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Volumn 80, Issue 5, 2006, Pages 1103-1110

Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: New therapeutic strategies

Author keywords

Anti HIV drugs; CCR5 coreceptor; gp41; Protease; Reverse transcriptase

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; APLAVIROC; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; INDINAVIR; LAMIVUDINE; MARAVIROC; NELFINAVIR; NEVIRAPINE; PHOSPHONIC ACID DERIVATIVE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; VICRIVIROC; ZALCITABINE; ZIDOVUDINE;

EID: 33750478020     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0606376     Document Type: Review
Times cited : (48)

References (101)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., Holmberg, S. D. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N. Engl. J. Med. 338, 853-860.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella, F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5    Satten, G.A.6    Aschman, D.J.7    Holmberg, S.D.8
  • 2
    • 0034977285 scopus 로고    scopus 로고
    • HAART is cost-effective and improves outcomes
    • Valenti, W. M. (2001) HAART is cost-effective and improves outcomes. AIDS Read. 11, 260-262.
    • (2001) AIDS Read. , vol.11 , pp. 260-262
    • Valenti, W.M.1
  • 3
    • 0037249691 scopus 로고    scopus 로고
    • Long-term HIV/AIDS survival estimation in the highly active antiretroviral therapy era
    • Collaboration in HIV Outcomes Research-US Program Team
    • King, J. T., Justice, A. C., Roberts, M. S., Chang, C. C., Fusco, J. S., Collaboration in HIV Outcomes Research-US Program Team. (2003) Long-term HIV/AIDS survival estimation in the highly active antiretroviral therapy era. Med. Decis. Making 23, 9-20.
    • (2003) Med. Decis. Making , vol.23 , pp. 9-20
    • King, J.T.1    Justice, A.C.2    Roberts, M.S.3    Chang, C.C.4    Fusco, J.S.5
  • 4
    • 0036308234 scopus 로고    scopus 로고
    • Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS
    • Williams, K. C., Hickey, W. F. (2002) Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu. Rev. Neurosci. 25, 537-562.
    • (2002) Annu. Rev. Neurosci. , vol.25 , pp. 537-562
    • Williams, K.C.1    Hickey, W.F.2
  • 5
    • 33747198759 scopus 로고    scopus 로고
    • The Src kinase Lyn is required for CCR5 signaling in response to MIP-1{β} and R5 HIV-1 gp120 in human macrophages
    • Tomkowicz, B., Lee, C., Ravyn, V., Cheung, R., Ptasznik, A., Collman, R. (2006) The Src kinase Lyn is required for CCR5 signaling in response to MIP-1{β} and R5 HIV-1 gp120 in human macrophages. Blood 108, 1145-1150.
    • (2006) Blood , vol.108 , pp. 1145-1150
    • Tomkowicz, B.1    Lee, C.2    Ravyn, V.3    Cheung, R.4    Ptasznik, A.5    Collman, R.6
  • 6
    • 0036892506 scopus 로고    scopus 로고
    • Macrophage activation and HIV infection: Can the Trojan horse turn into a fortress?
    • Herbein, G., Coaquette, A., Perez-Bercoff, D., Pancino, G. (2002) Macrophage activation and HIV infection: can the Trojan horse turn into a fortress? Curr. Mol. Med. 2, 723-738.
    • (2002) Curr. Mol. Med. , vol.2 , pp. 723-738
    • Herbein, G.1    Coaquette, A.2    Perez-Bercoff, D.3    Pancino, G.4
  • 7
    • 0025090578 scopus 로고
    • Full-length recombinant CD4 and recombinant gp120 inhibit fusion between HIV infected macrophages and uninfected CD4-expressing T-lymphoblastoid cells
    • Crowe, S. M., Mills, J., Kirihara, J., Boothman, J., Marshall, J. A., McGrath, M. S. (1990) Full-length recombinant CD4 and recombinant gp120 inhibit fusion between HIV infected macrophages and uninfected CD4-expressing T-lymphoblastoid cells. AIDS Res. Hum. Retroviruses 6, 1031-1037.
