-
1
-
-
0037840541
-
Products of secondary metabolites
-
Pühler, A., Stadler, P., Eds., Weinheim: VCH
-
Kleinkauf, H.; von Döhren, H. Products of secondary metabolites. In: Pühler, A., Stadler, P., Eds. Biotechnology. Weinheim: VCH: 1997; 1-55.
-
(1997)
Biotechnology
, pp. 1-55
-
-
Kleinkauf, H.1
Von Döhren, H.2
-
2
-
-
0029896295
-
Amino acid activation and polymerization at modular multienzymes in nonribosomal peptide biosynthesis
-
Stein, T.; Vater, J. Amino acid activation and polymerization at modular multienzymes in nonribosomal peptide biosynthesis. Amino Acids 1996, 10, 201-227.
-
(1996)
Amino Acids
, vol.10
, pp. 201-227
-
-
Stein, T.1
Vater, J.2
-
3
-
-
0028272082
-
Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis
-
Hoffmann, K.; Schneider-Scherzer, E.; Kleinkauf, H.; Zocher, R. Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis. J. Biol. Chem. 1994, 17, 12710-12714.
-
(1994)
J. Biol. Chem
, vol.17
, pp. 12710-12714
-
-
Hoffmann, K.1
Schneider-Scherzer, E.2
Kleinkauf, H.3
Zocher, R.4
-
4
-
-
0030937465
-
Omphalotin, a new cyclic peptide with potent nematicidal activity from Omphalotus olearius. 2. Isolation and structure determination
-
Sterner, O.; Etzel, W.; Mayer, A.; Anke, H. Omphalotin, a new cyclic peptide with potent nematicidal activity from Omphalotus olearius. 2. Isolation and structure determination. Nat. Prod. Lett. 1997, 9, 33-38.
-
(1997)
Nat. Prod. Lett
, vol.9
, pp. 33-38
-
-
Sterner, O.1
Etzel, W.2
Mayer, A.3
Anke, H.4
-
5
-
-
0035732760
-
Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum
-
Hoppert, M.; Gentzsch, C.; Schörgendorfer, K. Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum. Arch. Microbiol. 2001, 176, 285-293.
-
(2001)
Arch. Microbiol
, vol.176
, pp. 285-293
-
-
Hoppert, M.1
Gentzsch, C.2
Schörgendorfer, K.3
-
6
-
-
0035478654
-
Tailoring enzymes that modify nonribosomal peptides during and after cain elongation on NRPS assembly lines
-
Walsh, C.T.; Chen, H.; Keating, T.A.; Hubbard, B.K.; Losey, H.C.; Luo, L.; Marshall, C.G.; Miller, D.A.; Patel, H.M. Tailoring enzymes that modify nonribosomal peptides during and after cain elongation on NRPS assembly lines. Curr. Opin. Chem. Biol. 2001, 5, 525-34.
-
(2001)
Curr. Opin. Chem. Biol
, vol.5
, pp. 525-534
-
-
Walsh, C.T.1
Chen, H.2
Keating, T.A.3
Hubbard, B.K.4
Losey, H.C.5
Luo, L.6
Marshall, C.G.7
Miller, D.A.8
Patel, H.M.9
-
7
-
-
0031060707
-
Thiol template peptide synthesis systems in bacteria and fungi
-
Zocher, R.; Keller, U. Thiol template peptide synthesis systems in bacteria and fungi. Adv. Micr. Phys. 1997, 38, 85-131.
-
(1997)
Adv. Micr. Phys.
, vol.38
, pp. 85-131
-
-
Zocher, R.1
Keller, U.2
-
8
-
-
0001296027
-
Multifunctional peptide synthetases
-
von Döhren, H.; Keller, U.; Vater, J.; Zocher, R. Multifunctional peptide synthetases. Chem. Rev. 1997, 97, 2651-2673.
-
(1997)
Chem. Rev
, vol.97
, pp. 2651-2673
-
-
Von Döhren, H.1
Keller, U.2
Vater, J.3
Zocher, R.4
-
9
-
-
9444278428
-
Modular peptide synthetases involved in nonribosomal peptide synthesis
-
Marahiel, M.A.; Stachelhaus, T.; Mootz, H.D. Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 1997, 97, 2651-2673.
-
(1997)
Chem. Rev
, vol.97
, pp. 2651-2673
-
-
Marahiel, M.A.1
Stachelhaus, T.2
Mootz, H.D.3
-
10
-
-
0034705130
-
Construction of hybrid peptide synthetases by module and domain fusions
-
Mootz, H.D.; Schwarzer, D.; Marahiel, M.A. Construction of hybrid peptide synthetases by module and domain fusions. Proc. Natl. Acad. Sci. 2000, 97, 5848-5853.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 5848-5853
-
-
Mootz, H.D.1
Schwarzer, D.2
Marahiel, M.A.3
-
11
-
-
0034613180
-
Mutational analysis of the N-methyltransferase domain of the multifunctional enzyme enniatin synthetase
-
Hacker, C.; Glinski, M.; Hornbogen, T.; Doller, A.; Zocher, R. Mutational analysis of the N-methyltransferase domain of the multifunctional enzyme enniatin synthetase. J. Biol. Chem. 2000, 275, 30826-30832.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 30826-30832
-
-
Hacker, C.1
Glinski, M.2
Hornbogen, T.3
Doller, A.4
Zocher, R.5
-
12
-
-
0014937563
-
Isolation of enzyme-bound peptide intermediates in tyrocidine synthesis
-
Roskoski, R.; Kleinkauf, H.; Gevers, W.; Lipmann, F. Isolation of enzyme-bound peptide intermediates in tyrocidine synthesis. Biochemistry 1970, 9, 4846-4851.
-
(1970)
Biochemistry
, vol.9
, pp. 4846-4851
-
-
Roskoski, R.1
Kleinkauf, H.2
Gevers, W.3
Lipmann, F.4
-
13
-
-
0035023450
-
Multimodular biocatalysts for natural product assembly
-
Schwarzer, D.; Marahiel, M.A. Multimodular biocatalysts for natural product assembly. Naturwissenschaften 2001, 88, 93-101.
-
(2001)
Naturwissenschaften
, vol.88
, pp. 93-101
-
-
Schwarzer, D.1
Marahiel, M.A.2
-
14
-
-
0025606149
-
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
-
Hopwood, D.A.; Sherman, D.H. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Ann. Rev. Genet. 1990, 24, 37-66.
-
(1990)
Ann. Rev. Genet.
, vol.24
, pp. 37-66
-
-
Hopwood, D.A.1
Sherman, D.H.2
-
15
-
-
0029978534
-
The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates
-
Stein, T.; Vater, J.; Kruft, V.; Otto, A.; Wittman-Liebold, B.; Franke, P.; Panico, M.; McDowell, R.; Morris, H.R. The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates. J. Biol. Chem. 1996, 271, 15428-15435.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 15428-15435
-
-
Stein, T.1
Vater, J.2
Kruft, V.3
Otto, A.4
Wittman-Liebold, B.5
Franke, P.6
Panico, M.7
McDowell, R.8
Morris, H.R.9
-
16
-
-
0002215808
-
Enzymatic Synthesis of Fungal N-Methylated cyclopeptides and depsipeptides
-
Kirst, H., Wu-Kuang, Y., Zmijewski, M., eds., New York: Marcel Dekker Inc
-
Glinski, M.; Hornbogen, T.; Zocher, R. Enzymatic Synthesis of Fungal N-Methylated cyclopeptides and depsipeptides. In: Kirst, H., Wu-Kuang, Y., Zmijewski, M., eds. Enzyme technologies for pharmaceutical and biotechnological applications. New York: Marcel Dekker Inc.: 2001; 471-497.
-
(2001)
Enzyme Technologies for Pharmaceutical and Biotechnological Applications
, pp. 471-497
-
-
Glinski, M.1
Hornbogen, T.2
Zocher, R.3
-
17
-
-
0028837014
-
Modular structure of genes encoding multifunctional peptide synthetases required for nonribosomal peptide synthesis
-
Stachelhaus, T.; Marahiel, M.A. Modular structure of genes encoding multifunctional peptide synthetases required for nonribosomal peptide synthesis. FEMS Microbiol. Lett. 1995, 125, 3-14.
-
(1995)
FEMS Microbiol. Lett.
