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Volumn 8, Issue 5, 2006, Pages 377-383

The ethics of gene therapy

Author keywords

Embryo research; Enhancement; Ethics; Gene therapy; Genetic modification; Stem cells

Indexed keywords

DNA; LIPOSOME;

EID: 33750006826     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (13)

References (73)
  • 2
    • 0042830374 scopus 로고    scopus 로고
    • Gene therapy: Theoretical and bioethical concepts
    • Smith KR: Gene therapy: Theoretical and bioethical concepts. Arch Med Res (2003) 34(4):247-268.
    • (2003) Arch Med Res , vol.34 , Issue.4 , pp. 247-268
    • Smith, K.R.1
  • 3
    • 0036369660 scopus 로고    scopus 로고
    • Strategies for engineering human chromosomes with therapeutic potential
    • Saffery R, Choo KH: Strategies for engineering human chromosomes with therapeutic potential. J Gene Med (2002) 4(1):5-13.
    • (2002) J Gene Med , vol.4 , Issue.1 , pp. 5-13
    • Saffery, R.1    Choo, K.H.2
  • 4
    • 27844596238 scopus 로고    scopus 로고
    • Artificial and engineered chromosomes: Developments and prospects for gone therapy
    • Grimes BR, Monaco ZL: Artificial and engineered chromosomes: Developments and prospects for gone therapy. Chromosome (2005) 114(4):230-241.
    • (2005) Chromosome , vol.114 , Issue.4 , pp. 230-241
    • Grimes, B.R.1    Monaco, Z.L.2
  • 5
    • 0036607376 scopus 로고    scopus 로고
    • Advances in human artificial chromosome technology
    • Larin Z, Mejia JE: Advances in human artificial chromosome technology. Trends Genet (2002) 18(6):313-319.
    • (2002) Trends Genet , vol.18 , Issue.6 , pp. 313-319
    • Larin, Z.1    Mejia, J.E.2
  • 7
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi MR: Altering the genome by homologous recombination. Science (1989) 244(4910):1288-1292.
    • (1989) Science , vol.244 , Issue.4910 , pp. 1288-1292
    • Capecchi, M.R.1
  • 10
    • 24944496766 scopus 로고    scopus 로고
    • Regenerating the heart
    • Laflamme MA, Murry CE: Regenerating the heart. Nat Biotechnol (2005) 23(7):845-856.
    • (2005) Nat Biotechnol , vol.23 , Issue.7 , pp. 845-856
    • Laflamme, M.A.1    Murry, C.E.2
  • 11
    • 3042828420 scopus 로고    scopus 로고
    • Adult stem cells - Reprogramming neurological repair?
    • Rice CM, Scolding NJ: Adult stem cells - reprogramming neurological repair? Lancet (2004) 364(9429):193-199.
    • (2004) Lancet , vol.364 , Issue.9429 , pp. 193-199
    • Rice, C.M.1    Scolding, N.J.2
  • 13
    • 22944488895 scopus 로고    scopus 로고
    • Genetic manipulation of human embryonic stem cells: A system to study early human development and potential therapeutic applications
    • Menendez P, Wang L, Bhatia M: Genetic manipulation of human embryonic stem cells: A system to study early human development and potential therapeutic applications. Curr Gene Ther (2005) 5(4):375-385.
    • (2005) Curr Gene Ther , vol.5 , Issue.4 , pp. 375-385
    • Menendez, P.1    Wang, L.2    Bhatia, M.3
  • 15
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A: Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol (2000) 18(4):399-404.
    • (2000) Nat Biotechnol , vol.18 , Issue.4 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 16
    • 0035479824 scopus 로고    scopus 로고
    • Human pluripotent stem cells: A program report
    • Pera MF: Human pluripotent stem cells: A program report. Curr Opin Genet Dev (2001) 11(5):595-599.
    • (2001) Curr Opin Genet Dev , vol.11 , Issue.5 , pp. 595-599
    • Pera, M.F.1
  • 17
    • 0038678846 scopus 로고    scopus 로고
    • Nuclear transplantation, embryonic stem cells, and the potential for cell therapy
    • Hochedlinger K, Jaenisch R: Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med (2003) 349(3):275-286.
    • (2003) N Engl J Med , vol.349 , Issue.3 , pp. 275-286
    • Hochedlinger, K.1    Jaenisch, R.2
  • 18
    • 11144219959 scopus 로고    scopus 로고
    • Human cloning - The science and ethics of nuclear transplantation
    • Jaenisch R: Human cloning - the science and ethics of nuclear transplantation. N Engl J Med (2004) 351(27):2787-2791.
