Neurosteroids in the cerebellar Purkinje neuron and their actions (Review)

International Journal of Molecular Medicine

Volumn 4, Issue 1, 1999, Pages 49-56

  Kazuyoshi, Tsutsui ^a   Kazuyoshi, Ukena ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

3 hydroxysteroid dehydrogenase 5 4 isomerase; Brain; Cytochrome P450 side chain cleavage; Neurosteroids; Pregnenolone; Pregnenolone sulfate; Progesterone; Purkinje neurons

Indexed keywords

ENZYME; STEROID;

AGING; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; BRAIN; CEREBELLUM; CYTOLOGY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PURKINJE CELL; REVIEW; TISSUE DISTRIBUTION; VERTEBRATE;

AGING; ANIMALS; BRAIN; CEREBELLUM; ENZYMES; GENE EXPRESSION; HUMANS; MODELS, NEUROLOGICAL; PURKINJE CELLS; STEROIDS; TISSUE DISTRIBUTION; VERTEBRATES;

EID: 0033159778     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Fuxe K, Gustafsson JA and Wetterberg L: Steroid Hormone Regulation of the Brain. Pergamon Press, Oxford, 1981.
2. McEwen BS: Steroid hormones are multifunctional messengers in the brain. Trends Endocrinol Mctab 2: 62-67, 1991.
3. Corpéchot C, Robel P, Axelson M, Sjövall J and Baulieu EE: Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 78: 4704-4707, 1981.
4. Corpéchot C, Synguelakis M, Talha S, Axelson M, Sjövall J, Vihko R, Baulieu EE and Robel P: Pregncnolone and its sulfate ester in rat brain. Brain Res 270: 119-125, 1983.
5. Jo DH, Abdaliah MA, Young J, Baulieu EE and Robel P: Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain. Steroids 54: 287-297, 1989.
6. Lanthier A and Patwardhan VV: Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves. J Steroid Biochcm 25: 445-449, 1986.
7. Mathur C, Prasad VVK, Raju VS, Welch M and Lieberman S: Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sei USA 90: 85-88, 1993.
8. S. Robcl P and Baulieu EE: Neuro-stcroids, 3β-hydroxy-Δ5-dcrivativcs in the rodent brain. Neurochcm Int 7: 953-958, 1985.
9. Robel P, Corpcchot C, Clarke C, Groyer A, Synguelakis M, Vourc'h C and Baulieu EE: Neuro-steroids: 3β-hydroxy-Δ5-dcrivatives in the rat brain. In: Neuroendocrine Molecular Biolosy. Fink G, Harmar AJ and McKerns KW (eds). Plenum Press, New York pp367-377, 1986.
10. Robel P, Bourreau E, Corpéchot C, Dang DC, Halberg F, Clarke C, Haug M, Schlegel ML, Synguelakis M, Vourc'h C and Baulieu EE: Neuro-steroids: 3β-hydroxy-Δ5-derivatives in rat and monkey brain. J Steroid Biochem 27: 649-655, 1987.
11. Ukena K, Usui M, Kohchi C and Tsutsui K: Cytochrome P450 side-chain cleavage enzyme in the cercbellar Purkinjc neuron and its neonatal chance in rats. Endocrinology 139: 137-147, 1998.
12. Takase M, Ukena K, Yamazaki T, Kominami S and Tsutsui K: Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes. Endocrinology 140: 1936-1944, 1999.
13. Tsutsui K and Yamazaki T: Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain. Brain Res 678: 1-9, 1995.
14. Tsutsui K, Yamazaki T, Usui M, Furukawa Y, Ukena K, Kohchi C and Kominami S: P450scc activity in the brain. In: Perspectives in Avian Endocrinology. Harvey S and Etches RJ (eds). Journal of Endocrinol Ltd, Bristol pp427-436, 1997.
15. Tsutsui K, Usui M, Yamazaki T, Ukena K and Kominami S: Neurosteroids in the avian brain. In: Frontiers in Environmental and Metabolic Endocrinology. Maitra SK (ed). Burdwan press, Burdwan. pp151-159, 1997.
