Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Obesity Research

Volumn 12, Issue 12, 2004, Pages 1967-1973

  Liu, Peng Yuan ^a,b   Li, Yu Mei ^a   Li, Miao Xin ^a,e   Malkin, Ida ^c   Qin, Yue Juan ^d   Chen, Xiang Ding ^a   Liu, Yong Jun ^b   Deng, Hong Wen ^a,b  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^e HUAIHUA UNIVERSITY   (China)

Author keywords

BMI; Chinese population; Familial correlation; Major genes; Segregation analysis

Indexed keywords

AGED; ARTICLE; BODY MASS; CHINA; CHROMOSOME SEGREGATION; FATHER; FEMALE; HEREDITY; HUMAN; MALE; MIDDLE AGED; MOTHER; NUCLEAR FAMILY;

AGED; BODY MASS INDEX; CHINA; CHROMOSOME SEGREGATION; FATHERS; FEMALE; HEREDITY; HUMANS; MALE; MIDDLE AGED; MOTHERS; NUCLEAR FAMILY;

EID: 18944394244     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.247     Document Type: Article

References (40)

1. Kopelman PG. Obesity as a medical problem. Nature. 2000; 404:635-43. (Pubitemid 30205068)
2. Barsh GS, Farooqi IS, O'Rahilly S. Genetics of body-weight regulation. Nature. 2000;404:644-51. (Pubitemid 30205069)
3. Selby JV, Reed T, Newman B, Fabsitz RR, Carmelli D. Effects of selective return on estimates of heritability for body mass index in the National Heart, Lung, and Blood Institute Twin Study. Genet Epidemiol. 1991;8:371-80.
4. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA. 1986;256:51-4. (Pubitemid 16093199)
5. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The body-mass index of twins who have been reared apart. N Engl J Med. 1990;322:1483-7. (Pubitemid 20179861)
6. Borecki IB, Higgins M, Schreiner PJ, et al. Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res. 1998;6:107-14. (Pubitemid 128679650)
7. Rice T, Perusse L, Bouchard C, Rao DC. Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study. Genet Epidemiol. 1999; 16:316-34. (Pubitemid 29115949)
8. Luke A, Guo X, Adeyemo AA, et al. Heritability of obesityrelated traits among Nigerians, Jamaicans and US black people. Int J Obes Relat Metab Disord. 2001;25:1034-41. (Pubitemid 32566059)
9. Price RA, Ness R, Laskarzewski P. Common major inheritance of extreme overweight. Hum Biol. 1990;62:747-65. (Pubitemid 20364296)
10. Province MA, Arnqvist P, Keller J, Higgins M, Rao DC. Strong evidence for a major gene for obesity in the large, unselected, total Community Health Study of Tecumseh. Am J Hum Genet Suppl. 1990;47:A143.
11. Nath SK, Chakravarti A, Chen CH, Cooper R, Weder A, Schork NJ. Segregation analysis of blood pressure and body mass index in a rural US community. Hum Biol. 2002;74:11-23. (Pubitemid 34220319)
12. Tiret L, Andre JL, Ducimetiere P, et al. Segregation analysis of height-adjusted weight with generation- and age-dependent effects: the Nancy Family Study. Genet Epidemiol. 1992;9:389-403. (Pubitemid 23052353)
13. Borecki IB, Bonney GE, Rice T, Bouchard C, Rao DC. Influence of genotype-dependent effects of covariates on the outcome of segregation analysis of the body mass index. Am J Hum Genet. 1993;53:676-87. (Pubitemid 23304141)
14. Comuzzie AG, Blangero J, Mahaney MC, et al. Major gene with sex-specific effects influences fat mass in Mexican- Americans. Genet Epidemiol. 1995;12:475-88.
15. Liu YJ, Araujo S, Recker RR, Deng HW. Molecular and genetic mechanisms of obesity: current treatments. Cur Mol Med. 2003;3:325-40. (Pubitemid 36621790)
16. Rankinen T, Perusse L, Weisnagel SJ, Snyder EE, Chagnon YC, Bouchard C. The human obesity gene map: the 2001 update. Obes Res. 2002;10:196-243.
17. Hasstedt SJ, Hoffman M, Leppert MF, Elbein SC. Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet. 1997;61:668-77. (Pubitemid 27418409)
