Downregulation of β2-microglobulin in human cord blood somatic stem cells after transplantation into livers of SCID-mice: An escape mechanism of stem cells?

Biochemical and Biophysical Research Communications

Volumn 294, Issue 5, 2002, Pages 1052-1063

  Beerheide, W ^a   Von Mach, M A ^b   Ringel, M ^b   Fleckenstein, C ^b   Schumann, S ^b   Renzing, N ^b   Hildebrandt, A ^b   Brenner, W ^b   Jensen, O ^a   Gebhard, S ^b   Reifenberg, K ^b   Bender, J ^a   Oesch, F ^b   Hengstler, J G ^b  

^a Kourion Therapeutics AG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

GATA4; Hepatocytes; Human stem cells; Immune escape; Plasticity; Transdifferentiation; Fetoprotein; 1 Antitrypsin; Actin; 2 Microglobulin

Indexed keywords

ALBUMIN; ALGINIC ACID; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; FLUORESCENT DYE; TRANSCRIPTION FACTOR GATA 4; ALBUMINOID; MESSENGER RNA;

ARTICLE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL ISOLATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HOST; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LIVER; LIVER CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR CELL; NATURAL KILLER CELL; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; STAINING; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; UMBILICAL CORD BLOOD; AGED; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DOWN REGULATION; FETUS BLOOD; GENE SILENCING; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; STEM CELL; TRANSACTIVATION; TRANSPLANTATION TOLERANCE;

AGED; ALBUMINS; ANIMALS; BETA 2-MICROGLOBULIN; DOWN-REGULATION; FETAL BLOOD; GENE SILENCING; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICE; MICE, SCID; RNA, MESSENGER; STEM CELL TRANSPLANTATION; STEM CELLS; TRANS-ACTIVATION (GENETICS); TRANSPLANTATION TOLERANCE;

EID: 18444391476     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00596-X     Document Type: Article

References (50)

1. Hepatocytes from non-hepatic adult stem cells
2. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells
3. Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo
4. The evolving concept of a stem cell: Entity or function?
5. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function
6. The SCID mouse mutant: Definition, characterization, and potential uses
7. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
8. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
9. Mesenchymal progenitor cells in human umbilical cord blood
10. Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning
11. Cytokines and the regulation of tolerance
12. Muscle regeneration by bone marrow-derived myogenic progenitors
13. Skeletal myogenic potential of human and mouse neural stem cells
14. Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts
15. The MHC-specific enhanceosome and its role in MHC class I and beta2-microglobulin gene transactivation
16. SCID mouse models of human stem cell engraftment
17. Dystrophin expression in the mdx mouse restored by stem cell transplantation
18. Characterization of the adherent cells developed in Dexter-type long-term cultures from human umbilical cord blood
19. Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice
20. Cultures with cryopreserved hepatocytes: Applicability for studies of enzyme induction
21. Cryopreserved primary hepatocytes as an in vitro model for the evaluation of drug metabolism and enzyme induction
22. Hematopoietic potential of stem cells isolated from murine skeletal muscle
23. Identification of a neural stem cell in the adult mammalian central nervous system
24. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
25. Purified hematipoietic stem cells can differentiate to hepatocytes in vivo
26. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
27. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
28. Isolation of human mesenchymal stem cells: Bone marrow versus umbilical cord blood
29. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand
30. Liver regeneration
31. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
32. c-erbB-2 expression in small cell lung cancer is associated with poor prognosis
33. Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity: Activation of caspase-3 and nuclear factor-kappaB
34. Albumin and alpha-fetoprotein gene expression in various nonhepatic rat tissues
35. Investigation of HLA class I downregulation in breast cancer by RT-PCR
36. Bone marrow as a potential source of hepatic oval cells
37. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
38. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
39. Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: Defective regulation of cytokine receptors and protein kinase C
40. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies
41. Derivation of pluripotent stem cells from cultured human primordial germ cells
42. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
43. Compactin enhances osteogenesis in murine embryonic stem cells
44. Liver from bone marrow in humans
45. Embryonic stem cell lines derived from human blastocysts
46. Stem cell plasticity in mammals and transdetermination in Drosophila: Common themes?
47. Detection of unrestricted multipotential stem cells in human cord blood
48. Neuronal development of embryonic stem cells: A model of GABAergic neuron differentiation
49. Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes
50. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes