pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength

Journal of Bone and Mineral Metabolism

Volumn 21, Issue 5, 2003, Pages 316-322

  Siu, Wing Sum ^a   Qin, Ling ^a   Leung, Kwok Sui ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bone strength index; Dual energy absorptiometry (DXA); Long bone; Peripheral quantitative computed tomography (pQCT); Three point bending test

Indexed keywords

ANIMAL TISSUE; ARTICLE; BONE BOWING; BONE DENSITY; BONE MASS; BONE MINERAL; BONE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FRAGILITY FRACTURE; HUMERUS; MALE; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS; ANIMAL; EVALUATION; FEMUR; FRACTURE; GOAT; HISTOLOGY; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTION AND FORECASTING; RADIOGRAPHY; TENSILE STRENGTH;

ANIMALS; BONE DENSITY; FEMALE; FEMUR; FRACTURES, BONE; GOATS; HUMERUS; MALE; PREDICTIVE VALUE OF TESTS; TENSILE STRENGTH; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0142182402     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-003-0427-5     Document Type: Article

References (47)

1. Kröger H, Kotaniemi A, Vainio P, Alhava E (1992) Bone densitometry of the spine and femur in children by dual X-ray absorptiometry. Bone Miner 17:75-85
2. Myers ER, Hecker AT, Rooks DS, Hipp JA, Hayes WC (1993) Geometric variables from DXA of the radius predict forearm fracture load in vitro. Calcif Tissue Int 52:199-204
3. Hui SL, Slemenda CW, Johnston CC (1989) Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med 111:355-361
4. Lau E, Woo J, Leung PC (1993) Low bone mineral density, grip strength and skin-fold thickness are important risk factors for hip fracture in Hong Kong Chinese. Osteoporo Int 3:66-69
5. Riis BJ, Hansne MA, Jensen AM, Overgaard K, Christianse NC (1996) Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture. A 15-year follow-up study. Bone (NY) 19:9-12
6. Cheng JCY, Qin L, Cheung SK, Sher A, Lee SM, Ng E, Guo X (2000) Generalized low areal and volumetric bone mineral density in adolescent idiopathic scoliosis. J Bone Miner Res 15:1587-1595
7. Ferretti JL (1995) Perspective of pQCT technology associated to biomechanical studies in skeletal research employing rat models. Bone (NY) 17:353-364
8. Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Haris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11:707-730
9. Rüeegsegger P (1996) Bone density measurement, In: Bröll H, Dambacher MA (eds) Osteoporosis: A Guide to Diagnosis and Treatment. Rheumatology. Karger, Basel, pp 103-116
10. Beck TJ, Ruff CB, Bissessur K (1993) Age-related changes in female femoral neck geometry: implications for bone strength. Calcif Tissue Int 53:41-46
11. Haapasalo H, Sievanen H, Kannus P, Heinonen A, Oja P, Vuori I (1996) Dimensions and estimated mechanical characteristics of the humerus after long-term tennis loading. J Bone Miner Res 11:864-872
12. Dambacher MA, Neff M, Kissling R, Qin L (1998) Highly precise peripheral quantitative computed tomography for the evaluation of bone density, loss of bone density and structures-consequence for prophylaxis and treatment. Drug Aging 12:15-24
13. Geusens P, Dequeker J, Verstraeten A (1986) Age-, sex- and menopause-related changes of vertebral and peripheral bone: population study using dual and single photon absorptiometry and radiogrammetry. J Nucl Med 27:1540
14. Leung KS, Siu WS, Cheung NM, Lui PY, Chow DHK, James A, Qin L (2001) Goats as osteopenic animal model. J Bone Miner Res 16:2348-2355
15. Miyasaka Y, Sakurai M, Yokobori AT (1991) Bending and torsion fractures in long bones (a mechanical and radiological assessment of clinical cases). Bio-Med Mater Eng 1:3-10
16. Rauch E, Schoenau E (2001) Changes in bone density during childhood and adolescence: an approach based on bone's biological organization. J Bone Miner Res 16:597-604
17. Ferretti JL, Capozza RF, Zanchetta JR (1996) Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength. Bone (NY) 18:97-102
18. Gasser JA (1995) Assessing bone quantity by pQCT. Bone (NY) 17(suppl):145-154
19. Jamsa T, Jalovaara P, Peng Z, Vaananen K, Tuukkanen N (1998) Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia. Bone (NY) 23:155-161
20. Lochmüller WM, Lill CA, Huhn V, Scheider E, Eckstein F (2002) Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 17:1629-1638
21. Gordon KR, Perl M, Levy C (1989) Structural alterations and breaking strength of mouse femora exposed to three activity regimens. Bone (NY) 10:303-312
