A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

Journal of Clinical Investigation

Volumn 107, Issue 7, 2001, Pages 899-907

  Mann, Val ^a   Hobson, Emma E ^a   Li, Baohua ^b   Stewart, Tracy L ^a   Grant, Struan F A ^a   Robins, Simon P ^c   Aspden, Richard M ^b   Ralston, Stuart H ^a,b  

^a Department of Medicine and Therapeutics ^*  (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

ALLELE; ARTICLE; BINDING AFFINITY; BINDING SITE; BODY MASS; BONE DENSITY; BONE MINERAL; BONE MINERALIZATION; BONE STRENGTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FRACTURE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; OSTEOBLAST; OSTEOPOROSIS; PRIORITY JOURNAL;

EID: 0035060434     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10347     Document Type: Article

References (35)

1. The diagnosis of osteoporosis
2. Role of genetic factors in the pathogenesis of osteoporosis
3. Reduced bone density, and osteoporosis associated with a polymorphic Sp1 site in the collagen type I alpha 1 gene
4. Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus
5. Association of a polymorphism in the collagen I α 1 gene with osteoporosis in French women
6. An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in men and women
7. Collagen I α 1 polymorphism, bone mass and bone turnover in healthy French pre-menopausal women: The OFELY study
8. Relation of alleles of the collagen type I α 1 gene to bone density and risk of osteoporotic fractures in postmenopausal women
9. Polymorphism at the type I collagen (COLIA1) locus is associated with reduced bone mineral density, increased fracture risk and increased collagen turnover
10. Collagen type I alpha 1 gene Sp1 polymorphism in premenopausal women with primary osteoporosis: Improved detection of Sp1 binding site polymorphism in the collagen type 1 gene
11. COLIA1 polymorphism contributes to bone mineral density to assess prevalent wrist fractures
12. Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites, at the COLIA1 locus
13. Association of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal women
14. Lack of influence of collagen type I alpha 1 Sp1 binding site polymorphism on the rate of bone loss in a cohort of post-menopausal Danish women followed for 18 years
15. Polymorphism at an Sp1 binding site of COLIA1 and bone mineral density in pre-menopausal female twins and elderly fracture patients
16. Genetic markers, bone mineral density and serum osteocalcin levels
17. Polymorphism at the Sp1 binding site in the collagen type I alpha 1 gene does not predict bone mineral density in postmenopausal women in sweden
18. Regulatory elements in the first intron contribute to transcriptional control of the human collagen alpha 1 (I) collagen gene
19. Associations of the collagen type I alpha 1 Sp1 polymorphism with five-year rates of bone loss in older adults
20. Bias in meta-analysis detected by a simple, graphical test
21. Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis
22. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase
23. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis
24. Contact pressures in the human hip joint measured in vivo
25. Reproducibility of techniques using Archimedes' principle in measuring cancellous bone volume by L. Zou, R. D. Bloebaum and K. N. Bachus
26. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
27. Bone density variation and its effects on risk of vertebral deformity in men and women studied in thirteen European centers: The EVOS Study
28. Altered helical structure of a homotrimer of alpha 1 (I) chains synthesized by fibroblasts from a variant of osteogenesis imperfecta
29. Identification of collagen alpha 1 (I) trimer in embryonic chick tendons and calvaria
30. Altered collagen structure in mouse tail tendon lacking the alpha 2(I) chain
31. Collagen biosynthesis in human oral submucous fibrosis fibroblast cultures
32. Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: A model of human osteogenesis imperfecta
33. Bone geometry and strength measurements in aging mice with the oim mutation
34. Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta
35. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies