Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase

Hypertension

Volumn 47, Issue 1, 2006, Pages 87-94

  Bevers, Lonneke M ^a   Braam, Branko ^a   Post, Jan Andries ^b   Van Zonneveld, Anton Jan ^c   Rabelink, Ton J ^c   Koomans, Hein A ^a   Verhaar, Marianne C ^a   Joles, Jaap A ^a,d  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Department of Nephrology and Hypertension F03223 ^*  (Netherlands)

Author keywords

Endothelium; Nitric oxide

Indexed keywords

4,5 DIAMINOFLUORESCEIN DIACETATE; ARGININE; DICHLORODIHYDROFLUORESCEIN DIACETATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TETRAHYDROBIOPTERIN; VASCULOTROPIN;

ARTERY; ARTICLE; ATHEROSCLEROSIS; CELL STIMULATION; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRON TRANSPORT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT RESPONSE;

ANTIOXIDANTS; ARGININE; BIOPTERIN; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; REACTIVE OXYGEN SPECIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 31744447370     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000196735.85398.0e     Document Type: Article

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