    • (1990) AIDS Res. Hum. Retroviruses , vol.6 , pp. 1031-1037
    • Crowe, S.M.1    Mills, J.2    Kirihara, J.3    Boothman, J.4    Marshall, J.A.5    McGrath, M.S.6
  • 8
    • 0031019006 scopus 로고    scopus 로고
    • Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor
    • Badley, A. D., Dockrell, D., Simpson, M., Schut, R., Lynch, D. H., Leibson, P., Paya, C. V. (1997) Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. J. Exp. Med. 185, 55-64.
    • (1997) J. Exp. Med. , vol.185 , pp. 55-64
    • Badley, A.D.1    Dockrell, D.2    Simpson, M.3    Schut, R.4    Lynch, D.H.5    Leibson, P.6    Paya, C.V.7
  • 9
    • 0032505065 scopus 로고    scopus 로고
    • Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
    • Herbein, G., Mahlknecht, U., Batliwalla, F., Gregersen, P., Pappas, T., Butler, J., O'Brien, W. A., Verdin, E. (1998) Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature 395, 189-194.
    • (1998) Nature , vol.395 , pp. 189-194
    • Herbein, G.1    Mahlknecht, U.2    Batliwalla, F.3    Gregersen, P.4    Pappas, T.5    Butler, J.6    O'Brien, W.A.7    Verdin, E.8
  • 16
    • 0005015528 scopus 로고
    • Mononuclear phagocytes of blood and bone marrow: Comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections
    • McElrath, M. J., Pruett, J. E., Cohn, Z. A. (1989) Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections. Proc. Natl. Acad. Sci. USA 86, 675-679.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 675-679
    • McElrath, M.J.1    Pruett, J.E.2    Cohn, Z.A.3
  • 17
    • 0022552689 scopus 로고
    • Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS
    • Gabuzda, D. H., Ho, D. D., de la Monte, S. M., Hirsch, M. S., Rota, T. R., Sobel, R. A. (1986) Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann. Neurol. 20, 289-295.
    • (1986) Ann. Neurol. , vol.20 , pp. 289-295
    • Gabuzda, D.H.1    Ho, D.D.2    De La Monte, S.M.3    Hirsch, M.S.4    Rota, T.R.5    Sobel, R.A.6
  • 18
    • 0025609978 scopus 로고
    • Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1
    • Giulian, D., Vaca, K., Noonan, C. A. (1990) Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250, 1593-1596.
    • (1990) Science , vol.250 , pp. 1593-1596
    • Giulian, D.1    Vaca, K.2    Noonan, C.A.3
  • 22
    • 0023678515 scopus 로고
    • Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: An ultrastructural study
    • Orenstein, J. M., Meltzer, M. S., Phipps, T., Gendelman, H. E. (1988) Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study. J. Virol. 62, 2578-2586.
    • (1988) J. Virol. , vol.62 , pp. 2578-2586
    • Orenstein, J.M.1    Meltzer, M.S.2    Phipps, T.3    Gendelman, H.E.4
  • 25
    • 4444256678 scopus 로고    scopus 로고
    • Antivirals and antiviral strategies
    • De Clercq, E. (2004) Antivirals and antiviral strategies. Nat. Rev. Microbiol. 2, 704-720.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 704-720
    • De Clercq, E.1
  • 26
    • 0034566114 scopus 로고    scopus 로고
    • Inhibitors of HIV-1 reverse transcriptase
    • Parniak, M. A., Sluis-Cremer, N. (2000) Inhibitors of HIV-1 reverse transcriptase. Acta. Pharmacol. 49, 67-109.
