메뉴 건너뛰기




Volumn 28, Issue SUPPL. 1, 2004, Pages 39-45

Molecular mechanisms of resistance of leukemia to imatinib mesylate

Author keywords

BCR ABL; CML; Imatinib; Tyrosine kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 AZA 2' DEOXYCYTIDINE; ADAPHOSTIN; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BAG 1 PROTEIN; BCR ABL PROTEIN; BORTEZOMIB; FR 901228; GRN 163; HISTONE DEACETYLASE INHIBITOR; HOMOHARRINGTONINE; IMATINIB; LONAFARNIB; OBLIMERSEN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEASOME INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN SYNTHESIS INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; TELOMERASE INHIBITOR; TELOMESTATIN; UNCLASSIFIED DRUG;

EID: 1342343033     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2003.10.007     Document Type: Article
Times cited : (53)

References (82)
  • 2
    • 0021674862 scopus 로고
    • An alternation of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
    • Konopka J.B., Watanabe S.M., Witte O.N. An alternation of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell. 37:1984;1035-1042.
    • (1984) Cell , vol.37 , pp. 1035-1042
    • Konopka, J.B.1    Watanabe, S.M.2    Witte, O.N.3
  • 3
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo T.G., Pendergast A.M., Muller A.J., Witte O.N. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science. 247:1990;1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 4
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers C.L. Chronic myeloid leukemia. N. Engl. J. Med. 340:1999;1330-1340.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 6
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by P210bcr/abl gene of the Philadelphia chromosome
    • Daley G.Q., Van Etten R.A., Baltimore D. Induction of chronic myelogenous leukemia in mice by P210bcr/abl gene of the Philadelphia chromosome. Science. 247:1990;824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 8
    • 0029947186 scopus 로고    scopus 로고
    • Efficacy of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL-positive cells
    • Druker B.J., Tamura S., Buchdunger E., Ohno S., Segal G.M., Fanning S.et al. Efficacy of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL-positive cells. Nat. Med. 2:1996;561-566.
    • (1996) Nat. Med. , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5    Fanning, S.6
  • 9
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E., Zimmermann J., Mett H., Meyer T., Muller M., Druker B.J. et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56:1996;100-104.
    • (1996) Cancer Res. , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Druker, B.J.6
  • 10
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor
    • Heinrich M.C., Griffith D.J., Druker B.J., Wait C.L., Ott K.A., Zigler A.J. Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor. Blood. 96:2000;925-932.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 12
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam M., Latek R.R., Daley G.Q. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell. 112:2003;831-843.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 14
    • 0034684075 scopus 로고    scopus 로고
    • Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL (+) leukemic cells to the abl inhibitor STI571
    • Gambacorti-Passerini C., Barni R., le Coutre P., Zucchetti M., Cabrita G., Cleris L.et al. Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL (+) leukemic cells to the abl inhibitor STI571. J. Natl. Cancer Inst. 92:2000;1641-1650.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1641-1650
    • Gambacorti-Passerini, C.1    Barni, R.2    Le Coutre, P.3    Zucchetti, M.4    Cabrita, G.5    Cleris, L.6
  • 16
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoprotein- mediated efflux
    • Marbach P., Lemaire M., Hayes M., Elmquist W.F. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J. Pharmacol. Exp. Ther. 304:2003;1085-1092.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1085-1092
    • Marbach, P.1    Lemaire, M.2    Hayes, M.3    Elmquist, W.F.4
  • 17
    • 0037130294 scopus 로고    scopus 로고
    • Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
    • Hegedus T., Orifi L., Seprodi A., Varadi A., Sarkadi B., Keri G. Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochem. Biophys. Acta. 1587:2002;318-325.
    • (2002) Biochem. Biophys. Acta , vol.1587 , pp. 318-325
    • Hegedus, T.1    Orifi, L.2    Seprodi, A.3    Varadi, A.4    Sarkadi, B.5    Keri, G.6
  • 18
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon F.X., Belloc F., Lagarde V., Chollet C., Moreau-Gaudry F., Reiffers J.et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood. 101:2003;2368-2373.