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2787-2791
    • Jaenisch, R.1
  • 21
    • 30544449468 scopus 로고    scopus 로고
    • Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts
    • Meissner A, Jaenisch R: Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts. Nature (2006) 439(7073):212-215.
    • (2006) Nature , vol.439 , Issue.7073 , pp. 212-215
    • Meissner, A.1    Jaenisch, R.2
  • 22
    • 31144451300 scopus 로고    scopus 로고
    • Editorial retraction
    • Kennedy D: Editorial retraction. Science (2006) 311(5759):335.
    • (2006) Science , vol.311 , Issue.5759 , pp. 335
    • Kennedy, D.1
  • 23
    • 0036837610 scopus 로고    scopus 로고
    • Going to the roots of the stem cell controversy
    • Holm S: Going to the roots of the stem cell controversy. Bioethics (2002) 16(6):493-507.
    • (2002) Bioethics , vol.16 , Issue.6 , pp. 493-507
    • Holm, S.1
  • 24
    • 0033143324 scopus 로고    scopus 로고
    • The ethics of funding embryonic stem cell research: A Catholic viewpoint
    • Doerflinger RM: The ethics of funding embryonic stem cell research: A Catholic viewpoint. Kennedy Inst Ethics J (1999) 9(2):137-150.
    • (1999) Kennedy Inst Ethics J , vol.9 , Issue.2 , pp. 137-150
    • Doerflinger, R.M.1
  • 25
    • 0033288425 scopus 로고    scopus 로고
    • The concept of the person and the value of life
    • Harris J: The concept of the person and the value of life. Kennedy Inst Ethics J (1999) 9(4):293-308.
    • (1999) Kennedy Inst Ethics J , vol.9 , Issue.4 , pp. 293-308
    • Harris, J.1
  • 26
    • 0033145411 scopus 로고    scopus 로고
    • Ethics and policy in embryonic stem cell research
    • Robertson JA: Ethics and policy in embryonic stem cell research. Kennedy Inst Ethics J (1999) 9(2):109-136.
    • (1999) Kennedy Inst Ethics J , vol.9 , Issue.2 , pp. 109-136
    • Robertson, J.A.1
  • 27
    • 33644909373 scopus 로고    scopus 로고
    • Embryos and eagles: Symbolic value in research and reproduction
    • Bortolotti L, Harris J: Embryos and eagles: Symbolic value in research and reproduction. Cambridge Quarterly Healthcare Ethics (2006) 15(1):22-34.
    • (2006) Cambridge Quarterly Healthcare Ethics , vol.15 , Issue.1 , pp. 22-34
    • Bortolotti, L.1    Harris, J.2
  • 28
    • 15044359307 scopus 로고    scopus 로고
    • Stem cell research, personhood and sentience
    • Bortolotti L, Harris J: Stem cell research, personhood and sentience. Reprod Biomed Online (2005) 10(Suppl 1):68-75.
    • (2005) Reprod Biomed Online , vol.10 , Issue.SUPPL. 1 , pp. 68-75
    • Bortolotti, L.1    Harris, J.2
  • 29
    • 0036837908 scopus 로고    scopus 로고
    • The embryonic stem cell lottery and the cannibalization of human beings
    • Savulescu J: The embryonic stem cell lottery and the cannibalization of human beings. Bioethics (2002) 16(6):508-529.
    • (2002) Bioethics , vol.16 , Issue.6 , pp. 508-529
    • Savulescu, J.1
  • 30
    • 33748580104 scopus 로고    scopus 로고
    • Human embryonic stem cell lines derived from single blastomeres
    • DOI: 10:1038/nature05142
    • Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R: Human embryonic stem cell lines derived from single blastomeres. Nature (2006): DOI: 10:1038/ nature05142.
    • (2006) Nature
    • Klimanskaya, I.1    Chung, Y.2    Becker, S.3    Lu, S.J.4    Lanza, R.5
  • 32
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripatent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S: Induction of pluripatent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 126(4):663-676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 33
    • 0034592814 scopus 로고    scopus 로고
    • The potentiality argument in the debate relating to the beginning of personhood
    • Wolbert W. The potentiality argument in the debate relating to the beginning of personhood. Hum Reprod Genet Ethics (2000) 6(2):19-26.