    • (2000) Acta. Pharmacol. , vol.49 , pp. 67-109
    • Parniak, M.A.1    Sluis-Cremer, N.2
  • 27
  • 28
    • 2942524068 scopus 로고    scopus 로고
    • Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
    • Balzarini, J. (2004) Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. Curr. Top. Med. Chem. 4, 921-944.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 921-944
    • Balzarini, J.1
  • 29
    • 0023785829 scopus 로고
    • Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides
    • Perno, C. F., Yarchoan, R., Cooney, D. A., Hartman, N. R., Webb, D. S., Hao, Z., Mitsuya, H., Johns, D. G., Broder, S. (1988) Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides. J. Exp. Med. 168, 1111-1125.
    • (1988) J. Exp. Med. , vol.168 , pp. 1111-1125
    • Perno, C.F.1    Yarchoan, R.2    Cooney, D.A.3    Hartman, N.R.4    Webb, D.S.5    Hao, Z.6    Mitsuya, H.7    Johns, D.G.8    Broder, S.9
  • 31
    • 0023265911 scopus 로고
    • The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′-dideoxyribonucleosides: A comparison with their parental 2′,3′-dideoxyribonucleosides
    • Balzarini, J., Kang, G. J., Dalal, M., Herdewijn, P., De Clercq, E., Broder, S., Johns, D. G. (1987) The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′- dideoxyribonucleosides: a comparison with their parental 2′,3′- dideoxyribonucleosides. Mol. Pharmacol. 32, 162-167.
    • (1987) Mol. Pharmacol. , vol.32 , pp. 162-167
    • Balzarini, J.1    Kang, G.J.2    Dalal, M.3    Herdewijn, P.4    De Clercq, E.5    Broder, S.6    Johns, D.G.7
  • 32
    • 0023925378 scopus 로고
    • Anti-retrovirus activity of 3′-fluoro- and 3′- azidosubstituted pyrimidine 2′,3′-dideoxynucleoside analogues
    • Balzarini, J., Baba, M., Pauwels, R., Herdewijn, P., De Clercq, E. (1988) Anti-retrovirus activity of 3′-fluoro- and 3′-azidosubstituted pyrimidine 2′,3′-dideoxynucleoside analogues. Biochem. Pharmacol. 37, 2847-2856.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2847-2856
    • Balzarini, J.1    Baba, M.2    Pauwels, R.3    Herdewijn, P.4    De Clercq, E.5
  • 33
    • 0024592935 scopus 로고
    • Differential patterns of intracellular metabolism of 2′,3′- didehydro-2′,3′-dideoxythymidine and 3′-azido-2′, 3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
    • Balzarini, J., Herdewijn, P., De Clercq, E. (1989) Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′,3′- dideoxythymidine and 3′-azido-2′,3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J. Biol. Chem. 264, 6127-6133.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6127-6133
    • Balzarini, J.1    Herdewijn, P.2    De Clercq, E.3
  • 34
    • 0024435381 scopus 로고
    • Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells
    • Johnson, M. A., Fridland, A. (1989) Phosphorylation of 2′,3′-dideoxyinosine by cytosolic 5′-nucleotidase of human lymphoid cells. Mol. Pharmacol. 36, 291-295.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 291-295
    • Johnson, M.A.1    Fridland, A.2
  • 35
    • 0025122369 scopus 로고
    • Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′- dideoxyuridine-5′-triphosphate
    • Hao, Z., Cooney, D. A., Farquhar, D., Perno, C. F., Zhang, K., Masood, R., Wilson, Y., Hartman, N. R., Balzarini, J., Johns, D. G. (1990) Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2′,3′-dideoxyuridine-5′- triphosphate. Mol. Pharmacol. 37, 157-163.
    • (1990) Mol. Pharmacol. , vol.37 , pp. 157-163
    • Hao, Z.1    Cooney, D.A.2    Farquhar, D.3    Perno, C.F.4    Zhang, K.5    Masood, R.6    Wilson, Y.7    Hartman, N.R.8    Balzarini, J.9    Johns, D.G.10
  • 38
    • 0031882085 scopus 로고    scopus 로고
    • Intracellular expression of p170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients
    • Malorni, W., Lucia, M. B., Rainaldi, G., Cauda, R., Cianfriglia, M., Donelli, G., Ortona, L. (1998) Intracellular expression of p170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients. Haematologica 83, 13-20.
