Inhibitors of acyl-CoA:cholesterol O-acyltransferase. Synthesis and pharmacological activity of (±)-2-dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2354-2366

  O'Brien, Patrick M ^a   Sliskovic, Drago R ^a   Picard, Joseph A ^a   Lee, Helen T ^a   Purchase II, Claude F ^a   Roth, Bruce D ^a   White, Andrew D ^a   Anderson, Maureen ^a   Mueller, Sandra Bak ^a   Bocan, Thomas ^a   Bousley, Richard ^a   Hamelehle, Katherine L ^a   Homan, Reynold ^a   Lee, Peter ^a   Krause, Brian R ^a   Reindel, J F ^a   Stanfield, Richard L ^a   Turluck, Daniel ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (11 DODECENYL) ALPHA PHENYL N (2,4,6 TRIMETHOXYPHENYL) 2H TETRAZOLE 5 ACETAMIDE; 2 DODECYL ALPHA PHENYL N (2,4,6 TRIMETHOXYPHENYL) 2H TETRAZOLE 5 ACETAMIDE; 2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; N [2,6 BIS(1 METHYLETHYL)PHENYL] 5 DODECYL 2H TETRAZOLE 2 ACETAMIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ADRENAL CORTEX FUNCTION; ARTICLE; CHOLESTEROL BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ARTERIOSCLEROSIS; CHOLESTEROL; CHOLESTEROL, DIETARY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GUINEA PIGS; HYPERCHOLESTEROLEMIA; MACROPHAGES; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RABBITS; RATS; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0029898322     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960170f     Document Type: Article

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