, vol.125
, pp. 3-14
-
-
Stachelhaus, T.1
Marahiel, M.A.2
-
18
-
-
0032484013
-
Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases
-
Guenzi, E.; Galli, G.; Grgurina, I.; Gross, D.C.; Grandi, G. Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases. J. Biol. Chem. 1998, 273, 32857-63.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32857-32863
-
-
Guenzi, E.1
Galli, G.2
Grgurina, I.3
Gross, D.C.4
Grandi, G.5
-
19
-
-
0033080078
-
How do peptide synthetases generate structural diversity
-
Konz, D.; Marahiel, M.A. How do peptide synthetases generate structural diversity. Chem. Biol. 1999, 6, 39-48.
-
(1999)
Chem. Biol
, vol.6
, pp. 39-48
-
-
Konz, D.1
Marahiel, M.A.2
-
20
-
-
0030756031
-
Structural basis for the activation of phenylalanine in the nonribosomal biosynthesis of gramicidin S
-
Conti, E.; Stachelhaus, T.; Marahiel, M.A.; Brick, P. Structural basis for the activation of phenylalanine in the nonribosomal biosynthesis of gramicidin S. EMBO Journal 1997, 16, 4174-4183.
-
(1997)
EMBO Journal
, vol.16
, pp. 4174-4183
-
-
Conti, E.1
Stachelhaus, T.2
Marahiel, M.A.3
Brick, P.4
-
21
-
-
0030669091
-
The tyrocidine biosynthesis operon of Bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
-
Mootz, H.D.; Marahiel, M.A. The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J. Bacteriol. 1997, 179, 6843-6850.
-
(1997)
J. Bacteriol
, vol.179
, pp. 6843-6850
-
-
Mootz, H.D.1
Marahiel, M.A.2
-
22
-
-
0028896569
-
Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases
-
Dieckmann, R.; Lee, Y.O.; van Liempt, H.; von Döhren, H.; Kleinkauf, H. Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases. FEBS Lett. 1995, 357, 212-216.
-
(1995)
FEBS Lett
, vol.357
, pp. 212-216
-
-
Dieckmann, R.1
Lee, Y.O.2
Van Liempt, H.3
Von Döhren, H.4
Kleinkauf, H.5
-
23
-
-
0027996536
-
Bacterial expression of catalytically active fragments of the multifunctional enzyme enniatin synthetase
-
Haese, A.; Pieper, R.; von Ostrowski, T.; Zocher, R. Bacterial expression of catalytically active fragments of the multifunctional enzyme enniatin synthetase. J. Mol. Biol. 1994, 247, 116-122.
-
(1994)
J. Mol. Biol
, vol.247
, pp. 116-122
-
-
Haese, A.1
Pieper, R.2
Von Ostrowski, T.3
Zocher, R.4
-
24
-
-
0026348903
-
An active site serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase
-
Schlumbohm, W.; Stein, T.; Ullrich, C.; Vater, J.; Krause, M.; Marahiel, M.A.; Kruft, V.; Wittmann-Liebold, B. An active site serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase. J. Biol. Chem. 1991, 266, 23135-23141.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 23135-23141
-
-
Schlumbohm, W.1
Stein, T.2
Ullrich, C.3
Vater, J.4
Krause, M.5
Marahiel, M.A.6
Kruft, V.7
Wittmann-Liebold, B.8
-
25
-
-
0032575648
-
Peptide Bond Formation in Nonribosomal Peptide Synthesis
-
Stachelhaus, T.; Mootz, H.D.; Bergendahl, V.; Marahiel, M.A. Peptide Bond Formation in Nonribosomal Peptide Synthesis. J. Biol. Chem. 1998, 273, 22773-22781.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 22773-22781
-
-
Stachelhaus, T.1
Mootz, H.D.2
Bergendahl, V.3
Marahiel, M.A.4
-
26
-
-
0028142411
-
Epimerization of the D-valine portion in the biosynthesis of actinomycin D
-
Stindl, A.; Keller, U. Epimerization of the D-valine portion in the biosynthesis of actinomycin D. Biochemistry 1994, 33, 9358-64.
-
(1994)
Biochemistry
, vol.33
, pp. 9358-9364
-
-
Stindl, A.1
Keller, U.2
-
27
-
-
0030916224
-
Enzymatic generation of complex peptides
-
Kleinkauf, H.; von Döhren, H. Enzymatic generation of complex peptides. Prog. Drug Res. 1997, 48, 27-51.
-
(1997)
Prog. Drug Res
, vol.48
, pp. 27-51
-
-
Kleinkauf, H.1
Von Döhren, H.2
-
28
-
-
0000013349
-
N-Methyltransferase function of the multifunctional enzyme enniatin synthetase
-
Billich, A.; Zocher, R. N-Methyltransferase function of the multifunctional enzyme enniatin synthetase. Biochemistry 1987, 26, 8417-8423.
-
(1987)
Biochemistry
, vol.26
, pp. 8417-8423
-
-
Billich, A.1
Zocher, R.2
-
29
-
-
0032829915
-
Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
-
Keating, T.A.; Walsh, C.T. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis. Curr. Opin. Chem. Biol. 1999, 3, 598-606.
-
(1999)
Curr. Opin. Chem. Biol
, vol.3
, pp. 598-606
-
-
Keating, T.A.1
Walsh, C.T.2
-
30
-
-
0035912883
-
Generality of Peptide Cyclization Catalyzed by Isolated Thioesterase Domains of Nonribosomal Peptide Synthetases
-
Rahul, M.K.; Trauger, J.W.; Schwarzer, D.; Marahiel, M.A.; Walsh, C.T. Generality of Peptide Cyclization Catalyzed by Isolated Thioesterase Domains of Nonribosomal Peptide Synthetases. Biochemistry 2001, 40, 7099-7108.
-
(2001)
Biochemistry
, vol.40
, pp. 7099-7108
-
-
Rahul, M.K.1
Trauger, J.W.2
Schwarzer, D.3
Marahiel, M.A.4
Walsh, C.T.5
-
31
-
-
18544390045
-
Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-SEnzyme Breakdown in Antibiotic and Siderophore Biosynthesis
-
Keating, T.A.; Ehmann, D.E.; Rahul, M.K.; Marshall, C.G.; Trauger, J.W.; Walsh, C.T. Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-SEnzyme Breakdown in Antibiotic and Siderophore Biosynthesis. Chem. Bio. Chem. 2001, 2, 99-107.
-
(2001)
Chem. Bio. Chem
, vol.2
, pp. 99-107
-
-
Keating, T.A.1
Ehmann, D.E.2
Rahul, M.K.3
Marshall, C.G.4
Trauger, J.W.5
Walsh, C.T.6
-
32
-
-
0026588298
-
Four homologous domains in the primary structure of GrsB are related to domains in superfamily of adenylate-forming enzymes
-
Turgay, K.; Krause, M.; Marahiel, M.A. Four homologous domains in the primary structure of GrsB are related to domains in superfamily of adenylate-forming enzymes. Mol. Microbiol. 1992, 6, 529-546.
-
(1992)
Mol. Microbiol
, vol.6
, pp. 529-546
-
-
Turgay, K.1
Krause, M.2
Marahiel, M.A.3
-
33
-
-
0033179468
-
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
-
Stachelhaus, T.; Mootz, H.D.; Marahiel, M.A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol. 1999, 6, 493-505.
-
(1999)
Chem. Biol
, vol.6
, pp. 493-505
-
-
Stachelhaus, T.1
Mootz, H.D.2
Marahiel, M.A.3
-
34
-
-
0034013269
-
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
-
Challis, G.L.; Ravel, J.; Townsend, C.A. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem. Biol. 2000, 7, 211-24.
-
(2000)
Chem. Biol
, vol.7
, pp. 211-224
-
-
Challis, G.L.1
Ravel, J.2
Townsend, C.A.3
-
35
-
-
0037199494
-
Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics
-
Eppelmann, K.; Stachelhaus, T.; Marahiel, M.A. Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry 2002, 41, 9718-26.
-
(2002)
Biochemistry
, vol.41
, pp. 9718-9726
-
-
Eppelmann, K.1
Stachelhaus, T.2
Marahiel, M.A.3
-
36
-
-
0034656331
-
Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases
-
Weber, T.; Baumgartner, R.; Renner, C.; Marahiel, M.A.; Holak, T.A. Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Structure Fold. Des. 2000, 8, 407-418.
-
(2000)
Structure Fold. Des
, vol.8
, pp. 407-418
-
-
Weber, T.1
Baumgartner, R.2
Renner, C.3
Marahiel, M.A.4
Holak, T.A.5
-
37
-
-
0027382486
-
Polyketide synthesis: Prospects for hybrid antibiotics
-
Katz, L.; Donadio, S. Polyketide synthesis: prospects for hybrid antibiotics. Annu. Rev. Microbiol. 1993, 47, 875-912.
