메뉴 건너뛰기




Volumn 108, Issue SUPPL. 2, 2000, Pages 225-240

Modes of action of trichloroethylene for kidney tumorigenesis

Author keywords

Cell proliferation; Cysteine conjugate lyase; Genotoxicity; Kidney; Oxidative stress; Peroxisome proliferation; Renal cancer; Trichloroethylene; (2u) globulin

Indexed keywords

ACYLTRANSFERASE; ALPHA 2 GLOBULIN; CALCIUM ION; CYTOCHROME P450; DNA; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; PROTEIN; S (1,2 DICHLOROVINYL)CYSTEINE; TRICHLOROETHYLENE;

EID: 0033945538     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.00108s2225     Document Type: Article
Times cited : (105)

References (209)
  • 2
    • 0005402937 scopus 로고    scopus 로고
    • Renal neoplasia
    • (Brenner BM, ed). Philadelphia:W.B. Saunders Company
    • Garnick MB, Richie JP. Renal neoplasia. In: The Kidney, Fifth Edition (Brenner BM, ed). Philadelphia:W.B. Saunders Company, 1996;1959-1977.
    • (1996) The Kidney, Fifth Edition , pp. 1959-1977
    • Garnick, M.B.1    Richie, J.P.2
  • 3
    • 0030719995 scopus 로고    scopus 로고
    • The national cancer data base: Report on kidney cancers
    • Marshall FF, Stewart AK, Menck HR. The national cancer data base: report on kidney cancers. Cancer 80:2167-2174 (1997).
    • (1997) Cancer , vol.80 , pp. 2167-2174
    • Marshall, F.F.1    Stewart, A.K.2    Menck, H.R.3
  • 5
    • 0003511663 scopus 로고    scopus 로고
    • Atlanta:American Cancer Society
    • ACS. Cancer Facts and Figures-1998. Atlanta:American Cancer Society, 1996.
    • (1996) Cancer Facts and Figures-1998
  • 6
    • 0003964361 scopus 로고    scopus 로고
    • Atlanta:American Cancer Society
    • ACS. Cancer Facts and Figures-1997. Atlanta:American Cancer Society, 1997.
    • (1997) Cancer Facts and Figures-1997
  • 10
    • 0028218588 scopus 로고
    • Risk factors for renal cell carcinoma in Denmark. I: Role of socioeconomic status, tobacco use, beverages, end family history
    • Mellemgaard A, Engholm G, McLaughlin JK, Olsen JH. Risk factors for renal cell carcinoma in Denmark. I: Role of socioeconomic status, tobacco use, beverages, end family history. Cancer Causes & Control 5:105-113 (1994).
    • (1994) Cancer Causes & Control , vol.5 , pp. 105-113
    • Mellemgaard, A.1    Engholm, G.2    McLaughlin, J.K.3    Olsen, J.H.4
  • 13
  • 20
    • 0027214533 scopus 로고
    • Risk of kidney cancer among patients using analgesics and diuretics: A population-based cohort study
    • Lindblad P, McLaughlin JK, Mellemgaard A, Adami HO. Risk of kidney cancer among patients using analgesics and diuretics: a population-based cohort study. Int J Cancer 55:5-9 (1993).
    • (1993) Int J Cancer , vol.55 , pp. 5-9
    • Lindblad, P.1    McLaughlin, J.K.2    Mellemgaard, A.3    Adami, H.O.4
  • 28
    • 0028123764 scopus 로고
    • Risk factors for renal-cell carcinoma in Denmark. III: Role of weight, physical activity and reproductive factors
    • Mellemgaard A, Engholm G, McLaugnlin JK, Olsen JH. Risk factors for renal-cell carcinoma in Denmark. III: Role of weight, physical activity and reproductive factors. Int J Cancer 56:66-71 (1994).
    • (1994) Int J Cancer , vol.56 , pp. 66-71
    • Mellemgaard, A.1    Engholm, G.2    McLaugnlin, J.K.3    Olsen, J.H.4
  • 30
    • 0027882439 scopus 로고
    • Renal cell cancer and exposure to gasoline: A review
    • McLaughlin JK. Renal cell cancer and exposure to gasoline: a review. Environ Health Perspect 101 (suppl 6):111-114 (1993).
    • (1993) Environ Health Perspect , vol.101 , Issue.SUPPL. 6 , pp. 111-114
    • McLaughlin, J.K.1
  • 34
    • 0024584089 scopus 로고
    • Critical review of cancer epidemiology in petroleum industry employees, with a quantitative meta-analysis by cancer site
    • Wong O, Raabe GK. Critical review of cancer epidemiology in petroleum industry employees, with a quantitative meta-analysis by cancer site. Am J Ind Med 15:283-310 (1989).
    • (1989) Am J Ind Med , vol.15 , pp. 283-310
    • Wong, O.1    Raabe, G.K.2
  • 35
    • 0030036445 scopus 로고    scopus 로고
    • A nested case-control study of kidney cancer among refinery/petrochemical workers
    • Gamble JF, Pearlman ED, Nicolich MJ. A nested case-control study of kidney cancer among refinery/petrochemical workers. Environ Health Perspect 104:642-650 (1996).
    • (1996) Environ Health Perspect , vol.104 , pp. 642-650
    • Gamble, J.F.1    Pearlman, E.D.2    Nicolich, M.J.3
  • 37
    • 0027291772 scopus 로고
    • Further follow-up of mortality in a United Kingdom oil distribution centre cohort
    • Rushton L. Further follow-up of mortality in a United Kingdom oil distribution centre cohort. Br J Ind Med 50:561-569 (1993).
    • (1993) Br J Ind Med , vol.50 , pp. 561-569
    • Rushton, L.1
  • 38
    • 0020554209 scopus 로고
    • Epidemiological survey of oil distribution centres in Britain
    • Rushton L, Alderson MR. Epidemiological survey of oil distribution centres in Britain. Br J Ind Med 40:330-339 (1981).
    • (1981) Br J Ind Med , vol.40 , pp. 330-339
    • Rushton, L.1    Alderson, M.R.2
  • 40
    • 0031445126 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Maher ER, Kaelin WG Jr. von Hippel-Lindau disease. Medicine 76:381-391 (1997).
    • (1997) Medicine , vol.76 , pp. 381-391
    • Maher, E.R.1    Kaelin W.G., Jr.2
  • 42
    • 0030932869 scopus 로고    scopus 로고
    • Gatekeepers and caretakers
    • Kinzler DW, Vogelstein B. Gatekeepers and caretakers. Nature 386:761-763 (1997).
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, D.W.1    Vogelstein, B.2
  • 44
    • 0024456735 scopus 로고
    • Urinary total protein and beta-2-microglobulin in workers exposed to trichloroethylene
    • Nagaya T, Ishikawa N, Hata H. Urinary total protein and beta-2-microglobulin in workers exposed to trichloroethylene. Environ Res 50:86-92 (1989).
    • (1989) Environ Res , vol.50 , pp. 86-92
    • Nagaya, T.1    Ishikawa, N.2    Hata, H.3
  • 45
    • 0027412485 scopus 로고
    • Subclinical effects on liver and kidney function and solvent exposure
    • Rasmussen K, Brogren CH, Sabroe S. Subclinical effects on liver and kidney function and solvent exposure. Int Arch Occup Environ Health 64:445-448 (1993).
    • (1993) Int Arch Occup Environ Health , vol.64 , pp. 445-448
    • Rasmussen, K.1    Brogren, C.H.2    Sabroe, S.3
  • 46
    • 0027468110 scopus 로고
    • Trichloroethylene exposure in vapor degreasing and the urinary excretion of N-acetyl-beta-D-glucosaminidase
    • Selden A, Hultberg B, Ulander A, Ahlbord G Jr. Trichloroethylene exposure in vapor degreasing and the urinary excretion of N-acetyl-beta-D-glucosaminidase. Arch Toxicol 67:224-226 (1993).
    • (1993) Arch Toxicol , vol.67 , pp. 224-226
    • Selden, A.1    Hultberg, B.2    Ulander, A.3    Ahlbord G., Jr.4
  • 47
    • 0031919809 scopus 로고    scopus 로고
    • Acute intoxication with trichloroethylene: Clinical symptoms, toxicokinetics, metabolism, and development of biochemical parameters for renal damage
    • Brüning T, Vamvakas S, Makropoulos V, Birner G. Acute intoxication with trichloroethylene: clinical symptoms, toxicokinetics, metabolism, and development of biochemical parameters for renal damage. Toxicol Sci 41:157-165 (1998).
    • (1998) Toxicol Sci , vol.41 , pp. 157-165
    • Brüning, T.1    Vamvakas, S.2    Makropoulos, V.3    Birner, G.4
  • 50
    • 0029075402 scopus 로고
    • Cancer incidence among Finnish workers exposed to halogenated hydrocarbons
    • Anttila A, Pukkala E, Sallmen M, Hernberg S, Hemminki K. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J Occup Med 37:797-806 (1995).
