Endotoxin-induced liver hypoxia: Defective oxygen delivery versus oxygen consumption

Nitric Oxide - Biology and Chemistry

Volumn 6, Issue 1, 2002, Pages 18-28

  James, Philip E ^a   Madhani, Melanie ^a,b   Roebuck, William ^b   Jackson, Simon K ^a   Swartz, Harold M ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

EPR; Hypoxia; Liver; Sepsis

Indexed keywords

ENDOTOXIN; INTERLEUKIN 13; N(G) METHYLARGININE; NITRIC OXIDE; LIPOPOLYSACCHARIDE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HEART OUTPUT; LIVER BLOOD FLOW; LIVER ISCHEMIA; LIVER SINUSOID; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SEPTIC SHOCK; TISSUE OXYGENATION; ANIMAL; ANOXIA; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; ELECTRON SPIN RESONANCE; HEMODYNAMICS; LIVER DISEASE; MALE; METABOLISM; PATHOLOGY; PRESSURE;

ANIMALS; ANOXIA; DISEASE MODELS, ANIMAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTOXINS; HEMODYNAMIC PROCESSES; INTERLEUKIN-13; LIPOPOLYSACCHARIDES; LIVER DISEASES; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; OMEGA-N-METHYLARGININE; OXYGEN; PARTIAL PRESSURE; SHOCK, SEPTIC;

EID: 0036330723     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2001.0383     Document Type: Article

References (31)

1. Nitric oxide and septic shock
2. Protective and pathological roles of nitric oxide in endotoxic shock
3. Tissue oxygenation and perfusion in endotoxemia
4. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats
5. A role for nitric oxide in liver inflammation and infection
6. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
7. Inhibition of nitric oxide synthesis improves survival in murine peritonitis model of sepsis that is not cured by antibiotics alone
8. Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension?
9. Nitric oxide synthases: Roles, tolls, controls
10. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo
11. Renal oxygenation during endotoxemia as monitored by in vivo EPR oximetry and MR imaging
12. 2 from tissue by in vivo EPR
13. Gloxy: An oxygen-sensitive coal for accurate measurement of low oxygen tensions in biological systems
14. 2 in liver using EPR oximetry
15. Unique in vivo applications of spin traps
16. Direct measurement of nitric oxide generation from nitric oxide synthase
17. Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron complexes distinguishes nitric oxide and nitroxyl anion in a redox-dependent manner: Applications in identifying nitrogen monoxide products from nitric oxide synthase
18. Validation of 1- and 2-mm transit-time ultrasound flow probes on mesenteric artery and aorta of rats
19. Optimized steps in fluorometric determination of thiobarbituric acid reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage
20. A fluorometric assay for the measurement of nitrite in biological samples
21. The role of nitric oxide in Kupffer cell-hepatocyte interactions
22. Inhibition of iNOS expression by IL-4 and IL-13 in human lung epithelial cells
23. Oxygen uptake in septic shock
24. Effect of modifying nitric oxide pathway on liver circulation in a rabbit endotoxin shock model
25. Abnormal vascular tone, defective oxygen transport and myocardial failure in human septic shock
26. Alterations in metabolite levels in carbohydrate and nergy metabolism of rat in haemorrhagic shock and sepsis
27. The cell, the mitochondrion, oxygen and sepsis
28. 2 in mouse liver in vivo by EPR oximetry using india ink
29. Expression of hypoxia-inducible factor 1: Mechanisms and consequences