    • (1998) Haematologica , vol.83 , pp. 13-20
    • Malorni, W.1    Lucia, M.B.2    Rainaldi, G.3    Cauda, R.4    Cianfriglia, M.5    Donelli, G.6    Ortona, L.7
  • 43
    • 0034622946 scopus 로고    scopus 로고
    • Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid
    • Cunningham, P. H., Smith, D. G., Satchell, C., Cooper, D. A., Brew, B. (2000) Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid. AIDS 14, 1949-1954.
    • (2000) AIDS , vol.14 , pp. 1949-1954
    • Cunningham, P.H.1    Smith, D.G.2    Satchell, C.3    Cooper, D.A.4    Brew, B.5
  • 44
    • 0034461212 scopus 로고    scopus 로고
    • Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma
    • Tang, Y. W., Huong, J. T., Lloyd, R. M., Spearman, P., Haas, D. W. (2000) Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma. J. Clin. Microbiol. 38, 4637-4639.
    • (2000) J. Clin. Microbiol. , vol.38 , pp. 4637-4639
    • Tang, Y.W.1    Huong, J.T.2    Lloyd, R.M.3    Spearman, P.4    Haas, D.W.5
  • 45
    • 0034048862 scopus 로고    scopus 로고
    • Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples
    • Venturi, G., Catucci, M., Romano, L., Corsi, P., Leoncini, F., Valensin, P. E., Zazzi, M. (2000) Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples. J. Infect. Dis. 181, 740-745.
    • (2000) J. Infect. Dis. , vol.181 , pp. 740-745
    • Venturi, G.1    Catucci, M.2    Romano, L.3    Corsi, P.4    Leoncini, F.5    Valensin, P.E.6    Zazzi, M.7
  • 47
    • 1542345591 scopus 로고    scopus 로고
    • Long-term virological effect of highly active antiretroviral therapy on cerebrospinal fluid and relationship with genotypic resistance
    • Bestetti, A., Presi, S., Pierotti, C., Bossolasco, S., Sala, S., Racca, S., Carrera, P., Lazzarin, A., Cinque, P. (2004) Long-term virological effect of highly active antiretroviral therapy on cerebrospinal fluid and relationship with genotypic resistance. J. Neurovirol. 10 (Suppl. 1), 52-57.
    • (2004) J. Neurovirol. , vol.10 , Issue.SUPPL. 1 , pp. 52-57
    • Bestetti, A.1    Presi, S.2    Pierotti, C.3    Bossolasco, S.4    Sala, S.5    Racca, S.6    Carrera, P.7    Lazzarin, A.8    Cinque, P.9
  • 48
    • 0029035638 scopus 로고
    • Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1
    • Boyer, P. L., Hughes, S. H. (1995) Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 39, 1624-1628.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1624-1628
    • Boyer, P.L.1    Hughes, S.H.2
  • 49
    • 0029757751 scopus 로고    scopus 로고
    • Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
    • Back, N. K., Nijhuis, M., Keulen, W., Boucher, C. A., Oude Essink, B. O., Van Kuilenburg, A. B., Van Gennip, A. H., Berkhout, B. (1996) Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J. 15, 4040-4049.
    • (1996) EMBO J. , vol.15 , pp. 4040-4049
    • Back, N.K.1    Nijhuis, M.2    Keulen, W.3    Boucher, C.A.4    Oude Essink, B.O.5    Van Kuilenburg, A.B.6    Van Gennip, A.H.7    Berkhout, B.8
  • 50
    • 0032875344 scopus 로고    scopus 로고
    • Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: A comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val
    • Sharma, P. L., Crumpacker, C. S. (1999) Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val. J. Virol. 73, 8448-8456.
