Molecular markers of trichloroethylene-induced toxicity in human kidney cells

Toxicology and Applied Pharmacology

Volumn 206, Issue 2, 2005, Pages 157-168

  Lash, Lawrence H ^a   Putt, David A ^a   Hueni, Sarah E ^a   Horwitz, Beth P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Human proximal tubular cells; Molecular markers; Signaling pathways; Trichloroethylene

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYSTEINE CONJUGATE; CYTOSKELETON PROTEIN; HEAT SHOCK PROTEIN 27; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MOLECULAR MARKER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN P53; S (1,2 DICHLOROVINYL)CYSTEINE; TRICHLOROETHYLENE;

APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; DNA SYNTHESIS; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IN VIVO STUDY; INCUBATION TIME; KIDNEY CELL; KIDNEY NECROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LD 50; MOUSE; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STRESS; TARGET ORGAN;

APOPTOSIS; BIOLOGICAL MARKERS; CELL PROLIFERATION; CELLS, CULTURED; CYSTEINE; HUMANS; KIDNEY TUBULES, PROXIMAL; NECROSIS; SIGNAL TRANSDUCTION; TRICHLOROETHYLENE;

ANIMALIA;

EID: 20444459421     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.09.023     Document Type: Conference Paper

References (43)

1. C. Aufricht, T. Ardito, G. Thulin, M. Kashgarian, N.J. Siegel, and S.K. Van Why Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia Am. J. Physiol. 274 1998 F215 F222
2. Q. Chen, K. Yu, N.J. Holbrook, and J.L. Stevens Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol J. Biol. Chem. 267 1992 8207 8212
3. R.S. Counts, G. Nowak, R.D. Wyatt, and R.G. Schnellmann Nephrotoxicant inhibition of renal proximal tubule cell regeneration Am. J. Physiol. 269 1995 F274 F281
4. B.S. Cummings, and L.H. Lash Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-l-cysteine in freshly isolated human proximal tubular cells Toxicol. Sci. 53 2000 458 466
5. B.S. Cummings, J.M. Lasker, and L.H. Lash Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney J. Pharmacol. Exp. Ther. 293 2000 677 685
6. N. Dmitrieva, L. Michea, and M. Burg p53 protects renal inner medullary cells from hypertonic stress by restricting DNA replication Am. J. Physiol. 281 2001 F522 F530
7. L. Dong, J.L. Stevens, D. Fabbro, and S. Jaken Regulation of protein kinase C isozymes in kidney regeneration Cancer Res. 53 1993 4542 4549
8. A.A. Elfarra, I. Jakobson, and M.W. Anders Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity Biochem. Pharmacol. 35 1986 283 288
9. J. Gailit, D. Colflesh, I. Rabiner, J. Simone, and M.S. Goligorsky Redistribution and dysfunction of integrins in cultured renal epithelial cells exposed to oxidative stress Am. J. Physiol. 264 1993 F149 F157
10. E. Healy, M. Dempsey, C. Lally, and M.P. Ryan Apoptosis and necrosis: mechanisms of cell death induced by cyclosporin A in a renal proximal tubular cell line Kidney Int. 54 1998 1955 1966
11. International Agency for Research on Cancer (IARC) Dry cleaning, some chlorinated solvents, and other industrial chemicals IARC Monogr. Eval. Carcinog. Risks Hum. 63 1995 75 158
12. S.E. Kays, and R.G. Schnellmann Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors Toxicol. Appl. Pharmacol. 132 1995 273 280
13. L.H. Lash, and M.W. Anders Cytotoxicity of S-(1,2-dichlorovinyl) glutathione and S-(1,2-dichlorovinyl)-l-cysteine in isolated rat kidney cells J. Biol. Chem. 261 1986 13076 13081
14. L.H. Lash, and M.W. Anders Mechanism of S-(1,2-dichlorovinyl)-l-cysteine- and S- (1,2-dichlorovinyl)-l-homocysteine-induced renal mitochondrial toxicity Mol. Pharmacol. 32 1987 549 556
15. L.H. Lash, P.J. Sausen, R.J. Duescher, A.J. Cooley, and A.A. Elfarra Roles of cysteine conjugate β-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-l-cysteine and S-(1,2-dichlorovinyl)-l- cysteine sulfoxide J. Pharmacol. Exp. Ther. 269 1994 374 383
16. L.H. Lash, J.J. Tokarz, and D.M. Pegouske Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity Toxicology 103 1995 85 103
17. L.H. Lash, Y. Xu, A.A. Elfarra, R.J. Duescher, and J.C. Parker Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity Drug Metab. Dispos. 23 1995 846 853
18. L.H. Lash, J.W. Fisher, J.C. Lipscomb, and J.C. Parker Metabolism of trichloroethylene Environ. Health Perspect. 108 Suppl. 2 2000 177 200
19. L.H. Lash, J.C. Parker, and C.S. Scott Modes of action of trichloroethylene for kidney tumorigenesis Environ. Health Perspect. 108 Suppl. 2 2000 225 240
