Rho/Rho kinase pathway regulates maintenance of the differentiated tubular epithelial cell phenotype on laminin-1

Nephron - Physiology

Volumn 104, Issue 2, 2006, Pages

  Reuters, Irith ^a,b   Weber, Manfred ^a,b   Schulze Lohoff, Eckhard ^a,b,c  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c Klinikum Koln Merheim   (Germany)

Author keywords

Epithelial cell migration; Laminin; Proximal tubular cells; Rho Rho kinase pathway

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; BETA CATENIN; BOVINE SERUM ALBUMIN; COLLAGEN TYPE 4; EXOTOXIN; LAMININ; LAMININ 1; LAMININ 10; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG; VIMENTIN; VINCULIN;

ANIMAL CELL; ARTICLE; CELL CONTACT; CELL CULTURE; CELL DIFFERENTIATION; CELL JUNCTION; CELL MIGRATION; CELL NUCLEUS; CELL STRAIN; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; FILOPODIUM; IMMUNOFLUORESCENCE MICROSCOPY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES; LAMININ; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SWINE;

EID: 33749023880     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094573     Document Type: Article

References (51)

1. Toback FG: Regeneration after acute tubular necrosis. Kidney Int 1992;41:226-246.
2. Humes HD: Acute renal failure: prevailing challenges and prospects for the future. Kidney Int 1995;48:26-32.
3. Thadhani R, Pascual M, Bonventre JV: Acute renal failure. N Engl J Med 1996;334:1448-1460.
4. Harris DC: Tubulointerstitial renal disease. Curr Opin Nephrol Hypertens 2001;10:303-313.
5. Zuk A, Bonventre JV, Brown D, Matlin KS: Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 1998;275:C711-C731.
6. Hay ED, Zuk A: Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Dis 1995;26:678-690.
7. Zeisberg M, Kalluri R: The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 2004;82:175-181.
8. Nelson WJ: Renal epithelial cell polarity. Curr Opin Nephrol Hypertens 1992;1:59-67.
9. Miner JH: Renal basement membrane components. Kidney Int 1999;56:2016-2024.
10. Ekblom M, Falk M, Salmivirta K, Durbeej M, Ekblom P: Laminin isoforms and epithelial development. Ann NY Acad Sci 1998;857:194-211.
11. Timpl R: Structure and biological activity of basement membrane proteins. Eur J Biochem 1989;180:487-502.
12. Paulsson M: Basement membrane proteins: structure, assembly, and cellular interactions. Crit Rev Biochem Mol Biol 1992;27:93-127.
13. Yurchenco PD, O'Rear JJ: Basal lamina assembly. Cur Opin Cell Biol 1994;6:674-681.
14. Timpl R: Macromolecular organization of basement membranes. Curr Opin Cell Biol 1996;8:618-624.
15. Adler S: Integrin matrix receptors in renal injury. Kidney Int 1994;45:86-89.
16. Goligorsky MS, Lieberthal W, Racusen L, Simon EE: Integrin receptors in renal tubular epithelium: new insights into pathophysiology of acute renal failure. Am J Physiol 1993;264:F1-F8.
17. 6 subunit is essential for epithelial polarization in developing kidney tubules. J Cell Biol 1990;111:1265-1273.
18. 1 is involved in kidney tubulogenesis in vitro. J Cell Sci 1996;109:2801-2810.
19. 3 isoform. J Cell Biol 1997;137:685-701.
20. 1-5 chains in developing and adult mouse kidney. Dev Dyn 1997;210:446-462.
21. Colognato H, Yurchenco PD: Form and function: the laminin family of heterotrimers. Dev Dyn 2000;218:213-234.
22. Li S, Edgar D, Fässler R, Wadsworth W, Yurchenco PD: The role of laminin in embryonic cell polarization and tissue organization. Dev Cell 2003;4:613-624.
23. Ekblom P, Lonai P, Talts JF: Expression and biological role of laminin-1. Matrix Biol 2003;22:35-47.