    • (2000) Hum Reprod Genet Ethics , vol.6 , Issue.2 , pp. 19-26
    • Wolbert, W.1
  • 34
    • 0004246774 scopus 로고
    • Harris J (Ed): Routledge & Keegan Paul, New York, NY, USA
    • Harris J (Ed): The Value of Life. Routledge & Keegan Paul, New York, NY, USA (1985).
    • (1985) The Value of Life
  • 35
    • 17444374680 scopus 로고    scopus 로고
    • The moral status of the embryo post-Dolly
    • Stanton C, Harris J: The moral status of the embryo post-Dolly. J Med Ethics (2005) 31(4):221-225.
    • (2005) J Med Ethics , vol.31 , Issue.4 , pp. 221-225
    • Stanton, C.1    Harris, J.2
  • 36
    • 0036076688 scopus 로고    scopus 로고
    • A defence of the potential future of value theory
    • Marquis D: A defence of the potential future of value theory. J Med Ethics (2002) 28(3):198-201.
    • (2002) J Med Ethics , vol.28 , Issue.3 , pp. 198-201
    • Marquis, D.1
  • 37
    • 13944273791 scopus 로고    scopus 로고
    • Savulescu's objections to the future of value argument
    • Marquis D: Savulescu's objections to the future of value argument. J Med Ethics (2005) 31(2):119-122.
    • (2005) J Med Ethics , vol.31 , Issue.2 , pp. 119-122
    • Marquis, D.1
  • 38
    • 0036075693 scopus 로고    scopus 로고
    • Abortion, embryo destruction and the future of value argument
    • Savulescu J: Abortion, embryo destruction and the future of value argument. J Med Ethics (2002) 28(3):133-135.
    • (2002) J Med Ethics , vol.28 , Issue.3 , pp. 133-135
    • Savulescu, J.1
  • 39
    • 17444426735 scopus 로고    scopus 로고
    • In the world of Dolly, when does a human embryo acquire respect?
    • Cameron C, Wiliamson R: In the world of Dolly, when does a human embryo acquire respect? J Med Ethics (2005) 31(4):215-220.
    • (2005) J Med Ethics , vol.31 , Issue.4 , pp. 215-220
    • Cameron, C.1    Wiliamson, R.2
  • 40
    • 17744369076 scopus 로고    scopus 로고
    • Altered nuclear transfer as a morally acceptable means for the procurement of human embryonic stem cells
    • Hurlbut WB: Altered nuclear transfer as a morally acceptable means for the procurement of human embryonic stem cells. Perspect Biol Med (2005) 48(2):211-228.
    • (2005) Perspect Biol Med , vol.48 , Issue.2 , pp. 211-228
    • Hurlbut, W.B.1
  • 41
    • 30644472617 scopus 로고    scopus 로고
    • What's in a name? Embryos, entities, and ANTities in the stem cell debate
    • Devolder K: What's in a name? Embryos, entities, and ANTities in the stem cell debate. J Med Ethics (2006) 32(1):43-48.
    • (2006) J Med Ethics , vol.32 , Issue.1 , pp. 43-48
    • Devolder, K.1
  • 42
    • 2442541844 scopus 로고    scopus 로고
    • Human embryonic stem cell research: Why the discarded-created-distinction cannot be based on the potentiality argument
    • Devolder K: Human embryonic stem cell research: Why the discarded-created-distinction cannot be based on the potentiality argument Bioethics (2005) 19(2):167-186.
    • (2005) Bioethics , vol.19 , Issue.2 , pp. 167-186
    • Devolder, K.1
  • 43
    • 20444446378 scopus 로고    scopus 로고
    • Creating and sacrificing embryos for stem cells
    • Devolder K: Creating and sacrificing embryos for stem cells. J Med Ethics (2005) 31(6):366-370.
    • (2005) J Med Ethics , vol.31 , Issue.6 , pp. 366-370
    • Devolder, K.1
  • 45
    • 1442275750 scopus 로고    scopus 로고
    • Sexual reproduction is a survival lottery
    • Harris J: Sexual reproduction is a survival lottery. Cambridge Quarterty Healthcare Ethics (2004) 13(1):75-89.
    • (2004) Cambridge Quarterty Healthcare Ethics , vol.13 , Issue.1 , pp. 75-89
    • Harris, J.1
  • 46
    • 1442349205 scopus 로고    scopus 로고
    • The creation lottery: Final lessons from natural reproduction: Why those who accept natural reproduction should accept cloning and other Frankenstein reproductive technologies
    • Savulescu J, Harris J: The creation lottery: Final lessons from natural reproduction: Why those who accept natural reproduction should accept cloning and other Frankenstein reproductive technologies. Cambridge Quarterly Healthcare Ethics (2004) 13(1):90-95.
