Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions.

Drug metabolism and pharmacokinetics

Volumn 19, Issue 5, 2004, Pages 339-351

  Naba, Hiroyasu ^a   Kuwayama, Chitose ^a   Kakinuma, Chihaya ^a   Ohnishi, Shuhei ^a   Ogihara, Takuo ^a  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABCC2 PROTEIN, RAT; ANION; CREATINE KINASE; FOLIC ACID ANTAGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHOTREXATE; PLASMA PROTEIN; PRAVASTATIN;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETICS; HALF LIFE TIME; HYPERBILIRUBINEMIA; MALE; METABOLISM; PATHOPHYSIOLOGY; PROTEIN BINDING; RAT; RAT STRAIN; SKELETAL MUSCLE; TOXICITY TESTING; WEIGHT GAIN;

ANIMALS; ANIONS; AREA UNDER CURVE; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD PROTEINS; CREATINE KINASE; DISEASE MODELS, ANIMAL; FOLIC ACID ANTAGONISTS; HALF-LIFE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERBILIRUBINEMIA; MALE; METHOTREXATE; MUSCLE, SKELETAL; PRAVASTATIN; PROTEIN BINDING; RATS; RATS, INBRED STRAINS; TOXICITY TESTS; WEIGHT GAIN;

EID: 16644364657     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.19.339     Document Type: Article

References (0)