et al.: A multivalent BCR-ABL fusion peptide vaccination trial in patients with chronic myeloid leukemia. Blood (2004) 103:1037-1042.
    • (2004) Blood , vol.103 , pp. 1037-1042
    • Cathcart, K.1    Pinilla-Ibarz, J.2    Korontsvit, T.3
  • 87
    • 0034161533 scopus 로고    scopus 로고
    • Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
    • PINILLA-IBARZ J, CATHCART K, KORONTSVIT T et al.: Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood (2000) 95:1781-1787.
    • (2000) Blood , vol.95 , pp. 1781-1787
    • Pinilla-Ibarz, J.1    Cathcart, K.2    Korontsvit, T.3
  • 88
    • 0033179344 scopus 로고    scopus 로고
    • A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct
    • TEN BOSCH GJ, KESSLER JH, JOOSTEN AM et al.: A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct. Blood (1999) 94:1038-1045.
    • (1999) Blood , vol.94 , pp. 1038-1045
    • Ten Bosch, G.J.1    Kessler, J.H.2    Joosten, A.M.3
  • 89
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet
    • BACCARANI M, SAGLIO G, GOLDMAN J et al.: Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet. Blood (2006) 108(6):1809-1820. A very important paper that reports the current essential guidelines for the management of CML patients.
    • (2006) Blood , vol.108 , Issue.6 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 90
    • 13844261144 scopus 로고    scopus 로고
    • A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
    • GUMIREDDY K, BAKER SJ, COSENZA SC et al.: A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc. Natl. Acad. Sci. USA (2005) 102:1992-1997.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1992-1997
    • Gumireddy, K.1    Baker, S.J.2    Cosenza, S.C.3
  • 91
    • 31644438945 scopus 로고    scopus 로고
    • Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor VX-680
    • YOUNG MA, SHAH NP, CHAO LH et al.: Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor VX-680. Cancer Res. (2006) 66:1007-1014.
    • (2006) Cancer Res. , vol.66 , pp. 1007-1014
    • Young, M.A.1    Shah, N.P.2    Chao, L.H.3
  • 92
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • DRUKER BJ, SAWYERS CL, KANTARJIAN H et al.: Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. (2001) 344:1038-1042.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3


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