    • (2003) Blood , vol.101 , pp. 2368-2373
    • Mahon, F.X.1    Belloc, F.2    Lagarde, V.3    Chollet, C.4    Moreau-Gaudry, F.5    Reiffers, J.6
  • 19
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N.et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 293:2001;876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6
  • 20
    • 0036431559 scopus 로고    scopus 로고
    • Differences between in vivo and in vitro sensitivity to imatinib of BCR-ABL positive cells obtained from leukemia patients
    • Gambacorti-Passerini C., Rossi F., Verga M., Ruchatz H., Gunby R., Frapolli R.et al. Differences between in vivo and in vitro sensitivity to imatinib of BCR-ABL positive cells obtained from leukemia patients. Blood Cells Mol. Dis. 28:2002;361-372.
    • (2002) Blood Cells Mol. Dis. , vol.28 , pp. 361-372
    • Gambacorti-Passerini, C.1    Rossi, F.2    Verga, M.3    Ruchatz, H.4    Gunby, R.5    Frapolli, R.6
  • 21
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A., Kreil S., Corbin A.S., La Rosee P., Muller M.C., Lahaye T. et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia. 16:2003;2190-2196.
    • (2003) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3    La Rosee, P.4    Muller, M.C.5    Lahaye, T.6
  • 22
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
    • Weisberg E., Griffin J.D. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood. 95:2000;3498-3505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 23
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon F.X., Deininger M.W., Schultheis B., Chabrol J., Reiffers J., Goldman J.M.et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood. 96:2000;1070-1079.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3    Chabrol, J.4    Reiffers, J.5    Goldman, J.M.6
  • 24
    • 0035163226 scopus 로고    scopus 로고
    • Marked ploidy and BCR-ABL gene amplification in vivo in a patient treated with STI571
    • Sirulink A., Silver R.T., Najfeld V. Marked ploidy and BCR-ABL gene amplification in vivo in a patient treated with STI571. Leukemia. 15:2001;1795-1797.
    • (2001) Leukemia , vol.15 , pp. 1795-1797
    • Sirulink, A.1    Silver, R.T.2    Najfeld, V.3
  • 26
    • 0344177196 scopus 로고    scopus 로고
    • Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib
    • Morel F., Le Bris M.J., Herry A., La Calvez G., Marion V., Abgrall J.F. et al. Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib. Eur. J. Hematol. 70:2003;235-239.
    • (2003) Eur. J. Hematol. , vol.70 , pp. 235-239
    • Morel, F.1    Le Bris, M.J.2    Herry, A.3    La Calvez, G.4    Marion, V.5    Abgrall, J.F.6
  • 27
    • 0035895106 scopus 로고    scopus 로고
    • Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells
    • Tipping A.J., Mahon F.X., Lagarde V., Goldman J.M., Melo J.V. Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells. Blood. 98:2001;3864-3867.
    • (2001) Blood , vol.98 , pp. 3864-3867
    • Tipping, A.J.1    Mahon, F.X.2    Lagarde, V.3    Goldman, J.M.4    Melo, J.V.5
  • 28
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
    • Von Bubnoff N., Schneller F., Peschel C., Duyster J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome- positive leukaemia to STI571: a prospective study. Lancet. 359:2002;487-491.
    • (2002) Lancet. , vol.359 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 29
    • 0036493544 scopus 로고    scopus 로고
    • Ph acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann W.K., Jones L.C., Lemp N.A., de Vos S., Gschaidmeier H., Hoelzer D.et al. Ph acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 99:2002;1860-1862.
