PDGF-BB induces expression of LTBP-1 but not TGF-β1 in a rat cirrhotic fat storing cell line

Growth Factors

Volumn 21, Issue 3-4, 2003, Pages 121-130

  Westhoff, Jens H ^a   Sawitza, Iris ^a   Keski Oja, Jorma ^b   Gressner, Axel M ^a   Breitkopf, Katja ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cytokines; Hepatic stellate cells; Liver fibrosis; LTBP; TGF

Indexed keywords

BINDING PROTEIN; CYTOKINE; MESSENGER RNA; PEPTIDE; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; LIPID STORAGE; LIVER CIRRHOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ANIMALS; ANTICOAGULANTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIVISION; CELL LINE; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROSIS; HEPATOCYTES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LATENT TGF-BETA BINDING PROTEINS; LUCIFERASES; PLATELET-DERIVED GROWTH FACTOR; PROMOTER REGIONS (GENETICS); RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 0346121466     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.1080/08977190310001637224     Document Type: Article

References (37)

1. Bascom, C.C., Wolfshohl, J.R., Coffey, R.J., Madisen, L., Webb, N.R., Purchio, A.R., Derynck, R. and Moses, H.L. (1989) "Complex regulation of transforming growth factor β1, β2, and β3, mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors β1 and β2", Mol. Cell Biol. 9, 5508-5515.
2. Bissell, D.M., Roulot, D. and George, J. (2001) "Transforming growth factor β and the liver", Hepatology 34, 859-867.
3. Boshart, M., Weber, F., Jahn, G., Dorsch-Hasler, K., Fleckenstein, B. and Schaffner, W. (1985) "A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus", Cell 41, 521-530.
4. Breitkopf, K., Lahme, B., Tag, C.G. and Gressner, A.M. (2001) "Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture", Hepatology 33, 387-396.
5. Chen, Y., Dabovic, B., Annes, J.P. and Rifkin, D.B. (2002) "Latent TGF-β binding protein-3 (LTBP-3) requires binding to TGF-β for secretion", FEBS Lett. 517, 277-280.
6. Dallas, S.L., Park-Snyder, S., Miyazono, K., Twardzik, D., Mundy, G.R. and Bonewald, L.F. (1994) "Characterizaation and autoregulation of latent transforming growth factor-β (TGF-β) complexes in osteoblast-like cell lines", J. Biol. Chem. 269, 6815-6822.
7. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S. and Gauthier, J.M. (1998) "Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene", EMBO J 17, 3091-3100.
8. 4-cirrhotic livers. Differences in the production of interleukin-6", Lab. Investig. 65, 644-653.
9. Gressner, A.M. (1996) "Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis", Kidney Int. 49, 39-45.
10. Gressner, A.M., Weiskirchen, R., Breitkopf, K. and Dooley, S. (2002) "Roles of TGF-β in hepatic fibrosis", Front. Biosci. 7, 793-807.
11. Heldin, C.H. and Westermark, B. (1996) In: Clark, R.A.F., ed, Role of Platelet-Derived Growth Factor In Vivo, 2nd Ed. (Plenum, New York), pp. 249-273.
12. Hori, Y., Katoh, T., Hirakata, M., Joki, N., Kaname, S., Fukagawa, M., Okuda, T., Ohashi, H., Fujita, T., Miyazono, K. and Kurokawa, K. (1998) "Anti-latent TGF-β binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells", Kidney Int. 53, 1616-1625.
13. Kanzaki, T., Olofsson, A., Moren, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson-Welsh, L. and Heldin, C.H. (1990) "TGF-β1 binding protein: a component of the large latent complex of TGF-β1 with multiple repeat sequences", Cell 61, 1051-1061.
14. Kim, S.J., Jeang, K.T., Glick, A.B., Sporn, M.B. and Roberts, A.B. (1989) "Promoter sequences of the human transforming growth factor-β1 gene responsive to transforming growth factor-β1 autoinduction", J. Biol. Chem. 264, 7041-7045.
15. 3 enhances the expression of transforming growth factor-β1 and its latent form binding protein in cultured breast carcinoma cells", Cancer Res. 55, 1540-1546.
16. Koli, K., Saharinen, J., Hyytiäinen, M., Penttinen, C. and Keski-Oja, J. (2001) "Latency, activation, and binding proteins of TGF-P", Microsc. Res. Technique 52, 354-362.
17. Koski, C., Saharinen, J. and Keski-Oja, J. (1999) "Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-β binding protein-1 (LTBP-1) in a cell type-specific manner", J. Biol. Chem. 274, 32619-32630.
