The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

Journal of Neurochemistry

Volumn 99, Issue 5, 2006, Pages 1351-1362

  Dello Russo, Cinzia ^b,c   Polak, Paul E ^b   Mercado, Pilar R ^b   Spagnolo, Alessandra ^b   Sharp, Anthony ^b   Murphy, Patricia ^b   Kamal, Adeela ^d   Burrows, Francis J ^d   Fritz, Lawrence C ^d   Feinstein, Douglas L ^a,b  

^a MC 513 ^*  (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c CATHOLIC UNIVERSITY   (Italy)

^d BIOGEN   (United States)

Author keywords

Astrocyte; Interleukin; Microglia; Multiple sclerosis; Nitric oxide

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; CD28 ANTIGEN; CD3 ANTIGEN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90 INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; GLIA CELL; IMMUNIZATION; INFLAMMATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; ENCEPHALITIS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME INHIBITORS; FEMALE; GLIOSIS; HSP72 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1BETA; INTERLEUKIN-2; LACTAMS, MACROCYCLIC; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES; TREATMENT OUTCOME;

EID: 33750945303     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04221.x     Document Type: Article

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