Neurosteroids in the brain neuron: Biosynthesis, action and medicinal impact on neurodegenerative disease

Central Nervous System Agents in Medicinal Chemistry

Volumn 6, Issue 1, 2006, Pages 73-82

  Tsutsui, Kazuyoshi ^a,b   Mellon, Synthia H ^c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allopregnanolone; Neurodegeneration; Neuronal growth; Neurosteroids; Niemann Pick type C disease; Progesterone; Purkinje neuron; Synaptogenesis

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CHOLESTEROL; ESTRADIOL; ESTROGEN; NEUROSTEROID; PROGESTERONE;

BIOSYNTHESIS; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CELL GROWTH; CELL SURVIVAL; CHEMICAL STRUCTURE; DEGENERATIVE DISEASE; DENDRITE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MEDICINE; NIEMANN PICK DISEASE; NONHUMAN; PURKINJE CELL; REVIEW; STEROID METABOLISM; STEROIDOGENESIS; SYNAPTOGENESIS;

EID: 33749239214     PISSN: 18715249     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152406776056555     Document Type: Review

References (98)

1. Fuxe, K.; Gustafsson, J.A.; Wetterberg, L. Steroid Hormone Regulation of the Brain, Pergamon Press: Oxford, 1981.
2. Arnold, A.P.; Gorski, R.A. Annu. Rev. Neurosci., 1984, 7, 413.
3. McEwen, B.S. Trends Endocrinol. Metab., 1991, 2, 62.
4. Baulieu, E.E. Rec. Progr. Hormone Res., 1997, 52, 1.
5. Tsutsui, K.; Ukena, K.; Takase, M.; Kohchi, C.; Lea, R.W. Comp. Biochem. Physiol. C, 1999, 124, 121.
6. Tsutsui, K.; Ukena, K.; Usui, M.; Sakamoto, H.; Takase, M. Neurosci. Res., 2000, 36, 261.
7. Compagnone, N.A.; Mellon, S.H. Frontiers Neuroendocrinol., 2000, 21, 1.
8. Mellon, S.H.; Vaudry, H. Int. Rev. Neurobiol., 2001, 46, 33.
9. Corpéchot, C.; Robel, P.; Axelson, M.; Sjövall, J.; Baulieu, E.E. Proc. Natl. Acad. Sci. USA, 1981, 78, 4704.
10. Corpéchot, C.; Synguelakis, M.; Talha, S.; Axelson, M.; Sjövall, J.; Vaihko, R.; Baulieu, E.E.; Robel, P. Brain Res., 1983, 270, 119.
11. Robel, P.; Baulieu, E.E. Neurochem. Int., 1985, 7, 953.
12. Lanthier, A.; Patwardhan, V.V. J. Steroid Biochem., 1986, 25, 445.
13. Robel, P.; Corpéchot, C.; Clarke, C.; Groyer, A.; Synguelakis, M.; Vourc'h, C.; Baulieu, E.E. In: Neuroendocrine Molecular Biology, G., Fink, A.J., Harmar, K.W., McKerns, Eds.; Plenum Press: New York, 1986, pp. 367-377.
14. Robel, P.; Bourreau, E.; Corpéchot, C.; Dang, D.C.; Halberg, F.; Clarke, C.; Haug, M.; Schlegel, M.L; Synguelakis, M.; Vourc'h, C.; Baulieu, E.E. J. Steroid Biochem., 1987, 27, 649.
15. Jo, D.H; Abdallah, M.A; Young, J.; Baulieu, E.E.; Robel, P. Steroids, 1989, 54, 287.
16. Mathur, C.; Prasad, V.V.K.; Raju, V.S.; Welch, M.; Lieberman, S. Proc. Natl. Acad. Sci. USA, 1993, 90, 85.
