Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck

Osteoporosis International

Volumn 17, Issue 11, 2006, Pages 1602-1607

  Xu, Hong ^a,b   Long, Ji Rong ^d   Yang, Yan Jun ^a   Deng, Fei Yan ^a   Deng, Hong Wen ^a,c  

^a HUNAN NORMAL UNIVERSITY   (China)

^b JIANGXI MEDICAL COLLEGE   (China)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

Body mass index; Body weight; Bone geometry; Genetic correlation; Genetic determination

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CHINESE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; GENETIC ANALYSIS; GEOMETRY; HERITABILITY; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; BODY WEIGHT; BONE DENSITY; DENSITOMETRY, X-RAY; FEMALE; FEMUR NECK; HUMANS; MALE; MIDDLE AGED; PHENOTYPE;

EID: 33749166191     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0141-y     Document Type: Article

References (48)

1. Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL (1993) Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8(10):1227-1233
2. De Laet CE, Van Hout BA, Burger H, Weel AE, Hofman A, Pols HA (1998) Hip fracture prediction in elderly men and women: validation in the Rotterdam study. J Bone Miner Res 13(13):1587-1593
3. Faulkner KG, Cummings SR, Black D, Palermo L, Gluer CC, Genant HK (1993) Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res 8(10):1211-1217
4. Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14(Suppl 3):S13-S18
5. Pulkkinen P, Partanen J, Jalovaara P, Jamsa T (2004) Combination of bone mineral density and upper femur geometry improves the prediction of hip fracture. Osteoporos Int 15(4):274-280
6. Myers ER, Hecker AT, Rooks DS, Hipp JA, Hayes WC (1993) Geometric variables from DXA of the radius predict forearm fracture load in vitro. Calcif Tissue Int 52(3):199-204
7. Siu WS, Qin L, Leung KS (2003) pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength. J Bone Miner Metab 21(5):316-322
8. Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J (2003) Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone 32(5):561-570
9. Filardi S, Zebaze RM, Duan Y, Edmonds J, Beck T, Seeman E (2004) Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging. Osteoporos Int 15(2):103-107
10. Rivadeneira F, Houwing-Duistermaat JJ, Beck TJ, Janssen JA, Hofman A, Pols HA, Van Duijn CM, Uitterlinden AG (2004) The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study. J Bone Miner Res 19(8):1280-1290
11. Slemenda CW, Turner CH, Peacock M, Christian JC, Sorbel J, Hui SL, Johnston CC (1996) The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. Osteoporos Int 6(2):178-182
12. Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Kimmel DB, Recker RR (2000) Genetic variations in bone density, histomorphometry, and strength in mice. Calcif Tissue Int 67(4):337-344
13. Klein RF, Turner RJ, Skinner LD, Vartanian KA, Serang M, Carlos AS, Shea M, Belknap JK, Orwoll ES (2002) Mapping quantitative trait loci that influence femoral cross-sectional area in mice. J Bone Miner Res 17(10):1752-1760
14. Shen H, Long JR, Xiong DH, Liu YJ, Liu YZ, Xiao P, Zhao LJ, Dvornyk V, Zhang YY, Rocha-Sanchez S, Liu PY, Li JL, Deng HW (2005) Mapping quantitative trait loci for cross-sectional geometry at the femoral neck. J Bone Miner Res 20(11):1973-1982
15. Yao WJ, Wu CH, Wang ST, Chang CJ, Chiu NT, Yu CY (2001) Differential changes in regional bone mineral density in healthy Chinese: age-related and sex-dependent. Calcif Tissue Int 68(6):330-336
16. van Rossum CT, Hoebee B, van Baak MA, Mars M, Saris WH, Seidell JC (2003) Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res 11:377-386
17. Liu PY, Li YM, Li MX, Malkin I, Qin YJ, Chen XD, Liu YJ, Deng HW (2004) Lack of evidence for a major gene in the Mendelian transmission of BMI in Chinese. Obes Res 12(12):1967-1973
18. De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16(11):1330-1338
19. Farahmand BY, Michaelsson K, Baron JA, Persson PG, Ljunghall S (2000) Body size and hip fracture risk. Swedish Hip Fracture Study Group. Epidemiology 11(2):214-219
20. Heaney RP, Barger-Lux MJ, Davies KM, Ryan RA, Johnson ML, Gong G (1997) Bone dimensional change with age: interactions of genetic, hormonal, and body size variables. Osteoporos Int 7(5):426-431
21. Livshits G, Pantsulaia Ia, Trofimov S, Kobyliansky E (2003) Genetic variation of circulating leptin is involved in genetic variation of hand bone size and geometry. Osteoporos Int 14(6):476-483