    • (2004) Cambridge Quarterly Healthcare Ethics , vol.13 , Issue.1 , pp. 90-95
    • Savulescu, J.1    Harris, J.2
  • 47
    • 1442300228 scopus 로고    scopus 로고
    • Embryo research: Are there any lessons from natural reproduction?
    • Savulescu J: Embryo research: Are there any lessons from natural reproduction? Cambridge Quarterly Healthcare Ethics (2004) 13(1):68-75.
    • (2004) Cambridge Quarterly Healthcare Ethics , vol.13 , Issue.1 , pp. 68-75
    • Savulescu, J.1
  • 49
    • 19344370234 scopus 로고    scopus 로고
    • Genetics. Ethical aspects of ES cell-derived gametes
    • Testa G, Harris J: Genetics. Ethical aspects of ES cell-derived gametes. Science (2004) 305(5691):1719.
    • (2004) Science , vol.305 , Issue.5691 , pp. 1719
    • Testa, G.1    Harris, J.2
  • 50
    • 17244379935 scopus 로고    scopus 로고
    • Ethics and synthetic gametes
    • Testa G, Harris J: Ethics and synthetic gametes. Bioethics (2005) 19(2):146-166.
    • (2005) Bioethics , vol.19 , Issue.2 , pp. 146-166
    • Testa, G.1    Harris, J.2
  • 52
    • 0033614701 scopus 로고    scopus 로고
    • Human germline gene modification: A dissent
    • Billings PR, Hubbard R, Newman SA: Human germline gene modification: A dissent. Lancet (1999) 363(9167):1873-1875.
    • (1999) Lancet , vol.363 , Issue.9167 , pp. 1873-1875
    • Billings, P.R.1    Hubbard, R.2    Newman, S.A.3
  • 53
    • 2942635867 scopus 로고    scopus 로고
    • A human germline modification scale
    • Adams H: A human germline modification scale. J Law Med Ethics (2004) 32(1):164-173.
    • (2004) J Law Med Ethics , vol.32 , Issue.1 , pp. 164-173
    • Adams, H.1
  • 54
    • 0003578532 scopus 로고    scopus 로고
    • Universal declaration on the human genome and human rights: Office of the United Nations High Commissioner for Human Rights
    • Geneva, Switzerland
    • Universal declaration on the human genome and human rights: Office of the United Nations High Commissioner for Human Rights, Geneva, Switzerland (1997). http://www.ohchr.org/english/law/genome.htm
    • (1997)
  • 55
    • 0036068916 scopus 로고    scopus 로고
    • Extending the human life span
    • Glannon W. Extending the human life span. J Med Philos (2002) 27(3):339-354.
    • (2002) J Med Philos , vol.27 , Issue.3 , pp. 339-354
    • Glannon, W.1
  • 56
    • 0036067001 scopus 로고    scopus 로고
    • Extending human lifespan and the precautionary paradox
    • Harris J, Holm S: Extending human lifespan and the precautionary paradox. J Med Philos (2002) 27(3):355-368.
    • (2002) J Med Philos , vol.27 , Issue.3 , pp. 355-368
    • Harris, J.1    Holm, S.2
  • 57
    • 0036050278 scopus 로고    scopus 로고
    • Human gene therapy and the slippery slope argument
    • Launis V: Human gene therapy and the slippery slope argument. Med Healthcare Philos (2002) 5(2):169-179.
    • (2002) Med Healthcare Philos , vol.5 , Issue.2 , pp. 169-179
    • Launis, V.1
  • 58
    • 69849113460 scopus 로고
    • On the distinction between disease and Illness
    • Bourse C: On the distinction between disease and Illness. Philos Public Affairs (1975) 5:49-68.
    • (1975) Philos Public Affairs , vol.5 , pp. 49-68
    • Bourse, C.1
  • 60
    • 5044242556 scopus 로고    scopus 로고
    • The case against perfection: Whats wrong with designer children, bionic athletes, and genetic engineering
    • Sandel MJ: The case against perfection: Whats wrong with designer children, bionic athletes, and genetic engineering. Atl Mon (2004) 292(3):50-54.