    • (1995) J Occup Med , vol.37 , pp. 797-806
    • Anttila, A.1    Pukkala, E.2    Sallmen, M.3    Hernberg, S.4    Hemminki, K.5
  • 51
    • 0028344623 scopus 로고
    • Updated and expanded Swedish cohort study of trichloroethylene and cancer risk
    • Axelsor O, Selden A, Andersson K, Hogstedt C. Updated and expanded Swedish cohort study of trichloroethylene and cancer risk. J Occup Med 36:556-562 (1994).
    • (1994) J Occup Med , vol.36 , pp. 556-562
    • Axelsor, O.1    Selden, A.2    Andersson, K.3    Hogstedt, C.4
  • 52
    • 0025784352 scopus 로고
    • Retrospective cohort mortality study of worker at an aircraft maintenance facility. II: Exposures and the assessment
    • Spirtas R, Stewart P, Lee S. Retrospective cohort mortality study of worker at an aircraft maintenance facility. II: Exposures and the assessment. Br J Ind Med 48:531-537 (1991).
    • (1991) Br J Ind Med , vol.48 , pp. 531-537
    • Spirtas, R.1    Stewart, P.2    Lee, S.3
  • 53
    • 0028929211 scopus 로고
    • Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene
    • Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol 69:291-299 (1995).
    • (1995) Arch Toxicol , vol.69 , pp. 291-299
    • Henschler, D.1    Vamvakas, S.2    Lammert, M.3    Dekant, W.4    Kraus, B.5    Thomas, B.6    Ulm, K.7
  • 54
    • 0029444026 scopus 로고
    • Increased incidence of renal cell tumors in a cohort of workers exposed to trichloroethylene
    • Bloemen LJ, Tomenson J. Increased incidence of renal cell tumors in a cohort of workers exposed to trichloroethylene [Letter to the Editor]. Arch Toxicol 70:129-130 (1995).
    • (1995) Arch Toxicol , vol.70 , pp. 129-130
    • Bloemen, L.J.1    Tomenson, J.2
  • 55
    • 0029444026 scopus 로고
    • Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene
    • Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene [Reply]. Arch Toxicol 70:131-133 (1995).
    • (1995) Arch Toxicol , vol.70 , pp. 131-133
    • Henschler, D.1    Vamvakas, S.2    Lammert, M.3    Dekant, W.4    Kraus, B.5    Thomas, B.6    Ulm, K.7
  • 56
    • 0000043292 scopus 로고
    • Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene
    • Swaen GMH. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene [Letter to the Editor]. Arch Toxicol 70:127-128 (1995).
    • (1995) Arch Toxicol , vol.70 , pp. 127-128
    • Swaen, G.M.H.1
  • 57
    • 0030768274 scopus 로고    scopus 로고
    • A critical review of epidemiology studies of trichloroethylene and perchloroethylene and risk of renal-cell cancer
    • McLaughlin JK, Blot WJ. A critical review of epidemiology studies of trichloroethylene and perchloroethylene and risk of renal-cell cancer. Int Arch Occup Environ Health 70:222-231 (1997).
    • (1997) Int Arch Occup Environ Health , vol.70 , pp. 222-231
    • McLaughlin, J.K.1    Blot, W.J.2
  • 58
    • 0030052417 scopus 로고    scopus 로고
    • Cancer in relation to occupational exposure to trichloroethylene
    • Weiss NS. Cancer in relation to occupational exposure to trichloroethylene. Occup Environ Med 53:1-5 (1996).
    • (1996) Occup Environ Med , vol.53 , pp. 1-5
    • Weiss, N.S.1
  • 59
    • 0031920256 scopus 로고    scopus 로고
    • Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: Extended follow up
    • Blair A, Hartge P, Stewart PA, McAdams M, Lubin J. Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up. Occup Environ Med 55:161-171 (1998).
    • (1998) Occup Environ Med , vol.55 , pp. 161-171
    • Blair, A.1    Hartge, P.2    Stewart, P.A.3    McAdams, M.4    Lubin, J.5
  • 60
    • 0031806607 scopus 로고    scopus 로고
    • Mortality of aerospace workers exposed to trichloroethylene
    • Morgan RW, Kelsh MA, Zhao K, Heringer S, Mortality of aerospace workers exposed to trichloroethylene. Epidemiology 9:424-431 (1998).
    • (1998) Epidemiology , vol.9 , pp. 424-431
    • Morgan, R.W.1    Kelsh, M.A.2    Zhao, K.3    Heringer, S.4
  • 63
    • 0029682040 scopus 로고    scopus 로고
    • Preexistence of chronic tubular damage in cases of renal cell cancer after long and high exposure to trichloroethylene
    • Brüning T, Golka K, Makropoulos V, Bolt HM. Preexistence of chronic tubular damage in cases of renal cell cancer after long and high exposure to trichloroethylene. Arch Toxicol 70:259-260 (1996).
    • (1996) Arch Toxicol , vol.70 , pp. 259-260
    • Brüning, T.1    Golka, K.2    Makropoulos, V.3    Bolt, H.M.4
  • 64
    • 0030900929 scopus 로고    scopus 로고
    • Renal cell carcinomas in trichloroethylene (TRI) exposed persons associated with somatic mutations in the von Hippel-Lindau (VHL) tumor suppressor gene
    • Brüning T, Weirich G, Hornauer MA, Hofler H, Brauch H. Renal cell carcinomas in trichloroethylene (TRI) exposed persons associated with somatic mutations in the von Hippel-Lindau (VHL) tumor suppressor gene. Arch Toxicol 71:332-335 (1997).
    • (1997) Arch Toxicol , vol.71 , pp. 332-335
    • Brüning, T.1    Weirich, G.2    Hornauer, M.A.3    Hofler, H.4    Brauch, H.5
  • 65
    • 0030755987 scopus 로고    scopus 로고
    • Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene
    • Brüning T, Lammert M, Kempkes M, Their R, Golka K, Bolt HM. Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene. Arch Toxicol 71:596-599 (1997).
    • (1997) Arch Toxicol , vol.71 , pp. 596-599
    • Brüning, T.1    Lammert, M.2    Kempkes, M.3    Their, R.4    Golka, K.5    Bolt, H.M.6
  • 66
    • 4243892922 scopus 로고    scopus 로고
    • Dose-dependent mutagenicity at the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell cancer (RCC) patients exposed to trichloroethylene (TRI)
    • Brüning T, Weirich G, Belt HM, Brauch H. Dose-dependent mutagenicity at the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell cancer (RCC) patients exposed to trichloroethylene (TRI) [Abstract]. Toxicologist/Toxicol Sci 42:238 (1998).
    • (1998) Toxicologist/Toxicol Sci , vol.42 , pp. 238
    • Brüning, T.1    Weirich, G.2    Belt, H.M.3    Brauch, H.4
  • 67
    • 4244171262 scopus 로고    scopus 로고
    • Personal communication
    • Brüning T. Personal communication.
    • Brüning, T.1
  • 68
    • 0018840773 scopus 로고    scopus 로고
    • Carcinogenicity studies of trichloroethylene by longterm inhalation in three animal species
    • Henschler D, Romen W, Elsasser HM, Reichert D, Eder E, Radwan Z. Carcinogenicity studies of trichloroethylene by longterm inhalation in three animal species. Arch Toxicol 43:237-248.
    • Arch Toxicol , vol.43 , pp. 237-248
    • Henschler, D.1    Romen, W.2    Elsasser, H.M.3    Reichert, D.4    Eder, E.5    Radwan, Z.6
  • 69
    • 0023690866 scopus 로고
    • Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice
    • Maltoni C, Lefemine G, Cotti G, Perino G. Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann NY Acad Sci 534:316-342 (1988).
    • (1988) Ann NY Acad Sci , vol.534 , pp. 316-342
    • Maltoni, C.1    Lefemine, G.2    Cotti, G.3    Perino, G.4
  • 73
    • 0003496877 scopus 로고
    • NTP TR 243. Research Triangle Park, NC: National Toxicology Program
    • 1 Mice (Gavage Study). NTP TR 243. Research Triangle Park, NC: National Toxicology Program, 1990.
    • (1990) 1 Mice (Gavage Study)
  • 74
    • 0003980471 scopus 로고
    • Office of Health and Environmental Assessment. EPA/600/8-82/006F. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. Health Assessment Document for Trichloroethylene. Final Report. Office of Health and Environmental Assessment. EPA/600/8-82/006F. Washington, DC:U.S. Environmental Protection Agency, 1985.
    • (1985) Health Assessment Document for Trichloroethylene. Final Report
  • 76
    • 0028842980 scopus 로고
    • Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway
    • Goeptar AR, Commandeur JNM, van Ommen B, van Bladeren PJ, Vermeulen NPE. Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway. Chem Res Toxicol 83-21 (1995).
    • (1995) Chem Res Toxicol , pp. 83-121
    • Goeptar, A.R.1    Commandeur, J.N.M.2    Van Ommen, B.3    Van Bladeren, P.J.4    Vermeulen, N.P.E.5
  • 77
    • 0028619861 scopus 로고
    • Role of renal metabolism in risk to toxic chemicals
    • Lash LH. Role of renal metabolism in risk to toxic chemicals. Environ Health Perspect 102:75-79 (1994).
