Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers

Journal of Pediatric Surgery

Volumn 35, Issue 12, 2000, Pages 1775-1781

  Loff, S ^a   Kabs, F ^a   Witt, K ^a   Sartoris, J ^a   Mandl, B ^a   Niessen, K H ^a   Waag, K L ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Diethylhexylphthalate; Extraction; Polyvinylchloride infusion lines

Indexed keywords

AMINO ACID; FENTANYL; GLUCOSE; INFUSION FLUID; LIPID EMULSION; MIDAZOLAM; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER; POLYVINYLCHLORIDE; PROPOFOL;

ARTICLE; CONTROLLED STUDY; DRUG CONTAMINATION; EMULSION; INFUSION SYSTEM; LIVER TOXICITY; LONG TERM CARE; MEASUREMENT; PRIORITY JOURNAL; TOTAL PARENTERAL NUTRITION;

EID: 0033668245     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1053/jpsu.2000.19249     Document Type: Article

References (38)

1. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis
2. Delivery of di-2-ethylhexyl phthalate to patients during hemodialysis
3. Bis(2-ethylhexyl) phthalate concentrations in the serum of hemodialysis patients
4. Hepatic effects of phthalate ester plasticizer leached from poly(vinyl chloride) blood bags following transfusion
5. Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components
6. Formation of mono(ethylhexyl)phthalate from di(ethylhexyl)phthalate in human plasma stored in PVC bags and its presence in fractionated plasma proteins
7. Extraction of diethylhexylphthalate from total nutrient solution-containing polyvinyl chloride bags
8. Phthalic acid esters in various foodstuffs and biological materials
9. Toxicity of the plasticizer di(2-ethylhexyl)phthalate
10. Comparative studies of the hepatic effects of di- and mono-n-octyl phthalates di(2-ethylhexy-1)phthalate and clofibrate in the rat
11. Effects of repeated intravenous infusions of the plasticizer di(2-ethylhexyl)phthalate in young male rats
12. Di-n-octyl phthalate (DOP) a relatively ineffective peroxisome inducing straight chain isomer of the environmental contaminant di(2-ethylhexyl) phthalate (DEHP) enhances the development of putative preneoplastic lesions in rat liver
13. Peroxisomal oxidases and catalase in liver and kidney homogenates of normal and di(ethylhexyl)phthalate-fed rats
14. Hepatic hyperplasia and cancer in rats: Metabolic alterations associated with cell growth
15. A glucose-regulated protein GRP 58 is down-regulated in C57B6 mouse liver after di(ethylhexyl)phthalate exposure
16. Effect of prolonged administration of phthalate ester on the liver
17. Purification and characterization of two forms of Cytochrom P-450 with omega-hydroxylase activities toward prostaglandin A and fatty acids from rabbit liver microsomes
18. Suppression of cytochrome P450 Cyp 2f2 mRNA levels in mice by the peroxisome proliferator di(ethylhexyl)phthalate
19. Effects of prolonged treatment with phthalate ester on rat liver
20. Effect of di(2-ethylhexyl)phthalate (DEHP) on glycogen metabolism in rat liver
21. Receptor and nonreceptor-mediated organspecific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice
22. Effects from plasticizer leached from polyvinyl chloride on the subhuman primate: A consequence of chronic transfusion therapy
23. Effects of chronic phthalate exposure on the kidney
24. Effect of testosterone on the testicular atrophy caused by di(2-ethylhexyl)phthalate (DEHP)
25. Di(2-ethylhexyl)phthalate as plasticizer in PVC respiratory tubing systems: Indications of hazardous effects on pulmonary function in mechanically ventilated preterm infants
26. Stability compatibility and plasticizer extraction of miconazole injectionadded to infusion solutions and stored in PVC containers
27. The occurence of phthalic acid esters in various samples of commercially available sodium chloride injections
28. Leachability of a new plasticizer tri(2-ethylhexyl) trimellitate from hemodialysis tubing
29. Longterm total parenteral nutrition-induced hepatobiliary dysfunction in a rabbit model
30. Serial liver biopsies in parenteral nutrition-associated cholestasis of early infancy
31. Total parenteral nutrition-associated cholestasis: Clinical and histopathologic correlation
32. Circulating concentrations of di(2-ethylhexyl)phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis
33. Hepatocarcinogenic potential of di(2-(ethylhexyl)phthalate in rodents and its implications on human risk
34. Phthalate esters and their effect on the liver
35. Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate aluminium clofibrate and simfibrate
36. Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl) phthalate for 2 years
37. A prospective analysis of cholestasis in infants supported with extracorporeal membrane oxygenation
38. Di-(2-ethylhexyl)phthalate as plasticizer in PVC respiratory tubing systems: Indications of hazardous effects on pulmonary function in mechanically ventilated preterm infants