-
1
-
-
0030585761
-
Assignment of the hypoxia-inducible factor 1 alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q
-
Semenza GL, Rue EA, Iyer NV, Pang MG, Kearns WG. Assignment of the hypoxia-inducible factor 1 alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Genomics 1996;34:437-439.
-
(1996)
Genomics
, vol.34
, pp. 437-439
-
-
Semenza, G.L.1
Rue, E.A.2
Iyer, N.V.3
Pang, M.G.4
Kearns, W.G.5
-
2
-
-
0034763859
-
Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas
-
Thorstensen L, Qvist H, Nesland JM, Giercksky KE, Lothe RA. Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas. Scand J Gastroenterol 2001;12:1327-1331.
-
(2001)
Scand J Gastroenterol
, vol.12
, pp. 1327-1331
-
-
Thorstensen, L.1
Qvist, H.2
Nesland, J.M.3
Giercksky, K.E.4
Lothe, R.A.5
-
3
-
-
10744225401
-
Delineation of a 2.8 megabases region harboring a potential tumor suppressor gene involved in renal cell carcinoma, that is commonly deleted from chromosome 14
-
Gallou C, Mejean A, Bouvier R, et al. Delineation of a 2.8 megabases region harboring a potential tumor suppressor gene involved in renal cell carcinoma, that is commonly deleted from chromosome 14. Anticancer Res 2003;23:4865-4870.
-
(2003)
Anticancer Res
, vol.23
, pp. 4865-4870
-
-
Gallou, C.1
Mejean, A.2
Bouvier, R.3
-
4
-
-
2942753982
-
Loss of 14q chromosome in oligoendroglial and astrocytic tumors
-
Dichamp C, Taillibert S, Aguirre-Cruz L, et al. Loss of 14q chromosome in oligoendroglial and astrocytic tumors. J Neuro oncol 2004;67:281-285.
-
(2004)
J Neuro Oncol
, vol.67
, pp. 281-285
-
-
Dichamp, C.1
Taillibert, S.2
Aguirre-Cruz, L.3
-
5
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995;92:5510-5514.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
6
-
-
0142166332
-
Targetin Hif-1 for cancer therapy
-
Semenza GL. Targetin Hif-1 for cancer therapy. Nat Rev Cancer 2003;3:721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
7
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, et al. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 2000;95:189-197.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
-
8
-
-
0035910429
-
Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelia growth factor gene induction by hypoxia and nitric oxide
-
Kimura H, Weisz A, Ogura T, et al. Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelia growth factor gene induction by hypoxia and nitric oxide. J Biol Chem 2001;276:2292-2298.
-
(2001)
J Biol Chem
, vol.276
, pp. 2292-2298
-
-
Kimura, H.1
Weisz, A.2
Ogura, T.3
-
9
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Mellilo G, Musso T, Sica A, Taylor LS, Cox GW, Varesio LA. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 1995;182:1683-1693.
-
(1995)
J Exp Med
, vol.182
, pp. 1683-1693
-
-
Mellilo, G.1
Musso, T.2
Sica, A.3
Taylor, L.S.4
Cox, G.W.5
Varesio, L.A.6
-
10
-
-
0033587146
-
The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, et al. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
11
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
-
13
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor α chains activated by prolyl hydroxylation
-
Masson N, William C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor α chains activated by prolyl hydroxylation. EMBO J 2001;20:5197-5206.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
William, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
14
-
-
0037035851
-
Structure of an HIF-1 alpha-pVHL hydroxyproline recognition in signaling
-
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Jr., Pavletich NP. Structure of an HIF-1 alpha-pVHL hydroxyproline recognition in signaling. Science 2002;296:1886-1889.
-
(2002)
Science
, vol.296
, pp. 1886-1889
-
-
Min, J.H.1
Yang, H.2
Ivan, M.3
Gertler, F.4
Kaelin Jr., W.G.5
Pavletich, N.P.6
-
15
-
-
0036678830
-
Two sequence motifs from HIF-1α bind to the DNA binding site of p53
-
Hansson LO, Friedler A, Feund S, Rüdinger S, Fersht AR. Two sequence motifs from HIF-1α bind to the DNA binding site of p53. Proc Natl Acad Sci 2002;99:10305-10309.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 10305-10309
-
-
Hansson, L.O.1
Friedler, A.2
Feund, S.3
Rüdinger, S.4
Fersht, A.R.5
-
16
-
-
0035899491
-
The pVHL associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma
-
Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PH, Maher ER. The pVHL associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma. Oncogene 2001;20:5067-5074.
-
(2001)
Oncogene
, vol.20
, pp. 5067-5074
-
-
Clifford, S.C.1
Astuti, D.2
Hooper, L.3
Maxwell, P.H.4
Ratcliffe, P.H.5
Maher, E.R.6
-
17
-
-
0242559086
-
Hypoxia-inducible factor 1a polymorphisms associated with enhanced transactivation capacity, implying clinical significance
-
Tanimoto K, Yoshiga K, Eguchi H, et al. Hypoxia-inducible factor 1a polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 2003;24:1779-1783.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1779-1783
-
-
Tanimoto, K.1
Yoshiga, K.2
Eguchi, H.3
-
18
-
-
0036213587
-
Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas
-
Fransen K, Dimberg J, Österström A, Olsson A, Söderkvist P, Sirsjö A. Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas. Surgery 2002;131:384-392.