-
(1993)
Annu. Rev. Microbiol
, vol.47
, pp. 875-912
-
-
Katz, L.1
Donadio, S.2
-
38
-
-
0031244337
-
Post-translational modification of polyketide and nonribosomal peptide synthetases
-
Walsh, C.T.; Gehring, A.M.; Weinreb, P.H.; Luis, E.N.; Flugel, R.S. Post-translational modification of polyketide and nonribosomal peptide synthetases. Curr. Opin. Chem. Biol. 1997, 1, 309-315.
-
(1997)
Curr. Opin. Chem. Biol.
, vol.1
, pp. 309-315
-
-
Walsh, C.T.1
Gehring, A.M.2
Weinreb, P.H.3
Luis, E.N.4
Flugel, R.S.5
-
39
-
-
0030294470
-
New enzyme superfamily—the phosphopantetheinyl transferases
-
Lambalot, R.H.; Gehring, A.M.; Flugel, R.S.; Zuber, P.; LaCelle, M.; Marahiel, M.A.; Reid, R.; Khoshla, C.; Walsh, C.T. A new enzyme superfamily—the phosphopantetheinyl transferases. Chem. Biol. 1996, 3, 923-36.
-
(1996)
Chem. Biol
, vol.3
, pp. 923-936
-
-
Lambalot, R.H.1
Gehring, A.M.2
Flugel, R.S.3
Zuber, P.4
Lacelle, M.5
Marahiel, M.A.6
Reid, R.7
Khoshla, C.8
Walsh, C.9
-
40
-
-
0035979338
-
In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: Characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities
-
Patel, H.M.; Walsh, C.T. In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities. Biochemistry 2001, 40, 9023-31.
-
(2001)
Biochemistry
, vol.40
, pp. 9023-9031
-
-
Patel, H.M.1
Walsh, C.T.2
-
41
-
-
0028807689
-
Multienzymatic non ribosomal peptide synthesis: Identification of the functional domains catalysing peptide elongation and epimerisation
-
de Crécy-Lagard, V.; Marlière, P.; Saurin, W. Multienzymatic non ribosomal peptide synthesis: identification of the functional domains catalysing peptide elongation and epimerisation. C. R. Acad. Sci. Paris 1995, 318, 927-936.
-
(1995)
C. R. Acad. Sci. Paris
, vol.318
, pp. 927-936
-
-
De Crécy-Lagard, V.1
Marlière, P.2
Saurin, W.3
-
42
-
-
0034730091
-
Control of Directionality in Nonribosomal Peptide Synthesis: Role of the Condensation Domain in Preventing Misinitiation and Timing of Epimerization
-
Linne, U.; Marahiel, M.A. Control of Directionality in Nonribosomal Peptide Synthesis: Role of the Condensation Domain in Preventing Misinitiation and Timing of Epimerization. Biochemistry 2000, 39, 10439-10447.
-
(2000)
Biochemistry
, vol.39
, pp. 10439-10447
-
-
Linne, U.1
Marahiel, M.A.2
-
43
-
-
0023620420
-
Functional implications of structural homologies between chloramphenicol acetyltransferase and dihydrolipoamide acetyltransferase
-
Guest, J.R. Functional implications of structural homologies between chloramphenicol acetyltransferase and dihydrolipoamide acetyltransferase. FEMS Microbiol. Lett. 1987, 44, 417-422.
-
(1987)
FEMS Microbiol. Lett
, vol.44
, pp. 417-422
-
-
Guest, J.R.1
-
44
-
-
0036161991
-
Mutational analysis of the C-domain in nonribosomal peptide synthesis
-
Bergenthal, V.; Linne, U.; Marahiel, M.A. Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur. J. Biochem. 2002, 269, 620-629.
-
(2002)
Eur. J. Biochem
, vol.269
, pp. 620-629
-
-
Bergenthal, V.1
Linne, U.2
Marahiel, M.A.3
-
45
-
-
0033574774
-
Aminoacyl-CoAs as Probes of Condensation Domain Selectivity in Nonribosomal Peptide Synthesis
-
Belshaw, P.J.; Walsh, C.T.; Stachelhaus, T. Aminoacyl-CoAs as Probes of Condensation Domain Selectivity in Nonribosomal Peptide Synthesis. Science 1999, 284, 486-489.
-
(1999)
Science
, vol.284
, pp. 486-489
-
-
Belshaw, P.J.1
Walsh, C.T.2
Stachelhaus, T.3
-
46
-
-
0037162408
-
Timing of epimerisation and condensation reactions in nonribosomal peptide assembly lines: Kinetic analysis of phenylalanine activation elongation modules of tyrocidine synthetase B
-
Luo, L.; Kohli, R.M.; Onishi, M.; Linne, U.; Marahiel, M.A.; Walsh, C.T. Timing of epimerisation and condensation reactions in nonribosomal peptide assembly lines: Kinetic analysis of phenylalanine activation elongation modules of tyrocidine synthetase B. Biochemistry 2002, 41, 9184-9196.
-
(2002)
Biochemistry
, vol.41
, pp. 9184-9196
-
-
Luo, L.1
Kohli, R.M.2
Onishi, M.3
Linne, U.4
Marahiel, M.A.5
Walsh, C.T.6
-
47
-
-
0000983242
-
The Mechanism of ACV Synthetase
-
Byford, M.F.; Baldwin, J.E.; Shiau, C.Y.; Schofield, C.J. The Mechanism of ACV Synthetase. Chem. Rev. 1997, 97, 2631-2649.
-
(1997)
Chem. Rev
, vol.97
, pp. 2631-2649
-
-
Byford, M.F.1
Baldwin, J.E.2
Shiau, C.Y.3
Schofield, C.J.4
-
48
-
-
0024466118
-
Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli
-
Pazirandeh, M.; Chirala, S.S.; Huang, W.Y.; Wakil, S.J. Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. J. Biol. Chem. 1989, 264, 18195-18201.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 18195-18201
-
-
Pazirandeh, M.1
Chirala, S.S.2
Huang, W.Y.3
Wakil, S.J.4
-
49
-
-
0033545834
-
Lysine biosynthesis in Saccharomyces cerevisiae: Mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5
-
Ehmann, D.E.; Gehring, A.M.; Walsh, C.T. Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry 1999, 38, 6171-6177.
-
(1999)
Biochemistry
, vol.38
, pp. 6171-6177
-
-
Ehmann, D.E.1
Gehring, A.M.2
Walsh, C.T.3
-
50
-
-
0029996171
-
Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus
-
Pospiech, A.; Bietenhader, J.; Schupp, T. Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus. Microbiology 1996, 142, 741-746.
-
(1996)
Microbiology
, vol.142
, pp. 741-746
-
-
Pospiech, A.1
Bietenhader, J.2
Schupp, T.3
-
51
-
-
0036037587
-
Enniatin synthetase is a monomer with extended structure: Evidence for an intramolecular reaction mechanism
-
Glinski, M.; Urbanke, C.; Hornbogen, T.; Zocher, R. Enniatin synthetase is a monomer with extended structure: Evidence for an intramolecular reaction mechanism. Arch. Microbiol. 2002, 178, 267-273.
-
(2002)
Arch. Microbiol.
, vol.178
, pp. 267-273
-
-
Glinski, M.1
Urbanke, C.2
Hornbogen, T.3
Zocher, R.4
-
52
-
-
0036753230
-
Evidence for a monomeric structure of nonribosomal Peptide synthetases
-
Sieber, S.A.; Linne, U.; Hillson, N.J.; Roche, E.; Walsh, C.T.; Marahiel, M.A. Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chem. Biol. 2002, 9, 997-1008.
-
(2002)
Chem. Biol
, vol.9
, pp. 997-1008
-
-
Sieber, S.A.1
Linne, U.2
Hillson, N.J.3
Roche, E.4
Walsh, C.T.5
Marahiel, M.A.6
-
53
-
-
0037469129
-
Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: Mutant domain activity regain and ultracentrifugation studies
-
Hillson, N.J.; Walsh, C.T. Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies. Biochemistry 2003, 42, 766-75.
