Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene

Toxicology and Applied Pharmacology

Volumn 216, Issue 2, 2006, Pages 319-330

  Lock, Edward A ^a   Barth, Jeremy L ^b   Argraves, Scott W ^b   Schnellmann, Rick G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Department of Cell Biology and Anatomy ^*  (United States)

Author keywords

Gene changes; Human proximal tubule cells; S (1,2 dichlorovinyl) l cysteine; Trichloroethylene

Indexed keywords

1,2 DICHLOROVINYLGLUTATHIONE; ACYLTRANSFERASE; ADENOSINE KINASE; COMPLEMENT FACTOR H; CYSTEINE CONJUGATE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; LYASE; MOLECULAR MARKER; S (1,2 DICHLOROVINYL)CYSTEINE; TRICHLOROETHYLENE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADULT; AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL REGENERATION; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE NUMBER; GENETIC ASSOCIATION; GENOME; GLUCOSE TRANSPORT; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; NONHUMAN;

ADENOSINE KINASE; ADOLESCENT; ADULT; AGED; ARYLAMINE N-ACETYLTRANSFERASE; CELL SURVIVAL; COMPLEMENT FACTOR H; CYSTEINE; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE; GLUTATHIONE; HUMANS; ISOENZYMES; KIDNEY TUBULES, PROXIMAL; LYASES; MALE; MIDDLE AGED; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRICHLOROETHYLENE;

ANIMALIA;

EID: 33749059556     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.06.002     Document Type: Article

References (52)