    • (1994) Environ Health Perspect , vol.102 , pp. 75-79
    • Lash, L.H.1
  • 78
    • 0008270722 scopus 로고
    • The role of metabolism in chemically-induced nephrotoxicity
    • (Goldstein RS, ed). Boca Raton, FL:CRC Press
    • Lash LH. The role of metabolism in chemically-induced nephrotoxicity. In: Mechanisms of Injury in Renal Disease and Toxicity (Goldstein RS, ed). Boca Raton, FL:CRC Press, 1994;207-234.
    • (1994) Mechanisms of Injury in Renal Disease and Toxicity , pp. 207-234
    • Lash, L.H.1
  • 79
    • 0026666663 scopus 로고
    • Evidence for elevation of cytochrone P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administraton
    • Kim H, Kim SG, Lee M-Y, Novak RF. Evidence for elevation of cytochrone P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administrat on Biochem Biophys Res Commun 186:846-853 (1992).
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 846-853
    • Kim, H.1    Kim, S.G.2    Lee, M.-Y.3    Novak, R.F.4
  • 80
    • 0028286317 scopus 로고
    • Characterization of pyrazole and 4-methylpyrazole induction of cytochrorne P4502E1 in rat kidney
    • Wu D, Cederbaum AI. Characterization of pyrazole and 4-methylpyrazole induction of cytochrorne P4502E1 in rat kidney. J Pharmacol Exp Ther 270:407-413 (1994).
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 407-413
    • Wu, D.1    Cederbaum, A.I.2
  • 81
    • 0029166099 scopus 로고
    • Glutathione-dependent metabolism of trichloroethylene in isolated liver end kidney cells of rats and its role in mitochondrial and cellular toxicity
    • Lash LH, Xu Y, Elfarra AA, Duescher RJ, Parker JC. Glutathione-dependent metabolism of trichloroethylene in isolated liver end kidney cells of rats and its role in mitochondrial and cellular toxicity. Drug Metab Dispos 23:846-853 (1995).
    • (1995) Drug Metab Dispos , vol.23 , pp. 846-853
    • Lash, L.H.1    Xu, Y.2    Elfarra, A.A.3    Duescher, R.J.4    Parker, J.C.5
  • 82
    • 0031919247 scopus 로고    scopus 로고
    • Glutathione conjugation of trichloroethylene in rats and mice: Sex-, species-, and tissue-dependent differences
    • Lash LH, Qian W, Putt DA, Jacobs K, Elfarra AA, Krause RJ, Parker JC. Glutathione conjugation of trichloroethylene in rats and mice: Sex-, species-, and tissue-dependent differences. Drug Metab Dispos 26:12-19 (1998).
    • (1998) Drug Metab Dispos , vol.26 , pp. 12-19
    • Lash, L.H.1    Qian, W.2    Putt, D.A.3    Jacobs, K.4    Elfarra, A.A.5    Krause, R.J.6    Parker, J.C.7
  • 84
    • 0032524925 scopus 로고    scopus 로고
    • Formic acid excretion in rats dosed with trichloroethylene a possible explanation for long term kidney damage
    • Green T, Dow J, Foster JR, Hext PM. Formic acid excretion in rats dosed with trichloroethylene a possible explanation for long term kidney damage. Toxicology 127:39-47 (1998).
    • (1998) Toxicology , vol.127 , pp. 39-47
    • Green, T.1    Dow, J.2    Foster, J.R.3    Hext, P.M.4
  • 85
    • 0033947603 scopus 로고    scopus 로고
    • Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate
    • Bull RJ. Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. Environ Health Perspect 108(suppl 2):241-259 (2000).
    • (2000) Environ Health Perspect , vol.108 , Issue.SUPPL. 2 , pp. 241-259
    • Bull, R.J.1
  • 86
    • 0027365916 scopus 로고
    • In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation
    • Bruschi SA, Bull RJ. In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation. Fundam Appl Toxicol 21:366-375 (1993).
    • (1993) Fundam Appl Toxicol , vol.21 , pp. 366-375
    • Bruschi, S.A.1    Bull, R.J.2
  • 87
    • 0027253691 scopus 로고
    • The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene
    • Bull RJ, Templin M, Larson JL, Stevens DK. The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene. Toxicol Lett 68:203-211 (1993).
    • (1993) Toxicol Lett , vol.68 , pp. 203-211
    • Bull, R.J.1    Templin, M.2    Larson, J.L.3    Stevens, D.K.4
  • 88
    • 0023269323 scopus 로고
    • Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity
    • Goldsworthy TL, Popp JA. Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity. Toxicol Appl Pharmacol 88:225-233 (1987).
    • (1987) Toxicol Appl Pharmacol , vol.88 , pp. 225-233
    • Goldsworthy, T.L.1    Popp, J.A.2
  • 89
    • 0023819178 scopus 로고
    • The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat
    • Odum J, Green T, Foster JR, Hext PM. The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol Appl Pharmacol 92:103-112 (1988).
    • (1988) Toxicol Appl Pharmacol , vol.92 , pp. 103-112
    • Odum, J.1    Green, T.2    Foster, J.R.3    Hext, P.M.4
  • 90
    • 0028289751 scopus 로고
    • Peroxisomes in liver, heart, and kidney of mice fed a commercial fish oil preparation: Original data and review on peroxisomal changes induced by high-fat diets
    • De Craemer D, Vamecq J, Roels F, Vallee L, Pauwels M, van den Branden C. Peroxisomes in liver, heart, and kidney of mice fed a commercial fish oil preparation: original data and review on peroxisomal changes induced by high-fat diets. J Lipid Res 35:1241-1250 (1994).
    • (1994) J Lipid Res , vol.35 , pp. 1241-1250
    • De Craemer, D.1    Vamecq, J.2    Roels, F.3    Vallee, L.4    Pauwels, M.5    Van Den Branden, C.6
  • 91
    • 0029073466 scopus 로고
    • Peroxisomes in mice fed a diet supplemented with low doses of fish oil
    • van den Branden C, De Craemer D, Pauwels M, Vamecq J. Peroxisomes in mice fed a diet supplemented with low doses of fish oil. Lipids 30:701-705 (1995).
    • (1995) Lipids , vol.30 , pp. 701-705
    • Van Den Branden, C.1    De Craemer, D.2    Pauwels, M.3    Vamecq, J.4
  • 92
    • 0028710166 scopus 로고
    • Effects of di-(2-ethylhexyl)phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups
    • Cimini AM, Sulli A, Stefanini S, Serafini B, Moreno S, Rossi L, Giorgi M, Ceru MP. Effects of di-(2-ethylhexyl)phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups. Cell Mol Biol 40:1063-1076 (1994).
    • (1994) Cell Mol Biol , vol.40 , pp. 1063-1076
    • Cimini, A.M.1    Sulli, A.2    Stefanini, S.3    Serafini, B.4    Moreno, S.5    Rossi, L.6    Giorgi, M.7    Ceru, M.P.8
  • 93
    • 0026671184 scopus 로고
    • Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone
    • Sundseth SS, Waxman DJ. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J Biol Chem 267:3915-3921 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 3915-3921
    • Sundseth, S.S.1    Waxman, D.J.2
  • 94
    • 0023755328 scopus 로고
    • Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat
    • Nemali MR, Usuda N, Reddy MK, Oyasu K, Hashimoto T, Osumi T, Rao MS, Reddy JK. Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat. Cancer Res 48:5316-5324 (1988).
    • (1988) Cancer Res , vol.48 , pp. 5316-5324
    • Nemali, M.R.1    Usuda, N.2    Reddy, M.K.3    Oyasu, K.4    Hashimoto, T.5    Osumi, T.6    Rao, M.S.7    Reddy, J.K.8
  • 95
    • 0024307512 scopus 로고
    • Changes in peroxisomes and mitochondria in liver of ethionine exposed rats: A biochemical and morphological investigation
    • Aersaether N, Aarsland A, Kryvi H, Nilsson A, Svardal A, Ueland PM, Berge RK. Changes in peroxisomes and mitochondria in liver of ethionine exposed rats: a biochemical and morphological investigation. Carcinogenesis 10:987-994 (1939).
    • (1939) Carcinogenesis , vol.10 , pp. 987-994
    • Aersaether, N.1    Aarsland, A.2    Kryvi, H.3    Nilsson, A.4    Svardal, A.5    Ueland, P.M.6    Berge, R.K.7
  • 96
    • 0025968912 scopus 로고
    • Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Oxidation of valproate by liver peroxisomes
    • Ponchaut S, Draye JP, Veitch K, van Hoof F. Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Oxidation of valproate by liver peroxisomes. Biochem Pharmacol 41:1419-1428 (1991).
    • (1991) Biochem Pharmacol , vol.41 , pp. 1419-1428
    • Ponchaut, S.1    Draye, J.P.2    Veitch, K.3    Van Hoof, F.4
  • 97
    • 0028051401 scopus 로고
    • The relevance of hepatic peroxisome proliferation in rats to assessment of human carcinogenic risk for pharmaceuticals
    • Kluwe WM. The relevance of hepatic peroxisome proliferation in rats to assessment of human carcinogenic risk for pharmaceuticals. Regul Toxicol Pharmacol 20:170-186 (1994).