16. Usui M, Yamazaki T, Kominami S and Tsutsui K: Avian neurosteroids. II. Localization of a cytochrome P450scc-like substance in the quail brain. Brain Res 678: 10-20, 1995.
17. 17: Akwa Y, Young J, Kabbadj K, Sancho MJ, Zucman D, Vourc'h C, Jung-Testas I, Hu ZY, Le Goascogne C, Jo DH, Corpéchot C, Simon P, Baulieu EE and Robel P: Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydrocpiandrosterone in the brain. J Steroid Biochem Mol Biol 40: 71-81, 1991.
18. Baulieu EE: Neurosteroids: a new function in the brain. Biol Cell 71: 3-10, 1991.
19. Baulieu EE and Robel P: Neurosteroids: A new brain function? J Steroid Biochem Mol Biol 37: 395-403, 1990.
20. Hu ZY, Bourreau E, Jung-Testas I, Robel P and Baulieu EE: Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc Natl Acad Sei USA 84: 8215-8219, 1987.
21. Jung-Testas I, Hu ZY, Baulieu EE and Robel P: Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125: 2083-2091, 1989.
22. Papadopoulos V, Guarneri P, Krueger KE, Guidotti A and Costa E: Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sei USA 89: 5113-5117, 1992.
23. Ukcna K, Kohchi C and Tsutsui K: Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomcrase in the rat Purkinje neuron during neonatal life. Endocrinology 140: 805-813, 1999.
24. Compagnone NA, Bulfone A, Rubenstein JLR and Mellon SH: Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology 136: 2689-2696,1995.
25. Iwahashi K, Ozaki HS, Tsubaki M, Ohnishi J, Takeuchi Y and Ichikawa Y: Studies of the immunohistochcmical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain. Biochim Biophys Acta 1035: 182-189, 1990.
26. Le Goascogne C, Robcl P, Gouézou M, Sananès N, Baulieu EE and Waterman M: Neurosteroids: cytochrome P-450scc in rat brain. Science 237: 1212-1215, 1987.
27. Mellon SH and Dcscheppcr CF: Neurostcroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res 629: 283-292, 1993.
28. Kohchi C, Ukena K and Tsutsui K: Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17 and 3B-HSD in the postnatal rat brain. Brain Res 801: 233-238, 1998.
29. Mason JI: The 3β-hydroxysteroid dehydrogcnase gene family of enzymes. Trends Endocrinol Metab 4: 199-203, 1993.
30. Dupont E, Simard J, Luu-The V, Labrie F and Pelletier G: Localization of 3β-hydro.xysteroid dchydrogenase in rat brain as studied by in situ hybridization. Mol Cell Neurosci 5: 119-123, 1994.
31. Guennoun R, Fiddes RJ, Gouézou M, Lombes M and Baulieu EE: A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxystcroid dehydrogenase/Δ5-Δ4-isomerase (3B-HSD), is expressed in rat brain. Mol Brain Res 30: 287-300, 1995.
32. Sannc JL and Krueger KE: Expression of cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase in the rat central nervous system: a study by polymerasc chain reaction and in situ hybridization. J Neurochcm 65: 528-536, 1995.
33. Akwa Y, Sananes N, Gouézou M, Robel P, Baulieu EE and Lc Goascogne C: Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density. J Cell Biol 121: 135-143, 1993.
34. Kabbadj K, El-Etr M, Baulieu EE and Robel P: Pregnenolone metabolism in rodent embryonic neurons and astrocytes. Glia 7: 170-175, 1993.
35. Weidenfeld J, Siegel RA and Chowers I: In vitro conversion of pregnenolone to progesterone by discrete brain areas of the male rat. J Steroid Biochem 13: 961-963, 1980.
36. Ukena K, Honda Y, Inai Y, Kohchi C, Lea RW and Tsutsui K: Expression and activity of 3β-hydroxystcroid dehydrogenase/ Δ5-Δ4-isomerase in different regions of the avian brain. Brain Res 818: 536-542, 1999.
