Heat shock activates the I-κBα promoter and increases I-κBα mRNA expression

Cell Stress and Chaperones

Volumn 4, Issue 1, 1999, Pages 1-7

  Wong, Hector R ^a   Ryan, Marnie A ^a   Menendez, Ingrid Y ^a   Wispé, Jonathan R ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; DACTINOMYCIN; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; NUCLEAR FACTOR I;

ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOPLASM; GENE ACTIVATION; GENETIC TRANSFECTION; HEAT SHOCK; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; LUNG ALVEOLUS CELL; NORTHERN BLOTTING; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

EID: 0032896725     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1054/csac.1998.0123     Document Type: Article

References (27)

1. Baldwin AS Jr (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14: 649-681
2. Beg AA, Sha WC, Bronson RT and Baltimore D (1995) Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in I-κBα-deficient mice. Genes Dev 9: 2736-2746
3. Blackwell TS and Christman JW (1997) The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Biol 17: 3-9
4. Bond U and Schlesinger MJ (1986) Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Mol Cell Biol 5: 949-956
5. Cahill CM, Waterman WR, Xie Y, Auron PE and Calderwood SK (1996) Transcriptional repression of the prointerleukin-1β gene by heat shock factor 1. J Biol Chem 271: 24874-24879
6. Chen CG, Malliaros J, Katerelos M, D'Apice AJF and Pearse MJ (1996) Inhibition of NF-κB by a dominant-negative mutant of IκBα. Mol Immunol 33, 57-61
7. Conway EM, Liu L, Nowakowski B, Steiner-Mosonyi M and Jackman RW (1994) Heat shock of vascular endothelial cells induces an up-regulatory transcriptional response of the thrombomodulin gene that is delayed in onset and does not attenuate. J Biol Chem 269: 22804-22810
8. Conway EM, Liu L, Nowakowski B, Steiner-Mosonyi M, Ribeiro SP and Michalak M (1995) Heat shock-sensitive expression of calreticulin, in vitro and in vivo up-regulation. J Biol Chem 270: 17011-17016
9. de Martin R, Vanhove B, Cheng Q, Hofer E, Csizmadia V, Winkler H and Bach FH (1993) Cytokine-inducible expression in endothelial cells of an IκBα-like gene is regulated by NFκB. EMBO J 12: 2773-2779
10. DeMeester SL, Buchman TG, Qiu Y et al (1997) Heat shock induces I-κBα and prevents stress-induced endothelial cell apoptosis. Arch Surg 132: 1283-1288
11. Feinstein DL, Galea E, Aquino DA, Li GC, Xu H and Reis DJ (1996) Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NF-κB activation. J Biol Chem 271: 17224-17232
12. Hauser GJ, Dayao EK, Wasserloos K, Pitt BR and Wong HR (1996) Heat shock protein induction inhibits inducible nitric oxide synthase mRNA expression and attenuates hypotension in endotoxin-challenged rats. Am J Physiol 271 : H2529-H2535
13. Ito CY, Kazantsev AG and Baldwin AS Jr (1994) Three NF-κB sites in the IκB-α promoter are required for induction of gene expression by TNFα. Nucleic Acids Res 22: 3787-3792
14. Klement JF, Rice NR, Car BD et al (1996) I-κBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol Cell Biol 16: 2341-2349
15. Klosterhalfen B, Hauptmann S, Offner F-A et al (1997) Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia. Shock 7: 254-262
16. Ribeiro SP, Villar J, Downey GP, Edelson JD and Slutsky AS (1996) Effects of the stress response in septic rats and LPS-stimulated alveolar macrophages: evidence for the TNF-α post-translational regulation. Am J Respir Crit Care Med 154: 1843-1850
17. Schmidt JA and Abdulla E (1988) Down-regulation of IL-1β biosynthesis by inducers of the heat-shock response. J Immunol 141: 2027-2034
18. Shibahara S, Muller RM and Taguchi H (1987) Transcriptional control of rat heme oxygenase by heat shock. J Biol Chem 262: 12889-12892
19. Snyder YL, Guthrie L, Evans GF and Zuckerman S (1992) Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritoneal macrophages. J Leuko Biol 51: 181-187
20. Wahl C, Liptay S, Adler G and Schmid RM (1998) Sulfasalzine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 101: 1163-1174
21. Welch WJ (1992) Mammalian stress response: cell physiology structure/function of stress proteins, and implications for medicine and disease. Physiol Rev 72: 1063-1081
22. Wong HR, Finder JD, Wasserloos K and Pitt BR (1995) Expression of inducible nitric oxide synthase in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. Am J Physiol 269: L843-L848
23. Wong HR and Wispé JR (1997) The stress response and the lung. Am J Physiol 273: L1-L9
24. Wong HR, Ryan M, Gebb S and Wispé JR (1997a) Selective and transient in vitro effects of heat shock on alveolar type II cell gene expression. Am J Physiol 272: L132-L138
25. Wong HR, Ryan M and Wispé JR (1997b) The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking Iκ-B degradation and NF-κB nuclear translocation. Biochem Biophys Res Comm 231: 257-263
26. Wong HR, Ryan M and Wispé JR (1997c) Stress response decreases NF-κB nuclear translocation and increases I-κBα expression in A549 cells. J Clin Invest 99: 2423-2428
27. Wrighton CJ, Hofer-Warbinek R, Moll T, Eytner R, Bach FH and de Martin R (1996) Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp Med 183: 1013-1022