20. L.H. Lash, S.E. Hueni, and D.A. Putt Apoptosis, necrosis and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells Toxicol. Appl. Pharmacol. 177 2001 1 16
21. L.H. Lash, W. Qian, D.A. Putt, S.E. Hueni, A.A. Elfarra, R.J. Krause, and J.C. Parker Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences J. Pharmacol. Exp. Ther. 297 2001 155 164
22. L.H. Lash, D.A. Putt, S.E. Hueni, R.J. Krause, and A.A. Elfarra Roles of necrosis, apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l- cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells J. Pharmacol. Exp. Ther. 305 2003 1163 1172
23. E.A. Maull, and L.H. Lash Trichloroethylene: metabolism, mode of action and regulatory considerations Toxic Subst. Mech. 17 1998 153 169
24. J. Megyesi, L. Andrade, J.M. Vieira Jr., R.L. Safirstein, and P.M. Price Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure Am. J. Physiol. 283 2002 F810 F816
25. National Toxicology Program (NTP), 2001. Report on Carcinogens 9th Ed., U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, Research Triangle Park, NC.
26. P.A. Nony, and R.G. Schnellmann Interactions between collagen IV and collagen-binding integrins in renal cell repair after sublethal injury Mol. Pharmacol. 60 2001 1226 1234
27. P.A. Nony, and R.G. Schnellmann Mechanisms of renal cell repair and regeneration after acute renal failure J. Pharmacol. Exp. Ther. 304 2003 905 912
28. P.A. Nony, G. Nowak, and R.G. Schnellmann Collagen IV promotes repair of renal cell physiological functions after toxicant injury Am. J. Physiol. 281 2001 F443 F453
29. G. Nowak Protein kinase C mediates repair of mitochondrial and transport functions after toxicant-induced injury in renal cells J. Pharmacol. Exp. Ther. 306 2003 157 165
30. G. Nowak, and R.G. Schnellmann Renal cell regeneration following oxidant exposure: inhibition by TGF-β1 and stimulation by ascorbic acid Toxicol. Appl. Pharmacol. 145 1997 175 183
31. G. Nowak, M.D. Aleo, J.A. Morgan, and R.G. Schnellmann Recovery of cellular functions following oxidant injury Am. J. Physiol. 274 1998 F509 F515
32. G. Nowak, K.B. Keasler, D.E. McKeller, and R.G. Schnellmann Differential effects of EGF on repair of cellular functions after dichlorovinyl-l-cysteine- induced injury Am. J. Physiol. 276 1999 F228 F236
33. S. Nurko, K. Sogabe, J.A. Davis, N.F. Roeser, M. Defrain, A. Chien, D. Hinshaw, B. Athey, W. Meixner, M.A. Venkatachalam, and J.M. Weinberg Contribution of actin cytoskeletal alterations to ATP depletion and calcium-induced proximal tubule cell injury Am. J. Physiol. 270 1996 F39 F52
34. C.S. Scott, and V.J. Cogliano Trichloroethylene health risks-state of the science Environ. Health Perspec. 108 Suppl. 2 2000 159 160
35. E.A. Shelden, J.M. Weinberg, D.R. Sorenson, C.A. Edwards, and F.M. Pollock Site-specific alteration of actin assembly visualized in living renal epithelial cells during ATP depletion J. Am. Soc. Nephrol. 13 2002 2667 2680
36. E.A. Shelden, M.J. Borrelli, F.M. Pollock, and R. Bonham Heat shock protein 27 associates with basolateral cell boundaries in heat-shocked and ATP-depleted epithelial cells J. Am. Soc. Nephrol. 13 2002 332 341
37. J.H. Todd, K.E. McMartin, and D.A. Sens Enzymatic isolation and serum-free culture of human renal cells G.E. Jones Methods in molecular medicine: human cell culture protocols 1995 Humana Press, Inc Totowa, NJ Chapter 32
38. V.S. Vaidya, K. Shankar, E.A. Lock, T.J. Bucci, and H.M. Mehendale Renal injury and repair following S-(1,2-dichlorovinyl)-l-cysteine administration to mice Toxicol. Appl. Pharmacol. 188 2003 110 121
39. V.S. Vaidya, K. Shankar, E.A. Lock, T.J. Bucci, and H.M. Mehendale Role of tissue repair in survival from S-(1,2-dichlorovinyl)-l-cysteine-induced acute renal tubular necrosis in the mouse Toxicol. Sci. 74 2003 215 227
40. B. van de Water, M. Kruidering, and J.F. Nagelkerke F-Actin disorganization in apoptotic cell death of cultured renal proximal tubular cells Am. J. Physiol. 270 1996 F593 F603
41. B. van de Water, J.F. Nagelkerke, and J.L. Stevens Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells J. Biol. Chem. 274 1999 13328 13337
42. 1) cells by focal adhesion kinase (FAK): role of FAK in maintaining focal adhesion organization after acute renal cell injury J. Biol. Chem. 276 2001 36183 36193
43. S.K. Van Why, A.S. Mann, T. Ardito, G. Thulin, S. Ferris, M.A. Macleod, M. Kashgarian, and N.J. Siegel Hsp27 associates with actin and limits injury in energy depleted renal epithelia J. Am. Soc. Nephrol. 14 2003 98 106