Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Journal of Lipid Research

Volumn 47, Issue 9, 2006, Pages 1950-1958

  Okazaki, Hiroaki ^a   Tazoe, Fumiko ^e   Okazaki, Sachiko ^a   Isoo, Naoyuki ^a   Tsukamoto, Kazuhisa ^a   Sekiya, Motohiro ^a   Yahagi, Naoya ^a   Iizuka, Yoko ^a   Ohashi, Ken ^a   Kitamine, Tetsuya ^a   Tozawa, Ryu Ichi ^a   Inaba, Toshihiro ^e   Yagyu, Hiroaki ^e   Okazaki, Mitsuyo ^b   Shimano, Hitoshi ^c   Shibata, Norihito ^d   Arai, Hiroyuki ^d   Nagai, Ryo Zo ^a   Kadowaki, Takashi ^a   Osuga, Jun Ichi ^a   Ishibashi, Shun ^a,e   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

3 hydroxy 3 methyglutaryl CoA reductase; Adenovirus; Cell proliferation; Farnesyl diphosphate; Feedback regulation; Hepatomegaly; Hyperlipoproteinemia; Lipoprotein; Mevalonate

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; KI 67 ANTIGEN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SQUALENE SYNTHASE; TYLOXAPOL; VERY LOW DENSITY LIPOPROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE TRANSFER; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIPOPROTEIN BLOOD LEVEL; LIVER; LIVER CELL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ACYL COENZYME A; ADENOVIRIDAE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BODY WEIGHT; CHOLESTEROL; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HYPERCHOLESTEROLEMIA; IN SITU NICK-END LABELING; LIPID METABOLISM; LIPIDS; LIPOPROTEINS; LIPOPROTEINS, VLDL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33748745482     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600224-JLR200     Document Type: Article

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