-
(2003)
Biochemistry
, vol.42
, pp. 766-775
-
-
Hillson, N.J.1
Walsh, C.T.2
-
54
-
-
84958116173
-
Welkstoffe und Antibiotika. Siebte Mitteilung äber die Isolierung neuartiger Antibiotika aus Fusarien
-
Plattner, P.A.; Nager, U.; Boller, A. Welkstoffe und Antibiotika. Siebte Mitteilung äber die Isolierung neuartiger Antibiotika aus Fusarien. Helv. Chim. Acta. 1948, 31, 594-602.
-
(1948)
Helv. Chim. Acta
, vol.31
, pp. 594-602
-
-
Plattner, P.A.1
Nager, U.2
Boller, A.3
-
55
-
-
0012933382
-
From the mangrove fungus Halosarpheia sp. (strain 732) from the South China Sea
-
Lin, Y.; Wang, J.; Wu, X.; Zhou, S.; Vrijmoed, L.L.P.; Jones, G.B.G. A novel compound enniatin G from the mangrove fungus Halosarpheia sp. (strain 732) from the South China Sea. Aust. J. Chem. 2002, 55, 225-227.
-
(2002)
Aust. J. Chem
, vol.55
, pp. 225-227
-
-
Lin, Y.1
Wang, J.2
Wu, X.3
Zhou, S.4
Vrijmoed, L.L.P.5
Jones, G.6
Novel Compound Enniatin, G.7
-
57
-
-
0038195791
-
PF1022A and related cyclodepsipeptides-A novel class of Anthelmintics
-
Scherkenbeck, J.; Jeschke, P.; Harder, A. PF1022A and related cyclodepsipeptides-A novel class of Anthelmintics. Current Topics in Medicinal Chemistry 2002, 2, 759-777.
-
(2002)
Current Topics in Medicinal Chemistry
, vol.2
, pp. 759-777
-
-
Scherkenbeck, J.1
Jeschke, P.2
Harder, A.3
-
58
-
-
0026498516
-
Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsipeptide antibiotics
-
Tomoda, H.; Huang, X.H.; Cao, J.; Nishida, H.; Nagoa, R.; Okuda, S.; Tanaka, H.; Omura, S. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J. Antibiotics 1992, 45, 1626-1632.
-
(1992)
J. Antibiotics
, vol.45
, pp. 1626-1632
-
-
Tomoda, H.1
Huang, X.H.2
Cao, J.3
Nishida, H.4
Nagoa, R.5
Okuda, S.6
Tanaka, H.7
Omura, S.8
-
59
-
-
0014410517
-
Komplexe von Enniatinen und anderen Antibiotika mit Alkalimetallionen
-
Wipf, H.K.; Pieoda, L.A.R.; Stefanac, Z.; Simon, W. Komplexe von Enniatinen und anderen Antibiotika mit Alkalimetallionen. Helv. Chim. Acta. 1968, 51, 377-381.
-
(1968)
Helv. Chim. Acta
, vol.51
, pp. 377-381
-
-
Wipf, H.K.1
Pieoda, L.A.R.2
Stefanac, Z.3
Simon, W.4
-
60
-
-
0001396261
-
-
Moss, M.O., Smith, J.E., Eds. Cambridge University Press: Cambridge
-
Drysdale, R.B. Applied Mycology of Fungi. Moss, M.O., Smith, J.E., Eds. Cambridge University Press: Cambridge, 1982; 95-105.
-
(1982)
Applied Mycology of Fungi
, pp. 95-105
-
-
Drysdale, R.B.1
-
61
-
-
0008249503
-
-
Kleinkauf, H., von Döhren, H., Eds. W. de Gruyter: Berlin
-
Walton, J.D. Biochemistry of peptide antibiotics. Kleinkauf, H., von Döhren, H., Eds. W. de Gruyter: Berlin, 1990; 179-203.
-
(1990)
Biochemistry of Peptide Antibiotics
, pp. 179-203
-
-
Walton, J.D.1
-
62
-
-
0030136829
-
Effect of disruption of the enniatin synthetase gene on the virulence of Fusarium avenaceum
-
Herrmann, M.; Haese, A.; Zocher, R. Effect of disruption of the enniatin synthetase gene on the virulence of Fusarium avenaceum. Mol. Plant-Microbe Interact 1996, 9, 226-232.
-
(1996)
Mol. Plant-Microbe Interact
, vol.9
, pp. 226-232
-
-
Herrmann, M.1
Haese, A.2
Zocher, R.3
-
63
-
-
0030054057
-
Enniatin production by Fusarium strains and its effect on potato tuber tissue
-
Herrmann, M.; Zocher, R.; Haese, A. Enniatin production by Fusarium strains and its effect on potato tuber tissue. Appl. Env. Microbiol. 1996, 62, 393-398.
-
(1996)
Appl. Env. Microbiol
, vol.62
, pp. 393-398
-
-
Herrmann, M.1
Zocher, R.2
Haese, A.3
-
64
-
-
0018880169
-
The insecticidal activity of beauvericin and the enniatin complex
-
Grove, J.F.; Pople, M. The insecticidal activity of beauvericin and the enniatin complex. Mycopathologia 1980, 70, 103-105.
-
(1980)
Mycopathologia
, vol.70
, pp. 103-105
-
-
Grove, J.F.1
Pople, M.2
-
65
-
-
0031927993
-
Beauvericin production by Fusarium species. Appl. Environ
-
Logrieco, A.; Moretti, A.; Castella, G.; Kostecki, M.; Golinski, P.; Ritieni, A.; Chelkowski, J. Beauvericin production by Fusarium species. Appl. Environ. Microbiol. 1998, 64, 3084-3088.
-
(1998)
Microbiol
, vol.64
, pp. 3084-3088
-
-
Logrieco, A.1
Moretti, A.2
Castella, G.3
Kostecki, M.4
Golinski, P.5
Ritieni, A.6
Chelkowski, J.7
-
66
-
-
0017173519
-
Biosynthesis of Enniatin B
-
Zocher, R.; Salnikow, J.; Kleinkauf, H. Biosynthesis of Enniatin B. FEBS Lett. 1976, 71, 13-17.
-
(1976)
FEBS Lett
, vol.71
, pp. 13-17
-
-
Zocher, R.1
Salnikow, J.2
Kleinkauf, H.3
-
67
-
-
0017879368
-
Biosynthesis of Enniatin B: Partial Purification and Characterization of the Synthesizing Enzyme and Studies of the Biosynthesis
-
Zocher, R.; Kleinkauf, H. Biosynthesis of Enniatin B: Partial Purification and Characterization of the Synthesizing Enzyme and Studies of the Biosynthesis. Biochem. Biophys. Res. Commun. 1978, 81, 1162-1167.
-
(1978)
Biochem. Biophys. Res. Commun
, vol.81
, pp. 1162-1167
-
-
Zocher, R.1
Kleinkauf, H.2
-
68
-
-
0020475126
-
Enniatin synthetase: A novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum
-
Zocher, R.; Keller, U.; Kleinkauf, H. Enniatin synthetase: A novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum. Biochemistry 1982, 21, 43-48.
-
(1982)
Biochemistry
, vol.21
, pp. 43-48
-
-
Zocher, R.1
Keller, U.2
Kleinkauf, H.3
-
69
-
-
0021102531
-
Mechanism of depsipeptide formation catalyzed by enniatin synthetase
-
Zocher, R.; Keller, U.; Kleinkauf, H. Mechanism of depsipeptide formation catalyzed by enniatin synthetase. Biochem. Biophys. Res. Commun. 1983, 110, 292-299.
-
(1983)
Biochem. Biophys. Res. Commun
, vol.110
, pp. 292-299
-
-
Zocher, R.1
Keller, U.2
Kleinkauf, H.3
-
70
-
-
0027466435
-
Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyl-depsipeptide formation in Fusarium scirpi
-
Haese, A.; Schubert, M.; Hermann, M.; Zocher, R. Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyl-depsipeptide formation in Fusarium scirpi. Mol. Microbiol. 1993, 7, 905-914.
-
(1993)
Mol. Microbiol
, vol.7
, pp. 905-914
-
-
Haese, A.1
Schubert, M.2
Hermann, M.3
Zocher, R.4
-
71
-
-
0011159824
-
Constitutive expression of enniatin synthetase during fermentative growth of Fusarium scirpi
-
Billich, A.; Zocher, R. Constitutive expression of enniatin synthetase during fermentative growth of Fusarium scirpi. Appl. Environ. Microbiol. 1988 2504-2509.