    • (1999) J. Virol. , vol.73 , pp. 8448-8456
    • Sharma, P.L.1    Crumpacker, C.S.2
  • 51
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
    • Huang, H., Chopra, R., Verdine, G. L., Harrison, S. C. (1998) Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282, 1669-1675.
    • (1998) Science , vol.282 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Verdine, G.L.3    Harrison, S.C.4
  • 53
    • 0029989972 scopus 로고    scopus 로고
    • Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxypropyl)-2-6-diaminopurine against human immunodeficiency virus in different human cell systems
    • Balzarini, J., Aquaro, S., Perno, C. F., Witvrouw, M., Holy, A., De Clercq, E. (1996) Activity of the (R)-enantiomers of 9-(2- phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxypropyl)-2-6- diaminopurine against human immunodeficiency virus in different human cell systems. Biochem. Biophys. Res. Commun. 219, 337-341.
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 337-341
    • Balzarini, J.1    Aquaro, S.2    Perno, C.F.3    Witvrouw, M.4    Holy, A.5    De Clercq, E.6
  • 56
    • 0031848314 scopus 로고    scopus 로고
    • Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
    • Perno, C. F., Newcomb, F. M., Davis, D. A., Aquaro, S., Humphrey, R. W., Caliò, R., Yarchoan, R. (1998) Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J. Infect. Dis. 178, 413-422.
    • (1998) J. Infect. Dis. , vol.178 , pp. 413-422
    • Perno, C.F.1    Newcomb, F.M.2    Davis, D.A.3    Aquaro, S.4    Humphrey, R.W.5    Caliò, R.6    Yarchoan, R.7
  • 57
    • 0037321703 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells
    • Ketas, T. J., Frank, I., Klasse, P. J., Sullivan, B. M., Gardner, J. P., Spenlehauer, C., Nesin, M., Olson, W. C., Moore, J. P., Pope, M. (2003) Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells. J. Virol. 77, 2762-2767.
    • (2003) J. Virol. , vol.77 , pp. 2762-2767
    • Ketas, T.J.1    Frank, I.2    Klasse, P.J.3    Sullivan, B.M.4    Gardner, J.P.5    Spenlehauer, C.6    Nesin, M.7    Olson, W.C.8    Moore, J.P.9    Pope, M.10
  • 60
    • 15344350690 scopus 로고    scopus 로고
    • Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
    • Walker, D. K., Abel, S., Comby, P., Muirhead, G. J., Nedderman, A. N., Smith D. A. (2005) Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab. Dispos. 33, 587-595.
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 587-595
    • Walker, D.K.1    Abel, S.2    Comby, P.3    Muirhead, G.J.4    Nedderman, A.N.5    Smith, D.A.6
  • 62
    • 0037045009 scopus 로고    scopus 로고
    • Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells
    • Balzarini, J., Van Herrewege, Y., Vanham, G. (2002) Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells. AIDS 16, 2159-2163.
    • (2002) AIDS , vol.16 , pp. 2159-2163
    • Balzarini, J.1    Van Herrewege, Y.2    Vanham, G.3
  • 66
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer, S., Azijn, H., Surleraux, D., Jochmans, D., Tahri, A., Pauwels, R., Wigerinck, P., de Bethune, M. P. (2005) TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob. Agents Chemother. 49, 2314-2321.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3    Jochmans, D.4    Tahri, A.5    Pauwels, R.6    Wigerinck, P.7    De Bethune, M.P.8
  • 67
    • 0344736982 scopus 로고    scopus 로고
    • Potent antiviral activity of amprenavir in primary macrophages infected by human immunodeficiency virus
    • Aquaro, S., Guenci, T., Di Santo, F., Francesconi, M., Caliò, R., Perno, C. F. (2004) Potent antiviral activity of amprenavir in primary macrophages infected by human immunodeficiency virus. Antiviral Res. 61, 133-137.
