Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines

Tetrahedron Letters

Volumn 37, Issue 36, 1996, Pages 6515-6518

  Wang, Guangyi ^a   Seifert, Wilfried E ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE; THYMIDINE DERIVATIVE;

ARTICLE; DNA SYNTHESIS; DRUG STABILITY; DRUG SYNTHESIS; HYBRIDIZATION;

SERPENTES;

EID: 0030565529     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01432-3     Document Type: Article

References (21)

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17. Saturation at 3.79-3.86 ppm (H51) gave 4.5% enhancement for H3', which is consistent with the results from another laboratory for 4'-benzoyloxymethyl-3'-(t-butyldimethylsilyl)thymidine (Reference 14).
18. +), 371 (-THP), 287 (-2THP), 127 (thymine).
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21. We simply followed the procedure in Reference 20 except that the pH of the buffer was 7.5 (higher nuclease activity at pH 7.5) and amount of oligonucleotides was 0.75 OD.