    • (1994) Regul Toxicol Pharmacol , vol.20 , pp. 170-186
    • Kluwe, W.M.1
  • 98
    • 0029557218 scopus 로고
    • Peroxisome proliferation current mechanisms relating to non-genotoxic carcinogenesis
    • Lake BG. Peroxisome proliferation current mechanisms relating to non-genotoxic carcinogenesis. Toxicol Lett 82/83:673-681 (1995).
    • (1995) Toxicol Lett , vol.82-83 , pp. 673-681
    • Lake, B.G.1
  • 99
  • 100
    • 0024232016 scopus 로고
    • Potential role of α-2u-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylere, and pentachloroethane
    • Goldsworthy TL, Lyght D, Burnett VL, Popp JA. Potential role of α-2u-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylere, and pentachloroethane. Toxicol Appl Pharmacol 96:367-379 (1988).
    • (1988) Toxicol Appl Pharmacol , vol.96 , pp. 367-379
    • Goldsworthy, T.L.1    Lyght, D.2    Burnett, V.L.3    Popp, J.A.4
  • 101
    • 0026706646 scopus 로고
    • An alternative hypothesis on the role of chemically induced protein droplet (α2u-globulin) nephropathy in renal carcinogenesis
    • Melnick RL. An alternative hypothesis on the role of chemically induced protein droplet (α2u-globulin) nephropathy in renal carcinogenesis. Regul Toxicol Pharmacol 16:111-125 (1992).
    • (1992) Regul Toxicol Pharmacol , vol.16 , pp. 111-125
    • Melnick, R.L.1
  • 102
    • 0027524742 scopus 로고
    • Critique of R. Melnick's "An Alternative Hypothesis on the Role of Chemically Induced Protein Droplet (α2u-Globulin) Nephropathy in Renal Carcinogenesis."
    • Borghoff SJ, Lehman-McKeeman LD, Short BG, Hard GC, Swenberg JA. Critique of R. Melnick's "An Alternative Hypothesis on the Role of Chemically Induced Protein Droplet (α2u-Globulin) Nephropathy in Renal Carcinogenesis." Regul Toxicol Pharmacol 18:357-364 (1993).
    • (1993) Regul Toxicol Pharmacol , vol.18 , pp. 357-364
    • Borghoff, S.J.1    Lehman-McKeeman, L.D.2    Short, B.G.3    Hard, G.C.4    Swenberg, J.A.5
  • 103
    • 0027423125 scopus 로고
    • Critique does not validate assumptons in the model on α2u-globulin and renal carcinogenesis
    • Melnick RL. Critique does not validate assumptons in the model on α2u-globulin and renal carcinogenesis. Regul Toxicol Pharmacol 18:365-368 (1993).
    • (1993) Regul Toxicol Pharmacol , vol.18 , pp. 365-368
    • Melnick, R.L.1
  • 104
    • 0003817412 scopus 로고
    • Chap 6. Washington:National Academy Press
    • National Research Council. Biologic Markets in Urinary Toxicology. Chap 6. Washington:National Academy Press, 1995.
    • (1995) Biologic Markets in Urinary Toxicology
  • 105
    • 0026011341 scopus 로고
    • The human relevance of the renal tumor-inducing potential of d-limonene in male rats: Implications for risk assessment
    • Flamm WG, Lehman-McKeeman LD. The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment. Regul Toxicol Pharmacol 13:70-86 (1991).
    • (1991) Regul Toxicol Pharmacol , vol.13 , pp. 70-86
    • Flamm, W.G.1    Lehman-McKeeman, L.D.2
  • 106
    • 0030345304 scopus 로고    scopus 로고
    • α2u-Globulin nephropathy in white ravens
    • Ashby J. α2u-Globulin nephropathy in white ravens [Letter]. Environ Health Perspect 104:1264 (1996).
    • (1996) Environ Health Perspect , vol.104 , pp. 1264
    • Ashby, J.1
  • 107
    • 0031228877 scopus 로고    scopus 로고
    • The relevance of mechanistic data to the interpretation and extrapolation to humans of rodent carcinogenicity data
    • Ashby J. The relevance of mechanistic data to the interpretation and extrapolation to humans of rodent carcinogenicity data [Letter]. Environ Health Perspect 105:902-903 (1997).
    • (1997) Environ Health Perspect , vol.105 , pp. 902-903
    • Ashby, J.1
  • 108
    • 0031226723 scopus 로고    scopus 로고
    • α2u-Globulin nephropathy and ravens: Do ravens of a different feather flock together?
    • de la Iglesia FA, Gough AW, Sigler RE. α2u-Globulin nephropathy and ravens: Do ravens of a different feather flock together? [Letter]. Environ Health Perspect 105:903-904 (1997).
    • (1997) Environ Health Perspect , vol.105 , pp. 903-904
    • De La Iglesia, F.A.1    Gough, A.W.2    Sigler, R.E.3
  • 109
    • 0030779515 scopus 로고    scopus 로고
    • Doubting nongenotoxic mechanisms of renal cancer: Comparing apples and oranges in the α2u-globulin hypothesis
    • Dietrich DR. Doubting nongenotoxic mechanisms of renal cancer: comparing apples and oranges in the α2u-globulin hypothesis [Letter]. Environ Health Perspect 105:898-902 (1997).
    • (1997) Environ Health Perspect , vol.105 , pp. 898-902
    • Dietrich, D.R.1
  • 110
    • 0029242698 scopus 로고
    • Mechanisms, chemical carcinogenesis, and risk assessment: Cell proliferation and cancer
    • Huff J. Mechanisms, chemical carcinogenesis, and risk assessment: cell proliferation and cancer. Am J Ind Med 27:293-300 (1995).
    • (1995) Am J Ind Med , vol.27 , pp. 293-300
    • Huff, J.1
  • 111
    • 0000623272 scopus 로고    scopus 로고
    • Response: α2u-Globulin nephropathy, proposed mechanisms, and white ravens
    • Huff J. Response: α2u-Globulin nephropathy, proposed mechanisms, and white ravens [Letter]. Environ Health Perspect 104:1264-1267 (1996).
    • (1996) Environ Health Perspect , vol.104 , pp. 1264-1267
    • Huff, J.1
  • 112
    • 0030733013 scopus 로고    scopus 로고
    • Weight of evidence versus weight of speculation to evaluate the α2u-globulin hypothesis
    • Melnick RL, Kohn MC, Huff J. Weight of evidence versus weight of speculation to evaluate the α2u-globulin hypothesis. Environ Health Perspect 105:904-906 (1997).
    • (1997) Environ Health Perspect , vol.105 , pp. 904-906
    • Melnick, R.L.1    Kohn, M.C.2    Huff, J.3
  • 113
    • 0020263329 scopus 로고
    • Mutagenicity of trichloroethylene in Salmonella typhimurium TA100
    • Crebelli R, Bignami M, Conti L, Carere A. Mutagenicity of trichloroethylene in Salmonella typhimurium TA100. Ann 1st Super Sanita 18:117-122 (1982).
    • (1982) Ann 1st Super Sanita , vol.18 , pp. 117-122
    • Crebelli, R.1    Bignami, M.2    Conti, L.3    Carere, A.4
  • 114
    • 0001296211 scopus 로고
    • Mutagenic activity of chemicals identified in drinking water
    • Simmon VF, Kauhanen K, Tardiff RG. Mutagenic activity of chemicals identified in drinking water. Prog Genet Toxicol 2:249-258 (1977).
    • (1977) Prog Genet Toxicol , vol.2 , pp. 249-258
    • Simmon, V.F.1    Kauhanen, K.2    Tardiff, R.G.3
  • 115
    • 0021967948 scopus 로고
    • Mutagenicity of trichloroethylene trichloroethanol and chloral hydrate in Asoergillus nidulan
    • Crebelli R, Conti G, Conti L, Carere A. Mutagenicity of trichloroethylene trichloroethanol and chloral hydrate in Asoergillus nidulan. Mutat Res 155:105-111 (1985).
    • (1985) Mutat Res , vol.155 , pp. 105-111
    • Crebelli, R.1    Conti, G.2    Conti, L.3    Carere, A.4
  • 116
    • 0018762855 scopus 로고
    • Sister chromatid exchange induced by inhaled anesthetics
    • White AE, Eger EI, Wolff S, Stevens WC. Sister chromatid exchange induced by inhaled anesthetics. Anesthesiology 50:426-430 (1979).
    • (1979) Anesthesiology , vol.50 , pp. 426-430
    • White, A.E.1    Eger, E.I.2    Wolff, S.3    Stevens, W.C.4
  • 117
    • 0021879775 scopus 로고
    • Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/ DNA repair assays under vapor phase exposure conditions
    • Shimada T, Swanson AF, Leber P, Williams GM. Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/ DNA repair assays under vapor phase exposure conditions. Cell Biol Toxicol 1:159-179 (1985).