-
(1988)
Appl. Environ. Microbiol
, pp. 2504-2509
-
-
Billich, A.1
Zocher, R.2
-
72
-
-
0031717488
-
Molecular Regulation of
-
Brakhage, A.A. Molecular Regulation of β-Lactam Biosynthesis in Filamentous Fungi. Microbiol. Mol. Biol. Rev. 1998, 62, 547-585.
-
(1998)
Microbiol. Mol. Biol. Rev
, vol.62
, pp. 547-585
-
-
Brakhage, A.A.1
-
73
-
-
0030584662
-
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes
-
Conti, E.; Franks, N.P.; Brick, P. Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure 1996, 4, 287-298.
-
(1996)
Structure
, vol.4
, pp. 287-298
-
-
Conti, E.1
Franks, N.P.2
Brick, P.3
-
74
-
-
85055208235
-
-
Studies on the Structure and Function of the Multienzyme Enniatin Synthetase
-
Studies on the Structure and Function of the Multienzyme Enniatin Synthetase.
-
-
-
-
75
-
-
0031958021
-
Molecular cloning of the actinomycin synthetase gene cluster from Streptomyces chrysomallus and functional heterologous expression of the gene encoding actinomycin synthetase II
-
Schauwecker, F.; Pfennig, F.; Schröder, W.; Keller, U. Molecular cloning of the actinomycin synthetase gene cluster from Streptomyces chrysomallus and functional heterologous expression of the gene encoding actinomycin synthetase II. J. Bacteriol. 1998, 180, 2468-2474.
-
(1998)
J. Bacteriol
, vol.180
, pp. 2468-2474
-
-
Schauwecker, F.1
Pfennig, F.2
Schröder, W.3
Keller, U.4
-
76
-
-
0027087171
-
The cyclic peptide synthetase catalysing HC-toxin production in the filamentous fungus Cochliobolus carboneum is encoded by a 15.7-kilobase open reading frame
-
Scott-Craig, D.G.; Panaccione, J.A.; Walton, J.D. The cyclic peptide synthetase catalysing HC-toxin production in the filamentous fungus Cochliobolus carboneum is encoded by a 15.7-kilobase open reading frame. J. Biol. Chem. 1992, 267, 26044-26049.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 26044-26049
-
-
Scott-Craig, D.G.1
Panaccione, J.A.2
Walton, J.D.3
-
77
-
-
0023339505
-
Monoclonal antibodies to the multienzyme enniatin synthetase
-
Billich, A.; Zocher, R.; Kleinkauf, H.; Braun, D.G.; Lavanchy, D.; Hochkeppel, H.K. Monoclonal antibodies to the multienzyme enniatin synthetase. Biol. Chem. Hoppe-Seyler 1987, 368, 521-529.
-
(1987)
Biol. Chem. Hoppe-Seyler
, vol.368
, pp. 521-529
-
-
Billich, A.1
Zocher, R.2
Kleinkauf, H.3
Braun, D.G.4
Lavanchy, D.5
Hochkeppel, H.K.6
-
78
-
-
0029041958
-
Arrangement of catalytic sites in the multifunctional enzyme enniatin synthetase
-
Pieper, R.; Haese, A.; Schröder, W.; Zocher, R. Arrangement of catalytic sites in the multifunctional enzyme enniatin synthetase. Eur. J. Biochem. 1995, 230, 119-126.
-
(1995)
Eur. J. Biochem
, vol.230
, pp. 119-126
-
-
Pieper, R.1
Haese, A.2
Schröder, W.3
Zocher, R.4
-
79
-
-
0027338134
-
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine
-
Cheng, X.; Kumar, S.; Posfai, J.; Pfugrath, J.W.; Roberts, R.J. Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell 1993, 74, 299-307.
-
(1993)
Cell
, vol.74
, pp. 299-307
-
-
Cheng, X.1
Kumar, S.2
Posfai, J.3
Pfugrath, J.W.4
Roberts, R.J.5
-
80
-
-
0028841409
-
Structure-guided analysis reveals nine sequence motifs conserved among DNAamino-methyl-transferases, and suggests a catalytic mechanism for these enzymes
-
Malone, T.; Blumenthal, R.M.; Cheng, X. Structure-guided analysis reveals nine sequence motifs conserved among DNAamino-methyl-transferases, and suggests a catalytic mechanism for these enzymes. J. Mol. Biol. 1995, 253, 618-632.
-
(1995)
J. Mol. Biol
, vol.253
, pp. 618-632
-
-
Malone, T.1
Blumenthal, R.M.2
Cheng, X.3
-
81
-
-
0034595501
-
Enhanced genome annotation using structural profiles in the program 3D-PSSM
-
Kelley, L.A.; MacCallum, R.M.; Sternberg, M.J.E. Enhanced genome annotation using structural profiles in the program 3D-PSSM. J. Mol. Biol. 2000, 299, 501-522.
-
(2000)
J. Mol. Biol
, vol.299
, pp. 501-522
-
-
Kelley, L.A.1
Maccallum, R.M.2
Sternberg, M.J.E.3
-
82
-
-
0032606140
-
CAFASP
-
Fischer, D.; Barret, C.; Bryson, K.; Elofsson, A.; Godzik, A.; Jones, D.; Karplus, K.J.; Kelley, L.A.; MacCallum, R.M.; Pawowski, K.; Rost, B.; Rychlewski, L.; Sternberg, M.J. CAFASP- 1: Critical assessment of fully automated structure prediction methods proteins: structure, function and genetics 1999 209-217.
-
(1999)
- 1: Critical Assessment of Fully Automated Structure Prediction Methods Proteins: Structure, Function and Genetics
, pp. 209-217
-
-
Fischer, D.1
Barret, C.2
Bryson, K.3
Elofsson, A.4
Godzik, A.5
Jones, D.6
Karplus, K.J.7
Kelley, L.A.8
Maccallum, R.M.9
Pawowski, K.10
Rost, B.11
Rychlewski, L.12
Sternberg, M.J.13
-
83
-
-
0031561804
-
Differential binding of S-adenosylmethionine, S-adenosylhomocysteine and sinefungin to the adenine-specific DNA methyltransferase M.TaqI
-
Schluckebier, G.; Kozak, M.; Bleimling, N.; Weinhold, E.; Saenger, W. Differential binding of S-adenosylmethionine, S-adenosylhomocysteine and sinefungin to the adenine-specific DNA methyltransferase M.TaqI. J. Mol. Biol. 1997, 265, 56-67.
-
(1997)
J. Mol. Biol.
, vol.265
, pp. 56-67
-
-
Schluckebier, G.1
Kozak, M.2
Bleimling, N.3
Weinhold, E.4
Saenger, W.5
-
84
-
-
0023427391
-
Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA
-
Ogawa, H.; Konishi, K.; Takata, Y.; Nakashima, H.; Fujioka, M. Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA. Eur. J. Biochem. 1987, 168, 141-151.
-
(1987)
Eur. J. Biochem
, vol.168
, pp. 141-151
-
-
Ogawa, H.1
Konishi, K.2
Takata, Y.3
Nakashima, H.4
Fujioka, M.5
-
85
-
-
0028956315
-
Universal catalytic domain structure of AdoMet-dependent methyltransferases
-
Schluckebier, G.; O’Gara, M.; Saenger, W.; Cheng, X. Universal catalytic domain structure of AdoMet-dependent methyltransferases. J. Mol. Biol. 1995, 247, 16-20.
-
(1995)
J. Mol. Biol
, vol.247
, pp. 16-20
-
-
Schluckebier, G.1
O’Gara, M.2
Saenger, W.3
Cheng, X.4
-
86
-
-
0028179364
-
Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine- dependent methyltransferases suggest a common structure for these enzymes. Arch. Biochem
-
Kagan, R.M.; Clarke, S. Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine- dependent methyltransferases suggest a common structure for these enzymes. Arch. Biochem. Biophys. 1994, 310, 417-427.
-
(1994)
Biophys
, vol.310
, pp. 417-427
-
-
Kagan, R.M.1
Clarke, S.2
-
87
-
-
0029556271
-
Highly conserved N-methyltransferase as an integral part of peptide synthetases
-
Burmester, J.; Haese, A.; Zocher, R. Highly conserved N-methyltransferase as an integral part of peptide synthetases. Biochem. Mol. Biol. Int. 1995, 37, 201-207.