17. Mellon, S.H.; Deschepper, C.F. Brain Res., 1993, 629, 283.
18. Compagnone, N.A.; Bulfone, A.; Rubenstein, J.L.R.; Mellon, S.H. Endocrinology, 1995, 136, 5212.
19. Tsutsui, K.; Yamazaki, T. Brain Res., 1995, 678, 1.
20. Usui, M.; Yamazaki, T.; Kominami, S.; Tsutsui, K. Brain Res., 1995, 678, 10.
21. Vanson, A.; Arnold, A.P.; Schlinger, B.A. Gen. Comp. Endocrinol., 1996, 102, 342.
22. Tsutsui, K.; Yamazaki, T.; Usui, M.; Furukawa, Y.; Ukena, K.; Kohchi, C.; Kominami, S. In: Perspectives in Avian Endocrinology, S., Harvey, R.J., Etches, Eds.; Journal of Endocrinol Ltd: Bristol, 1997; pp. 427-436.
23. Tsutsui, K.; Usui, M.; Yamazaki, T.; Ukena, K.; Kominami, S. In: Frontiers in Environmental and Metabolic Endocrinology, S.K., Maitra, Ed.; Burdwan Press: Burdwan, 1997; pp. 151-159.
24. Ukena, K.; Honda, Y.; Inai, Y.; Kohchi, C.; Lea, R.W.; Tsutsui, K. Brain Res., 1999, 818, 536.
25. Schlinger, B.A.; Lane, N.I.; Grisham, W.; Thompson, L. Gen. Comp. Endocrinol., 1999, 113, 46.
26. Freking, F.; Nazairians, T.; Schlinger, B.A. Gen. Comp. Endocrinol., 2000, 119, 140.
27. Ukena, K.; Honda, Y.; Lea, R.W.; Tsutsui, K. Brain Res., 2001, 898, 190.
28. Matsunaga, M.; Ukena, K.; Tsutsui, K. Brain Res., 2001, 899, 112.
29. Tsutsui, K.; Schlinger, B.A. In: Avian Endocrinology, A., Dawson, C.M., Chaturvedi, Eds.; Narosa Publishing House: New Delhi, 2001; pp. 59-77.
30. Matsunaga, M.; Ukena, K.; Tsutsui, K. Brain Res., 2002, 948, 180.
31. Soma, K.K.; Alday, N.A.; Hau, M.; Schlinger, B.A. Endocrinology, 2003, 145, 1668.
32. Tsutsui, K.; Matsunaga, M.; Ukena, K. Avian Poultry Biol. Reviews, 2003, 14, 63.
33. Mensah-Nyagan, A.G.; Feuilloley, M.; Dupont, E.; Do-Rego, J. L.; Leboulenger, F.; Pelletier, G.; Vaudry, H. J. Neurosci., 1994, 14, 7306.
34. Mensah-Nyagan, A.G.; Feuilloley, M.; Do-Rego, J.L.; Marcual, A.; Lange, C.; Tonon, M.C.; Pelletier, G.; Vaudry, H. Proc. Natl. Acad. Sci. USA, 1996, 93, 1423.
35. Mensah-Nyagan, A.G.; Do-Rego, J.L.; Feuilloley, M.; Marcual, A.; Lange, C.; Pelletier, G.; Vaudry, H. J. Neurochem., 1996, 67, 413.
36. Takase, M.; Ukena, K.; Yamazaki, T.; Kominami, S.; Tsutsui, K. Endocrinology, 1999, 140, 1936.
37. Inai, Y.; Nagai, K.; Ukena, K.; Oishi, T.; Tsutsui, K. Brain Res., 2003, 959, 214.
38. Matsunaga, M.; Ukena, K.; Baulieu, E.E.; Tsutsui, K. Proc. Natl. Acad. Sci. USA, 2004, 101, 17282.
39. Sakamoto, H.; Ukena, K.; Tsutsui, K. J. Comp. Neurol., 2001, 439, 291.
40. Ukena, K.; Usui, M.; Kohchi, C.; Tsutsui, K. Endocrinology, 1998, 139, 137.
41. Ukena, K.; Kohchi, C.; Tsutsui K. Endocrinology, 1999, 140, 805.
42. Sakamoto, H.; Mezaki, Y.; Shikimi, H.; Ukena, K.; Tsutsui, K. Endocrinology, 2003, 144, 4466.
