A macrokinetic and regulator model for myeloma cell culture based on metabolic balance of pathways

Process Biochemistry

Volumn 41, Issue 10, 2006, Pages 2207-2217

  Zhou, Feng ^a   Bi, Jing Xiu ^b   Zeng, An Ping ^c   Yuan, Jing Qi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b INSTITUTE OF PROCESS ENGINEERING   (China)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Metabolic pathways; Metabolic shift; Myeloma; Regulator model; Stoichiometric model

Indexed keywords

BIODIVERSITY; BIOREACTORS; ENZYME KINETICS; METABOLISM;

METABOLIC PATHWAYS; METABOLIC SHIFTS; MYELOMA; REGULATOR MODELS; STOICHIOMETRIC MODELS;

CELL CULTURE;

EID: 33748575874     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2006.08.001     Document Type: Article

References (46)

1. Miller W.M., Blanch H.W., and Wilke C.R. A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: effect of nutrient concentration, dilution rate, and pH. Biotechnol. Bioeng. 32 (1988) 947-965
2. Miller W.M., and Blanch H.W. Regulation of animal cell metabolism in bioreactors. In: Ho C.S., and Wang D.I.C. (Eds). Animals Cells Bioreactors (1991), Butterworth-Henemann, Stoneham, MA 119-161
3. Zupke C., Sinskey A.J., and Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridoma. Appl. Microb. Biotechnol. 44 (1995) 27-36
4. Ljunggren J., and Haggstrom L. Specific growth rate as a parameter for tracing growth-limiting substances in animal cultures. J. Biotechnol. 42 (1995) 163-175
5. Zeng A.-P. Quantitative assessment of cell density effect on the metabolism and antibody production rate of hybridoma cells at high cell density. J. Biotechnol. 45 (1996) 243-251
6. Zeng A.-P., Deckwer W.-D., and Hu W.-S. Determinant and rate laws of growth and death of hybridoma cells in continuous culture. Biotechnol. Bioeng. 57 (1998) 642-654
7. Portner R., and Schafer T. Modeling hybridoma cell growth and metabolism-a comparison of selected models and data. J. Biotechnol. 49 (1996) 119-135
8. Bibila T., and Flickinger M.C. A structured model for monoclonal antibody synthesis in exponentially crowing and stationary phase hybridoma cells. Biotechnol. Bioeng. 37 (1991) 210-226
9. Sanderson C.S., Barford J.P., and Barton G.W. A structured, dynamic model for animal cell culture system. Biochem. Eng. J. 3 (1999) 203-211
10. Sanderson C.S., Barford J.P., and Barton G.W. A structured, dynamic model for animal cell culture system: application to murine hybridoma. Biochem. Eng. J. 3 (1999) 213-218
11. Sanderson C.S., Barford J.P., and Barton G.W. A structured, dynamic model for animal cell culture: application to baculovius/insect cell system. Biochem. Eng. J. 3 (1999) 219-229
12. Namjoshi A.A., Hu W.-S., and Ramkrishna D. Unveiling steady-state multiplicity in hybridoma cultures: the cybernetic approach. Biotechnol. Bioeng. 81 (2003) 80-91
13. K.H. Bellgardt, Modellbildung des wachstums von Saccharomyces cerevisiae in ruehrkesselreaktoren. PhD thesis, University of Hannover, 1983.
14. Pham H.T.B., Larsson G., and Enfors S.-O. Growth and energy metabolism in aerobic fed-batch cultures of Saccharomyces cerevisiae simulation and model verification. Biotechnol. Bioeng. 60 (1998) 474-482
15. Ren H.T., Yuan J.Q., and Bellgardt K.H. Macrokinetic model for methylotrophic Pichia pastoris based on stoichiometric balance. J. Biotechnol. 106 1 (2003) 53-68
16. Xie L.Z., and Wang D.I.C. Material balance studies on animal cell metabolism using a stoichiometrically based reaction network. Biotechnol. Bioeng. 52 (1996) 579-590
17. Xie L.Z., and Wang D.I.C. Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network. Biotechnol. Bioeng. 52 (1996) 591-601
18. Bonarius H.P.J., Hatzimanikatis V., Meesters K.P.H., de Gooijer C.D., Schmid G., and Tramper J. Metabolic flux analysis of hybridoma cells in different culture media using mass balances. Biotechnol. Bioeng. 50 (1996) 299-318
19. 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing. Biotechnol. Bioeng. 74 (2001) 529-538
20. Korke R., de Leon G.M., Lau A., Lei Y., Lim J.W.E., Seow T.K., Chung M.C.M., and Hu W.-S. Large scale gene expression profiling of metabolic shift of mammalian cells in culture. J. Biotechnol. 107 (2004) 1-17