-
(1995)
Biochem. Mol. Biol. Int
, vol.37
, pp. 201-207
-
-
Burmester, J.1
Haese, A.2
Zocher, R.3
-
88
-
-
0026643381
-
Identification of a tyrosine residue in rat guanidinoacetate methyltransferase that is photolabeled with S-adenosyl-L-methionine
-
Takata, Y.; Fujioka, M. Identification of a tyrosine residue in rat guanidinoacetate methyltransferase that is photolabeled with S-adenosyl-L-methionine. Biochemistry 1992, 31, 4369-4374.
-
(1992)
Biochemistry
, vol.31
, pp. 4369-4374
-
-
Takata, Y.1
Fujioka, M.2
-
89
-
-
0030000857
-
Vaccinia virus mRNA (Guanine-7-)methyltransferase: Mutational effects on cap methylation and AdoHcy-dependent photo-cross-linking of the cap to the methyl acceptor site
-
Mao, X.; Shuman, S. Vaccinia virus mRNA (guanine-7-)methyltransferase: Mutational effects on cap methylation and AdoHcy-dependent photo-cross-linking of the cap to the methyl acceptor site. Biochemistry 1996, 35, 6900-6910.
-
(1996)
Biochemistry
, vol.35
, pp. 6900-6910
-
-
Mao, X.1
Shuman, S.2
-
90
-
-
0033636188
-
The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity
-
Healy, F.G.; Wach, M.; Krasnoff, S.B.; Gibson, D.M.; Loria, R. The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity. Mol. Microbiol. 2000, 38, 794-804.
-
(2000)
Mol. Microbiol
, vol.38
, pp. 794-804
-
-
Healy, F.G.1
Wach, M.2
Krasnoff, S.B.3
Gibson, D.M.4
Loria, R.5
-
92
-
-
0028211466
-
Detection of 4′-phosphopantetheine at the thioester binding site for L-valine of gramicidin S synthetase
-
Stein, T.; Vater, J.; Wittmann-Liebold, B.; Franke, B.; Panico, M.; McDowell, R.; Morris, H.R. Detection of 4′-phosphopantetheine at the thioester binding site for L-valine of gramicidin S synthetase. FEBS Lett. 1994, 340, 39-44.
-
(1994)
FEBS Lett
, vol.340
, pp. 39-44
-
-
Stein, T.1
Vater, J.2
Wittmann-Liebold, B.3
Franke, B.4
Panico, M.5
McDowell, R.6
Morris, H.R.7
-
93
-
-
0034176433
-
Construction and in vitro analysis of a new bi-modular polypeptide synthetase for the synthesis of N-methylated acyl-peptides
-
Schauwecker, F.; Pfennig, F.; Grammel, N.; Keller, U. Construction and in vitro analysis of a new bi-modular polypeptide synthetase for the synthesis of N-methylated acyl-peptides. Chem. Biol. 2000, 7, 287-297.
-
(2000)
Chem. Biol
, vol.7
, pp. 287-297
-
-
Schauwecker, F.1
Pfennig, F.2
Grammel, N.3
Keller, U.4
-
94
-
-
0026488610
-
Enniatin synthetases from different Fusaria exhibiting distinct amino acid specificities
-
Pieper, R.; Kleinkauf, H.; Zocher, R. Enniatin synthetases from different Fusaria exhibiting distinct amino acid specificities. J. Antibiotics 1992, 45, 1273-1277.
-
(1992)
J. Antibiotics
, vol.45
, pp. 1273-1277
-
-
Pieper, R.1
Kleinkauf, H.2
Zocher, R.3
-
95
-
-
0020579509
-
Enniatin production by Fusarium oxysporum in chemically defined media
-
Madry, N.; Zocher, R.; Kleinkauf, H. Enniatin production by Fusarium oxysporum in chemically defined media. Eur. J. Appl. Microbiol. Biotechnol. 1983, 17, 75-79.
-
(1983)
Eur. J. Appl. Microbiol. Biotechnol
, vol.17
, pp. 75-79
-
-
Madry, N.1
Zocher, R.2
Kleinkauf, H.3
-
96
-
-
0034013269
-
Predictive, structure-based model of amino acid recognition by NRPS adenylation domains
-
Challis, G.L.; Ravel, J.; Townsend, C.A. Predictive, structure-based model of amino acid recognition by NRPS adenylation domains. Chem. Biol. 2000, 7, 211-224.
-
(2000)
Chem. Biol
, vol.7
, pp. 211-224
-
-
Challis, G.L.1
Ravel, J.2
Townsend, C.A.3
-
97
-
-
0342981803
-
Prediction of substrate-specific pockets in cyclosporin synthetase
-
Husi, H.; Schörgendorfer, K.; Stempfer, G.; Taylor, P.; Walkinshaw, M.D. Prediction of substrate-specific pockets in cyclosporin synthetase. FEBS Lett. 1997, 414, 532-536.
-
(1997)
FEBS Lett
, vol.414
, pp. 532-536
-
-
Husi, H.1
Schörgendorfer, K.2
Stempfer, G.3
Taylor, P.4
Walkinshaw, M.D.5
-
98
-
-
0004008865
-
-
Cantoni, G.L.; Richards, H.H.; Chiang, P.K. Usdin, E., Borchardt, R.T., Creveling, C.R., Eds. Transmethylation. 1979 155-164.
-
(1979)
Transmethylation
, pp. 155-164
-
-
Cantoni, G.L.1
Richards, H.H.2
Chiang, P.K.3
Usdin, E.4
Borchardt, R.T.5
Creveling, C.R.6
-
99
-
-
0021049221
-
Cell-free synthesis of the depsipeptide beauvericin
-
Peeters, H.; Zocher, R.; Madry, N.; Oelrichs, P.B.; Kleinkauf, H.; Kraepelin, G. Cell-free synthesis of the depsipeptide beauvericin. J. Antibiot. 1983, 36, 1762-1766.
-
(1983)
J. Antibiot
, vol.36
, pp. 1762-1766
-
-
Peeters, H.1
Zocher, R.2
Madry, N.3
Oelrichs, P.B.4
Kleinkauf, H.5
Kraepelin, G.6
-
100
-
-
0029069784
-
Isolation of novel beauvericin analogues from the fungus Beauveria bassiana
-
Gupta, S.; Montilor, C.; Hwang, Y. Isolation of novel beauvericin analogues from the fungus Beauveria bassiana. J. Nat. Prod. 1995, 58, 733-738.
-
(1995)
J. Nat. Prod
, vol.58
, pp. 733-738
-
-
Gupta, S.1
Montilor, C.2
Hwang, Y.3
-
101
-
-
0026735964
-
Highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum
-
Lee, C.; Görisch, H.; Kleinkauf, H.; Zocher, R. A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum. J. Biol. Chem. 1992, 267, 11741-11744.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 11741-11744
-
-
Lee, C.1
Görisch, H.2
Kleinkauf, H.3
Zocher, R.A.4
-
102
-
-
0030376478
-
The biochemical characterization of D-hydroxyisovalerate dehydrogenase, a key enzyme in the biosynthesis of enniatins
-
Lee, C.; Zocher, R. The biochemical characterization of D-hydroxyisovalerate dehydrogenase, a key enzyme in the biosynthesis of enniatins. J. Biochem. Mol. Biol. 1996, 29, 493-499.
-
(1996)
J. Biochem. Mol. Biol
, vol.29
, pp. 493-499
-
-
Lee, C.1
Zocher, R.2
-
103
-
-
0000222386
-
Depsipeptides from Metarhizium anisopliae
-
Païs, M.; Das, B.C.; Ferron, P. Depsipeptides from Metarhizium anisopliae. Phytochemistry 1981, 20, 715-723.
-
(1981)
Phytochemistry
, vol.20
, pp. 715-723
-
-
Païs, M.1
Das, B.C.2
Ferron, P.3
-
104
-
-
0016747528
-
The crystal and molecular structure of the triclinic and monoclinic forms of valinomycin
-
Smith, G.D.; Duax, W.L.; Langs, D.A.; Detitta, G.T.; Edmonds, J.W.; Rohrer, D.C.; Weeks, C.M. The crystal and molecular structure of the triclinic and monoclinic forms of valinomycin. J. Am. Chem. Soc. 1975, 97, 7242-7247.
-
(1975)
J. Am. Chem. Soc
, vol.97
, pp. 7242-7247
-
-
Smith, G.D.1
Duax, W.L.2
Langs, D.A.3
Detitta, G.T.4
Edmonds, J.W.5
Rohrer, D.C.6
Weeks, C.M.7
-
105
-
-
2642590441
-
Biochemistry and Genetic Regulation of Commercially Important Antibiotics
-
L.C., Ed. Addison-Wesley
-
Okumura, Y. Biochemistry and Genetic Regulation of Commercially Important Antibiotics. Reading, Mass. Vining, L.C., Ed. Addison-Wesley: 1983; 147-178.