43. Le Goascogne, C.; Robel, P.; Gouézou, M.; Sananès, N.; Baulieu, E.E.; Waterman, M. Science, 1987, 237, 1212.
44. Hu, Z.Y.; Bourreau, E.; Jung-Testas, I.; Robel, P.; Baulieu, E.E. Proc. Natl. Acad. Sci. USA, 1987, 84, 8215.
45. Jung-Testas, I.; Hu, Z.Y.; Baulieu, E.E.; Robel, P. Endocrinology, 1989, 125, 2083.
46. Baulieu, E.E.; Robel, P. J. Steroid Biochem. Mol. Biol., 1990, 37, 395.
47. Baulieu, E.E. Biol. Cell, 1991, 71, 3.
48. Akwa, Y.; Young, J.; Kabbadj, K.; Sancho, M.J.: Zucman, D.; Vourc'h, C.; Jung-Testas, I.; Hu Z.Y.; Le Goascogne, C.; Jo, D.H.; Corpéchot, C.; Simon, P.; Baulieu, E.E.; Robel, P. J. Steroid Biochem. Mol. Biol., 1991, 40, 71.
49. Papadopoulos, V.; Guarneri, P.; Krueger, K.E.; Guidotti, A.; Costa, E. Proc. Natl. Acad. Sci. USA, 1992, 89, 5113.
50. Lea, R.W.; Clark, J.A.; Tsutsui, K. Microsc. Res. Tech., 2001, 55, 12.
51. Tsutsui, K.; Sakamoto, H.; Ukena, K. J. Steroid Biochem. Mol. Biol., 2003, 85, 311.
52. Kimoto, T.; Tsurugizawa, T.; Ohta, Y.; Makino, J.; Tamura, H.; Hojo, Y.; Takata, N.; Kawato, S. Endocrinology, 2001, 142, 3578.
53. Hojo, Y.; Hattori, T.A.; Enami, T.; Furukawa, A.; Suzuki, K.; Ishii, H.T.; Mukai, H.; Morrison, J.H.; Janssen, W.G.; Kominami, S.; Harada, N.; Kimoto, T.; Kawato, S. Proc. Natl. Acad. Sci. USA, 2004, 101, 865.
54. Guarneri, P.; Guarneri, R.; Cascio, C.; Pavasant, P.; Piccoli, F.; Papadopoulos, V. J. Neurochem., 1994, 63, 86.
55. Furukawa, A.; Miyatake, A.; Ohnishi, T.; Ichikawa, Y. J. Neurochem., 1998, 71, 2231.
56. Clark, B.J.; Wells, J.; King, S.R.; Stocco, D.M. J. Biol. Chem., 1994, 269, 28314.
57. Stocco, D.M.; Clark, B.J. Endocr. Rev., 1996, 17, 221.
58. Mason, J.I. Trends Endocrinol. Metab., 1993, 4, 199.
59. Kohchi, C.; Ukena, K.; Tsutsui, K. Brain Res., 1998, 801, 233.
60. Tsutsui, K.; Ukena, K.; Sakamoto, H. In: Neuroplasticity, Development, and Steroid Hormone Action, R.J., Handa, M., Kawata, S., Hayashi, Eds.; CRC Press: Boca Raton, 2001; pp. 101-116.
61. Tsutsui, K.; Ukena, K. Int. J. Mol. Med., 1999, 4, 49.
62. Tsutsui, K.; Ukena, K.; Sakamoto, H. Cerebellum, 2003, 2, 215.
63. Tsutsui, K.; Sakamoto, H.; Shikimi, H.; Ukena, K. Neurosci. Res., 2004, 49, 273.
64. Altman, J. J. Comp. Neurol., 1972, 145, 353.
65. Altman, J. J. Comp. Neurol., 1972, 145, 399.
66. Sakamoto, H.; Ukena, K.; Tsutsui, K. J. Neurosci., 2001, 21, 6221.
67. Sakamoto, H.; Ukena, K.; Tsutsui, K. Neurosci. Lett., 2002, 322, 111.
68. Sakamoto, H.; Shikimi, H.; Ukena, K.; Tsutsui, K. Neurosci. Lett., 2003, 343, 163.
69. Sakamoto, H.; Ukena, K.; Takemori, H.; Okamoto, M.; Kawata, M.; Tsutsui, K. Neuroscience, 2004, 126, 325.
70. Price, R.H.; Handa, R.J. Neurosci. Lett., 2000, 288, 115.
