Functional coassembly of KCNQ4 with KCNE-β-subunits in Xenopus oocytes

Cellular Physiology and Biochemistry

Volumn 18, Issue 1-3, 2006, Pages 57-66

  Strutz Seebohm, Nathalie ^a   Seebohm, Guiscard ^a   Fedorenko, Olga ^a   Baltaev, Ravshan ^a   Engel, Jutta ^a   Knirsch, Martina ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Channel kinetics; Gating Kv7; Kinase; MinK; Mirp

Indexed keywords

EID: 33749003474     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000095158     Document Type: Article

References (44)

1. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK: A potassium channel mutation in neonatal human epilepsy. Science 1998;279:403-406.
2. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M: A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 1998;18:53-55.
3. Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK: Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc Natl Acad Sci U S A 2001;98:12272-12277.
4. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El Amraoui A, Marlin S, Petit C, Jentsch TJ: KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 1999;96:437-446.
5. Schroeder BC, Kubisch C, Stein V, Jentsch TJ: Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 1998;396:687-690.
6. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT: Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996;12:17-23.
7. Coucke PJ, Van Hauwe P, Kelley PM, Kunst H, Schatteman I, Van Velzen D, Meyers J, Ensink RJ, Verstreken M, Declau F, Marres H, Kastury K, Bhasin S, McGuirt WT, Smith RJ, Cremers CW, Van de HP, Willems PJ, Smith SD, Van Camp G: Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Hum Mol Genet 1999;8:1321-1328.
8. Talebizadeh Z, Kelley PM, Askew JW, Beisel KW, Smith SD: Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss. Hum Mutat 1999;14:493-501.
9. Marcotti W, Kros CJ: Developmental expression of the potassium current IK,n contributes to maturation of mouse outer hair cells. J Physiol 1999;520 Pt 3:653-660.
10. Oliver D, Knipper M, Derst C, Fakler B: Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels. J Neurosci 2003;23:2141-2149.
11. Kharkovets T, Hardelin JP, Safieddine S, Schweizer M, El Amraoui A, Petit C, Jentsch TJ: KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci U S A 2000;97:4333-4338.
12. Kharkovets T, Dedek K, Maier H, Schweizer M, Khimich D, Nouvian R, Vardanyan V, Leuwer R, Moser T, Jentsch TJ: Mice with altered KCNQ4 K(+) channels implicate sensory outer hair cells in human progressive deafness. EMBO J 2006;25:642-652.
13. Hougaard C, Klaerke DA, Hoffmann EK, Olesen SP, Jorgensen NK: Modulation of KCNQ4 channel activity by changes in cell volume. Biochim Biophys Acta 2004;1660:1-6.
14. Chambard JM, Ashmore JF: Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. Pflugers Arch 2005;450:34-44.
15. Seebohm G, Strutz-Seebohm N, Baltaev R, Korniychuk G, Knirsch M, Engel J, Lang F: Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes. Cell Physiol Biochem 2005;16:255-262.
16. Ljungstrom T, Grunnet M, Jensen BS, Olesen SP: Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels. Pflugers Arch 2003;446:684-694.
17. Selyanko AA, Hadley JK, Wood IC, Abogadie FC, Jentsch TJ, Brown DA: Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. J Physiol 2000;522 Pt 3:349-355.
18. Seebohm G, Scherer CR, Busch AE, Lerche C: Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome. J Biol Chem 2001;276:13600-13605.
19. Jespersen T, Grunnet M, Angelo K, Klaerke DA, Olesen SP: Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques 2002;32:536-8, 540.
20. Michna M, Knirsch M, Hoda JC, Muenkner S, Langer P, Platzer J, Striessnig J, Engel J: Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice. J Physiol 2003;553:747-758.
21. Stuhmer W: Electrophysiological recording from Xenopus oocytes. Methods Enzymol 1992;207:319-339.
22. Strutz N, Villmann C, Breitinger HG, Werner M, Wenthold RJ, Kizelsztein P, Teichberg VI, Hollmann M: Kainate-binding proteins are rendered functional ion channels upon transplantation of two short pore-flanking domains from a kainate receptor. J Biol Chem 2002;277:48035-48042.
23. Abbott GW, Goldstein SA, Sesti F: Do all voltage-gated potassium channels use MiRPs? Circ Res 2001;88:981-983.
24. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G: K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 1996;384:78-80.
25. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT: Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 1996;384:80-83.
26. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA: MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999;97:175-187.
27. Decher N, Bundis F, Vajna R, Steinmeyer K: KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Pflugers Arch 2003;446:633-640.
28. Grunnet M, Rasmussen HB, Hay-Schmidt A, Rosenstierne M, Klaerke DA, Olesen SP, Jespersen T: KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. Biophys J 2003;85:1525-1537.
29. McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, Abbott GW: MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci 2003;23:8077-8091.
30. Deschenes I, Tomaselli GF: Modulation of Kv4.3 current by accessory subunits. FEBS Lett 2002;528:183-188.
31. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ: A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 2000;403:196-199.
32. Grunnet M, Olesen SP, Klaerke DA, Jespersen T: hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics. Biochem Biophys Res Commun 2005;328:1146-1153.
33. Pusch M: Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK. Pflugers Arch 1998;437:172-174.
34. Yang Y, Sigworth FJ: Single-channel properties of IKs potassium channels. J Gen Physiol 1998;112:665-678.
35. Pusch M, Magrassi R, Wollnik B, Conti F: Activation and inactivation of homomeric KvLQT1 potassium channels. Biophys J 1998;75:785-792.
36. Tristani-Firouzi M, Sanguinetti MC: Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits. J Physiol 1998;510 ( Pt 1):37-45.
37. Sakagami M, Fukazawa K, Matsunaga T, Fujita H, Mori N, Takumi T, Ohkubo H, Nakanishi S: Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation. Hear Res 1991;56:168-172.
38. Ruttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, Knirsch M, Arntz C, Langer P, Hirt B, Muller M, Kopschall I, Pfister M, Munkner S, Rohbock K, Pfaff I, Rusch A, Ruth P, Knipper M: Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A 2004;101:12922-12927.
39. Chen H, Kim LA, Rajan S, Xu S, Goldstein SA: Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex. Neuron 2003;40:15-23.
40. Chen H, Sesti F, Goldstein SA: Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits. Biophys J 2003;84:3679-3689.
41. Lerche C, Seebohm G, Wagner CI, Scherer CR, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch AE: Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols. Br J Pharmacol 2000;131:1503-1506.
42. Melman YF, Um SY, Krumerman A, Kagan A, McDonald TV: KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron 2004;42:927-937.
43. Panaghie G, Tai KK, Abbott GW: Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol 2005;
44. Tai KK, Goldstein SA: The conduction pore of a cardiac potassium channel. Nature 1998;391:605-608.