Identification of novel regulators in T-cell differentiation of aplastic anemia patients

BMC Genomics

Volumn 7, Issue , 2006, Pages

  Franzke, Anke ^a   Geffers, Robert ^b   Hunger, J Katrin ^a   Pförtner, Susanne ^b   Piao, Wenji ^a   Ivanyi, Philipp ^a   Grosse, Jens ^a   Probst Kepper, Michael ^a   Ganser, Arnold ^a   Buer, Jan ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CX3C CHEMOKINE; CYCLOSPORIN A; DIPEPTIDYL PEPTIDASE IV; EARLY GROWTH RESPONSE FACTOR 1; GRANZYME B; IMMUNOGLOBULIN FC FRAGMENT; INSULIN RECEPTOR SUBSTRATE 2; INTERFERON REGULATORY FACTOR 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 6 RECEPTOR; JAGGED1; PROTEIN BCL 3; PROTEIN KINASE LYN; PROTEOGLYCAN; RIBONUCLEASE; STAT1 PROTEIN; STAT5B PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; THROMBOCYTE FACTOR 4; THYMOCYTE ANTIBODY; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; VASCULOTROPIN;

ADULT; AGED; APLASTIC ANEMIA; ARTICLE; BLOOD SAMPLING; BONE MARROW; BONE MARROW BIOPSY; BONE MARROW DEPRESSION; CELL MEDIATED CYTOTOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC REGULATION; HEMATOPOIESIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MALE; MICROARRAY ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL;

ADULT; AGED; ANEMIA, APLASTIC; ANTIGENS, CD3; ANTILYMPHOCYTE SERUM; BONE MARROW CELLS; CELL DIFFERENTIATION; CLUSTER ANALYSIS; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IMMUNOTHERAPY; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 33750480880     PISSN: 14712164     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-7-263     Document Type: Article

References (47)