    • (2002) Blood , vol.99 , pp. 1860-1862
    • Hofmann, W.K.1    Jones, L.C.2    Lemp, N.A.3    De Vos, S.4    Gschaidmeier, H.5    Hoelzer, D.6
  • 30
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR-ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemias who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., Grigg A., Arthur C., Taylor K.et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR-ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemias who develop imatinib (STI571) resistance. Blood. 99:2002;3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6
  • 31
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C., Soenen-Cornu V., Gradel-Duflos N., Lai J.L., Philippe N., Facon T.et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood. 100:2002;1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Gradel-Duflos, N.3    Lai, J.L.4    Philippe, N.5    Facon, T.6
  • 32
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain p-loop
    • Roumiantsev S., Shah N.P., Gorre M.E., Nicoll J., Brasher B.B., Sawyers C.L.et al. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain p-loop. Proc. Natl. Acad. Sci. U.S.A. 99:2002;10700-10705.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 10700-10705
    • Roumiantsev, S.1    Shah, N.P.2    Gorre, M.E.3    Nicoll, J.4    Brasher, B.B.5    Sawyers, C.L.6
  • 33
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor (STI571) in chronic phase and blastic crisis chronic myeloid leukemia
    • Shah N.P., Nicoll J.M., Nagar B., Gorre M.E., Paquette R.L., Kuriyan J. et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor (STI571) in chronic phase and blastic crisis chronic myeloid leukemia. Cancer Cell. 2:2002;117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6
  • 34
    • 0036827727 scopus 로고    scopus 로고
    • Mutation in the ATP-binding pocket of the ABL kinase domain in an STI571-resistant BCR/ABL-positive cell line
    • Ricci C., Scappini B., Divoky V., Gatto S., Onida F., Verstovsek S.et al. Mutation in the ATP-binding pocket of the ABL kinase domain in an STI571-resistant BCR/ABL-positive cell line. Cancer Res. 62:2002;5995-5998.
    • (2002) Cancer Res. , vol.62 , pp. 5995-5998
    • Ricci, C.1    Scappini, B.2    Divoky, V.3    Gatto, S.4    Onida, F.5    Verstovsek, S.6
  • 35
    • 0038375012 scopus 로고    scopus 로고
    • Several BCR-ABL kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • Corbin A.S., La Rosee P., Stoffregen E.P., Druker B.J., Deininger M.W. Several BCR-ABL kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood. 101:2003;4611-4614.
    • (2003) Blood , vol.101 , pp. 4611-4614
    • Corbin, A.S.1    La Rosee, P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 36
    • 10744232328 scopus 로고    scopus 로고
    • The detection of BCR-ABL mutations in imatinib-treated CML patients is virtually always accompanied by clinical resistance and mutations in the ATP phosphate-binding loop (P-loop) are associated with poor prognosis
    • Branford S., Rudzki Z., Walsh S., Parkinson I., Grigg A., Szer J.et al. The detection of BCR-ABL mutations in imatinib-treated CML patients is virtually always accompanied by clinical resistance and mutations in the ATP phosphate-binding loop (P-loop) are associated with poor prognosis. Blood. 102:2003;276-283.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6
  • 37
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecular inhibitors PD173955 and imatinib (STI-571)
    • Nagar B., Bornmann W.G., Pellicena P., Schnidler T., Veach D.R., Miller W.T.et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecular inhibitors PD173955 and imatinib (STI-571). Cancer Res. 62:2002;4236-4243.
    • (2002) Cancer Res. , vol.62 , pp. 4236-4243
    • Nagar, B.1    Bornmann, W.G.2    Pellicena, P.3    Schnidler, T.4    Veach, D.R.5    Miller, W.T.6
  • 38
    • 0037115644 scopus 로고    scopus 로고
    • Activity of the BCR-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571)
    • La Rosee P., Corbin A.S., Stoffregen E.P., Deininger M.W., Druker B.J. Activity of the BCR-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res. 62:2002;7149-7153.
    • (2002) Cancer Res. , vol.62 , pp. 7149-7153
    • La Rosee, P.1    Corbin, A.S.2    Stoffregen, E.P.3    Deininger, M.W.4    Druker, B.J.5
  • 39
    • 0012907461 scopus 로고    scopus 로고
    • A novel pyridopyrimidine inhibitor of Abl kinase is a picomolar inhibitor of BCR-ABL-driven K562 cells and is effective against STI571-resistant BCR-ABL mutants
    • Huron D.R., Gorre M.E., Kraker A.J., Sawyers C.L., Rosen N., Moasser M.M. A novel pyridopyrimidine inhibitor of Abl kinase is a picomolar inhibitor of BCR-ABL-driven K562 cells and is effective against STI571-resistant BCR-ABL mutants. Clin. Cancer Res. 9:2003;1267-1273.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1267-1273
    • Huron, D.R.1    Gorre, M.E.2    Kraker, A.J.3    Sawyers, C.L.4    Rosen, N.5    Moasser, M.M.6
  • 40
    • 0035282735 scopus 로고    scopus 로고
    • Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in p190 transgenic mice with the farnesyl transferase inhibitor SCH66336
    • Reichert A., Heisterkamp N., Daley G.Q., Groffen J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in p190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood. 97:2001;1399-1403.