24. Miner JH: Building the glomerulus: a matricentric view. J Am Soc Nephrol 2005;16:857-861.
25. Walker PD: Alterations in renal tubular extracellular matrix components after ischemia-reperfusion injury to the kidney. J Lab Invest 1994;70:339-346.
26. Zeisberg M, Bonner G, Maeshima Y, Colorado P, Muller GA, Strutz F, Kalluri R: Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am J Pathol 2001;159:1313-1321.
27. Evers EE, Zondag GCM, Malliri A, Price LS, ten Klooster JP, van Kammen RA, Collard JG: Rho family proteins in cell adhesion and cell migration. Eur J Cancer 2000;36:1269-1274.
28. Schmitz AAP, Govek EE, Böttner B, Van Aelst L: Rho GTPases: signaling, migration, and invasion. Exp Cell Res 2000;261:1-12.
29. Hall A: Rho GTPases and the actin cytoskeleton. Science 1998;279:509-514.
30. Kjoller L, Hall A: Signaling to Rho GTPases. Exp Cell Res 1999;253:166-179.
31. Petit V, Thiery JP: Focal adhesions: structure and dynamics. Biol Cell 2000;92:477-494.
32. Ridley AJ: Rho GTPases and cell migration. J Cell Sci 2001;114:2713-2722.
33. Kreisberg JI, Wilson PD: Renal cell culture. J Electron Microsc Tech 1988;9:235-263.
34. Balcarnova J, Pfeiffer SE, Fuller SD, Simons K: Development of cell surface polarity in the Madin-Darby canine kidney cell line. EMBO J 1984;3:2687-2694.
35. Schulze-Lohoff E, Hugo C, Rost S, Arnold S, Gruber A, Brüne, B, Sterzel, RB: Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors. Am J Physiol 1998;275:F962-F971.
36. Pozzi A, Zent R: Integrins: Sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol 2003;94:e77-e84.
37. Raftopoulou M, Hall A: Cell migration: Rho GTPases lead the way. Dev Biol 2004;265:23-32.
38. Kapadia R, Yurchenco PD, Amsler K: Binding of the renal epithelial cell line LLC-PK1 to laminin is regulated by protein kinase C. J Am Soc Nephrol 1999;10:1214-1223.
39. Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003;112:1776-1784.
40. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of fibroblast-specific protein 1 (FSP1). J Cell Biol 1995;130:393-405.
41. 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-968.
42. Malliri A, Collard JG: Role of rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol 2003;15:583-589.
43. Zhou H, Kramer RH: Integrin engagement differently modulates epithelial cell motility by Rho/ROCK and PAK1. J Biol Chem 2005;280:10624-10635.
44. Borisoff JF, Chan CC, Hiebert GW, Oschipok L, Robertson GS, Zamboni R, Steeves JD, Tetzlaff W: Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates. Mol Cell Neurosci 2003;22:405-416.
45. Braga VMM, Machesky LM, Hall A, Hotchin NA: The small GTPases rho and rac are required for the establishment of cadherin-dependent cell-cell-contacts. J Cell Biol 1997;137:1421-1431.
46. Gopalakrishnan S, Raman N, Atkinson SJ, Marrs JA: Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am J Physiol 1998;275:C798-C809.
47. Moriyama T, Nagatoya K: The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis. Drug News Perspect 2004;17:29-34.
48. Sharpe CC, Hendry BM: Signaling: focus on rho in renal disease. J Am Soc Nephrol 2003;14:261-264.
49. Nagatoya K, Moriyama T, Kawada N, Takeji M, Oseto S, Murozono T, Ando A, Imai E, Hori M: Y27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int 2002;61:1684-1695.
50. Kanda T, Wakino S, Hayashi K, Homma K, Ozawa Y, Saruta T: Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 2003;64:2009-2019.
51. Cavarape A, Endlich N, Assaloni R, Bartoli E, Steinhausen M, Parekh N, Endlich K: Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. J Am Soc Nephrol 2003;14:37-45.