-
(1983)
Reading, Mass. Vining
, pp. 147-178
-
-
Okumura, Y.1
-
107
-
-
0017089709
-
Cyclosporin A and C, new metabolites from Trichoderma polysporum
-
Dreyfuss, M.M.; Härri, E.; Hoffmann, H.; Kobel, H.; Pache, W.; Tscherter, H. Cyclosporin A and C, new metabolites from Trichoderma polysporum. Eur. J. Appl. Microbiol. 1976, 3, 125-133.
-
(1976)
Eur. J. Appl. Microbiol
, vol.3
, pp. 125-133
-
-
Dreyfuss, M.M.1
Härri, E.2
Hoffmann, H.3
Kobel, H.4
Pache, W.5
Tscherter, H.6
-
108
-
-
0022482553
-
Ciclosporin and its future
-
Borel, J.F. Ciclosporin and its future. Prog. Allergy 1986, 38, 9-18.
-
(1986)
Prog. Allergy
, vol.38
, pp. 9-18
-
-
Borel, J.F.1
-
109
-
-
0024829634
-
Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi
-
Aarino, T.H.; Agathos, S.N. Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnol. Lett. 1989, 11, 759-764.
-
(1989)
Biotechnol. Lett
, vol.11
, pp. 759-764
-
-
Aarino, T.H.1
Agathos, S.N.2
-
110
-
-
0007759041
-
Production of cyclosporin by fungi belonging to the genus Neocosmospora
-
Nakajima, H.; Hamasaki, T.; Tanaka, K.; Kimura, Y.; Udagawa, S.I.; Horie, Y. Production of cyclosporin by fungi belonging to the genus Neocosmospora. Agric. Biol. Chem. 1988, 53, 2291-2292.
-
(1988)
Agric. Biol. Chem
, vol.53
, pp. 2291-2292
-
-
Nakajima, H.1
Hamasaki, T.2
Tanaka, K.3
Kimura, Y.4
Udagawa, S.I.5
Horie, Y.6
-
111
-
-
0024146165
-
Cyclosporins-fungal metabolites with immunosuppressive activities
-
von Wartburg, A.; Traber, R. Cyclosporins-fungal metabolites with immunosuppressive activities. Prog. Med. Chem. 1988, 25, 1-33.
-
(1988)
Prog. Med. Chem
, vol.25
, pp. 1-33
-
-
Von Wartburg, A.1
Traber, R.2
-
112
-
-
0024948241
-
Cyclosporin A: Recent developments in the mechanism of action and clinical application
-
Feutren, G. Cyclosporin A: Recent developments in the mechanism of action and clinical application. Curr. Opin. Immunol. 1989, 2, 239-245.
-
(1989)
Curr. Opin. Immunol
, vol.2
, pp. 239-245
-
-
Feutren, G.1
-
113
-
-
0017395051
-
Die Struktur von Cyclosporin C
-
Traber, R.; Kuhn, M.; Räegger, A.; Lichti, H.; Loosli, H.R.; von Wartburg, A. Die Struktur von Cyclosporin C. Helv. Chim. Acta. 1977, 60, 1247-1255.
-
(1977)
Helv. Chim. Acta
, vol.60
, pp. 1247-1255
-
-
Traber, R.1
Kuhn, M.2
Räegger, A.3
Lichti, H.4
Loosli, H.R.5
Von Wartburg, A.6
-
114
-
-
0017374512
-
Neue Cyclopeptide aus Trychoderma polysporum: Die Cyclosporine B, D und E. Helv
-
Traber, R.; Kuhn, M.; Loosli, H.R.; Pache, W.; von Wartburg, A. Neue Cyclopeptide aus Trychoderma polysporum: die Cyclosporine B, D und E. Helv. Chim. Acta. 1977, 60, 1568-1578.
-
(1977)
Chim. Acta
, vol.60
, pp. 1568-1578
-
-
Traber, R.1
Kuhn, M.2
Loosli, H.R.3
Pache, W.4
Von Wartburg, A.5
-
115
-
-
0020418988
-
Isolierung und Strukturermittlung der neuen Cyclosporine E, F, G, H und I. Helv
-
Traber, R.; Loosli, H.R.; Hofmann, H.; Kuhn, M.; von Wartburg, A. Isolierung und Strukturermittlung der neuen Cyclosporine E, F, G, H und I. Helv. Chim. Acta. 1982, 65, 1655-1677.
-
(1982)
Chim. Acta
, vol.65
, pp. 1655-1677
-
-
Traber, R.1
Loosli, H.R.2
Hofmann, H.3
Kuhn, M.4
Von Wartburg, A.5
-
116
-
-
0023118157
-
Neue Cyclosporine aus Tolypocladium inflatum. Die Cyclosporine K-Z
-
Traber, R.; Hoffmann, H.; Loosli, H.R.; Ponelle, M.; von Wartburg, A. Neue Cyclosporine aus Tolypocladium inflatum. Die Cyclosporine K-Z. Helv. Chim. Acta. 1987, 70, 13-36.
-
(1987)
Helv. Chim. Acta
, vol.70
, pp. 13-36
-
-
Traber, R.1
Hoffmann, H.2
Loosli, H.R.3
Ponelle, M.4
Von Wartburg, A.5
-
117
-
-
0027445429
-
Biosynthesis of the unusual amino acid (4R)-4-[E]-2-butenyl]-4-methyl-L-threonine of cyclosporin A
-
Offenzeller, M.; Su, Z.; Santer, G.; Moser, H.; Traber, R.; Memmert, K.; Schneider-Scherzer, E. Biosynthesis of the unusual amino acid (4R)-4-[E]-2-butenyl]-4-methyl-L-threonine of cyclosporin A. J. Biol. Chem. 1993, 268, 2426127-26134.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 2426127-2426134
-
-
Offenzeller, M.1
Su, Z.2
Santer, G.3
Moser, H.4
Traber, R.5
Memmert, K.6
Schneider-Scherzer, E.7
-
118
-
-
0001462909
-
Biosynthesis of cyclosporin A
-
Zocher, R.; Madry, N.; Peeters, H.; Kleinkauf, H. Biosynthesis of cyclosporin A. Phytochemistry 1984, 23, 549-551.
-
(1984)
Phytochemistry
, vol.23
, pp. 549-551
-
-
Zocher, R.1
Madry, N.2
Peeters, H.3
Kleinkauf, H.4
-
119
-
-
0025193843
-
Cyclosporin synthetase-the most complex peptide synthesizing multienzyme polypeptide so far described
-
Lawen, A.; Zocher, R. Cyclosporin synthetase-the most complex peptide synthesizing multienzyme polypeptide so far described. J. Biol. Chem. 1990, 265, 11355-11360.
-
(1990)
J. Biol. Chem
, vol.265
, pp. 11355-11360
-
-
Lawen, A.1
Zocher, R.2
-
120
-
-
0023046561
-
Biosynthesis of cyclosporin A: Partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum
-
Zocher, R.; Nihira, T.; Paul, E.; Madry, N.; Peeters, H.; Kleinkauf, H.; Keller, U. Biosynthesis of cyclosporin A: Partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum. Biochemistry 1986, 25, 550-553.
-
(1986)
Biochemistry
, vol.25
, pp. 550-553
-
-
Zocher, R.1
Nihira, T.2
Paul, E.3
Madry, N.4
Peeters, H.5
Kleinkauf, H.6
Keller, U.7
-
121
-
-
0028122932
-
Mechanism of cyclosporin A biosynthesis
-
Dittmann, J.; Wenger, R.M.; Kleinkauf, H.; Lawen, A. Mechanism of cyclosporin A biosynthesis. J. Biol. Chem. 1994, 269, 2841-2846.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 2841-2846
-
-
Dittmann, J.1
Wenger, R.M.2
Kleinkauf, H.3
Lawen, A.4
-
122
-
-
0028284699
-
The peptide synthetase catalysing cyclosporin production in Tolypocladium niveum is encoded by a giant 45.8- kilobase open reading frame
-
Weber, G.; Schörgendörfer, K.; Schneider-Scherzer, E.; Leitner, E. The peptide synthetase catalysing cyclosporin production in Tolypocladium niveum is encoded by a giant 45.8- kilobase open reading frame. Curr. Genet. 1994, 26, 120-125.