    • (2004) Antiviral Res. , vol.61 , pp. 133-137
    • Aquaro, S.1    Guenci, T.2    Di Santo, F.3    Francesconi, M.4    Caliò, R.5    Perno, C.F.6
  • 70
    • 0035915372 scopus 로고    scopus 로고
    • Structured treatment interruptions for the management of HIV infection
    • Lori, F., Lisziewicz, J. (2001) Structured treatment interruptions for the management of HIV infection. JAMA 286, 2981-2987.
    • (2001) JAMA , vol.286 , pp. 2981-2987
    • Lori, F.1    Lisziewicz, J.2
  • 71
    • 23944491920 scopus 로고    scopus 로고
    • HIV protease inhibitors activate the unfolded protein response in macrophages: Implication for atherosclerosis and cardiovascular disease
    • Zhou, H., Pandak, W. M., Lyall, V., Natarajan, R., Hylemon, P. B. (2005) HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease. Mol. Pharmacol. 68, 690-700.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 690-700
    • Zhou, H.1    Pandak, W.M.2    Lyall, V.3    Natarajan, R.4    Hylemon, P.B.5
  • 74
    • 0038069784 scopus 로고    scopus 로고
    • Impact of HIV-1 gp41 amino acid substitutions (position 36-45) on susceptibility to T20 (Enfuvirtide) in vitro; analysis of primary virus isolates recovered from patients during chronic Enfuvirtide treatment and site-directed mutants in NL4-3
    • Mink, M., Greenberg, M. L., Mosier, S. (2002) Impact of HIV-1 gp41 amino acid substitutions (position 36-45) on susceptibility to T20 (Enfuvirtide) in vitro; analysis of primary virus isolates recovered from patients during chronic Enfuvirtide treatment and site-directed mutants in NL4-3. Antivir. Ther. 7, 17-18.
    • (2002) Antivir. Ther. , vol.7 , pp. 17-18
    • Mink, M.1    Greenberg, M.L.2    Mosier, S.3
  • 75
    • 4544381403 scopus 로고    scopus 로고
    • HIV fusion and its inhibition in antiretroviral therapy
    • Greenberg, M., Cammack, N., Salgo, M., Smiley, L. (2004) HIV fusion and its inhibition in antiretroviral therapy. Rev. Med. Virol. 14, 321-337.
    • (2004) Rev. Med. Virol. , vol.14 , pp. 321-337
    • Greenberg, M.1    Cammack, N.2    Salgo, M.3    Smiley, L.4
  • 76
    • 2942536481 scopus 로고    scopus 로고
    • HIV resistance to the fusion inhibitor enfuvirtide: Mechanisms and clinical implications
    • Miller, M. D., Hazuda, D. J. (2004) HIV resistance to the fusion inhibitor enfuvirtide: mechanisms and clinical implications. Drug Resist. Updat. 7, 89-95.
    • (2004) Drug Resist. Updat. , vol.7 , pp. 89-95
    • Miller, M.D.1    Hazuda, D.J.2
  • 77
    • 16244380203 scopus 로고    scopus 로고
    • Enfuvirtide resistance mutations: Impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization
    • Reeves, J. D., Lee, F. H., Miamidian, J. L., Jabara, C. B., Juntilla, M. M., Doms, R. W. (2005) Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization. J. Virol. 79, 4991-4999.
    • (2005) J. Virol. , vol.79 , pp. 4991-4999
    • Reeves, J.D.1    Lee, F.H.2    Miamidian, J.L.3    Jabara, C.B.4    Juntilla, M.M.5    Doms, R.W.6
  • 79
    • 0030018156 scopus 로고    scopus 로고
    • CCCKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., Berger, E. A. (1996) CCCKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3    Feng, Y.4    Kennedy, P.E.5    Murphy, P.M.6    Berger, E.A.7
  • 81
    • 0031901134 scopus 로고    scopus 로고
    • Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1
    • Tuttle, D. L., Harrison, J. K., Anders, C., Sleasman, J. W., Goodenow, M. M. (1998) Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1. J. Virol. 72, 4962-4969.
