The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells

Journal of Endocrinology

Volumn 190, Issue 3, 2006, Pages 897-902

  Takeshita, Akira ^c   Inagaki, Keiji ^c   Igarashi Migitaka, Junko ^a   Ozawa, Yasunori ^c   Koibuchi, Noriyuki ^b  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c TORANOMON HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MULTIDRUG RESISTANCE PROTEIN 1; MUTANT PROTEIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLYVINYLCHLORIDE; STEROID RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; XENOBIOTIC AGENT;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL POPULATION; COLON CANCER; CONTROLLED STUDY; ENZYME ASSAY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; HUMAN CELL; LEACHING; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; GENES, MDR; HUMANS; LUCIFERASES; PLASTICIZERS; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TRANSFECTION; XENOBIOTICS;

EID: 33749860753     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06664     Document Type: Article

References (36)

1. Anonymous 2002 Safety Assessment ofDi(2ethylhexyl)phthalate (DEHP) Released from PVC Medical Devices: US Food and Drug Administration.
2. Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, Tramier V, Boyer A & Chopineau J 2005 Leaching of diethylhexyl phthalate from multilayer tubing into etoposide infusion solutions. American Journal of Health System Pharmacy 62 182-188.
3. Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P & Berkenstam. A 1998 Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. PNAS 95 12208-12213.
4. Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES & Evans RM 1998 SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes and Development 12 3195-3205.
5. Cohen RN, Putney A, Wondisford FE & Hollenberg AN 2000 The nuclear corepressors recognize distinct nuclear receptor complexes. Molecular Endocrinology 14 900-914.
6. Dotzlaw H, Leygue E, Watson P & Murphy LC 1999 The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clinical Cancer Research 5 2103-2107.
7. Faouzi MA, Dine T Gressier B, Kambia, K, Luyckx M, Pagniez D, Brunet C, Cazin M, Belabed A & Cazin JC 1999 Exposure of hemodialysis patients to di-2-ethylhexyl phthalate. International Journal of Pharmaceutics 180 113-121.
8. Fujimaki S, Funato T, Harigae H, Fujiwara J, Kameoka J, Meguro K, Kaku M & Sasaki T 2002 Quantitative analysis of a MDR1 transcript for prediction of drug resistance in acute leukemia. Clinical Chemistry 48 811-817.
9. Geick A, Eichelbaum M & Burk O 2001 Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. Journal of Biological Chemistry 276 14581-14587.
10. Glass CK & Rosenfeld MG 2000 The coregulator exchange in transcriptional functions of nuclear receptors. Genes and Development 14 121-141.
11. Goodwin B, Hodgson E & Liddle C 1999 The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Molecular Pharmacology 56 1329-1339.
12. Gottesman MM, Fojo T & Bates SE 2002 Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Reviews Cancer 2 48-58.
13. Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R & Hirata K 2005 Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis. European Journal of Endocrinology 153 595-604.
14. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH et al. 1998 An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 73-82.
15. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT & Kliewer SA 1998 The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Journal of Clinical Investigation 102 1016-1023.
16. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 402-408.
17. Loff S, Kabs F, Witt K, Sartoris J, Mandl B, Niessen KH & Waag KL 2000 Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. Journal of Pediatric Surgery 35 1775-1781.
18. Loo TW & Clarke DM 1999 Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein. Biochemistry and Cell Biology 77 11-23.
19. McKenna NJ, Lanz RB & O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews 20 321-344.
20. Masuyama H, Hiramatsu Y, Kodama J & Kudo T 2003 Expression and potential roles of pregnane X receptor in endometrial cancer. Journal of Clinical Endocrinology and Metabolism 88 4446-4454.
21. Masuyama H, Suwaki N, Tateishi Y, Nakatsukasa H, Segawa T & Hiramatsu Y 2005 The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Molecular Endocrinology 19 1170-1180.
22. Nordeen SK 1988 Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6 454-458.
23. Pearson SD & Trissel LA 1993 Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components. American Journal of Hospital Pharmacology 50 1405-1409.
24. Pollack GM, Buchanan JF, Slaughter RL, Kohli RK & Shen DD 1985 Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicology and Applied Pharmacology 79 257-267.
25. Robert J 1999 Multidrug resistance in oncology: diagnostic and therapeutic approaches. European Journal of Clinical Investigation 29 536-545.
26. Shea KM 2003 Pediatric exposure and potential toxicity of phdialate plasticizers. Pediatrics 111 1467-1474.
27. Synold TW, Dussault I & Forman BM 2001 The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nature Medicine 7 584-590.
28. Takeshita A, Koibuchi N, Oka J, Taguchi M, Shishiba Y & Ozawa Y 2001 Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. European Journal of Endocrinology 145 513-517.
29. Takeshita A, Taguchi M, Koibuchi N & Ozawa Y 2002 Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. Journal of Biological Chemistry 277 32453-32458.
30. Thiesen J & Kramer I 1999 Physico-chemical stability of docetaxel premix solution and docetaxel infusion solutions in PVC bags and polyolefine containers. Pharmacy World Science 21 137-141.
31. Tickner JA, Schettler T, Guidotti T, McCally M & Rossi M 2001 Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. American Journal of Industrial Medicine 39 100-111.
32. Tom BH, Rutzky LP, Jakstys MM, Oyasti R, Kaye CI & Kahan BD 1976 Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 12 180-191.
33. Trissel LA 1997 Pharmaceutical properties of paclitaxel and their effects on preparation and administration. Pharmacotherapy 17 133S-139S.
34. Tsumura Y, Ishimitsu S, Saito I, Sakai H, Tsuchida Y & Tonogai Y 2003 Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. Food Additives Contaminants 20 317-324.
35. Wams TJ 1987 Diethylhexylphthalate as an environmental contaminant - a review. Science of the Total Environment 66 1-16.
36. Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA & Redinbo MR 2001 The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292 2329-2333.