    • (2001) Blood , vol.97 , pp. 1399-1403
    • Reichert, A.1    Heisterkamp, N.2    Daley, G.Q.3    Groffen, J.4
  • 41
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR-ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
    • Peters D.G., Hoover R.R., Gerlach M.J., Koh E.Y., Zhang H., Choe K.et al. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR-ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 97:2001;1404-1412.
    • (2001) Blood , vol.97 , pp. 1404-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3    Koh, E.Y.4    Zhang, H.5    Choe, K.6
  • 42
    • 0036683409 scopus 로고    scopus 로고
    • Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
    • Hoover R.R., Mahon F.X., Melo J.V., Daley G.Q. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 100:2002;1068-1071.
    • (2002) Blood , vol.100 , pp. 1068-1071
    • Hoover, R.R.1    Mahon, F.X.2    Melo, J.V.3    Daley, G.Q.4
  • 43
    • 0037369288 scopus 로고    scopus 로고
    • Apoptotic synergism between STI571 and the farnesyl transferase inhibitor SCH66336 on an imatinib-sensitive cell line
    • Brodsky A.L. Apoptotic synergism between STI571 and the farnesyl transferase inhibitor SCH66336 on an imatinib-sensitive cell line. Blood. 101:2003;2070.
    • (2003) Blood , vol.101 , pp. 2070
    • Brodsky, A.L.1
  • 44
    • 0344611212 scopus 로고    scopus 로고
    • Efficacy of SCH66336, a farnesyl transferase inhibitor, in conjunction with imatinib against BCR-ABL-positive cells
    • Nakajima A., Tauchi T., Sumi M., Bishop W.R., Ohyashiki K. Efficacy of SCH66336, a farnesyl transferase inhibitor, in conjunction with imatinib against BCR-ABL-positive cells. Mol. Cancer Ther. 2:2003;219-224.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 219-224
    • Nakajima, A.1    Tauchi, T.2    Sumi, M.3    Bishop, W.R.4    Ohyashiki, K.5
  • 45
    • 0034284027 scopus 로고    scopus 로고
    • Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
    • Reuter C.W.M., Morgan M.A., Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. 96:2000;1655-1669.
    • (2000) Blood , vol.96 , pp. 1655-1669
    • Reuter, C.W.M.1    Morgan, M.A.2    Bergmann, L.3
  • 46
    • 0034722890 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
    • Sebti S.M., Hamilton A.D. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies. Oncogene. 19:2000;6584-6593.
    • (2000) Oncogene , vol.19 , pp. 6584-6593
    • Sebti, S.M.1    Hamilton, A.D.2
  • 47
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • Liu M., Bryant M.S., Chen J., Lee S., Yaremko B., Lipari P.et al. Antitumor activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 58:1998;4947-4956.
    • (1998) Cancer Res. , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3    Lee, S.4    Yaremko, B.5    Lipari, P.6
  • 48
    • 0034730625 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
    • Ashar H.R., James L., Gray K., Carr D., Black S., Armstrong L.et al. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J. Biol. Chem. 275:2000;30451-30457.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30451-30457
    • Ashar, H.R.1    James, L.2    Gray, K.3    Carr, D.4    Black, S.5    Armstrong, L.6
  • 49
    • 0035887454 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein
    • Wang E., Casciano C.N., Clement P.R., Johnson W.W. The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. Cancer Res. 61:2001;7525-7529.
    • (2001) Cancer Res. , vol.61 , pp. 7525-7529
    • Wang, E.1    Casciano, C.N.2    Clement, P.R.3    Johnson, W.W.4
  • 50
    • 10744231480 scopus 로고    scopus 로고
    • Results of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha
    • Cortes J., Giles F., O'Brien S., Thomas D., Garcia-Manero G., Riso M.B. et al. Results of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha. Blood. 102:2003;82-86.