18. Mangasser-Stephan, K. and Gressner, A.M. (1999) "Molecular and functional aspects of latent transforming growth factor-β binding protein: just a masking protein?", Cell Tissue Res. 297, 363-370.
19. Miyazono, K., Olofsson, A., Colosetti, P. and Heldin, C.H. (1991) "A role of the latent TGF-β1-binding protein in the assembly and secretion of TGF-β1", EMBO J. 10, 1091-1101.
20. Munger, J.S., Harpel, J.G., Gleizes, P.E., Mazzieri, R., Nunes, I. and Rifkin, D.B. (1997) "Latent transforming growth factor-β: structural features and mechanisms of activation", Kidney Int. 51, 1376-1382.
21. Nunes, I., Gleizes, P.E., Metz, C.N. and Rifkin, D.B. (1997) "Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β", J. Cell Biol. 136, 1151-1163.
22. Olofsson, A., Ichijo, H., Moren, A., ten Dijke, P., Miyazono, K. and Heldin, C.H. (1995) "Efficient association of an amino-terminally extended form of human latent transforming growth factor-β binding protein with the extracellular matrix", J. Biol. Chem. 270, 31294-33127.
23. Penttinen, C., Saharinen, J., Weikkolainen, K., Hyytiainen, M. and Keski-Oja, J. (2002) "Secretion of human latent TGF-β-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-β", J. Cell Sci. 115, 3457-3468.
24. Qian, S.W., Kondaiah, P., Roberts, A.B. and Sporn, M.B. (1990) "CDNA cloning by PCR of rat transforming growth factor β-1", Nucleic Acids Res. 18, 3059.
25. Raines, E.W., Bowen-Pope, D.F. and Ross, R. (1990) In: Sporn, M.B. and Roberts, A.B., eds, Platelet-Derived Growth Factor (Springer-Verlag, Heidelberg) Vol. 95, pt. I, pp. 173-262.
26. Roth, S., Schurek, J. and Gressner, A.M. (1997) "Expression and release of the latent TGF-β binding protein (LTBP) by hepatocytes from rat liver", Hepatology 25, 1398-1405.
27. Roth, S., Michel, K. and Gressner, A.M. (1998) "(Latent) transforming growth factor-β in liver parenchymal cells, its injury-dependent release and paracrine effects on hepatic stellate cells", Hepatology 27, 1003-1012.
28. Roth-Eichhorn, S., Kuhl, K. and Gressner, A.M. (1998) "Subcellular localization of (latent) transforming growth factor β and the latent TGF-β binding protein in rat hepatocytes and hepatic stellate cells", Hepatology 28, 1588-1596.
29. Saharinen, J. and Keski-Oja, J. (2000) "Specific sequence motif of 8-Cys repeats of TGF-β binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-β", Mol. Biol. Cell 11, 2691-2704.
30. Saharinen, J., Hyytiäinen, M., Taipale, J. and Keski-Oja, J. (1999) "Latent transforming growth factor-β binding proteins (LTBPs) -structural extracellular matrix proteins for targeting TGF-β action", Cytokine Growth Factor Rev. 10, 99-117.
31. Sato, Y. and Rifkin, D.B. (1989) "Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-β1-like molecule by plasmin during coculture", J. Cell Biol. 109, 309-315.
32. Shipley, J.M., Mecham, R.P., Maus, E., Bonadio, J., Rosenbloom, J., McCarthy, R.T., Baumann, M.L., Frankfater, C., Segade, F. and Shapiro, S.D. (2000) "Developmental expression of latent transforming growth factor β binding protein 2 and its requirement early in mouse development", Mol. Cell. Biol. 20, 4879-4887.
33. Taipale, J., Miyazono, K., Heldin, C.-H. and Keski-Oja, J. (1994) "Latent transforming growth factor-β1 associates to fibroblast extracellular matrix via latent TGF-β binding protein", J. Cell Biol. 124, 171-181.
34. Tsuji, T., Okada, F., Yamaguchi, K. and Nakamura, T. (1990) "Molecular cloning of the large subunit of transforming growth factor type β masking protein and expression of the mRNA in various rat tissues", Proc. Natl Acad. Sci. 87, 8835-8839.
35. van Obberghen-Schilling, E., Roche, N.S., Flanders, K.C., Sporn, M.B. and Roberts, A.B. (1988) "Transforming growth factor β1 positively regulates its own expression in normal and transformed cells", J. Biol. Chem. 263, 7741-7746.
36. Weigert, C., Sauer, U., Brodbeck, K., Pfeiffer, A., Haring, H.U. and Schleicher, E.D. (2000) "AP-1 proteins mediate hyperglycemia-induced activation of the human TGF β1 promoter in mesangial cells", J. Am. Soc. Nephrol. 11, 2007-2016.
37. Weikkolainen, K., Keski-Oja, J. and Koli, K. (2003) "Expression of latent TGF-β binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblast", Growth Factors 21(2), 51-60.