-
(1994)
Curr. Genet
, vol.26
, pp. 120-125
-
-
Weber, G.1
Schörgendörfer, K.2
Schneider-Scherzer, E.3
Leitner, E.4
-
123
-
-
0034681448
-
Eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis
-
Cheng, Y.Q.; Walton, J.D. A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis. J. Biol. Chem. 2000, 275, 4906-4911.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 4906-4911
-
-
Cheng, Y.Q.1
Walton, J.2
-
124
-
-
0030058413
-
Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A: Enzymatic analysis of the reaction sequence including identification of the methylation precursor in a polyketide pathway
-
Offenzeller, M.; Santer, G.; Totschnig, K.; Su, Z.; Moser, H.; Traber, R.; Schneider-Scherzer, E. Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A: Enzymatic analysis of the reaction sequence including identification of the methylation precursor in a polyketide pathway. Biochemistry 1996, 35, 8401-8412.
-
(1996)
Biochemistry
, vol.35
, pp. 8401-8412
-
-
Offenzeller, M.1
Santer, G.2
Totschnig, K.3
Su, Z.4
Moser, H.5
Traber, R.6
Schneider-Scherzer, E.7
-
125
-
-
0028251292
-
Disruption of the cyclosporin synthetase gene of Tolypocladium niveum
-
Weber, G.; Leitner, E. Disruption of the cyclosporin synthetase gene of Tolypocladium niveum. Curr. Genet. 1994, 26, 461-467.
-
(1994)
Curr. Genet
, vol.26
, pp. 461-467
-
-
Weber, G.1
Leitner, E.2
-
126
-
-
0018787606
-
Guanidoacetate methyltransferase
-
Im, Y.S.; Chiang, P.K.; Cantoni, G.L. Guanidoacetate methyltransferase. J. Biol. Chem. 1979, 254, 11047-11050.
-
(1979)
J. Biol. Chem
, vol.254
, pp. 11047-11050
-
-
Im, Y.S.1
Chiang, P.K.2
Cantoni, G.L.3
-
127
-
-
0015810305
-
Inhibition of indolethylamine-N-methyltransferase by S-adenosylhomocysteine
-
Lin, R.H.; Narasimhachari, N.; Himwich, H.E. Inhibition of indolethylamine-N-methyltransferase by S-adenosylhomocysteine. Biochem. Biophys. Res. Commun. 1973, 54, 751-759.
-
(1973)
Biochem. Biophys. Res. Commun
, vol.54
, pp. 751-759
-
-
Lin, R.H.1
Narasimhachari, N.2
Himwich, H.E.3
-
128
-
-
85055186503
-
-
Biosynthesis of cyclosporin A and enniatin B
-
Biosynthesis of cyclosporin A and enniatin B.
-
-
-
-
129
-
-
0037428469
-
Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase
-
Velkov, T.; Lawen, A. Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase. J. Biol. Chem. 2003, 278, 1137.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 1137
-
-
Velkov, T.1
Lawen, A.2
-
130
-
-
0027250118
-
Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase
-
Lawen, A.; Traber, R. Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. J. Biol. Chem. 1993, 268, 20452-20465.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 20452-20465
-
-
Lawen, A.1
Traber, R.2
-
131
-
-
0026766758
-
Cyclosporin synthetase is a 1.4 MDa multienzyme. Re-evaluation of the molecular mass of various peptide synthetases
-
Schmidt, B.; Riesner, D.; Kleinkauf, H. Cyclosporin synthetase is a 1.4 MDa multienzyme. Re-evaluation of the molecular mass of various peptide synthetases. FEBS Letters 1992, 307, 355-360.
-
(1992)
FEBS Letters
, vol.307
, pp. 355-360
-
-
Schmidt, B.1
Riesner, D.2
Kleinkauf, H.3
-
132
-
-
0025925357
-
In vitro biosynthesis of [Thr2, Leu5, DHIV8, Leu10]- cyclosporin, a cyclosporin-related peptolide, with immunosuppressive activities by a multienzyme polypeptide
-
Lawen, A.; Traber, R.; Geyl, D. In vitro biosynthesis of [Thr2, Leu5, DHIV8, Leu10]- cyclosporin, a cyclosporin-related peptolide, with immunosuppressive activities by a multienzyme polypeptide. J. Biol. Chem. 1991, 266, 15567-15570.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 15567-15570
-
-
Lawen, A.1
Traber, R.2
Geyl, D.3
-
133
-
-
0026683249
-
A new anthelmintic cyclodepsipeptide PF1022
-
Sasaki, T.; Takagi, M.; Yaguchi, T.; Miyadoh, S.; Okada, T.; Koyama, M. A new anthelmintic cyclodepsipeptide PF1022. J. Antibiotics 1992, 45, 692-697.
-
(1992)
J. Antibiotics
, vol.45
, pp. 692-697
-
-
Sasaki, T.1
Takagi, M.2
Yaguchi, T.3
Miyadoh, S.4
Okada, T.5
Koyama, M.6
-
134
-
-
0000953375
-
Effect of PF1022 A on developing larvae of Angiostrongylus costaricensis in mice, with special reference to route, dose, and formulation
-
Terada, M.; Ishih, A.; Tungtrongchitr, A.; Sano, M.; Shomura, T. Effect of PF1022 A on developing larvae of Angiostrongylus costaricensis in mice, with special reference to route, dose, and formulation. Jpn. J. Parasitol. 1993, 42, 199-210.
-
(1993)
Jpn. J. Parasitol.
, vol.42
, pp. 199-210
-
-
Terada, M.1
Ishih, A.2
Tungtrongchitr, A.3
Sano, M.4
Shomura, T.5
-
135
-
-
0030045460
-
Characterization of subtypes of gamma-aminobutyric acid receptors in an Ascaris muscle preparation by binding assay and binding of PF1022A, a new anthelmintic, on the receptors
-
Chen, W.; Terada, M.; Cheng, J.T. Characterization of subtypes of gamma-aminobutyric acid receptors in an Ascaris muscle preparation by binding assay and binding of PF1022A, a new anthelmintic, on the receptors. Parasitol. Res. 1996, 82, 97-101.
-
(1996)
Parasitol. Res
, vol.82
, pp. 97-101
-
-
Chen, W.1
Terada, M.2
Cheng, J.T.3
-
136
-
-
0000834267
-
Bassianolide, a new insecticidal cyclodepsipeptide from Beauveria bassiana and Verticillium lecanii
-
Suzuki, A.; Kanaoka, M.; Isogai, A.; Murakoshi, S.; Ichinoe, M.; Tamura, S. Bassianolide, a new insecticidal cyclodepsipeptide from Beauveria bassiana and Verticillium lecanii. Tetrahedron Lett. 1977, 25, 2167-2170.
-
(1977)
Tetrahedron Lett
, vol.25
, pp. 2167-2170
-
-
Suzuki, A.1
Kanaoka, M.2
Isogai, A.3
Murakoshi, S.4
Ichinoe, M.5
Tamura, S.6
-
137
-
-
0034625433
-
Biosynthesis of PF1022 and related cyclooctadepsipeptides
-
Weckwerth, W.; Miyamoto, K.; Iinuma, K.; Krause, M.; Glinski, M.; Storm, T.; Bonse, G.; Kleinkauf, H.; Zocher, R. Biosynthesis of PF1022 and related cyclooctadepsipeptides. J. Biol. Chem. 2000, 275, 17909-17915.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 17909-17915
-
-
Weckwerth, W.1
Miyamoto, K.2
Iinuma, K.3
Krause, M.4
Glinski, M.5
Storm, T.6
Bonse, G.7
Kleinkauf, H.8
Zocher, R.9
-
138
-
-
85055201281
-
-
Patent AU6874100 (Meiji Seika Kaisha, Ltd.)
-
Futamura, T.; Aihara, S.; Midoh, N.; Okakura, K.; Kleinkauf, H.; Miyamoto, K.; Watanabe, M.; Yanai, K.; Murakami, T.; Yasutake, T. Cyclic depsipeptide synthases, genes thereof and mass production system of cyclic depsipeptide. Patent AU6874100 (Meiji Seika Kaisha, Ltd.). 2001.
-
(2001)
Cyclic Depsipeptide Synthases, Genes Thereof and Mass Production System of Cyclic Depsipeptide
-
-
Futamura, T.1
Aihara, S.2
Midoh, N.3
Okakura, K.4
Kleinkauf, H.5
Miyamoto, K.6
Watanabe, M.7
Yanai, K.8
Murakami, T.9
Yasutake, T.10
|