    • (1998) J. Virol. , vol.72 , pp. 4962-4969
    • Tuttle, D.L.1    Harrison, J.K.2    Anders, C.3    Sleasman, J.W.4    Goodenow, M.M.5
  • 82
    • 21244467221 scopus 로고    scopus 로고
    • The molecular mechanism of human resistance to HIV-1 infection in persistently infected individuals - A review, hypothesis and implications
    • Becker, Y. (2005) The molecular mechanism of human resistance to HIV-1 infection in persistently infected individuals-a review, hypothesis and implications. Virus Genes 31, 113-119.
    • (2005) Virus Genes , vol.31 , pp. 113-119
    • Becker, Y.1
  • 84
    • 22644440543 scopus 로고    scopus 로고
    • The CCR5-Δ32 mutation: Impact on disease outcome in individuals with hepatitis C infection from a single source
    • Goulding, C., McManus, R., Murphy, A., MacDonald, G., Barrett, S., Crowe, J., Hegarty, J., McKiernan, S., Kelleher, D. (2005) The CCR5-Δ32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut 54, 1157-1161.
    • (2005) Gut , vol.54 , pp. 1157-1161
    • Goulding, C.1    McManus, R.2    Murphy, A.3    MacDonald, G.4    Barrett, S.5    Crowe, J.6    Hegarty, J.7    McKiernan, S.8    Kelleher, D.9
  • 86
    • 24344496912 scopus 로고    scopus 로고
    • Emerging drug targets for antiretroviral therapy
    • Reeves, J. D., Piefer, A. J. (2005) Emerging drug targets for antiretroviral therapy. Drugs 65, 1747-1766.
    • (2005) Drugs , vol.65 , pp. 1747-1766
    • Reeves, J.D.1    Piefer, A.J.2
  • 87
    • 28544434492 scopus 로고    scopus 로고
    • CCR5 antagonists: Host-targeted antivirals fort he treatment of HIV infection
    • Westby, M., Van der Ryst, E. (2005) CCR5 antagonists: host-targeted antivirals fort he treatment of HIV infection. Antivir. Chem. Chemother. 16, 339-354.
    • (2005) Antivir. Chem. Chemother. , vol.16 , pp. 339-354
    • Westby, M.1    Van Der Ryst, E.2
  • 88
    • 27644593773 scopus 로고    scopus 로고
    • Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: Effects of viral diversity, target cell and receptor density
    • Willey, S., Peters, P. J., Sullivan, W. M., Dorr, P., Perros, M., Clapham, P. R. (2005) Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density. Antiviral Res. 68, 96-108.
    • (2005) Antiviral Res. , vol.68 , pp. 96-108
    • Willey, S.1    Peters, P.J.2    Sullivan, W.M.3    Dorr, P.4    Perros, M.5    Clapham, P.R.6
  • 89
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby, M., Lewis, M., Whitcomb, J., Youle, M., Pozniak, A. L., James, I. T., Jenkins, T. M., Perros, M., Van der Ryst, E. (2006) Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J. Virol. 80, 4909-4920.
    • (2006) J. Virol. , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3    Youle, M.4    Pozniak, A.L.5    James, I.T.6    Jenkins, T.M.7    Perros, M.8    Van Der Ryst, E.9
  • 90
    • 26044476780 scopus 로고    scopus 로고
    • In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides
    • Baritaki, S., Dittmar, M. T., Spandidos, D. A., Krambovitis, E. (2005) In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides. Int. J. Mol. Med. 16, 333-336.