    • (1985) Cell Biol Toxicol , vol.1 , pp. 159-179
    • Shimada, T.1    Swanson, A.F.2    Leber, P.3    Williams, G.M.4
  • 118
    • 0024600976 scopus 로고
    • Sister chromatid exchanges in lymphocytes of workers exposed to trichloroethylene
    • Nagaya T, Ishikawa N, Hata H. Sister chromatid exchanges in lymphocytes of workers exposed to trichloroethylene. Mutat Res 222:279-282 (1989).
    • (1989) Mutat Res , vol.222 , pp. 279-282
    • Nagaya, T.1    Ishikawa, N.2    Hata, H.3
  • 119
    • 0023023223 scopus 로고
    • Bacterial β-lyase and the mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene
    • Dekant W, Vamvakas S, Berthold K, Schmidt S, Wild D, Henschler D. Bacterial β-lyase and the mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem-Biol Interact 60:31-45 (1985).
    • (1985) Chem-Biol Interact , vol.60 , pp. 31-45
    • Dekant, W.1    Vamvakas, S.2    Berthold, K.3    Schmidt, S.4    Wild, D.5    Henschler, D.6
  • 120
  • 121
    • 0025734238 scopus 로고
    • Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene
    • Commandeur JN, Boogaard PJ, Mulder GJ, Vermeulen NP. Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Arch Toxicol 65:373-380 (1991).
    • (1991) Arch Toxicol , vol.65 , pp. 373-380
    • Commandeur, J.N.1    Boogaard, P.J.2    Mulder, G.J.3    Vermeulen, N.P.4
  • 122
    • 0024259272 scopus 로고
    • Incuction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons
    • Vamvakas S, Dekant W, Schiffmann D, Henschler D. Incuction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons. Cell Biol Toxicol 4:393-403 (1988).
    • (1988) Cell Biol Toxicol , vol.4 , pp. 393-403
    • Vamvakas, S.1    Dekant, W.2    Schiffmann, D.3    Henschler, D.4
  • 123
    • 0024535906 scopus 로고
    • Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes
    • Vamvakas S, Dekant W, Herschler D. Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes. Mutat Res 222:329-335 (1989).
    • (1989) Mutat Res , vol.222 , pp. 329-335
    • Vamvakas, S.1    Dekant, W.2    Herschler, D.3
  • 125
    • 0021867892 scopus 로고
    • Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro-and fluoroalkenes
    • Green T, Odum J. Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro-and fluoroalkenes. Chem-Biol Interact 54:15-31 (1985).
    • (1985) Chem-biol Interact , vol.54 , pp. 15-31
    • Green, T.1    Odum, J.2
  • 126
    • 0031670446 scopus 로고    scopus 로고
    • Chlorothionetene, the ultimate reactive intermediate formed by cysteine conjugate β-lyase-mediated cleavage of the trichloroethene metabolite S-(1,2-dichlorovinyl)-L-cysteine, forms cytosine adducts in organic solvents, but not in aqueous solution
    • Völkel W, Dekant W. Chlorothionetene, the ultimate reactive intermediate formed by cysteine conjugate β-lyase-mediated cleavage of the trichloroethene metabolite S-(1,2-dichlorovinyl)-L-cysteine, forms cytosine adducts in organic solvents, but not in aqueous solution. Chem Res Toxicol 11:1082-1088 (1998).
    • (1998) Chem Res Toxicol , vol.11 , pp. 1082-1088
    • Völkel, W.1    Dekant, W.2
  • 127
    • 0023833943 scopus 로고
    • Studies of acute nephrotoxic potential of trichloroethylene in Fischer 344 rats
    • Chakrabarti SK, Tuchweber B. Studies of acute nephrotoxic potential of trichloroethylene in Fischer 344 rats. J Toxicol Environ Health 23:147-158 (1988).
    • (1988) J Toxicol Environ Health , vol.23 , pp. 147-158
    • Chakrabarti, S.K.1    Tuchweber, B.2
  • 128
    • 0024582131 scopus 로고
    • Lipid peroxidation: A possible mechanism of trichloroethylene-induced nephrotoxicity
    • Cojocel C, Beuter W, Mullet W, Mayer D. Lipid peroxidation: a possible mechanism of trichloroethylene-induced nephrotoxicity. Toxicology 55:131-141 (1989).
    • (1989) Toxicology , vol.55 , pp. 131-141
    • Cojocel, C.1    Beuter, W.2    Mullet, W.3    Mayer, D.4
  • 129
    • 50549203697 scopus 로고    scopus 로고
    • A pathological study on the toxicity of S-d-chlorovinyl-L-cysteine
    • Terracini B, Parker VH. A pathological study on the toxicity of S-d-chlorovinyl-L-cysteine. Food Cosmet Toxicol 3:67-74 (1965).
    • (1965) Food Cosmet Toxicol , vol.3 , pp. 67-74
    • Terracini, B.1    Parker, V.H.2
  • 130
    • 0021729969 scopus 로고
    • Chronic toxicity of S-(trans-1,2-dichlorovinyl)-L-cysteine in mice
    • Jafte DR, Gandolfi AJ, Nagle RB. Chronic toxicity of S-(trans-1,2-dichlorovinyl)-L-cysteine in mice. J Appl Toxicol 4:315-319 (1984).
    • (1984) J Appl Toxicol , vol.4 , pp. 315-319
    • Jafte, D.R.1    Gandolfi, A.J.2    Nagle, R.B.3
  • 131
    • 0022492563 scopus 로고
    • Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity
    • Elfarra AA, Jakobsor I, Anders MW. Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem Pharmacol 35:283-288 (1986).
    • (1986) Biochem Pharmacol , vol.35 , pp. 283-288
    • Elfarra, A.A.1    Jakobsor, I.2    Anders, M.W.3
  • 132
    • 0024452086 scopus 로고
    • Dichlorovinyl cysteine (DCVC) in the mouse kidney tissue-binding and toxicity after glulathione depletion and probenecid treatment
    • Darnerud PO, Brandt I, Feil VJ, Bakke JE. Dichlorovinyl cysteine (DCVC) in the mouse kidney tissue-binding and toxicity after glulathione depletion and probenecid treatment. Arch Toxicol 63:345-350 (1989).
    • (1989) Arch Toxicol , vol.63 , pp. 345-350
    • Darnerud, P.O.1    Brandt, I.2    Feil, V.J.3    Bakke, J.E.4
  • 134
    • 0024425380 scopus 로고
    • In vitro and n vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine
    • Wolfgang GH, Gandolfi AJ, Stevens JL, Brendel K. In vitro and n vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine. Toxicology 58:33-42 (1989).
    • (1989) Toxicology , vol.58 , pp. 33-42
    • Wolfgang, G.H.1    Gandolfi, A.J.2    Stevens, J.L.3    Brendel, K.4
  • 135
    • 0030069864 scopus 로고    scopus 로고
    • Alterations of the renal function in the solated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine
    • Ilinskaja O, Vamvakas S. Alterations of the renal function in the solated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine. Arch Toxicol 70:224-229 (1996).
    • (1996) Arch Toxicol , vol.70 , pp. 224-229
    • Ilinskaja, O.1    Vamvakas, S.2
  • 136
    • 0023500127 scopus 로고
    • Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation
    • Dekant W, Martens G, Vamvakas S, Metzler M, Henschler D. Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation. Drug Metab Dispos 15:702-709 (1987).
    • (1987) Drug Metab Dispos , vol.15 , pp. 702-709
    • Dekant, W.1    Martens, G.2    Vamvakas, S.3    Metzler, M.4    Henschler, D.5
  • 137
    • 0023937244 scopus 로고
    • Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichorovinyl)-L-cysteine by cysleme conjugate β-lyase
    • Dekant W, Berthold K, Vamvakas S, Henschler D, Anders MW. Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichorovinyl)-L-cysteine by cysleme conjugate β-lyase. Chem Res Toxicol 1:175-178 (1988).
    • (1988) Chem Res Toxicol , vol.1 , pp. 175-178
    • Dekant, W.1    Berthold, K.2    Vamvakas, S.3    Henschler, D.4    Anders, M.W.5
  • 138
    • 0022870699 scopus 로고
    • Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells
    • Lash LH, Anders MW. Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. J Biol Chem 261:13076-13081 (1986).
    • (1986) J Biol Chem , vol.261 , pp. 13076-13081
    • Lash, L.H.1    Anders, M.W.2
  • 140
    • 0025284579 scopus 로고
    • Assessment of S-(1,2-dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity
    • Wolfgang GHI, Gandolfi AJ, Nagle RB, Brendel K, Stevens JL. Assessment of S-(1,2-dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity. Chem-Biol Interact 75:153-170 (1990).
    • (1990) Chem-Biol Interact , vol.75 , pp. 153-170
    • Wolfgang, G.H.I.1    Gandolfi, A.J.2    Nagle, R.B.3    Brendel, K.4    Stevens, J.L.5
  • 141
    • 0020962550 scopus 로고
    • Regulation of a S(trans-1,2-dichlorovinyl)-L-cysteine-induced renal tubular toxicity by glutathione
    • Hassall CD, Brendel K, Gandolfi AJ. Regulation of a S(trans-1,2-dichlorovinyl)-L-cysteine-induced renal tubular toxicity by glutathione. J Appl Toxicol 3:321-325 (1983).