21. Sanfeliu A., Paredes C., Cairo J.J., and Godia F. Identification of key patterns in the metabolism of hybridoma cells in culture. Enzyme Microb. Technol. 21 (1997) 421-428
22. Zhou W., Rehm J., Europa A., and Hu W.-S. Alteration of mammalian cell metabolism by dynamic nutrient feeding. Cytotechnology 14 (1997) 99-108
23. Follstad B.D., Balcarel R.R., Stephanopoulous G., and Wang D.I.C. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnol. Bioeng. 63 (1999) 675-683
24. Europa A.F., Gambhir A., Fu P.-C., and Hu W.-S. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells. Biotechnol. Bioeng. 67 (2000) 25-34
25. Zhou W., Chen C.C., Buckland B., and Aumins J. Fed-batch culture of recombinant NS0 myeloma cells with high monoclonal antibody production. Biotechnol. Bioeng. 55 (1997) 783-792
26. Xie L.Z., and Wang D.I.C. Stoichiometric analysis of animal cell growth and its application in medium design. Biotechnol. Bioeng. 43 (1994) 1164-1174
27. 13C NMR. Biotechnol. Bioeng. 45 (1995) 292-303
28. C. Zupke, Metabolic flux analysis in mammalian cell culture. PhD thesis, Massachusetts Institute of Technology, 1993.
29. Paredes C., Sanfeliu A., Cairo J.J., and Godia F. Estimation of the intracellular fluxes for a hybridoma cell line by material balances. Enzyme Microb. Technol. 23 (1998) 187-198
30. Pirt S.J. The maintenance energy of bacteria in growing culture. Proc. R. Soc. Lond. Ser. B: Biol. Sci. 163 (1965) 224-231
31. Dalili M., Sayles G.D., and Ollis D.F. Glutamine-limited batch hybridoma growth and antibody production: experiment and model. Biotechnol. Bioeng. 36 (1990) 74-82
32. Lei F., Rotboll M., and Jorgensen S.B. A biochemically structured model for Saccharomyces cerevisiae. J. Biotechnol. 88 (2001) 205-221
33. Provost A., and Bastin G. Dynamic metabolic modeling under the balanced growth condition. J. Proc. Cont. 14 (2004) 717-728
34. Jeong Y.-H., and Wang S.S. Role of glutamine in hybridoma cell culture: effects on cell growth, antibody production, and cell metabolism. Enzyme Microb. Technol. 17 (1995) 47-55
35. Banik G.G., and Heath C.A. Hybridoma growth and antibody production as a function of cell density and specific growth rate in perfusion culture. Biotechnol. Bioeng. 48 (1995) 289-300
36. Bellgardt K.H., Meyer H.D., Kuhlmann W., Schuegerl K., and Thoma M. Application of an extended Kalman filter for state estimation for state estimation of a yeast fermentation. IEEE Proc. 133 (1986) 226-241
37. Schneider M., Alaoui M.E.I., von Stokar U., and Marison I.W. Batch cultures of a hybridoma cell line performed with in situ ammonia removal. Enzyme Microb. Technol. 20 (1997) 268-276
38. Bonarius H.P.J., Houtman J.H.M., de Gooijer C.D., Tramper J., and Schimid G. Activity of glutamate dehydrogenase is increased in ammonia-stressed hybridoma cells. Biotechnol. Bioeng. 57 (1998) 447-453
39. Simpson N.H., Singh R.P., Perani A., Goldenzon C., and Rubeai M.A. In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene. Biotechnol. Bioeng. 59 (1998) 90-98
40. Tinto A., Gabernet C., Vives J., Prats E., Cairo J.J., Cornudella L., and Godia F. The protection of hybridoma cells from apoptosis by caspase inhibition allows culture recovery when exposed to non-inducing conditions. J. Biotechnol. 95 (2002) 205-214
41. Zeng A.-P., and Bi J. Cell culture kinetics and modeling. In: Ozturk S.S., and Hu W.-S. (Eds). Cell Culture Technology for Pharmaceutical and Cellular Therapies (2005), Taylor and Francis Group, Atlanta 299-347
42. Claes J.E., and Van Impe J.E. Combining yield coefficients and exit-gas analysis for monitoring of the baker's yeast fed-batch fermentation. Bioproc. Eng. 22 (2000) 195-200
43. Nelder R., and Mead J.A. A simplex method for function minimization. Comput. J. 7 (1965) 308-313
44. Zeng A.P., Ross A., and Deckwer W.-D. A method to estimate the efficiency of oxidative phosphorylation and biomass yield from ATP of a facultative anaerobe in continuous culture. Biotechnol. Bioeng. 36 (1990) 965-969
45. Fontaine E.M., Devin A., Rigoulet M., and Leverve X.M. The yield of oxidative phosphorylation is controlled both by force and flux. Biochem. Biophys. Res. Commun. 232 (1997) 532-535
46. Kadenbach B. Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Biochim. Biophys. Acta 1604 (2003) 77-94