1. Young NS, Maciejewski JP: The pathophysiology of aquired aplastic anemia. N Eng J Med 1997, 336:1365-1372.
2. Marsh JC, Chang J, Testa NG, Hows JM, Dexter TM: The hematopoietic defect in aplastic anemia assessed by long-term marrow culture. Blood 1990, 76(9):1748-1757.
3. Gordon MY: Stem cells and the microenvironment in aplastic anaemia. Br J Haematol 1994, 86(1):190-192.
4. Frickhofen N, Kaltwasser JP, Schrezenmeier H, Ragavachar A, Vogt HG, Herrmann F, Freund M, Meusers P, Salama A, Heimpel H: Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. N Engl J Med 1991, 324:1297-1304.
5. Nakao S, Takami A, Takamatsu H, Zeng W, Sugimori N, Yamazaki H, Miura Y, Ueda M, Shiobara S, Yoshioka T, Kaneshige T, Yasukawa M, Matsuda T: Isolation of a T cell clone showing HLA-DRBI *0405-restricted cytotoxicity for hematopoietic cells in a patient with aplastic anemia. Blood 1997, 89:3691-3699.
6. Philpot NJ, Scopes J, Marsh JCW, Gordon Smith EC, Gibson FM: Increased apoptosis in aplastic anemia bone marrow progenitor cells: Possible pathophysiologic significance. Exp Hematol 1995, 23:1642-1648.
7. Maciejewski JP, Selleri C, Sato T, Anderson S, Young NS: Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anemia. Br J Haematol 1995, 91:245-252.
8. Maciejewski JP, Hibbs JR, Anderson S, Katevas P, Young NS: Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Exp Hematol 1994, 22:1102-1110.
9. Maciejewski JP, Selleri C, Anderson S, Young NS: Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine mediated hematopoietic suppression in vitro. Blood 1995, 85:3183-3190.
10. Nagafuji K, Shibuya T, Harada M, Mizuno S, Takenaka K, Miyamoto T, Okamura T, Gondo H, Niho Y: Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells. Blood 1995, 86:883-889.
11. Giannakoulas NC, Karakantza M, Theodorou GL, Pagoni M, Galanopoulos A, Kakagianni T, Kouraklis-Symeonidis A, Matsouka P, Maniatis A, Zoumbos NC: Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anemia patients. Br J Haematol 2004, 124:97-105.
12. [http://www.ncbi.nlm.nih.gov/geo/]. accession number GSE3807
13. [http://www.ebi.ac.uk/arrayexpress]. accession number E-MEXP-750
14. [http://www.ebi.ac.uk/arrayexpress]. accession number E-TABM-40
15. Zeng W, Nakao S, Takamatsu H, Yachie A, Takami A, Kondo Y, Sugimori N, Yamazaki H, Miura Y, Shiobara S, Matsuda T: Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: Evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. Blood 1999, 93(9):3008-3016.
16. Zeng W, Maciejewski JP, Chen G, Young NS: Limited heterogeneity of T cell receptor BV usage in aplastic anemia. J Clin Invest 2001, 108(5):765-773.
17. Risitano AM, Kook H, Zeng W, Chen G, Young NS, Maciejewski JP: Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry. Blood 2002, 100(1):178-183.
18. Piao W, Grosse J, Czwalinna A, Ivanyi P, Ganser A, Franzke A: Antigen-recognition sites of micromanipulated T cells in patients with acquired aplastic anemia. Exp Hematol 2005, 33(7):804-810.
19. Zeng W, Kajigaya S, Chen G, Risitano AM, Nunez O, Young NS: Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients. Exp Hematol 2004, 32(9):806-814.
20. Jattela M, Mouritzen H, Elling F, Bastholm L: A20 zinc finger protein inhibits TNF and IL-1 signaling. J Immunol 1996, 156(3):1166-1173.
21. Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C: A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med 1999, 190(8):1135-1146.
22. Avalos BR, Bartynski KJ, Elder PJ, Kotur MS, Burton WG, Wilkie NM: The active monomeric form of macrophage inflammatory protein-1 alpha interacts with high- and low-affinity classes of receptors on human hematopoietic cells. Blood 1994, 84(6):1790-1801.
23. Hsu HC, Tsai WH, Chen LY, Hsu ML, Ing-Tiau Kuo B, Ho CH, Lin CK, Wang SY: Production of hematopoietic regulatory cytokines by peripheral blood mononuclear cells in patients with aplastic anemia. Exp Hematol 1996, 24(1):31-36.
24. Broxmeyer HE, Cooper S, Hangoc G, Gao JL, Murphy PM: Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J Exp Med 1999, 189(12):1987-1992.
25. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 1999, 286(5440):771-774.
26. Charo IF, Peters W: Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation 2003, 10(3-4):259-264.
27. Fraticelli P, Sironi M, Bianchi G, D'Ambrosio D, Albanesi C, Stoppacciaro A, Chieppa M, Allavena P, Ruco L, Girolomoni G, Sinigaglia F, Vecchi A, Mantovani A: Fractalkine (CX3CL1) as an amplification circuits of polarized Th1 resonses. J. Clin Invest 2001, 107(9):1173-1181.
28. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L: Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002, 8(5):500-508.
29. Jee Y, Yoon WK, Okura Y, Tanuma N, Matsumoto Y: Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2002, 128(1-2):49-57.
30. Dang NH, Morimoto C: CD26: An expanding role in immune regulation and cancer. Histol Histopathol 2002, 17(4):1213-1226.
31. Willheim M, Ebner C, Baier K, Kern W, Schrattbauer K, Thien R, Kraft D, Breiteneder H, Reinisch W, Scheiner O: Cell surface characterization of T lymphocytes and allergen-specific T cell clones - correlation of CD26 expression with Th1 subsets. J Allergy Clin Immunol 1997, 100:348-255.
32. Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S: Targeting dipeptidyl peptidase (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta1 secretion in vivo. J Immunol 2001, 166(3):2041-2048.
33. Fleischer B, Sturm E, De-Vries JE, Spits H: Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex. J Immunol 1988, 141:1103-1107.
34. Fleischer J, Grage-Griebenow E, Kasper B, Heine H, Ernst M, Brandt E, Flad HD, Petersen F: Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells. J Immunol 2002, 169(2):770-777.
35. Hultqvist M, Olofsson P, Holmberg J, Backstrom BT, Tordsson J, Holmdahl R: Enhanced autoimmunity, arthritis and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA 2004, 101(34):12646-12651.
36. Kobayashi K, Hernandez LD, Galan JE, Janeway CA, Medzhitov R, Flavell RA: IRAK-M is a negative regulator of Toll-like receptor signalling. Cell 2002, 101:191-202.
37. Fibbe WE, Willemze R: The role of interleukin-1 in hematopoiesis. Acta Haematol 1991, 86(3):148-154.
38. Nakao S, Matsushima K, Young N: Decreased interleukin-1 production in aplastic anemia. Br J Haematol 1989, 71(3):431-436.
39. Anderson JP, Mueller JL, Rosengren S, Boyle DL, Schaner P, Cannon SB, Goodyear CS, Hoffman HM: Structural, expression and evolutionary analysis of mouse CIAS1. Gene 2004, 338(1):25-34.
40. Porksen G, Lohse P, Rosen-Wolff A, Heyden S, Forster T, Wendisch J, Heubner G, Bernuth H, Sallmann S, Gahr M, Roesler J: Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients - expanding phenotype of CIAS1 related autoinflammatory syndrome. Eur J Haematol 2004, 73(2):123-127.
41. Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM: Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol 1996, 6(7):897-899.
42. Xu JL, Nagasaka T, Nakashima N: Involvement of cytotoxic granules in the apoptosis of aplastic anaemia. Br J Haematol 2003, 20(5):850-852.
43. Gulan G, Ravlic-Gulan J, Strbo N, Sotosek V, Nemec B, Matovinovic D, Rubinic D, Podack ER, Rukavina D: Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis. J Rheumatol 2003, 30(4):660-670.
44. Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell 2000, 101(7):777-787.
45. Kaufman DW, Kelly J, Levy M, Shapiro S: Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol 1996, 60:23-30.
46. Camitta BM, Thomas ED, Nathan DG, Gale RP, Kopecky KJ, Rappeport JM, Santos G, Gordon-Smith EC, Storb R: A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood 1979, 53:504-514.
47. Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W: Neuropilin-1: A surface marker of regulatory T cells. Eur J Immunol 2004, 34(3):623-630.