    • (2003) Blood , vol.102 , pp. 82-86
    • Cortes, J.1    Giles, F.2    O'brien, S.3    Thomas, D.4    Garcia-Manero, G.5    Riso, M.B.6
  • 51
    • 0031007491 scopus 로고    scopus 로고
    • Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense of bcl-2, after intravenous administration or continuous subcutaneous infusion to mice
    • Raynaud F.I., Orr R.M., Goddard P.M., Lacey H.A., Lancashire H., Judson I.R.et al. Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense of bcl-2, after intravenous administration or continuous subcutaneous infusion to mice. J. Pharmacol. Exp. Ther. 281:1997;420-427.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 420-427
    • Raynaud, F.I.1    Orr, R.M.2    Goddard, P.M.3    Lacey, H.A.4    Lancashire, H.5    Judson, I.R.6
  • 55
    • 1642618055 scopus 로고    scopus 로고
    • Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin
    • Lopes de Menezes D.E., Hudon N., Mclntosh N., Mayer L.D. Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin. Clin. Cancer Res. 6:2000;2891-2902.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2891-2902
    • Lopes De Menezes, D.E.1    Hudon, N.2    Mclntosh, N.3    Mayer, L.D.4
  • 56
    • 0034606686 scopus 로고    scopus 로고
    • Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides
    • Miyake H., Tolcher A., Gleave M.E. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. J. Natl. Cancer Inst. 92:2000;34-41.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 34-41
    • Miyake, H.1    Tolcher, A.2    Gleave, M.E.3
  • 57
    • 0034784534 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model
    • Wacheck V., Heere-Ress E., Halaschek-Wiener J., Lucas T., Meyer H., Eichler H.G.et al. Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model. J. Mol. Med. 79:2001;587-593.
    • (2001) J. Mol. Med. , vol.79 , pp. 587-593
    • Wacheck, V.1    Heere-Ress, E.2    Halaschek-Wiener, J.3    Lucas, T.4    Meyer, H.5    Eichler, H.G.6
  • 58
    • 0035678781 scopus 로고    scopus 로고
    • A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense™) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
    • Chi K.N., Gleave M.E., Klasa R., Murray N., Bryce C., Lopes de Menezes D.E.et al. A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense™) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin. Cancer Res. 7:2001;3920-3927.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3920-3927
    • Chi, K.N.1    Gleave, M.E.2    Klasa, R.3    Murray, N.4    Bryce, C.5    Lopes De Menezes, D.E.6
  • 59
    • 0036137646 scopus 로고    scopus 로고
    • Phamacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts
    • Lopes de Menezes D.E., Mayer L.D. Phamacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts. Cancer Chemother. Pharmacol. 49:2002;57-68.
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 57-68
    • Lopes De Menezes, D.E.1    Mayer, L.D.2
  • 60
    • 0036236808 scopus 로고    scopus 로고
    • A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer
    • Rudin C.M., Otterson G.A., Mauer A.M., Villalona-Calero M.A., Tomek R., Prange B.et al. A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer. Ann. Oncol. 13:2002;539-545.
    • (2002) Ann. Oncol. , vol.13 , pp. 539-545
    • Rudin, C.M.1    Otterson, G.A.2    Mauer, A.M.3    Villalona-Calero, M.A.4    Tomek, R.5    Prange, B.6
  • 61
    • 0037438586 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
    • Marcucci G., Byrd J.C., Dai G., Klisovic M.I., Youg D.C., Cataland S.R. et al. Phase I and pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 102:2003;425-432.
    • (2003) Blood , vol.102 , pp. 425-432
    • Marcucci, G.1    Byrd, J.C.2    Dai, G.3    Klisovic, M.I.4    Youg, D.C.5    Cataland, S.R.6
  • 62
    • 0141790036 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotide, Genasense™, is active against imatinib-resistant BCR-ABL-positive cells
    • Tauchi T., Sumi M., Nakajima A., Sashida G., Shimamoto T., Ohyashiki K. Bcl-2 antisense oligonucleotide, Genasense™, is active against imatinib-resistant BCR-ABL-positive cells. Clin. Cancer Res. 9:2003;4267-4273.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4267-4273
    • Tauchi, T.1    Sumi, M.2    Nakajima, A.3    Sashida, G.4    Shimamoto, T.5    Ohyashiki, K.6
  • 63
    • 0030900214 scopus 로고    scopus 로고
    • The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myelogenous leukemia
    • Iwama H., Ohyashiki K., Ohyashiki J.H., Hayashi S., Kawakubo K., Shay J.W.et al. The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myelogenous leukemia. Cancer. 79:1997;1552-1560.