    • (1983) J Appl Toxicol , vol.3 , pp. 321-325
    • Hassall, C.D.1    Brendel, K.2    Gandolfi, A.J.3
  • 142
    • 0027565003 scopus 로고
    • Differential cellular effects in the toxicity of haloalkene and tialoalkane cysteine conjugates to rabbit renal proximal tubules
    • Groves CE, Hayden PJ, Lock EA, Schnellmann RG. Differential cellular effects in the toxicity of haloalkene and tialoalkane cysteine conjugates to rabbit renal proximal tubules. J Biochem Toxicol 8:49-56 (1993).
    • (1993) J Biochem Toxicol , vol.8 , pp. 49-56
    • Groves, C.E.1    Hayden, P.J.2    Lock, E.A.3    Schnellmann, R.G.4
  • 143
    • 0025228615 scopus 로고
    • Purification and characterization of human kidney cytosolic cysteine conjugate β-lyase activity
    • Lash LH, Nelson RM, Van Dyke RA, Anders MW. Purification and characterization of human kidney cytosolic cysteine conjugate β-lyase activity. Drug Metab Dispos 18:50-54 (1990).
    • (1990) Drug Metab Dispos , vol.18 , pp. 50-54
    • Lash, L.H.1    Nelson, R.M.2    Van Dyke, R.A.3    Anders, M.W.4
  • 144
    • 0025252253 scopus 로고
    • Renal cysteine conjugate β-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells
    • Chen JC, Stevens JL, Trifillis AL, Jones TW. Renal cysteine conjugate β-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells. Toxicol Appl Pharmacol 103:463-473 (1990).
    • (1990) Toxicol Appl Pharmacol , vol.103 , pp. 463-473
    • Chen, J.C.1    Stevens, J.L.2    Trifillis, A.L.3    Jones, T.W.4
  • 145
    • 0033975309 scopus 로고    scopus 로고
    • Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells
    • Cummings BS, Lasb LH. Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells. Toxicol Sci 53:458-466 (2000).
    • (2000) Toxicol Sci , vol.53 , pp. 458-466
    • Cummings, B.S.1    Lasb, L.H.2
  • 146
    • 0031911559 scopus 로고    scopus 로고
    • Cysteine conjugate β-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A
    • Iyer RA, Fook EJ Jr, Ebert TJ, Anders MW. Cysteine conjugate β-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A. Anesthesiology 88:611-618 (1998).
    • (1998) Anesthesiology , vol.88 , pp. 611-618
    • Iyer, R.A.1    Fook E.J., Jr.2    Ebert, T.J.3    Anders, M.W.4
  • 149
    • 0028988860 scopus 로고
    • Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluomethyl)vinyl ether] in rats: Evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate β-lyase
    • Jin L, Baillie TA, Davis MR, Kharasch ED. Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluomethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate β-lyase. Biochem Biophys Res Commun 210:498-506 (1995).
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 498-506
    • Jin, L.1    Baillie, T.A.2    Davis, M.R.3    Kharasch, E.D.4
  • 152
    • 0031020994 scopus 로고    scopus 로고
    • Role of renal cysteine conjugate β-lyase in the mechanism of compound A nephrotoxicity in rats
    • Kharasch ED, Thorning D, Garton K, Hankins DC, Kilty GC. Role of renal cysteine conjugate β-lyase in the mechanism of compound A nephrotoxicity in rats. Anesthesiology 86:160-171 (1997).
    • (1997) Anesthesiology , vol.86 , pp. 160-171
    • Kharasch, E.D.1    Thorning, D.2    Garton, K.3    Hankins, D.C.4    Kilty, G.C.5
  • 155
    • 0029917278 scopus 로고    scopus 로고
    • Identification in rat bile of glutathione conjugates of fluoromethyl-2,2-difluoro-1-(trifluomethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane
    • Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA. Identification in rat bile of glutathione conjugates of fluoromethyl-2,2-difluoro-1-(trifluomethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. Chem Res Toxicol 9:555-561 (1996).
    • (1996) Chem Res Toxicol , vol.9 , pp. 555-561
    • Jin, L.1    Davis, M.R.2    Kharasch, E.D.3    Doss, G.A.4    Baillie, T.A.5
  • 156
    • 0027537201 scopus 로고
    • Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices
    • Stijntjes GJ, Commandeur JN, te Koppele JM, McGuiness S, Gandolfi AJ, Vermeulen NP. Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices. Toxicology 79:67-79 (1993).
    • (1993) Toxicology , vol.79 , pp. 67-79
    • Stijntjes, G.J.1    Commandeur, J.N.2    Te Koppele, J.M.3    McGuiness, S.4    Gandolfi, A.J.5    Vermeulen, N.P.6
  • 157
    • 0024378682 scopus 로고
    • N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: Differential transport and metabolism
    • Wolfgang GH, Gandolfi AJ, Stevens JL, Brendel K. N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism. Toxicol App Pharmacol 101:205-219 (1989).
    • (1989) Toxicol App Pharmacol , vol.101 , pp. 205-219
    • Wolfgang, G.H.1    Gandolfi, A.J.2    Stevens, J.L.3    Brendel, K.4
  • 158
    • 0023125921 scopus 로고
    • α-Ketoacids stimulate rat renal cysteine conjugate β-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine
    • Elfarra AA, Lash LH, Anders MW. α-Ketoacids stimulate rat renal cysteine conjugate β-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine. Mol Pharmacol 31:208-212 (1987).
    • (1987) Mol Pharmacol , vol.31 , pp. 208-212
    • Elfarra, A.A.1    Lash, L.H.2    Anders, M.W.3
  • 159
    • 0028268997 scopus 로고
    • Role of cysteine conjugate β-lyase and S-oxidase in nephrotoxicity: Studies with S-(1,2dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide
    • Lash LH, Sausen PJ, Duescher RJ, Cooley AJ, Elfarra AA. Role of cysteine conjugate β-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide. J Pharmacol Exp Ther 269:374-383 (1994).
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 374-383
    • Lash, L.H.1    Sausen, P.J.2    Duescher, R.J.3    Cooley, A.J.4    Elfarra, A.A.5
  • 160
    • 0024518795 scopus 로고
    • Cysteine conjugate β-lyase of rat kidney cytosol: Characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity
    • MacFarlane M, Foster JR, Gibson GG, King LJ, Lock EA. Cysteine conjugate β-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity. Toxicol Appl Pharmacol 98:185-197 (1989).
    • (1989) Toxicol Appl Pharmacol , vol.98 , pp. 185-197
    • MacFarlane, M.1    Foster, J.R.2    Gibson, G.G.3    King, L.J.4    Lock, E.A.5
  • 161
    • 0024208162 scopus 로고
    • Immunohistochemical localization of glutamine transaminase K, a rat kidney cysteine conjugate β-lyase, and the relationship to the segment specificity of cysteine conjugate nephrotoxicity
    • Jones TW, Qin C, Schaeffer VH, Stevens JL. Immunohistochemical localization of glutamine transaminase K, a rat kidney cysteine conjugate β-lyase, and the relationship to the segment specificity of cysteine conjugate nephrotoxicity. Mol Pharmacol 34:621-627 (1988).
    • (1988) Mol Pharmacol , vol.34 , pp. 621-627
    • Jones, T.W.1    Qin, C.2    Schaeffer, V.H.3    Stevens, J.L.4
  • 163
    • 0024395315 scopus 로고
    • Quantitation of multiple pathways for the metabolism of nephrotoxic cysteine conjugates using selective inhibitors of L-α-hydroxy acid oxidase (L-amino acid oxidase) and cysteine conjugate β-lyase
    • Stevens JL, Hatzinger PB, Hayden PJ. Quantitation of multiple pathways for the metabolism of nephrotoxic cysteine conjugates using selective inhibitors of L-α-hydroxy acid oxidase (L-amino acid oxidase) and cysteine conjugate β-lyase. Drug Metab Dispos 17:297-303 (1989).
    • (1989) Drug Metab Dispos , vol.17 , pp. 297-303
    • Stevens, J.L.1    Hatzinger, P.B.2    Hayden, P.J.3
  • 164
    • 0025824680 scopus 로고
    • Reactivity of cysteine S-conjugate sulfoxides: Formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione
    • Sausen PJ, Elfarra AA. Reactivity of cysteine S-conjugate sulfoxides: Formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione. Chem Res Toxicol 4:655-660 (1991).
    • (1991) Chem Res Toxicol , vol.4 , pp. 655-660
    • Sausen, P.J.1    Elfarra, A.A.2
  • 165
    • 0026672950 scopus 로고
    • Bioactivation mechanism of S-(3-propyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein
    • Hashmi M, Vamvakas S, Anders MW. Bioactivation mechanism of S-(3-propyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein. Chem Res Toxicol 5:360-365 (1992).
