A "bottom-up" approach to process development: Application of physicochemical properties of reaction products toward the development of direct-drop processes

Organic Process Research and Development

Volumn 5, Issue 5, 2001, Pages 508-513

  Chen, Chien Kuang ^a   Singh, Ambarish K ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035537542     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0102114     Document Type: Article

References (14)

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3. Oiling or heavy precipitation may be prevented by either working at slightly lower product concentration or by identifying three-solvent systems for crystallization. The third solvent is selected on the basis of the dielectric constant and solubility characteristics of the substrate in the third solvent.
4. Le Chatelier's principle states that, "if, to a system in equilibrium, a stress is applied, the system will react so as to relieve the stress". (a) Thomsen, V. E. J. Chem. Educ. 2000, 77, 173.
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7. Although acetonitrile is not a preferred solvent from environmental and cost points of view, it was selected in this example because it offered unique opportunities to simplify the overall process.
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9. (a) Mueller, R. M. A Practical Synthesis of Ifetroban Sodium. In Process Chemistry in the Pharmaceutical Industry; Gadamasetti, K. G., Ed.; Marcel Dekker: New York, 1999; p 37.
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