    • (2004) Atl Mon , vol.292 , Issue.3 , pp. 50-54
    • Sandel, M.J.1
  • 61
    • 1842473093 scopus 로고    scopus 로고
    • The inevitability of genetic enhancement technologies
    • Baylis F, Robert JS: The inevitability of genetic enhancement technologies. Bioethics (2004) 18(1):1-26.
    • (2004) Bioethics , vol.18 , Issue.1 , pp. 1-26
    • Baylis, F.1    Robert, J.S.2
  • 62
    • 15044354899 scopus 로고    scopus 로고
    • New breeds of humans: The moral obligation to enhance
    • Savulescu J: New breeds of humans: The moral obligation to enhance. Reprod Biomed Online (2005) 10(Suppl 1):36-39.
    • (2005) Reprod Biomed Online , vol.10 , Issue.SUPPL. 1 , pp. 36-39
    • Savulescu, J.1
  • 63
    • 0032923258 scopus 로고    scopus 로고
    • Prenatal diagnosis and discrimination against the disabled
    • Gillam L: Prenatal diagnosis and discrimination against the disabled. J Med Ethics (1999) 25(2):163-171.
    • (1999) J Med Ethics , vol.25 , Issue.2 , pp. 163-171
    • Gillam, L.1
  • 64
    • 0035663027 scopus 로고    scopus 로고
    • One principle and three fallacies of disability studies
    • Harris J: One principle and three fallacies of disability studies. J Med Ethics (2001) 27(6):383-387.
    • (2001) J Med Ethics , vol.27 , Issue.6 , pp. 383-387
    • Harris, J.1
  • 65
    • 15044355283 scopus 로고    scopus 로고
    • Gay science: Assisted reproductive technologies and the sexual orientation of children
    • Murphy TF: Gay science: Assisted reproductive technologies and the sexual orientation of children. Reprod Biomed Online (2005) 10(Suppl 1):102-106.
    • (2005) Reprod Biomed Online , vol.10 , Issue.SUPPL. 1 , pp. 102-106
    • Murphy, T.F.1
  • 66
    • 0034769433 scopus 로고    scopus 로고
    • Harm, ethics committees and the gone therapy death
    • Savulescu J: Harm, ethics committees and the gone therapy death. J Med Ethics (2001) 27(3):148-150.
    • (2001) J Med Ethics , vol.27 , Issue.3 , pp. 148-150
    • Savulescu, J.1
  • 68
    • 0037020112 scopus 로고    scopus 로고
    • Clinical research. Gene therapy a suspect in leukemia-like disease
    • Marshall E: Clinical research. Gene therapy a suspect in leukemia-like disease. Science (2002) 298(5591):34-35.
    • (2002) Science , vol.298 , Issue.5591 , pp. 34-35
    • Marshall, E.1
  • 69
    • 0037449534 scopus 로고    scopus 로고
    • Gene therapy. Second child in French trial is found to have leukemia
    • Marshall E: Gene therapy. Second child in French trial is found to have leukemia. Science (2003) 299(5605):320.
    • (2003) Science , vol.299 , Issue.5605 , pp. 320
    • Marshall, E.1
  • 70
    • 11844303500 scopus 로고    scopus 로고
    • Recent developments in gene transfer: Risk and ethics
    • Kimmelman J: Recent developments in gene transfer: Risk and ethics. Br Med J (2005) 330(7482):79-82.
    • (2005) Br Med J , vol.330 , Issue.7482 , pp. 79-82
    • Kimmelman, J.1
  • 71
    • 17444372789 scopus 로고    scopus 로고
    • Scientific research is a moral duty
    • Harris J: Scientific research is a moral duty. J Med Ethics (2005) 31(4):242-248.
    • (2005) J Med Ethics , vol.31 , Issue.4 , pp. 242-248
    • Harris, J.1
  • 72
    • 0042093638 scopus 로고    scopus 로고
    • Should we presume moral turpitude in our children? - Small children and consent to medical research
    • Harris J, Holm S: Should we presume moral turpitude in our children? - small children and consent to medical research. Theor Med Bioeth (2003) 24(2):121-129.
    • (2003) Theor Med Bioeth , vol.24 , Issue.2 , pp. 121-129
    • Harris, J.1    Holm, S.2
  • 73
    • 0004050596 scopus 로고
    • Cornford FM (Ed) Bowes and Bowes, London, UK
    • Cornford FM (Ed): Microcosmographia Academica. Bowes and Bowes, London, UK (1908).
    • (1908) Microcosmographia Academica


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