37. Vanson A, Arnold AP and Schlinger BA: 3β-Hydroxysteroid dehydrogenase/isomerase and aromatase activity in primary cultures of developing zebra finch telencephalon: dehydroepiandrosterone as substrate for synthesis of androstenedione and estrogens. Gen Comp Endocrinol 102: 342-350, 1996.
38. Mensah-Nyagan AG, Feuilloley M, Dupont E, Do-Rego JL, Leboulenger F, Pelletier G and Vaudry H: Immunocytochemical localization and biological activity of 3β-hydroxysteroid dehydrogenase in the central nervous system of the frog. J Neurosci 14: 7306-7318, 1994.
39. Strömstedt M and Waterman MR: Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain. Mol Brain Res 34: 75-88, 1995.
40. Compagnone NA, Bulfone A, Rubcnstein JLR and Mellon SH: Steroidogenic enzyme P450c17 is expressed in-the embryonic central nervous system. Endocrinology 136: 5212-5223, 1995.
41. Guarneri P, Guarneri R, Cascio C, Pavasant P, Piccoli F and Papadopoulos V: Ncurosteroidogenesis in rat retinas. J Neurochem 63: 86-96, 1994.
42. Altman J: Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J Comp Neurol 145: 353-397, 1972.
43. Altman J: Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol 145: 399-463, 1972.
44. A receptor complex: electrophysiological studies. Ciba Found Symp 153: 56-71, 1990.
45. A-benzodiazepine receptor. Eur J Pharmacol 188:403-406, 1990.
46. A receptor: mechanism of action and physiological significance. Prog Neurobiol 38: 379-395, 1992.
47. Majewska MD and Schwartz RD: Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in the brain? Brain Res 404: 355-360, 1987.
48. Majewska MD, Harrison NL, Schwartz RD, Barker JL and Paul SM: Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232: 1004-1007, 1986.
49. Morrow AL, Pace JR, Purdy RH and Paul SM: Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chroride ion channels: evidence for multiple steroid recognition sites. Mol Pharmacol 37: 263-270, 1990.
50. A receptors. Neuron 4: 759-765, 1990.
51. A receptor on the response to a neurosteroid. Eur J Pharmacol 206: 77-80, 1991.
52. Wu F-S, Gibbs TT and Farb DH: Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartatc receptor. Mol Pharmacol 40: 333-336, 1991.
53. Majewska MD, Mienville JM and Vicini S: Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Ncurosci Lett 90: 279-284, 1988.
54. Mienville JM and Vicini S: Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency. Brain Res 489: 190-194, 1989.
55. Patchev VK, Shoaib M, Holsboer F and Almeida OFX: The neurosteroid tetrahydroprogesterone counteracts corticotropinreleasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 62: 265-271, 1994.
56. Paul SM and Purdy RH: Neuroactive steroids. FASEB J 6: 2311-2322,1992.
57. Rupprecht R, Rcul JMHM, Trapp T, van Steensel B, Wctzcl C, Damm K, Zieglgänsberger W and Holsboer F: Progesterone receptor-mediated effects of neuroactive steroids. Neuron 11-523-530, 1993.
58. Valera S, Ballivet M and Bertrand D: Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sei USA 89: 9949-9953, 1992.
59. Koenig HL, Schumacher M, Ferzaz B, Do Thi AN, Ressouches A, Guennoun R, Jung-Testas I, Robel P, Akwa Y and Baulieu EE: Progesterone synthesis and myelin formation by Schwann cells. Science 268: 1500-1503, 1995.
60. Brinton RD: The neurosteroid 3α-hydroxy-5α-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons. J Neurosci 14:2763-2774, 1994.