Mutational analysis of the liver, colon and kidney of Big Blue® rats treated with 2-amino-3-methlylimidazo[4,5-f]quinoline

Carcinogenesis

Volumn 21, Issue 1, 2000, Pages 1-6

  Bol, Sandra A M ^a   Horlbeck, Janine ^a   Markovic, Jovanka ^a   De Boer, Johan G ^b   Turesky, Robert J ^a   Constable, Anne ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; AROMATIC AMINE; GUANINE; TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DOSE RESPONSE; GENE DELETION; GENE LOCUS; GENE MUTATION; KIDNEY; LIVER; MUTAGENICITY; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL PROTEINS; BASE SEQUENCE; CARCINOGENS; COLON; DNA ADDUCTS; ESCHERICHIA COLI PROTEINS; IMIDAZOLES; KIDNEY; LIVER; MALE; MUTAGENS; MUTATION; ORGAN SPECIFICITY; QUINOLINES; RATS; RATS, INBRED F344; REPRESSOR PROTEINS;

EID: 0033977633     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Sugimura, T. (1988) Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans. Mutat. Res., 205, 33-39.
2. Nagao, M. and Sugimura, T. (1993) Carcinogenic factors in food with relevance to colon cancer development. Mutat. Res., 290, 43-51.
3. Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. (1992) Food-derived mutagens and carcinogens. Cancer Res., 52 (suppl.), 2092s-2098s.
4. Takayama, S., Nakatsuru, Y., Masuda, M., Ohgaki, H., Sato, S. and Sugimura, T. (1984) Demonstration of carcinogenicity in F344 rats of 2-amino-3-methylimidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract. Gann, 75, 467-470.
5. Sugimura, T. (1985) Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. Mutat. Res., 150, 33-41.
6. Ohgaki, H., Takayama, S. and Sugimura, T. (1991) Carcinogenicities of heterocyclic amines in cooked food. Mutat. Res., 259, 399-410.
7. Adamson, R.H., Thorgeirsson, U., Snyderwine, E.G., Thorgeirsson, S.S., Reeves, J., Dalgard, D., Takayama, S. and Sugimura, T. (1990) Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques. Jpn. J. Cancer Res., 81, 10-14.
8. Yamazoe, Y., Shimada, M., Shinohara, A., Saito, K., Kamataki, T. and Kato, R. (1983) Microsomal activation of of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. Cancer Res., 43, 5768-5774.
9. Kato, R. (1986) Metabolic activation of mutagenic helerocyclic amines from protein pyrolysates. CRC Crit. Rev. Toxicol., 16, 308-347.
10. Turesky, R., Lang, N., Butler, M., Teitel, C. and Kadlubar, F. (1991) Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis, 12, 1839-1845.
11. Davis, C.D., Schut, H.A.J. and Snyderwine, E.G. (1993) Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats. Carcinogenesis, 14, 2091-2096.
12. Snyderwine, E.G., Roller, P.P., Adamson, R.H., Sato, S. and Thorgeirsson, S.S. (1988) Reaction of the N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosine-8-yl)-IQ. Carcinogenesis, 9, 1061-1065.
13. 2 atoms of guanine. Chem. Res. Toxicol., 5, 479-490.
14. Fruscoe, J.C., Wu, R., Shen, N.H., Healy, S.K. and Felton, J.S. (1988) Base chain analysis of revertants of the hisD3032 allele in Salmonella typhimurium. Mutat. Res., 201, 241-251.
15. Marwood, T.M., Meyer, D. and Josephy, P.D. (1995) Escherichia coli lacZ strains engineered for detection of frameshift mutations induced by aromatic amines and nitroaromatic compounds. Carcinogenesis, 16, 2037-2043.
16. Endo, H., Schut, H.A.J. and Snyderwine, E.G. (1994) Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline in the supF shuttle vector system. Cancer Res., 54, 3745-3751.
17. Broschard, T.H., Lebrun-Gardia, A. and Fuchs, R.P.P. (1998) Mutagenic specificity of the food mulagen 2-amino-3-methylimidazo[4,5-f]quinoline in Escherichia coli using the yeast URA3 gene as a target. Carcinogenesis, 19, 305-310
18. Lee, H. and Shih, M.-K. (1995) Mutational specificity of 2-amino-3-methylimidazo[4,5-f]quinoline in the hprt locus of CHO-K1 cells. Mol. Carcinog., 13, 122-127.
19. Leong-Morgenthaler, P.M., Op Het Velt, C., Jaccaud, E. and Turesky, R.J. (1998) Mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in human lymphoblastoid cells. Carcinogenesis, 19, 1749-1754.
20. Leong-Morgenthaler, P.M. and Holzhauser, D (1995) Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine (PhIP) in human lymphoblastoid cells. Carcinogenesis, 16, 713-718.
21. Kohler, S.W., Provost, S.G., Fieck, A., Kretz, P.L., Bullock, W.O., Putman, D.L., Sorge, J.A. and Short, J.M. (1991) Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ. Mol. Mutagen., 18, 316-321.
22. Dycaico, M.J., Provost, S. G., Kretz, P.L., Ransom, S.L., Moores, J.C. and Short, J.M. (1994) The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat. Res., 307, 461-478.