22. Qin L, Chan KM, Rahn BA, Guo X (1997) Bone mineral content measurement using QCT (Densiscan 1000) for predicting the cortical and trabecular bone mechanical properties. Zhonghua Guke Zazhi 17:66-70
23. Burr DB, Forwood MR, Fyrhie DP, Martin RB, Schaffler MB, Turner CH (1997) Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12:6-15
24. Ferretti JL, Spiaggi EP, Capozza RF, Cointry G, Zanchetta JR (1992) Interrelationships between geometric and mechanical properties of long bones from three rodent species with very different biomass: phylogenetic implications. J Bone Miner Res 7:S433-S435
25. Ferretti JL, Capozza RF, Mondelo N, Zanchetta JR (1993) Interrelationships between densitometric, geometric, and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling. J Bone Miner Res 8:1389-1396
26. Leung KS, Ng SWE, Cheung WK, Lee KM (1999) Changes in the BMD in the diaphyses of long bones with age: an attempt to explain the low incidence of diaphyseal fractures in aged population. In: Proceedings of the Annual Meeting of the Hong Kong Orthopaedics Association, 1999, Hong Kong
27. Salminen ST, Pihlajamaki HK, Avikainen VJ, Bostman OM (2000) Population based epidemiologic and morphologic study of femoral shaft fractures. Clin Orthop Relat Res 372:241-249
28. Weinans H, Blankevoort L (1995) Reconstruction of bone loading conditions from in vivo strain measurements. J Biomech 28:739-744
29. Biewener AA, Taylor CR (1986) Bone strain: a determinant of gait and speed? J Exp Biol 123:383-400
30. Chitty LS, Altman DG (2002) Charts of fetal size: limb bones. Br J Obstet Gynaecol 109:919-929
31. Pettersson U, Nordstrom P, Alfredson H, Henriksson-Larsen K, Lorentzon R (2000) Effect of high impact activity on bone mass and size in adolescent females: a comparative study between two different types of sports. Calcif Tissue Int 67:207-214
32. Haapasalo H, Kontulainen S, Sievanen H, Kannus P, Jarvinen M, Vuori I (2000) Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players. Bone (NY) 27:351-357
33. Patel R, Blake GM, Rymer J, Fogelman I (2000) Long-term precision of DXA scanning assessed over seven years in forty postmenopausal women. Osteoporo Int 11:68-75
34. Goh JC, Low SL, Bose K (1995) Effect of femoral rotation on bone mineral density measurements with dual energy X-ray absorptiometry. Calcif Tissue Int 57:340-343
35. Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone (NY) 14:595-608
36. Evans FG (1992) Mechanical properties of bone. C. Thomas, Springfield
37. Lewandrowski KU, Bonassar L, Uhthoff HK (1998) Mechanical properties of perforated and partially demineralized bone grafts. Clin Orthop 353:238-246
38. Reichel H, Lebek S, Alter C, Hein W (1998) Biomechanical and densitometric bone properties after callus distraction in sheep. Clin Orthop 357:237-246
39. Vazquez-Seoane P, Yoo J, Zou D, Fay LA, Fredrickson BE, Handal JC, Yuan HA, Edwards WT (1993) Interference screw fixation of cervical grafts. A combined in vitro biomechanical and in vivo animal study. Spine 18:946-954
40. Wilke HJ, Jungkunz B, Wenger K, Claes LE (1998) Spinal segment range of motion as a function of in vitro test conditions: effects of exposure period, accumulated cycles, angular-deformation rate, and moisture condition. Anat Rec 251:15-19
41. Hornby SB, Ford SL, Mase CA, Evans GP (1995) Skeletal changes in the ovariectomised ewe and subsequent response to treatment with 17-oestradiol. Bone (NY) 17:389S-394S
42. Turner AS, Park RD, Aberman HM, Villanueva AR, Nett TM, Trotter GW, Eckhoff DG (1993) Effects of age and ovariectomy on trabecular bone of the proximal femur and iliac crest in sheep. In: Proceedings of the 39th Annual Meeting, Orthopaedic Research Society, San Francisco, CA
43. Turner AS, Alvis M, Myer W, Stevens ML, Lundy MW (1995) Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone (NY) 17:395S-402S
44. Augat P, Reeb H, Claes LE (1996) Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 11:1536-1363
45. Mallmin H, Ljunghall S, Persson I, Naessen T, Krusemo U, Bergstrom R (1993) Fracture of the distal forearm as a forecaster of subsequent hip fracture: a population-based cohort study with 24 years of follow-up. Calcif Tissue Int 52:269-272
46. Gardsell P, Johnell O, Nilsson BE, Gullberg B (1993) Predicting various fragility fractures in women by forearm bone densitometry: a follow-up study. Calcif Tissue Int 52:348-353
47. Jiang Y, Zhao J, Augat P, Ouyang X, Lu Y, Majumdar S, Genant HK (1998) Trabecular bone mineral and calculated structure of human bone specimens scanned by peripheral quantitative computed tomography: relation to biomechanical properties. J Bone Miner Res 13:1783-1790