71. Orikasa, C.; Kondo, Y.; Hayashi, S.; McEwen, B.S.; Sakuma, Y. Proc. Natl. Acad. Sci. USA, 2002, 99, 3306.
72. Ikeda, Y.; Nagai, A.; Ikeda, M.A.; Hayashi, S. Endocrinology, 2003, 144, 5098.
73. Gould, E.; Woolley, C.S.; Frankfurt, M.; McEwen, B.S. J. Neurosci., 1990, 10, 1286.
74. Woolley, C.S.; Gould, E.; Frankfurt, M.; McEwen, B.S. J. Neurosci., 1990, 10, 4035.
75. Woolley, C.S.; McEwen, B.S. J. Neurosci., 1992, 12, 2549.
76. Woolley, C.S.; McEwen, B.S. J. Neurosci., 1994, 14, 7680.
77. McEwen, B.; Akama, K.; Alves, S.; Brake, W.G.; Bulloch, K.; Lee, S.; Li, C.; Yuen, G.; Milner, T.A. Proc. Natl. Acad. Sci. USA, 2001, 98, 7093.
78. Murphy, D.D.; Segal, M. J. Neurosci., 1996, 16, 4059.
79. Pérez, J.; Luquín, S.; Naftolin, F.; García-Segura, L.M. Brain Res., 1993, 608, 38.
80. Langub, M.C.; Maley, B.E.; Watson, R.E. Brain Res., 1994, 641, 303.
81. Rocamora, N.; Garcia-Ladona, F.J.; Palacios, J.M.; Mengod, G. Mol. Brain Res., 1993, 17, 1.
82. Ernfors, P.; Lee, K.F.; Jaenisch, R. Nature, 1994, 368, 147.
83. Schwartz, P.M.; Borghesani, P.R.; Levy, R.L.; Pomeroy, S.L.; Segal, R.A. Neuron, 1997, 19, 269.
84. Bates, B.; Rios, M.; Trumpp, A.; Chen, C.; Fan, G.; Bishop, J.M.; Jaenisch, R. Nat. Neurosci., 1999, 2, 115.
85. th Ed., Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D., Eds.; McGraw-Hill: New York, 2001.
86. Patterson, M.C. Neurologist, 2003, 9, 301.
87. Vanier, M.T., and Millat, G. Clin. Genet., 2003, 64, 269.
88. Morris, M.D., Bhuvaneswaran, C., Shio, H., and Fowler, S. Am. J. Pathol., 1982, 108, 140.
89. Loftus, S.K., Morris, J.A., Carstea, E.D., Gu, J.Z., Cummings, C., Brown, A., Ellison, J., Ohno, K., Rosenfeld, M.A., Tagle, D.A., Pentchev, P.G., and Pavan, W.J. Science, 1997, 277, 232.
90. Griffin, L.D., Gong, W., Verot, L., and Mellon, S.H. Nat. Med., 2004, 10, 704.
91. rd, Goldin, E., Jaffe, H., Patterson, M.C. Agritellis, G.C., Hibbs, A.M., Garfield, M., Brady, R.O., and Pentchev, P.G. Endocrinology, 1993, 133, 2913.
92. Gevry, N.Y. and Murphy, B.D. Endocr. Res., 2002, 28, 403.
93. Gebry, N.Y., Lopes, F.L., Ledoux, S., and Murphy, B.D. Mol. Endocrinol., 2004, 18, 1778.
94. Henderson, L.P., Lin, L., Prasad, A., Paul, C.A., Chang, T.-Y., and Maue, R.A. J. Biol. Chem., 2000, 275, 20179.
95. Karten, B., Vance, D., Campenot, R., and Vance, J. J. Neurochem., 2002, 83, 1154.
96. Sooksawate, T., and Simmonds, M.A. Neuropharmacology 2001, 40, 178.
97. Black, S.M., Sklarz, G.D., Harikrishna, J.A., Lin, D., Wolf, C.R., and Miller, W.L. Endocrinology 1993, 132, 539.
98. Doody, K.M., Carr, B.R., Rainey, W.E., Byrd, W., Murry, B.A., Strickler, R.C., Thomas, J.L. and Mason, J.I. Endocrinology, 1990, 126, 2487.