23. Fang, F. and Strobel, H. (1978) Activation of carcinogens and mutagens by rat colon mucosa. Cancer Res., 38, 2939-2944.
24. de Boer, J.G., Erfle, H.L., Walsh, D., Holcroft,J. and Glickman, B.W. (1996) The use of lacl transgenic mice in genetic toxicology. In Pfeifer, G.P. (ed.) Technologies for Detection of DNA Damage and Mutations. Plenum Press, New York, NY, pp. 411-429.
25. Turesky, R.J. and Markovic, J. (1995) DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in liver, kidney and colo-rectum of rats. Carcinogenesis, 16, 2275-2279.
26. Turesky, R.J., Markovic, J. and Aeschlimann, J.-M. (1996) Formation and differential removal of C-8 and N2-guanine adducts of the food carcinogen of 2-amino-3-methylimidazo[4,5-f]quinoline in the liver, kidney and colorectum of the rat. Chem. Res. Toxicol. 9, 397-402.
27. Davis, C.D., Dacquel, E., Schut, H.A.J., Thorgeirsson, S.S. and Snyderwine, E.G. (1996) In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta-Mice® and c-mycllacZ double transgenic mice. Muter. Res., 356, 287-296.
28. Suzuki, T., Itoh, T, Hayashi, M., Nishikawa, Y., Ikezaki, S., Furukawa, F., Takahashi, M. and Sofuni, T. (1996) Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue® mice. Environ. Mol. Mutagen., 28, 348-353.
29. deBoer, J.G., Mirsalis, J.C., Provost, S.G., Tindall, K.R. and Glickman, B. W. (1996) Spectrum of mutations in kidney, stomach and liver from lacl transgenic mice recovered after treatment with Tris (2,3-dibromopropyl) phosphate. Environ. Mol. Mutagen., 28, 418-423.
30. Okonogi, H., Stuart, G.R., Okochi, E., Ushijima, T., Sugimura, T., Glickman, B.W. and Nagao, M. (1997) Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacl transgene. Mutat. Res., 395, 93-99.
31. Okonogi, H., Ushijima, T., Zhang, X. B., Heddle, J. A., Suzuki, T., Sofuni, T., Felton, J.S., Tucker, J.D., Sugimura, T. and Nagao, M. (1997) Agreement of mutational characteristics of heterocyclic amines in lad of the Big Blue® mouse with those in tumour related genes in rodents. Carcinogenesis, 18, 745-748.
32. Ushijima, T., Hosoya, Y., Ochiai, M., Kushida, H., Wakabayashi, K., Suzuki, T. Hayashi, M., Sofuni, T., Sugimura, T. and Nagao, M. (1994) Tissue specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of transgenic mice. Carginogenesis, 15, 2805-2809.
33. Ochiai, M., Ishida, K., Ushijima, T. Suzuki, T., Sofuni, T., Sugimura, T. and Nagao, M. (1998) DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue® mice does not correlate with mutagenicity. Mutagenesis, 13, 381-384.
34. Nagao, M., Fujita, H., Ochiai, M., Wakabayashi, K., Sofuni, T., Matsushima, T., Sugimura, T. and Ushijima, T. (1998) No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of the Big Blue® mice. Mutat. Res., 400, 251-257.
35. Suzuki, T., Hayashi, M., Ochiai, M., Wakabayashi, K., Ushijima, T., Sugimura, T., Nagao, M. and Sofuni, T. (1996) Organ variation in the mutagenicity of MeIQ in Big Blue® lacl transgenic mice. Mutat. Res., 369, 45-49.
36. Makino, H., Ochiai, M., Caignard, A., Ishizaka, Y., Onda, M., Sugimura, T. and Nagao, M. (1992) Detection of Ha-ras point mutation by polymerase chain reaction single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline induced mouse forestomach tumors. Cancer Lett., 62, 115-121.
37. Kudo, M., Ogura, T., Esumi, H. and Sugimura, T. (1991) Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines. Mol. Carcinog., 4, 36-42.
38. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. (1995) Specific 5′-GGGA-3′ → 5′-GGA-3′ mutation of the Apc gene in rat colon tumours induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc. Natl Acad. Sci. USA, 92, 910-914.
39. Nagao, M., Wakabayashi, K., Ushijima, T., Toyota, M., Totsuka, Y. and Sugimura, T. (1996) Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals. Environ. Health Perspect., 104, 497-501.
40. Takahashi, M., Minamoto, T., Sugimura, T. and Esumi, H. (1993) High frequency and low specificity of ras gene mutations in rat Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis, 14, 1355-1357.
41. Makino, H., Ishizaka, Y., Tsujimoto, A., Nakamura, T., Onda, M., Sugimura, T. and Nagao, M. (1992) Rat p53 gene mutations in primary Zymbal gland tumours induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. Proc. Natl Acad. Sci. USA, 89, 4850-4854.
42. Skopek, T.R. (1998) Transgenic mutation models: research, testing, and reality checks. Environ. Mol. Mutagen., 32, 104-105.