18. Colilla S, Rotimi C, Cooper R, Goldberg J, Cox N. Genetic inheritance of body mass index in African-American and African families. Genet Epidemiol. 2000;18:360-76. (Pubitemid 30252594)
19. Wu Y, Zhou B, Tao S, et al. Prevalence of overweight and obesity in Chinese middle-aged populations: current status and trend of development. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23:11-5.
20. Popkin BM. The nutrition transition and obesity in the developing world. J Nutr. 2001;131:871-3S.
21. Liu ZH, Piao JH, Pang LP, et al. The diagnosis criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab. 2002;20:181-90.
22. S.A.G.E. Statistical analysis for genetic epidemiology, Release 4.2. 2001; Computer program package available from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Reseach, MetroHealth Campus, Case Western Reserve University, Cleveland, OH.
23. Sokal RR, Rohlf FJ. Biometry. 2nd ed. WH Freeman and Company, San Francisco, CA; 1981.
24. Rice T, Despres JP, Daw EW, et al. Familial resemblance for abdominal visceral fat: the HERITAGE family study. Int J Obes Relat Metab Disord. 1997;21:1024-31. (Pubitemid 27462407)
25. Lynch M, Walsh B. Genetics and Analysis of Quantitative Traits. Sinauer Associates, Sunderland, MA; 1998.
26. Bonney GE. On statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet. 1984;18:731-49. (Pubitemid 14075001)
27. Ginsburg E, Livshits G. Segregation analysis of quantitative traits. Ann Hum Biol. 1999;26:103-29. (Pubitemid 29208033)
28. Elston RC. Introduction and overview: statistical methods in genetic epidemiology. Stat Methods Med Res. 2000;9: 527-41.
29. Blangero J, Williams JT, Almasy L. Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol. 2000;19(Suppl 1):S8 -14.
30. Demenais F, Lathrop M, Lalouel JM. Robustness and power of the unified model in the analysis of quantitative measurements. Am J Hum Genet. 1986;38:228-34. (Pubitemid 16068008)
31. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Control. 1974;19:716-23.
32. Cupples LA, Myers RH, Ordovas JM, Wilson PWF, Schaefer EJ. Heritability of risk factor for coronary heart disease: the Framingham study. Am J Hum Genet. 1995;57: 1834.
33. Wu KD, Hsiao CF, Ho LT, et al. Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study. Hypertens Res. 2002;25:529-36.
34. Korkeila M, Kaprio J, Rissanen A, Koskenvuo M. Effects of gender and age on the heritability of body mass index. Int J Obes. 1991;15:647-54.
35. Borecki IB, Blangero J, Rice T, Perusse L, Bouchard C, Rao DC. Evidence for at least two major loci influencing human fatness. Am J Hum Genet. 1998;63:831-8. (Pubitemid 30422684)
36. Jarvik GP. Complex segregation analyses: uses and limitations. Am J Hum Genet. 1998;63:942-6. (Pubitemid 30418561)
37. Bouchard C, Rice T, Lemieux S, Despres JP, Perusse L, Rao DC. Major gene for abdominal visceral fat area in the Quebec Family Study. Int J Obes Relat Metab Disord. 1996;20:420-7.
38. Lee JH, Reed DR, Price RA. Familial risk ratios for extreme obesity: implications for mapping human obesity genes. Int J Obes Relat Metab Disord. 1997;21:935-40. (Pubitemid 27427484)
39. Rice T, Sjöström CD, Perusse L, Rao DC, Sjöström L, Bouchard C. Segregation analysis of body mass index in a large sample selected for obesity: the Swedish Obese Subjects study. Obes Res. 1999;7:246-55. (Pubitemid 129710583)
40. Malkin I, Ginsburg E. MAN (Version 6): Program Package for Mendelian Analysis of Pedigree Data. Tel Aviv, Israel: Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, 2003.