22. Qin YJ, Shen H, Huang QR, Zhao LJ, Zhou Q, Li MX, He JW, Mo XY, Lu JH, Recker RR, Deng HW (2003) Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. J Bone Miner Res 18:1028-1035
23. Williams JT, Van Eerdewegh P, Almasy L, Blangero J (1999) Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet 65(4):1134-1147
24. Rainwater DL, Martin LJ, Comuzzie AG (2001) Genetic control of coordinated changes in HDL and LDL size phenotypes. Arterioscler Thromb Vasc Biol 21:1829-1833
25. Comuzzie AG, Blanger J, Mahaney MC, Sharp RM, VandeBerg JL, Stern MP, MacCluer JW (1996) Triiodothyronine exerts a major pleiotropic effect on reverse cholesterol transport phenotypes. Arterioscler Thromb Vasc Biol 16:289-293
26. Comuzzie AG, Railnwater DL, Blangero J, Mahaney MC, VandeBerg JL, MacCluer JW (1997) Shared and unique genetic effects among seven HDL phenotypes. Arterioscler Thromb Vasc Biol 17:859-864
27. Deng HW, Lai DB, Conway T, Li J, Xu FH, Davies KM, Recker RR (2001) Characterization of genetic and lifestyle factors for determining variation in body mass index, fat mass, percentage of fat mass, and lean mass. J Clin Densitom 4(4):353-361
28. Frost HM (1987) Bone "mass" and the "mechanostat": a proposal. Anat Rec 219:1-9
29. Frost HM (2000) Muscle, bone, and the Utah paradigm: a 1999 overview. Med Sci Sports Exercise 32:911-917
30. Petit MA, Beck TJ, Shults J, Zemel BS, Foster BJ, Leonard MB (2005) Proximal femur bone geometry is appropriately adapted to lean mass in overweight children and adolescents. Bone 36(3):568-576
31. Grundberg E, Brandstrom H, Ribom EL, Ljunggren O, Mallmin H, Kindmark A (2004) Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. Eur J Endocrinol 150(3):323-328
32. Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE (2005) Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20(1):88-99
33. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334(5):292-295
34. Reseland JE, Syversen U, Bakke I, Qvigstad G, Eide LG, Hjertner O, Gordeladze JO, Drevon CA (2001) Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res 16(8):1426-1433
35. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G (2000) Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2):197-207
36. Joyner JM, Hutley LJ, Cameron DP (2001) Estrogen receptors in human preadipocytes. Endocrine 15(2):225-230
37. Schiessl H, Frost HM, Jee WS (1998) Estrogen and bone-muscle strength and mass relationships. Bone 22(1):1-6
38. Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L (2003) Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature 424(6947):389
39. Mann V, Hobson EE, Li B, Stewart TL, Grant SF, Robins SP, Aspden RM, Ralston SH (2001) A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest 107(7):899-907
40. Xu H, Xiong DH, Xu FH, Zhang YY, Lei SF, Deng HW (2005) Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: a study on postmenopausal Chinese women. Acta Biochim Biophys Sin 37(1):61-67
41. Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID (2002) Association of the TNF-alpha-308 G/A promoter polymorphism with insulin resistance in obesity. Obes Res 10(5):401-407
42. Moffett SP, Zmuda JM, Oakley JI, Beck TJ, Cauley JA, Stone KL, Lui LY, Ensrud KE, Hillier TA, Hochberg MC, Morin P, Peltz G, Greene D, Cummings SR (2005) Tumor necrosis factor-{alpha} polymorphism, bone strength phenotypes, and the risk of fracture in older women. J Clin Endocrinol Metab 90(6):3491-3497
43. Deng FY, Liu MY, Li MX, Lei SF, Qin YJ, Zhou Q, Liu YJ, Deng HW (2003) Tests of linkage and association of the COL1A2 gene with bone phenotypes' variation in Chinese nuclear families. Bone 33(4):614-619
44. Xu H, Zhao LJ, Lei SF, Li MX, Sun X, Deng FY, Jiang DK, Deng HW (2005) The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families. J Hum Genet 50(6):301-304
45. MacKelvie KJ, Petit MA, Khan KM, Beck TJ, McKay HA (2004) Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone 34(4):755-764
46. Petit MA, Beck TJ, Lin HM, Bentley C, Legro RS, Lloyd T (2004) Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: the Penn State Young Women's Health Study. Bone 35(3):750-759
47. Jiang DK, Shen H, Li MX, Jiang C, Yang N, Zhu J, Wu Y, Qin YJ, Zhou Q, Deng HW (2005) No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women. Bone 36(4):694-699
48. Lei SF, Zhang YY, Deng FY, Liu MY, Liu XH, Zhou XG, Deng HW (2005) Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications. Maturitas 51(2):199-206