1. Aleo M.D., and Schnellmann R.G. Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells. Am. J. Physiol. 262 (1992) F77-F85
2. Argraves G.L., Barth J.L., and Argraves W.S. The MUSC DNA microarray database. Bioinformatics 19 (2003) 2473-2474
3. Bruning T., and Bolt H.M. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Crit. Rev. Toxicol. 30 (2000) 253-285
4. Chen Q., Yu K., Holbrook N.J., and Stevens J.L. Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol. J. Biol. Chem. 267 (1992) 8207-8212
5. Counts R.S., Nowak G., Wyatt R.D., and Schnellmann R.G. Nephrotoxicant inhibition of renal proximal tubule cell regeneration. Am. J. Physiol. 269 (1995) F274-F281
6. Courjault F., Chevalier J., Leroy D., and Toutain H.J. Effect of glucose and insulin deprivation on differentiation and carbohydrate metabolism of rabbit proximal tubular cells in primary culture. Biochem. Biophys. Acta 1177 (1993) 147-159
7. Courjault-Gautier F., Chevalier J., Abbou C.C., Chopin D.K., and Toutain H.J. Consecutive use of hormonally defined serum-free media to establish highly differentiated human renal proximal tubule cells in primary culture. J. Am. Soc. Nephrol. 5 (1995) 1949-1963
8. Cummings B.S., and Lash L.H. metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in freshly isolated human proximal tubular cells. Toxicol. Sci. 53 (2000) 458-466
9. Delinsky A.D., Delinsky D.C., Muralidhara S., Fisher J.W., Bruckner J.V., and Bartlett M.G. Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry. Rapid Comm. Mass Spectrom. 19 (2005) 1075-1083
10. Detrisac C.J., Sens M.A., Garvin A.J., Spicer S.S., and Sens D.A. Tissue culture of human kidney epithelial cells of proximal tubule origin. Kidney Int. 25 (1984) 383-390
11. Dow J.L., and Green T. Trichloroethylene induced vitamin B12 and folate deficiency leads to increased formic acid excretion in the rat. Toxicology 146 (2000) 123-136
12. Green T., Dow J., Ong C.N., Ng V., Ong H.Y., Zhuang Z.X., Yang X.F., and Bloemen L. Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene. Occup. Environ. Med. 61 (2004) 312-317
13. Groves C.A., Lock E.A., and Schnellmann R.G. Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates. Toxicol. Appl. Pharmacol. 107 (1991) 54-62
14. Han W.K., Bailly V., Abichandani R., Thadhani R., and Bonventre J.V. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 62 (2002) 237-244
15. Hawksworth G.M. Isolation and culture of human renal cortical cells with characteristics of proximal tubules. Methods Mol. Med. 107 (2005) 283-290
16. Hazen-Martin D.J., Tarnowski B.I., Todd J.H., Sens M.A., Bylander J.E., Smyth B.J., Garvin A.J., and Sens D.A. Serum-free culture and characterization of renal epithelial cells isolated from human fetal kidneys of varying gestational age. In vitro Cell Dev. Biol. 30A (1994) 356-365
17. Ichimura T., Hung C.C., Yang S.A., Stevens J.L., and Bonventre J.V. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am. J. Renal Physiol. 286 (2004) F552-F563
18. Kays S.E., and Schnellmann R.G. Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors. Toxicol. Appl. Pharmacol. 132 (1995) 273-280
19. Kempson S.A., McAteer J.A., Al-Mahrouq H.A., Dousa T.P., Dougherty G.S., and Evans A.P. Proximal tubule characteristics of cultured human renal cortex epithelium. J. Lab.Clin. Med. 113 (1989) 285-296
20. Korrapti M.C., Lock E.A., and Mehendale H.M. Molecular mechanism of enhanced renal cell division in protection against S-(1,2-dichlorovinyl)-l-cysteine-induced renal failure and death. Am. J. Renal. Physiol. 289 (2005) F175-F185
21. Lash L.H., and Anders M.W. Mechanism of S-(1,2-dichlorovinyl)-l-cysteine and S-(1,2-dichlorovinyl)-l-homocysteine-induced renal mitochondrial toxicity. Mol. Pharmacol. 32 (1987) 549-556
22. Lash L.H., Fisher J.W., Lipscomb J.C., and Parker J.C. Metabolism of trichloroethylene. Environ. Health Perspect. 108 (2000) 177-200
23. Lash L.H., Parker J.C., and Scott C.S. Modes of action of trichloroethylene for kidney tumorigenesis. Environ. Health Perspect. 108 (2000) 225-240
24. Lash L.H., Hueni S.E., and Putt D.A. Apoptosis, necrosis and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells. Toxicol. Appl. Pharmacol. 177 (2001) 1-16
25. Lash L.H., Putt D.A., Hueni S.E., Krause R.J., and Elfarra A.A. Roles of necrosis, apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorvinyl)-l-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells. J. Pharmacol. Exp. Ther. 305 (2003) 1163-1172
26. Lash L.H., Putt D.A., Hueni S.E., and Horwitz B.P. Molecular markers of trichloroethylene-induced toxicity in human kidney cells. Toxicol. Appl. Pharmacol. 206 (2005) 157-168
27. Li C., and Wong W.H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. 98 (2001) 31-36
28. Li C., and Wong W.H. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2 (2001) (Research 0032.1-0032.11; Abstract)
29. Liu G., Loraine AE., Shigeta R., Cline M., Cheng J., Valmeekam V., Sun S., Kulp D., and Siani-Rose MA. Netaffx: Affymetrix probe sets and annotations. Nucleic Acids Res. 31 (2003) 82-86
30. Lock E.A., and Hard G.C. Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Crit. Rev. Toxicol. 34 (2004) 211-299
31. Lock E.A., and Reed C.J. Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment. Toxicol. Sci. 91 (2006) 313-331
32. McGoldrick T.A., Lock E.A., Rodilla V., and Hawksworth G.M. Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells. Arch. Toxicol. 77 (2003) 365-370
33. Megyesi J., Andrade L., Vieira Jr. J.M., Safirstein R.L., and Price P.M. Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure. Am. J. Physiol. 283 (2002) F810-F816
34. Nony P.A., and Schnellmann R.G. Interactions between collagen IV and collagen-binding integrins in renal cell repair after sublethal injury. Mol. Pharmacol. 60 (2001) 1226-1234
35. Nony P.A., and Schnellmann R.G. Mechanisms of renal cell repair and regeneration after acute renal failure. J. Pharmacol. Exp. Ther. 304 (2003) 905-912
36. Nony P.A., Nowak G., and Schnellmann R.G. Collagen IV promotes repair of renal cell physiological functions after toxicant injury. Am. J. Renal Physiol. 281 (2001) F443-F453
37. Nowak G., and Schnellmann R.G. Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells. Am. J. Physiol. 268 (1995) C1053-C1061
38. Nowak G., and Schnellmann R.G. l-ascorbic acid regulates growth and metabolism of renal cells in culture. Am. J. Physiol. 271 (1996) C2072-C2080
39. Nowak G., and Schnellmann R.G. Renal cell regeneration following oxidant exposure: inhibition by TGF-beta1 and stimulation by ascorbic acid. Toxicol. Appl. Pharmacol. 145 (1997) 175-183
40. Nowak G., Aleo M.D., Morgan J.A., and Schnellmann R.G. Recovery of cellular functions following oxidant injury. Am. J. Physiol. 274 (1998) F509-F515
41. Nowak G., Keasler K.B., McKeller D.E., and Schnellmann R.G. Differential effects of EGF on repair of cellular functions after dichlorovinyl-l-cysteine-induced injury. Am. J. Physiol. 276 (1999) F228-F236
42. Schnellmann R.G. Measurement of oxygen consumption. In: Tyson C.A., and Frazier J.M. (Eds). Methods in Toxicology. (1994), Academic Press, New York 128-139
43. Scott S.C., and Cogliano V.J. Trichloroethylene health risk-State of the science. Environ. Health. Perspect. 108 (2000) 159-160
44. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., and Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150 (1985) 76-85
45. Tomasi A., Albano E., Biasi F., Slater T., Vannini V., and Dianzani M.U. Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat liver in vivo as detected by ESP-Spin trapping technique. Chem.-Biol. Interact. 55 (1985) 303-316
46. Toutain H., Vauclin-Jacques N., Fillastre J.P., and Morin J.P. Biochemical, functional and morphological characterization of a primary culture of rabbit proximal tubule cells. Exp. Cell Res. 194 (1991) 9-18
47. Trifillis A.L., Regec A.L., and Trump B.F. Isolation, culture and characterization of human renal tubular cells. J. Urol. 133 (1985) 324-329
48. Vaidya V.S., Shankar K., Lock E.A., Bucci T.J., and Mehendale H.M. Role of tissue repair in survival from S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol. Sci. 74 (2003) 215-227
49. Vaidya V.S., Shankar K., Lock E.A., Bucci T.J., and Mehendale H.M. Renal injury and repair following S-1, 2 dichlorovinyl-l-cysteine administration to mice. Toxicol Appl. Pharmacol. 188 (2003) 110-121
50. Vaidya V.S., Shankar K., Lock E.A., Dixon D., and Mehendale H.M. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol. Pathol. 31 (2003) 604-618
51. Vamvakas S., Bittner D., and Koster U. Enhanced expression of the protooncogenes c-myc and c-fos in normal and malignant renal growth. Toxicol. Lett. 67 (1993) 161-172
52. Wartenberg D., Reyner D., and Scott C.S. Trichloroethylene and cancer: epidemiologic evidence. Environ. Health Perspect. 108 (2000) 161-176