-
(2002)
Surgery
, vol.131
, pp. 384-392
-
-
Fransen, K.1
Dimberg, J.2
Österström, A.3
Olsson, A.4
Söderkvist, P.5
Sirsjö, A.6
-
19
-
-
0032419024
-
Assessment of vascularity in histological sections: Effects of methodology and value as an index of angiogenesis in breast tumours
-
Schor AM, Pendleton N, Pazouki S, et al. Assessment of vascularity in histological sections: Effects of methodology and value as an index of angiogenesis in breast tumours. Histochem J 1998;30:849-856.
-
(1998)
Histochem J
, vol.30
, pp. 849-856
-
-
Schor, A.M.1
Pendleton, N.2
Pazouki, S.3
-
20
-
-
0027968068
-
CLUSTAL W: Improving the sensitivity of progressivemultiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Higgins D, Thompson J, Gibson T, Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: Improving the sensitivity of progressivemultiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994;22:4673-4680.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4673-4680
-
-
Higgins, D.1
Thompson, J.2
Gibson, T.3
Thompson, J.D.4
Higgins, D.G.5
Gibson, T.J.6
-
21
-
-
2442690353
-
Flat and polypoid adenocarcinoas of the colorectum: A comparative histomorphologic analysis of 47 cases
-
Nasir A, Boulware D, Kaiser HE, et al. Flat and polypoid adenocarcinoas of the colorectum: A comparative histomorphologic analysis of 47 cases. Hum Pathol 2004;35:604-611.
-
(2004)
Hum Pathol
, vol.35
, pp. 604-611
-
-
Nasir, A.1
Boulware, D.2
Kaiser, H.E.3
-
22
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1 alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
-
Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM. Coordinate up-regulation of hypoxia inducible factor (HIF)-1 alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 2000;60:6189-6195.
-
(2000)
Cancer Res
, vol.60
, pp. 6189-6195
-
-
Elson, D.A.1
Ryan, H.E.2
Snow, J.W.3
Johnson, R.4
Arbeit, J.M.5
-
23
-
-
0037340247
-
Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease
-
Giatromanolaki A, Sivridis E, Maltezos E, et al. Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. J Clin Pathol 2003;56:209-213.
-
(2003)
J Clin Pathol
, vol.56
, pp. 209-213
-
-
Giatromanolaki, A.1
Sivridis, E.2
Maltezos, E.3
-
24
-
-
0037189565
-
The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine
-
Gradin K, Takasaki C, Fujii-Kuriyama Y, Sogawa K. The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. J Biol Chem 2002;277:23508-23514.
-
(2002)
J Biol Chem
, vol.277
, pp. 23508-23514
-
-
Gradin, K.1
Takasaki, C.2
Fujii-Kuriyama, Y.3
Sogawa, K.4
-
25
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha
-
Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha. J Biol Chem 2002;277:40112-40117.
-
(2002)
J Biol Chem
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
26
-
-
0037047057
-
Mutations in APC, Kirstenras, and p53-Alternative genetic pathways to colorectal cancer
-
Smith G, Carey FA, Beattie J, et al. Mutations in APC, Kirstenras, and p53-Alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 2002;99:9433-9438.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9433-9438
-
-
Smith, G.1
Carey, F.A.2
Beattie, J.3
-
27
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
28
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
29
-
-
0036968713
-
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers
-
Zhou XP, Loukola A, Salovaara R, et al. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol 2002;161:439-447.
-
(2002)
Am J Pathol
, vol.161
, pp. 439-447
-
-
Zhou, X.P.1
Loukola, A.2
Salovaara, R.3
-
30
-
-
0842308265
-
PTEN mutations are common in sporadic microsatellite stable colorectal cancer
-
Nassif NT, Lobo GP, Wu X, et al. PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene 2004;23:617-628.
-
(2004)
Oncogene
, vol.23
, pp. 617-628
-
-
Nassif, N.T.1
Lobo, G.P.2
Wu, X.3
-
31
-
-
4043086934
-
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation
-
Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang/ SNM> LE. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. FASEB J 2004;18:1028-1030.
-
(2004)
FASEB J
, vol.18
, pp. 1028-1030
-
-
Kageyama, Y.1
Koshiji, M.2
To, K.K.3
Tian, Y.M.4
Ratcliffe, P.J.5
Huang, L.E.6
-
32
-
-
2942624259
-
A common polymorphism in the oxygen dependent degradation (ODD) domain of hypoxia inducible factor-1a (HIF-1α) does not impair Pro-564 hydroxylation
-
Percy MJ, Mooney SM, McMullin MF, Flores A, Lappin TRJ, Lee FS. A common polymorphism in the oxygen dependent degradation (ODD) domain of hypoxia inducible factor-1a (HIF-1α) does not impair Pro-564 hydroxylation. Mol Cancer 2003;2:31.
-
(2003)
Mol Cancer
, vol.2
, pp. 31
-
-
Percy, M.J.1
Mooney, S.M.2
McMullin, M.F.3
Flores, A.4
Lappin, T.R.J.5
Lee, F.S.6
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