    • (1997) Cancer , vol.79 , pp. 1552-1560
    • Iwama, H.1    Ohyashiki, K.2    Ohyashiki, J.H.3    Hayashi, S.4    Kawakubo, K.5    Shay, J.W.6
  • 64
    • 0031050032 scopus 로고    scopus 로고
    • Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression
    • Ohyashiki K., Ohyashiki J.H., Iwama H., Hayashi S., Shay J.W., Toyama K. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia. 11:1997;190-194.
    • (1997) Leukemia , vol.11 , pp. 190-194
    • Ohyashiki, K.1    Ohyashiki, J.H.2    Iwama, H.3    Hayashi, S.4    Shay, J.W.5    Toyama, K.6
  • 66
    • 0036845833 scopus 로고    scopus 로고
    • Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib
    • Tauchi T., Nakajima A., Sashida G., Shimamoto T., Ohyashiki J.H., Abe K.et al. Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib. Clin. Cancer Res. 8:2002;3341-3347.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3341-3347
    • Tauchi, T.1    Nakajima, A.2    Sashida, G.3    Shimamoto, T.4    Ohyashiki, J.H.5    Abe, K.6
  • 67
    • 0035122485 scopus 로고    scopus 로고
    • Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
    • Vigneri P., Wang J.Y.J. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat. Med. 7:2001;228-234.
    • (2001) Nat. Med. , vol.7 , pp. 228-234
    • Vigneri, P.1    Wang, J.Y.J.2
  • 68
    • 0034142368 scopus 로고    scopus 로고
    • Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express BCR-ABL or overexpressed MDR, MRP, Bcl-2, or Bcl-XL
    • Perkins C., Kim C.N., Fang G., Bhalla K.N. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express BCR-ABL or overexpressed MDR, MRP, Bcl-2, or Bcl-XL. Blood. 95:2000;1014-1022.
    • (2000) Blood , vol.95 , pp. 1014-1022
    • Perkins, C.1    Kim, C.N.2    Fang, G.3    Bhalla, K.N.4
  • 69
    • 18844477979 scopus 로고    scopus 로고
    • BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity
    • Puccetti E., Guller S., Orleth A., Bruggenolte N., Hoelzer D., Ottmann O.G.et al. BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. Cancer Res. 60:2000;3409-3413.
    • (2000) Cancer Res. , vol.60 , pp. 3409-3413
    • Puccetti, E.1    Guller, S.2    Orleth, A.3    Bruggenolte, N.4    Hoelzer, D.5    Ottmann, O.G.6
  • 70
    • 0034743735 scopus 로고    scopus 로고
    • Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against BCR-ABL-positive acute leukemia cells
    • Porosnicu M., Nimmanapalli R., Nguyen D., Worthington E., Perkin C., Bhalla K.N. Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against BCR-ABL-positive acute leukemia cells. Leukemia. 15:2001;772-778.
    • (2001) Leukemia , vol.15 , pp. 772-778
    • Porosnicu, M.1    Nimmanapalli, R.2    Nguyen, D.3    Worthington, E.4    Perkin, C.5    Bhalla, K.N.6
  • 72
    • 0030725774 scopus 로고    scopus 로고
    • Activation of p65 NF-kappaB protein by p210 BCR-ABL in a myeloid cell line (p210 BCR-ABL activates p65 NF-kappaB)
    • Hamdane M., David-Cordonnier M.H., D'Halluin J.C. Activation of p65 NF-kappaB protein by p210 BCR-ABL in a myeloid cell line (p210 BCR-ABL activates p65 NF-kappaB). Oncogene. 15:1997;2267-2275.