    • (1992) Chem Res Toxicol , vol.5 , pp. 360-365
    • Hashmi, M.1    Vamvakas, S.2    Anders, M.W.3
  • 166
    • 0026524079 scopus 로고
    • Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates
    • Park SB, Osterloh JD, Vamvakas S, Hashmi M, Anders MW, Cashman JR. Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates. Chem Res Toxicol 5:193-201 (1992).
    • (1992) Chem Res Toxicol , vol.5 , pp. 193-201
    • Park, S.B.1    Osterloh, J.D.2    Vamvakas, S.3    Hashmi, M.4    Anders, M.W.5    Cashman, J.R.6
  • 167
    • 0030071456 scopus 로고    scopus 로고
    • Sulfoxidation of mercapturic acids derived from tri- and tetrachloroethene by cytochromes P450 3A: A bioactivation reaction in addition to deacetylation and cysteine conjugate β-lyase mediated cleavage
    • Werner M, Birner G, Dekant W. Sulfoxidation of mercapturic acids derived from tri-and tetrachloroethene by cytochromes P450 3A: a bioactivation reaction in addition to deacetylation and cysteine conjugate β-lyase mediated cleavage. Chem Res Toxicol 9:41-49 (1996).
    • (1996) Chem Res Toxicol , vol.9 , pp. 41-49
    • Werner, M.1    Birner, G.2    Dekant, W.3
  • 168
    • 0027467330 scopus 로고
    • Further characterization and purification of the flavin-dependent S-benzyl-L-cysteine S-oxidase activities of rat liver and kidney microsomes
    • Sausen PJ, Duescher RJ, Elfarra AA. Further characterization and purification of the flavin-dependent S-benzyl-L-cysteine S-oxidase activities of rat liver and kidney microsomes. Mol Pharmacol 43:388-396 (1993).
    • (1993) Mol Pharmacol , vol.43 , pp. 388-396
    • Sausen, P.J.1    Duescher, R.J.2    Elfarra, A.A.3
  • 169
    • 0029439509 scopus 로고
    • Oxidative stress: The paradox of aerobic life
    • Davies KJA. Oxidative stress: the paradox of aerobic life. Biochem Soc Symp 61:1-31 (1995).
    • (1995) Biochem Soc Symp , vol.61 , pp. 1-31
    • Davies, K.J.A.1
  • 170
    • 0025685477 scopus 로고
    • The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells: Covalent binding leads to thiol depletion and lipid peroxidation
    • Chen Q, Jones TW, Brown PC, Stevens JL. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells: covalent binding leads to thiol depletion and lipid peroxidation. J Biol Chem 265:21603-21611 (1990).
    • (1990) J Biol Chem , vol.265 , pp. 21603-21611
    • Chen, Q.1    Jones, T.W.2    Brown, P.C.3    Stevens, J.L.4
  • 171
    • 0028109768 scopus 로고
    • Early events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates
    • Chen Q, Jones TW, Stevens JL. Early events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates. J Cell Physiol 161:293-302 (1994).
    • (1994) J Cell Physiol , vol.161 , pp. 293-302
    • Chen, Q.1    Jones, T.W.2    Stevens, J.L.3
  • 172
    • 0026099018 scopus 로고
    • Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates
    • Groves CE, Lock EA, Schnellmann RG. Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates. Toxicol Appl Pharmacol 107:54-62 (1991).
    • (1991) Toxicol Appl Pharmacol , vol.107 , pp. 54-62
    • Groves, C.E.1    Lock, E.A.2    Schnellmann, R.G.3
  • 173
    • 0023003510 scopus 로고
    • Renal cysteine conjugate β-lyase: Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane
    • Lash LH, Elfarra AA, Anders MW. Renal cysteine conjugate β-lyase: bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. J Biol Chem 261:5930-5935 (1986).
    • (1986) J Biol Chem , vol.261 , pp. 5930-5935
    • Lash, L.H.1    Elfarra, A.A.2    Anders, M.W.3
  • 174
    • 0023492515 scopus 로고
    • Mechanism of S-(1,2-dichlorovinyl)-L-cysteine-and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity
    • Lash LH, Anders MW. Mechanism of S-(1,2-dichlorovinyl)-L-cysteine-and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity. Mol Pharmacol 32:549-556 (1987).
    • (1987) Mol Pharmacol , vol.32 , pp. 549-556
    • Lash, L.H.1    Anders, M.W.2
  • 175
    • 0028786131 scopus 로고
    • Inhibition of succinate:Ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury
    • van de Water B, Zoeteweij JP, de Bont HJGM, Nagelkerke JF. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury. Mol Pharmacol 48:928-937 (1995).
    • (1995) Mol Pharmacol , vol.48 , pp. 928-937
    • Van De Water, B.1    Zoeteweij, J.P.2    De Bont, H.3    Nagelkerke, J.F.4
  • 176
    • 0025490873 scopus 로고
    • The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in suspensions of rat renal proximal tubules
    • Groves CE, Lock EA, Schnellmann RG. The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in suspensions of rat renal proximal tubules. J Biochem Toxicol 5:187-192 (1990).
    • (1990) J Biochem Toxicol , vol.5 , pp. 187-192
    • Groves, C.E.1    Lock, E.A.2    Schnellmann, R.G.3
  • 177
    • 0025092615 scopus 로고
    • Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates
    • Vamvakas S, Sharma VK, Sheu SS, Anders MW. Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates. Mol Pharmaco 38:455-461 (1990).
    • (1990) Mol Pharmaco , vol.38 , pp. 455-461
    • Vamvakas, S.1    Sharma, V.K.2    Sheu, S.S.3    Anders, M.W.4
  • 178
    • 50549203697 scopus 로고    scopus 로고
    • A biochemical study of the toxicity of S-(1,2-dichlorovinyl)-L-cysteine
    • Parker VH. A biochemical study of the toxicity of S-(1,2-dichlorovinyl)-L-cysteine. Food Cosmet Toxicol 3:75-84.
    • Food Cosmet Toxicol , vol.3 , pp. 75-84
    • Parker, V.H.1
  • 179
    • 0015120455 scopus 로고
    • 2-Oxoacid dehydrogenases of rat liver mitochondria as the site of action of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-3-mercaptopropionic acid
    • Stonard MD, Parker VH. 2-Oxoacid dehydrogenases of rat liver mitochondria as the site of action of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-3-mercaptopropionic acid Biochem Pharmacol 20:2417-2427 (1971).
    • (1971) Biochem Pharmacol , vol.20 , pp. 2417-2427
    • Stonard, M.D.1    Parker, V.H.2
  • 180
    • 0015122869 scopus 로고
    • The metabolism of S-(1,2-dichlorovinyl)-L-cysteine by rat liver mitochondria
    • Stonard MD, Parker VH. The metabolism of S-(1,2-dichlorovinyl)-L-cysteine by rat liver mitochondria. Biochem Pharmacol 20:2429-2437 (1971).
    • (1971) Biochem Pharmacol , vol.20 , pp. 2429-2437
    • Stonard, M.D.1    Parker, V.H.2
  • 181
    • 0028175993 scopus 로고
    • 2+ in the oxidatve stress-induced dissipation of the mitochondrial membrane potential: Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine
    • 2+ in the oxidatve stress-induced dissipation of the mitochondrial membrane potential: studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine. J Biol Chem 269:14546-14552 (1994).
    • (1994) J Biol Chem , vol.269 , pp. 14546-14552
    • Van De Water, B.1    Zoeteweij, J.P.2    De Bont, H.J.G.M.3    Mulder, G.J.4    Nagelkerke, J.F.5
  • 182
    • 0025261923 scopus 로고
    • Cysteine conjugate toxicity, metabolism, and binding to macromolecules in isolated rat kidney mitochondria
    • Hayden PJ, Stevens JL. Cysteine conjugate toxicity, metabolism, and binding to macromolecules in isolated rat kidney mitochondria. Mol Pharmacol 37:468-476 (1990).
    • (1990) Mol Pharmacol , vol.37 , pp. 468-476
    • Hayden, P.J.1    Stevens, J.L.2
  • 183
    • 0027336575 scopus 로고
    • 2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine
    • 2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine. Biochem Pharmacol 45:2259-2267 (1993).
    • (1993) Biochem Pharmacol , vol.45 , pp. 2259-2267
    • Van De Water, B.1    Zoeteweij, J.P.2    De Bont, H.J.G.M.3    Mulder, G.J.4    Nagelkerke, J.F.5
  • 184
    • 0026094269 scopus 로고
    • Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts
    • Hayden PJ, Ichimura T, McCann DJ, Pohl LR, Stevens JL. Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts. J Biol Chem 266:18415-18418 (1991).
    • (1991) J Biol Chem , vol.266 , pp. 18415-18418
    • Hayden, P.J.1    Ichimura, T.2    McCann, D.J.3    Pohl, L.R.4    Stevens, J.L.5
  • 186
    • 0024506911 scopus 로고
    • Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates
    • Banki K, Anders MW. Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates. Carcinogenesis 10:767-772 (1989).
    • (1989) Carcinogenesis , vol.10 , pp. 767-772
    • Banki, K.1    Anders, M.W.2
  • 187
    • 0029609146 scopus 로고
    • Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethylene metabolism
    • Eyre RJ, Stevens DK, Parker JC, Bull RJ. Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethylene metabolism. J Toxicol Environ Health 46:443-464 (1995).