    • (2005) Int. J. Mol. Med. , vol.16 , pp. 333-336
    • Baritaki, S.1    Dittmar, M.T.2    Spandidos, D.A.3    Krambovitis, E.4
  • 91
    • 0141713810 scopus 로고    scopus 로고
    • Update on D-ala-peptide T-amide (DAPTA): A viral entry inhibitor that blocks CCR5 chemokine receptors
    • Ruff, M. R., Polianova, M., Yang, Q. E., Leoung, G. S., Ruscetti, F. W., Pert, C. B. (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr. HIV Res. 1, 51-67.
    • (2003) Curr. HIV Res. , vol.1 , pp. 51-67
    • Ruff, M.R.1    Polianova, M.2    Yang, Q.E.3    Leoung, G.S.4    Ruscetti, F.W.5    Pert, C.B.6
  • 95
    • 0042925297 scopus 로고    scopus 로고
    • Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1
    • Chen, X., Yang, L., Zhang, N., Turpin, J. A., Buckheit, R. W., Osterling, C., Oppenheim, J. J., Howard, O. M. (2003) Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 47, 2810-2816.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2810-2816
    • Chen, X.1    Yang, L.2    Zhang, N.3    Turpin, J.A.4    Buckheit, R.W.5    Osterling, C.6    Oppenheim, J.J.7    Howard, O.M.8
  • 96
    • 28844481759 scopus 로고    scopus 로고
    • Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120. A new therapeutic concept to hit the Achilles heel of HIV
    • Balzarini, J., Van Laethem, K., Hatse, S., Froeyen, M., Peumans, W., Van Damme, E., Schols, D. (2005) Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120. A new therapeutic concept to hit the Achilles heel of HIV. J. Biol. Chem. 280, 41005-41014.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41005-41014
    • Balzarini, J.1    Van Laethem, K.2    Hatse, S.3    Froeyen, M.4    Peumans, W.5    Van Damme, E.6    Schols, D.7
  • 98
    • 27144525215 scopus 로고    scopus 로고
    • Targeting the glycans of gp120: A novel therapeutic approach aimed at the Achilles heel of HIV
    • Balzarini, J. (2005) Targeting the glycans of gp120: a novel therapeutic approach aimed at the Achilles heel of HIV. Lancet Infect. Dis. 5, 726-731.
    • (2005) Lancet Infect. Dis. , vol.5 , pp. 726-731
    • Balzarini, J.1
  • 99
    • 33646494006 scopus 로고    scopus 로고
    • Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity
    • Watanabe, N., Nishihara, Y., Yamaguchi, T., Koito, A., Miyoshi, H., Kakeya, H., Osada, H. (2006) Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 580, 2598-2602.
    • (2006) FEBS Lett. , vol.580 , pp. 2598-2602
    • Watanabe, N.1    Nishihara, Y.2    Yamaguchi, T.3    Koito, A.4    Miyoshi, H.5    Kakeya, H.6    Osada, H.7
  • 100
    • 2542441626 scopus 로고    scopus 로고
    • Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages
    • Ewart, G. D., Nasr, N., Naif, H., Cox, G. B., Cunningham, A. L., Gage, P. W. (2004) Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages. Antimicrob. Agents Chemother. 48, 2325-2330.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2325-2330
    • Ewart, G.D.1    Nasr, N.2    Naif, H.3    Cox, G.B.4    Cunningham, A.L.5    Gage, P.W.6
  • 101
    • 26444487600 scopus 로고    scopus 로고
    • Oxadiazols: A new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein
    • Haffar, O., Dubrovsky, L., Lowe, R., Berro, R., Kashanchi, F., Godden, J., Vanpouille, C., Bajorath, J., Bukrinsky, M. (2005) Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein. J. Virol. 79, 13028-13036.
    • (2005) J. Virol. , vol.79 , pp. 13028-13036
    • Haffar, O.1    Dubrovsky, L.2    Lowe, R.3    Berro, R.4    Kashanchi, F.5    Godden, J.6    Vanpouille, C.7    Bajorath, J.8    Bukrinsky, M.9


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