Cell death: Regulation by the Bcl-2 protein family

Psychogeriatrics

Volumn 6, Issue SUPPL. 2, 2006, Pages

  Tsujimoto, Yoshihide ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Bcl 2; Mitochondria; Necrosis

Indexed keywords

APOPTOSIS INHIBITOR; BH4 PROTEIN; CASPASE; CYTOCHROME C; PROTEIN BCL 2; PROTEIN BCL XL; PROTEINASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN ISCHEMIA; CELL DEATH; CYTOPLASM; HEART MUSCLE ISCHEMIA; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REPERFUSION INJURY;

EID: 33749624514     PISSN: 13463500     EISSN: 14798301     Source Type: Journal    
DOI: 10.1111/j.1479-8301.2006.00173.x     Document Type: Article

References (35)

1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
2. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998; 281: 1312-1316.
3. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15: 2922-2933.
4. Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G, Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene 2004; 12: 2861-2874.
5. Peter ME, Krammer PH. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003; 10: 26-35.
6. Scaffidi C, Fulda S, Srinivasan A et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998; 17: 1675-1687.
7. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440-1443.
8. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440-442.
9. Tsujimoto Y. Stress-resistance conferred by high level of bcl-2α protein in human B lymphoblastoid cell. Oncogene 1989; 4: 1331-1336.
10. Tsujimoto Y. Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 2003; 195: 158-167.
11. Tsujimoto Y, Shimizu S. The voltage-dependant anion channel: An essential player in apoptosis. Biochimie 2002; 9: 187-193.
12. Minn AJ, Velez P, Schendel SL et al. Bcl-x (L) forms an ion channel in synthetic lipid membranes. Nature 1997; 385: 353-357.
13. Schendel SL, Montai M, Reed JC. Bcl-2 family proteins as ion-channels. Cell Death Diff 1998; 5: 372-380.
14. Puthalakath H, Strasser A. Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Diff 2002; 9: 505-512.
15. Wei MC, Zong WX, Cheng EH et al. Proapoptotic Bax and Bak: A requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727-730.
16. Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 2000; 345: 271-278.
17. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399: 483-487.
18. Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y. Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol 2001; 152: 237-250.
19. Saito M, Korsmeyer SJ, Schlesinger PH. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2000; 2: 553-555.
20. Kuwana T, Mackey MR, Perkins G et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002; 111: 331-342.
21. Marchetti P, Castedo M, Susin SA et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 1996; 184: 1155-1160.
22. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulation in apoptosis and necrosis. Ann Rev Physiol 1998; 60: 619-642.
23. Zoratti M, Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1995; 1241: 139-176.
24. Nakagawa T, Shimizu S, Watanabe T et al. Cyclophilin d-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic death. Nature 2005; 434: 652-658.
25. Baines CP, Kaiser RA, Purcell NH et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434: 658-662.
26. Shimizu S, Eguchi Y, Kamiike W et al. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA 1998; 95: 1455-1459.
27. Marzo I, Brenner C, Zamzami N et al. The permeability transition pore complex: A target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med 1998; 187: 1261-1271.
28. Shimizu S, Eguchi Y, Kamiike W et al. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by bcl-2 and bcl-xL. Cancer Res 1996; 56: 2161-2166.
29. Shimizu S, Eguchi Y, Kamiike W et al. Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible common steps in apoptosis and necrosis. Oncogene 1996; 12: 2045-2050.
30. Shimizu S, Konishi A, Kodama T, Tsujimoto Y. BH4 domain of anti-apoptotic Bcl-2 family members closes VDAC, and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci USA 2000; 97: 3100-3105.
31. Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: Unrestricted delivery into all cells? Trends Cell Biol 2000; 10: 290-295.
32. Sugioka R, Shimizu S, Funatsu T et al. BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene 2003; 22: 8432-8440.
33. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001; 8: 569-581.
34. Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6: 463-477.
35. Shimizu S, Kanaseki T, Mizushima N et al. A role of Bcl-2 family of proteins in non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol 2004; 6: 1221-1228.