    • (1995) J Toxicol Environ Health , vol.46 , pp. 443-464
    • Eyre, R.J.1    Stevens, D.K.2    Parker, J.C.3    Bull, R.J.4
  • 188
    • 0029563085 scopus 로고
    • Renal activation of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice
    • Eyre RJ, Stevens DK, Parker JC, Bull RJ. Renal activation of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice. J Toxicol Environ Health 46:465-481 (1995).
    • (1995) J Toxicol Environ Health , vol.46 , pp. 465-481
    • Eyre, R.J.1    Stevens, D.K.2    Parker, J.C.3    Bull, R.J.4
  • 189
    • 0025327018 scopus 로고
    • The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities
    • Lock EA, Schnellmann RG. The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Toxicol Appl Pharmacol 104:180-190 (1990).
    • (1990) Toxicol Appl Pharmacol , vol.104 , pp. 180-190
    • Lock, E.A.1    Schnellmann, R.G.2
  • 190
    • 0026493759 scopus 로고
    • Regulation of the cellular stress response by reactive electrophiles: The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock gene by nephrotoxic cysteine conjugates
    • Chen Q, Yu K, Stevens JL. Regulation of the cellular stress response by reactive electrophiles: the role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock gene by nephrotoxic cysteine conjugates. J Biol Chem 267:24322-24327 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 24322-24327
    • Chen, Q.1    Yu, K.2    Stevens, J.L.3
  • 191
    • 0027491608 scopus 로고
    • Mitochondrial HSP60 (P1 protein) and HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity
    • Bruschi SA, West KA, Crabb JW, Gupta RS, Stevens JL. Mitochondrial HSP60 (P1 protein) and HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity. J Biol Chem 268:23157-23161 (1993).
    • (1993) J Biol Chem , vol.268 , pp. 23157-23161
    • Bruschi, S.A.1    West, K.A.2    Crabb, J.W.3    Gupta, R.S.4    Stevens, J.L.5
  • 192
    • 0026717771 scopus 로고
    • 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells
    • 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells. Lab Invest 66:474-484 (1992).
    • (1992) Lab Invest , vol.66 , pp. 474-484
    • Wallin, A.1    Zhang, G.2    Jones, T.W.3    Jaken, S.4    Stevens, J.L.5
  • 193
    • 0026687709 scopus 로고
    • Vimentin metaplasia in renal cortical tubules of pre-neoplastic, neoplastic, aging, and regenerative lesions of rats and humans
    • Ward JM, Stevens JL, Konishi N, Kurata Y, Uno H, Diwan BA, Ohmori T. Vimentin metaplasia in renal cortical tubules of pre-neoplastic, neoplastic, aging, and regenerative lesions of rats and humans. Am J Pathol 141:955-964 (1992).
    • (1992) Am J Pathol , vol.141 , pp. 955-964
    • Ward, J.M.1    Stevens, J.L.2    Konishi, N.3    Kurata, Y.4    Uno, H.5    Diwan, B.A.6    Ohmori, T.7
  • 194
    • 0028878120 scopus 로고
    • Nephrotoxicant inhibition of renal proximal tubule cell regeneration
    • Counts RS, Nowak G, Wyatt RD, Schnellmann RG. Nephrotoxicant inhibition of renal proximal tubule cell regeneration. Am J Physiol 269:F274-F281 (1995).
    • (1995) Am J Physiol , vol.269
    • Counts, R.S.1    Nowak, G.2    Wyatt, R.D.3    Schnellmann, R.G.4
  • 195
    • 0029003545 scopus 로고
    • Regeneration of renal proximal tubule cells in primary culture following toxicant injury: Response to growth factors
    • Kays SE, Schnellmann RG. Regeneration of renal proximal tubule cells in primary culture following toxicant injury: Response to growth factors. Toxicol Appl Pharmacol 132:273-280 (1995).
    • (1995) Toxicol Appl Pharmacol , vol.132 , pp. 273-280
    • Kays, S.E.1    Schnellmann, R.G.2
  • 197
    • 0027193334 scopus 로고
    • 1 cells: A comparative investigation with growth factors and 12-O-tetradecanoylphorbolacelate
    • 1 cells: a comparative investigation with growth factors and 12-O-tetradecanoylphorbolacelate. Cell Biol Toxicol 9:1-13 (1993).
    • (1993) Cell Biol Toxicol , vol.9 , pp. 1-13
    • Vamvakas, S.1    Köster, J.2
  • 199
    • 0026669286 scopus 로고
    • Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and cithiothreitol
    • Chen Q, Yu K, Holbrook NJ, Stevens JL. Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and cithiothreitol. J Biol Chem 267:8207-8212 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 8207-8212
    • Chen, Q.1    Yu, K.2    Holbrook, N.J.3    Stevens, J.L.4
  • 200
  • 201
    • 0032963856 scopus 로고    scopus 로고
    • Glutathione conjugation of trichloroethylene in human liver and kidney kinetics and individual variation
    • Lash LH, Lipscomb JC, Futt DA, Parker JC. Glutathione conjugation of trichloroethylene in human liver and kidney kinetics and individual variation. Drug Metab Dispos 27:351-350 (1999).
    • (1999) Drug Metab Dispos , vol.27 , pp. 351-1350
    • Lash, L.H.1    Lipscomb, J.C.2    Futt, D.A.3    Parker, J.C.4
  • 202
    • 0033534408 scopus 로고    scopus 로고
    • Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene
    • Lash LH, Putt DA, Brashear WT, Abbas R, Parker JC, Fisher JW. Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene. J Toxicol Environ Health 56:1-21 (1999).
    • (1999) J Toxicol Environ Health , vol.56 , pp. 1-21
    • Lash, L.H.1    Putt, D.A.2    Brashear, W.T.3    Abbas, R.4    Parker, J.C.5    Fisher, J.W.6
  • 203
    • 0032210675 scopus 로고    scopus 로고
    • Biotransformation of perchloroethene: Dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation
    • Völkel W, Friedewald M, Lederer E, Pähler A, Parker J, Dekant W. Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation. Toxicol Appl Pharmacol 153:20-27 (1998).
    • (1998) Toxicol Appl Pharmacol , vol.153 , pp. 20-27
    • Völkel, W.1    Friedewald, M.2    Lederer, E.3    Pähler, A.4    Parker, J.5    Dekant, W.6
  • 204
    • 0033214849 scopus 로고    scopus 로고
    • Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats
    • Kharasch ED, Jubert C, Spracklin DK, Hoffman GM. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. Toxicol Appl Pharmacol 160:49-59 (1999).
    • (1999) Toxicol Appl Pharmacol , vol.160 , pp. 49-59
    • Kharasch, E.D.1    Jubert, C.2    Spracklin, D.K.3    Hoffman, G.M.4
  • 205
    • 0032702882 scopus 로고    scopus 로고
    • Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: Biomarkers for exposure, risk assessment, and interspecies comparison
    • Kharasch ED, Jubert C. Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Anesthesiology 91:1267-1278 (1999).
    • (1999) Anesthesiology , vol.91 , pp. 1267-1278
    • Kharasch, E.D.1    Jubert, C.2
  • 206
    • 0033958342 scopus 로고    scopus 로고
    • Role of cytochrome P450 and glutathione S-transferase α in the metabolism and cytotoxicity of trichloroethylene in rat kidney
    • in press
    • Cummings BS, Parker JC, Lash LH. Role of cytochrome P450 and glutathione S-transferase α in the metabolism and cytotoxicity of trichloroethylene in rat kidney. Biochem Pharmacol (in press).
    • Biochem Pharmacol
    • Cummings, B.S.1    Parker, J.C.2    Lash, L.H.3
  • 207
    • 0034056796 scopus 로고    scopus 로고
    • Expression of glutathione-dependent enzymes and cytochrome P450s in freshly-isolated and primary cultures of proximal tubular cells from human kidney
    • in press
    • Cummings BS, Lasker JM, Lash LH. Expression of glutathione-dependent enzymes and cytochrome P450s in freshly-isolated and primary cultures of proximal tubular cells from human kidney. J Pharmacol Exp Ther (in press).
    • J Pharmacol Exp Ther
    • Cummings, B.S.1    Lasker, J.M.2    Lash, L.H.3
  • 208
    • 0030800178 scopus 로고    scopus 로고
    • The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene
    • Green T, Dow J, Ellis MK, Foster JR, Odum J. The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene. Chem-Biol Interact 105:99-117 (1997).
    • (1997) Chem-Biol Interact , vol.105 , pp. 99-117
    • Green, T.1    Dow, J.2    Ellis, M.K.3    Foster, J.R.4    Odum, J.5
  • 209
    • 0344327101 scopus 로고    scopus 로고
    • Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation
    • Pähler A, Parker J, Dekant W. Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation. Toxicol Sci 48:5-13 (1999).
    • (1999) Toxicol Sci , vol.48 , pp. 5-13
    • Pähler, A.1    Parker, J.2    Dekant, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.