Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4- isomerase in different regions of the avian brain

Brain Research

Volumn 818, Issue 2, 1999, Pages 536-542

  Ukena, Kazuyoshi ^a   Honda, Yoko ^a   Inai, Yuto ^a   Kohchi, Chie ^a   Lea, Robert W ^b   Tsutsui, Kazuyoshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

3 Hydroxysteroid dehydrogenase 5 4 isomerase; Enzymatic activity; Gene expression; Progesterone; Quail brain; Reverse transcription polymerase chain reaction

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; PREGNENOLONE; PROGESTERONE; TRILOSTANE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROTEIN EXPRESSION; QUAIL; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL MATURATION; SOUTHERN BLOTTING; ANIMAL; BRAIN MAPPING; COMPARATIVE STUDY; COTURNIX; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC CODE; GENETICS; METABOLISM; PHYSIOLOGY;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BRAIN; BRAIN MAPPING; COTURNIX; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC CODE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0033550548     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01296-7     Document Type: Article

References (42)

1. Akwa Y., Young J., Kabbadj K., Sancho M.J., Zucman D., Vourc'h C., Jung-Testas I., Hu Z.Y., Le Goascogne C., Jo D.H., Corpéchot C., Simon P., Baulieu E.E., Robel P. Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J. Steroid Biochem. Mol. Biol. 40:1991;71-81.
2. Baulieu E.E. Neurosteroids: a new function in the brain. Biol. Cell. 71:1991;3-10.
3. Baulieu E.E., Robel P. Neurosteroids: a new brain function? J. Steroid Biochem. Mol. Biol. 37:1990;395-403.
4. C.I. Bliss, The Statistics of Bioassay, Academic Press, New York, 1952.
5. Brenner P.F., Guerrero R., Cekan Z., Diczfalusy E. Radioimmunoassay method for six steroids in human plasma. Steroids. 22:1973;775-794.
6. Compagnone N.A., Bulfone A., Rubenstein J.L.R., Mellon S.H. Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology. 136:1995;2689-2696.
7. Corpéchot C., Robel P., Axelon M., Sjövall J., Baulieu E.E. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc. Natl. Acad. Sci. USA. 78:1981;4704-4707.
8. Corpéchot C., Synguelakis M., Talha S., Axelson M., Sjövall J., Vihko R., Baulieu E.E., Robel P. Pregnenolone and its sulfate ester in rat brain. Brain Res. 270:1983;119-125.
9. Dupont E., Simard J., Luu-The V., Labrie F., Pelletier G. Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Mol. Cell. Neurosci. 5:1994;119-123.
10. 4-isomerase (3β-HSD), is expressed in rat brain. Mol. Brain Res. 30:1995;287-300.
11. Hu Z.Y., Bourreau E., Jung-Testas I., Robel P., Baulieu E.E. Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc. Natl. Acad. Sci. USA. 84:1987;8215-8219.
12. Jo D.H., Abdallah M.A., Young J., Baulieu E.E., Robel P. Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain. Steroids. 54:1989;287-297.
13. Jung-Testas I., Hu Z.Y., Baulieu E.E., Robel P. Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology. 125:1989;2083-2091.
14. Kohchi C., Ukena K., Tsutsui K. Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17 and 3β-HSD in the postnatal rat brain. Brain Res. 801:1998;233-238.
15. Lacroix C., Fiet J., Benais J.P., Gueux B., Bonete R., Villette J.M., Gourmel B., Dreux C. Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain. J. Steroid. Biochem. 28:1987;317-325.
16. A receptor complex: electrophysiological studies. Ciba Found. Symp. 153:1990;56-71.
17. A-benzodiazepine receptor. Eur. J. Pharmacol. 188:1990;403-406.
18. Lanthier A., Patwardhan V.V. Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves. J. Steroid Biochem. 25:1986;445-449.
19. Le Goascogne C., Robel P., Gouézou, M., Sananès N., Baulieu E.E., Waterman M. Neurosteroids: cytochrome P-450scc in rat brain. Science. 237:1987;1212-1215.
20. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
21. A receptor: mechanism of action and physiological significance. Prog. Neurobiol. 38:1992;379-395.
22. Majewska M.D., Schwartz R.D. Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in the brain? Brain Res. 404:1987;355-360.
23. Mellon S.H., Deschepper C.F. Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629:1993;283-292.
24. Mensah-Nyagan A.G., Feuilloley M., Dupont E., Do-Rego J.-L., Leboulenger F., Pelletier G., Vaudry H. Immunocytochemical localization and biological activity of 3β-hydroxysteroid dehydrogenase in the central nervous system of the frog. J. Neurosci. 14:1994;7306-7318.
25. Miller W.L. Molecular biology of steroid hormone synthesis. Endocrinol. Rev. 9:1988;295-318.
26. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol. Pharmacol. 37:1990;263-270.
27. 5→4 isomerase unique to major steroidogenic tissues. Gene. 162:1995;261-265.
28. Papadopoulos V., Guarneri P., Krueger K.E., Guidotti A., Costa E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc. Natl. Acad. Sci. USA. 89:1992;5113-5117.
29. A receptors. Neuron. 4:1990;759-765.
30. Robel P., Baulieu E.E. Neurosteroids: biosynthesis and function. Trends Endocrinol. Metab. 5:1994;1-8.
31. 5-derivatives in the rodent brain. Neurochem. Int. 7:1985;953-958.
32. 5-derivatives in rat and monkey brain. J. Steroid Biochem. 27:1987;649-655.
33. 5-derivatives in the rat brain, in: G. Fink, A.J. Harmar, K.W. McKerns (Eds.), Neuroendocrine Molecular Biology, Plenum, New York, 1986, pp. 367-377.
34. Sanne J.L., Krueger K.E. Expression of cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase in the rat central nervous system: a study by polymerase chain reaction and in situ hybridization. J. Neurochem. 65:1995;528-536.
35. A receptor on the response to a neurosteroid. Eur. J. Pharmacol. 206:1991;77-80.
36. Tsutsui K. Pituitary and gonadal hormone-dependent and -independent induction of follicle-stimulating hormone receptors in the developing testis. Endocrinology. 128:1991;477-487.
37. Tsutsui K., Yamazaki T. Avian neurosteroids: I. Pregnenolone biosynthesis in the quail brain. Brain Res. 678:1995;1-9.
38. K. Tsutsui, T. Yamazaki, M. Usui, Y. Furukawa, K. Ukena, C. Kohchi, S. Kominami, P450scc activity in the brain, in: R. Etches, S. Harvey (Eds.), Perspectives in Avian Endocrinology, J. Endocrinol., Bristol, UK, 1997, pp. 427-436.
39. Ukena K., Usui M., Kohchi C., Tsutsui K. Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats. Endocrinology. 139:1998;137-147.
40. Usui M., Yamazaki T., Kominami S., Tsutsui K. Avian neurosteroids: II. Localization of a cytochrome P450scc-like substance in the quail brain. Brain Res. 678:1995;10-20.
41. Vanson A., Arnold A.P., Schlinger B.A. 3β-Hydroxysteroid dehydrogenase/isomerase and aromatase activity in primary cultures of developing zebra finch telencephalon: dehydroepiandrosterone as substrate for synthesis of androstenedione and estrogens. Gen. Comp. Endocrinol. 102:1996;342-350.
42. Weidenfeld J., Siegel R.A., Chowers I. In vitro conversion of pregnenolone to progesterone by discrete brain areas of the male rat. J. Steroid Biochem. 13:1980;961-963.