Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl- L-threonine of cyclosporin A: Enzymatic analysis of the reaction sequence including identification of the methylation precursor in a polyketide pathway

Biochemistry

Volumn 35, Issue 25, 1996, Pages 8401-8412

  Offenzeller, Manuela ^a   Sanler, Gerhard ^a   Totschnig, Klaus ^a   Su, Zhuang ^b,d   Mo, Hanspeter ^c   Traber, René ^b   Schneider Scherzer, Elisabeth ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Preclinical Research   (Switzerland)

^c Sandoz Pharma Ltd   (Switzerland)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYME A; CYCLOSPORIN A; CYCLOSPORIN A [4 (2 BUTENYL) 4 METHYLTHREONINE]; DRUG METABOLITE; POLYKETIDE; SYNTHETASE; THIOESTER; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; ENZYME ASSAY; ENZYME BINDING; ENZYME SPECIFICITY; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

CHROMATOGRAPHY, THIN LAYER; COENZYME A; CYCLOSPORINE; FATTY ACIDS, UNSATURATED; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHYLATION; MITOSPORIC FUNGI; MULTIENZYME COMPLEXES; NADP; OXIDATION-REDUCTION; POTENTIOMETRY; THREONINE;

FUNGI;

EID: 0030058413     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960224n     Document Type: Article

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