    • (1997) Oncogene , vol.15 , pp. 2267-2275
    • Hamdane, M.1    David-Cordonnier, M.H.2    D'halluin, J.C.3
  • 74
    • 79960970804 scopus 로고    scopus 로고
    • In vitro effects of PS-341 alone and in combination with STI571 in BCR-ABL positive cell lines both sensitive and resistant to STI571
    • Gatto S.R., Scappini B., Verstovsek S., Milella M., Onida F., Ball G.et al. In vitro effects of PS-341 alone and in combination with STI571 in BCR-ABL positive cell lines both sensitive and resistant to STI571. Blood. 98:2001;101a.
    • (2001) Blood , vol.98
    • Gatto, S.R.1    Scappini, B.2    Verstovsek, S.3    Milella, M.4    Onida, F.5    Ball, G.6
  • 75
    • 0028035056 scopus 로고
    • Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia
    • Zion M., Ben-Yehuda D., Avraham A., Cohen O., Wetzler M., Melloul D.et al. Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. Proc. Natl. Acad. Sci. U.S.A. 91:1994;10722-10726.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 10722-10726
    • Zion, M.1    Ben-Yehuda, D.2    Avraham, A.3    Cohen, O.4    Wetzler, M.5    Melloul, D.6
  • 76
    • 0031454221 scopus 로고    scopus 로고
    • Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia
    • Ben-Yehuda D., Krichevsky S., Rachmilewitz E.A., Avraham A., Palumbo G.A., Frassoni F.et al. Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia. Blood. 90:1997;4918-4923.
    • (1997) Blood , vol.90 , pp. 4918-4923
    • Ben-Yehuda, D.1    Krichevsky, S.2    Rachmilewitz, E.A.3    Avraham, A.4    Palumbo, G.A.5    Frassoni, F.6
  • 77
    • 0000572532 scopus 로고    scopus 로고
    • Minimal effective dose of hypomethylating agent decitabine in hematopoietic malignancies
    • Issa J.P., Garcia-Manero G., Mnnari R., Thomas D., Giles F., Cortes J.et al. Minimal effective dose of hypomethylating agent decitabine in hematopoietic malignancies. Blood. 98:2001;594a.
    • (2001) Blood , vol.98
    • Issa, J.P.1    Garcia-Manero, G.2    Mnnari, R.3    Thomas, D.4    Giles, F.5    Cortes, J.6
  • 78
    • 0034667856 scopus 로고    scopus 로고
    • Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia
    • Kantarjian H.M., Talpaz M., Smith T.L., Cortes J., Giles F.J., Rios M.B.et al. Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia. J. Clin. Oncol. 18:2000;3512-3513.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3512-3513
    • Kantarjian, H.M.1    Talpaz, M.2    Smith, T.L.3    Cortes, J.4    Giles, F.J.5    Rios, M.B.6
  • 79
    • 0037108448 scopus 로고    scopus 로고
    • BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
    • Gorre M.E., Ellwood-Yen K., Chiosis G., Rosen N., Sawyers C.L. BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood. 100:2002;3041-3044.
    • (2002) Blood , vol.100 , pp. 3041-3044
    • Gorre, M.E.1    Ellwood-Yen, K.2    Chiosis, G.3    Rosen, N.4    Sawyers, C.L.5
  • 80
    • 0037194613 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
    • Klejman A., Rushen L., Morrione A., Slupianek A., Skorski T. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene. 21:2002;5868-5876.
    • (2002) Oncogene , vol.21 , pp. 5868-5876
    • Klejman, A.1    Rushen, L.2    Morrione, A.3    Slupianek, A.4    Skorski, T.5
  • 81
    • 1342271451 scopus 로고    scopus 로고
    • Erk1/2 phosphorylation: A biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006
    • Hilger R.A., Kredke S., Hedley D., Moeller J.G., Bauer R.J., Stellberg W.et al. Erk1/2 phosphorylation: a biomarker analysis within a phase I study with the new Raf kinase inhibitor BAY43-9006. Int. J. Clin. Pharmacol. Ther. 40:2002;567-568.
    • (2002) Int. J. Clin. Pharmacol. Ther. , vol.40 , pp. 567-568
    • Hilger, R.A.1    Kredke, S.2    Hedley, D.3    Moeller, J.G.4    Bauer, R.J.5    Stellberg, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.