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Volumn 60, Issue 9, 2006, Pages 554-560

Process research and scale-up of the κ-opioid receptor agonist CJ-15,161 drug candidate

Author keywords

Aziridinium; Copper; N Arylation; Oxazolidinone; Palladium; Process chemistry

Indexed keywords


EID: 33749828349     PISSN: 00094293     EISSN: None     Source Type: Journal    
DOI: 10.2533/chimia.2006.554     Document Type: Article
Times cited : (8)

References (50)
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    • note
    • 2 was used for other ArCl substrates.
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    • note
    • The yields are lower with benzoate protected substrate 35a due to competing hydrolysis of the starting amine. With silyl protection the % yields were in the 80s.
  • 46
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    • The effect of various diamine ligands on the efficiency of the aryl amidation reaction has been reported: b) A. Klapars, X. Huang, S.L. Buchwald, J. Am. Chem. Soc. 2002, 124, 7421-7428.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 7421-7428
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    • For the first report on intramolecular amidations under relatively mild conditions, see: c) T. Ohsawa, T. Kametani, M. Ihara, Heterocycles 1980, 14, 277-280.
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    • Lindley, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.