Cell surface characterization of T lymphocytes and allergen-specific T cell clones: Correlation of CD26 expression with TH1 subsets

Journal of Allergy and Clinical Immunology

Volumn 100, Issue 3, 1997, Pages 348-355

  Willheim, Martin ^a,b   Ebner, Christof ^a   Baier, Karin ^a   Kern, Wolfgang ^a   Schrattbauer, Karl ^a   Thien, Ralf ^a   Kraft, Dietrich ^a   Breiteneder, Heimo ^a   Reinisch, Walter ^a   Scheiner, Otto ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

CD26; Cell surface molecules; Cytokine production; Cytokine receptors; T cell clones; T helper cell subsets

Indexed keywords

DIPEPTIDYL PEPTIDASE IV;

ALLERGY; ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; CLINICAL ARTICLE; CORRELATION FUNCTION; HELPER CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030851771     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70248-3     Document Type: Article

References (37)

1. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989;7:145-73.
2. + T lymphocytes in atopic patients. J Immunol 1990;144: 4651-6.
3. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1991;12:256-7.
4. Mosman TR, Sad S. The expanding universe of T-cell subsets: Th, Th2 and more. Immunol Today 1996;17:138-46.
5. + T cell clones. Science 1991;254:279-81.
6. Kemeny DM, Noble A, Holmes BJ, Diaz-Sanchez D. Immune regulation: a new role for the CD8+ T cell. Immunol Today 1994;15:107-10.
7. Ebner C, Schenk S, Szépfalusi Z, Hoffmann K, Ferreira F, Willheim M, et al. Multiple T cell specificities for Bet v I, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides. Eur J Immunol 1993;23:1523-7.
8. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, et al. Nonallergic individuals recognize the same T cell epitopes of Bet v I, the major birch pollen allergen, as atopic patients. J Immunol 1995;154:1932-40.
9. Kelso A. Th1 and Th2 subsets: paradigms lost? Immunol Today 1995;16:374-9.
10. + T cells producing Th2-type cytokines. FASEB J 1995;9:81-6.
11. Del Prete G, De Carli M, D'Elios MM, Daniel KC, Almerigogna F, Alderson M, et al. CD30-mediated signaling promotes the development of human T helper type 2-like T cells. J Exp Med 1995;182: 1655-61.
12. Romagnani S. Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 1992;98:279-85.
13. + T cells. Ann Rev Immunol 1994;12:635-73.
14. O'Garra A, Murphy K. Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 1994;6:458-66.
15. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989;170:827-46.
16. Trinchieri G, Scott P. The role of interleukin 12 in the immune response, disease and therapy. Immunol Today 1994;15:460-3.
17. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-76.
18. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, et al. Induction of interferon production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 1991;173:869-79.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-9.
20. Finkelman FD. Madden KB, Cheever AW, Katona IM, Morris SC, Gately MK, et al. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med 1994;179:1563-72.
21. Minami Y, Kono T, Miyazaki T, Taniguchi T. The IL-2 receptor complex: its structure, function and target genes. Ann Rev Immunol 1993;11:245-68.
22. Fleischer B. CD26: a surface protease involved in T-cell activation. Immunol Today 1994;15:180-4.
23. Torimoto Y, Dang NH, Vivier E, Tanaka T, Schlossman SF, Morimoto C. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 1991;147: 2514-7.
24. Subramanyam M, Gutheil WG, Bachovin WM, Huber BT. Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness. J Immunol 1993;150:2544-53.
25. Scheel-Toellner D, Richter E, Toellner KM, Reiling N, Wacker HH, Flad HD, et al. CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-γ. Lab Invest 1995;73:685-90.
26. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, et al. The gene coding for the major birch pollen allergen Bet v I, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-8.
27. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, et al. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44:385-95.
28. Ebner C, Szépfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, et al. Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993;150:1047-54.
29. Ferreira F, Hoffmann-Sommergruber K, Breiteneder H, Pettenburger K, Ebner C, Sommergruber W, et al. Purification and characterization of recombinant Bet v I, the major birch pollen allergen: immunological equivalence to natural Bet v I. J Biol Chem 1993;268:19574-80.
30. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993;159:197-207.
31. Assenmacher M, Schmitz J, Radbruch A. Flow cytometric determination of cytokines in activated murine Th lymphocytes. Expression of IL-10 in IFN-γ and IL-4 expressing cells. Eur J Immunol 1994;24:1097-101.
32. Renz H, Jujo K, Bradley KL, Domenico J, Gelfand EW, Leung DYM. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-gamma. J Invest Dermatol 1992;99:403-8.
33. H1 cells. Science 1995;269:245-7.
34. Seder RA, Boulay JL, Finkelman S, Barbier S, Ben Sasson SZ, Le Gros G, et al. CD8+ T cells can be primed in vitro to produce IL-4. J Immunol 1992;148:1652-6.
35. Croft M, Carter S, Swain SL, Dutton RW. Generation of polarized anti-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994;180:1715-28.
36. Noble A, Macaray PA, Kemeny DM. IFN-γ and IL-4 regulate the growth and differentiation of CD8+ T cells into subpopulations with distinct cytokine profiles. J Immunol 1995;155:2928-37.
37. Hamann D, Hilkens CMU, Grogan JL, Lens SM, Kapsenberg ML, Yazdanbakhsh M, et al. CD30 expression does not discriminate between human Th1- and Th2-type T cells. J Immunol 1996;156: 1387-91.